NUCLEIC ACIDS

• To name a nucleoside derived from a pyrimidine base, use

the suffix “-idine”.

• To name a nucleoside derived from a purine base, use the

suffix “-osine”.

• For deoxyribonucleosides, add the prefix “deoxy-”.

DNA – Deoxyribonucleic Acid
LEVELS OF DNA STRUCTURE
RIBONUCLEIC ACID (RNA)
Central Dogma of
Molecular Biology
The flow of information from
DNA to RNA to protein.
INITIATION
• Unwinding by HELICASES
• These enzymes bind to ssDNA near
the replication fork and then move
into the neighboring double-stranded
region, forcing the strands apart (in
effect, unwinding the double helix)
• During replication with the fork, the
helix destabilizing proteins bind to
the single-stranded regions
preventing the strands from rejoining.
ELONGATION
Via DNA Polymerase
TERMINATION
Mediated by sequence-specific binding of protein Tus
(terminus utilization substance) to replication (ter) sites on
the DNA, stopping the movement of the replication fork.