Prosthetic

C- floxaein)
endocarditis
•

CIDAL
Rifampicin (TB)
who DNA gyrase
⊖
.

' value

"B¥%fpolymerase
.

DNA dependent
.

*
-011:#
Daptomycin →
celtmenhomeb-g.ph ( n-hinfg-g.si?jks7
•

Polymyxin TIDAL
◦

② ,
_
305 .

Trimethoprim
ng↑gµ*☒ 5zs MRÑA streptomycin
THEA
•
1-

→ ↳

sulfonamide DHEA Capromyscin

%AY"ʰaʰ Protein KANA mycin

Dihtduoptenidine }
PABA *
thesis .

AMIKAC.in
%aaye.in
want to cross -50
50g
of

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Lots -

Linezolid CIDAL
•

•
Vance •
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erythromycin

Yfct ᵈindamyeiⁿ
↳

.
www.moein
Azithromycin
Trimethoprim -

Pethidine
analog" -

bacteriostatic
•
lluinpuistinffidal
Dalfopuistin .

↳ used combined cidal [ lotuimexagol] •

chloramphenicol
effect
.

Italic
-

te
influenza Cida
↳ .
-

Ff -

Cida .

Aminoglycosides -

Cida .

Mostly all protein synthesis .

are STATIC .

Pneumosistic Jiroveci in HIV pt .

eotgeimexayal CIDAL
synergistic effect
→
; →
.

- -
→

Trimethoprim ¢ .
→
Septum . .
.
.
etc .

Doe
80mm 400mg .
No randiest
1 : 5 •

Respi infection .

•
STD , GIT , Peeotatitis .

I
?⃝
?⃝
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"

t Grey Baby sign

"
-
.

5. E. : Nausea &
Vomiting
-

New Born
"

Kernicterus
"

Karina yellow baby syndrome

Cry in
•

for Ashwaria Geystéduuia & Renal

toxicity
•

Anemia -

Hemolytic in GGPD pts .

SIS
•

Rashes
•

HPS reaction - → MC S E seen

-
.

Contraindications : -
•
in & NB
Porphyria
pregnancy
-

Karina
got Phin Sa Pts renal
failure /pre excising renal stone
•

in -

④ REGS •

GGPD pts
•

Sulpha drug allergy

Floscacim -

DNA
gyrase
inhibitor .

→ Doc
- i -

Anthrax .

→
Me utilized
Shorted +42 hrs
Ciprofloxacin 3-4
→

breathe
.

0M Love U are

}
my
Leprosy
←
.

0
flonacin TB)
respiratory EQ leg
.

aka .
-

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QTR Cpuolongation
floracin
.

two -

PE
flonacin
Gati flonacin
Spare flonacir
Germi
floroacin
 ʳʰ
Use : -

5. E- : -

DOC UTI
NIU
• -

"" ᵗᵗᵈᵗ
%ᵈᵗ ☐ ""
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Photosensitivity
•

TB FQ
Respiratory
:

↳
Max afuo SPAR
#acin
Leprosy oflonacin Dgsphycemia
: •
.

alwbeatiflooeacin
only eyedropform .

•
Tendinitis .
Arthuopathy
↓
Tendon Rupture !
"

Rifampicin -

RNA polymerase inhibitor .

B- Lactams Dn
-

"

Cefazolin Cefoperozone
-
'
•

µ Fi Gynw;¥ Pseudomonas
/
-

EfEÑme
'

Cephalexin
•
•

Anerobe
ii.
Éfuneximé
-

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•

PCCM Cephalosporin .tt#-eta-n--EieEanoTinceftobimeoegoeilRS.tt#

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•

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a%ram

/
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-

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-

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thetas :/Inactive
! rarity metabolic

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beta comi
penem
.

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atiniihnaldihydnonertidase
inhibitor -0

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Nam
1.
Gem ive infection
axoegicrt.asattertiuefaw.g.gg?7fidfem&#
use
.

-
-

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→
Zteeeonam .

.
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* ☒ "" ° "
Mahatma Gandhi
"
"" °"

M Meningitis Chisteuio
-
"
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catheter assoc .
: staph _ Enidermidis .

infection .

G Gonorrhea 5 /E. Nausea µ Puff : Oral route -

Psuedoimanb colitis : .

Ccommunity A9•PD
Difficile
↓
( CAM
Ofo toxicity
U
org
.

. ↳ : : -

Renal toxicity 3ʳᵈ

Gw gen cephalosporins
•

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chancroid "

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risk
.

apu .
.

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, ,

:
Metronidazole
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from histamine .

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Doc -

Meningococcal inf .

,
Anthrax , Syphilis ,
Tetanus (Doc : -

Metronidazole)
(Doc
Ceftriaxone
-

Puff : -

Gonorrhea ,
Actinomycosis ,

☆ Antibiotics of choice in Penicillin

Allergy
↳
Macrolides .
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a­
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to Map .

Act
.

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{
cover
org
-

•
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.
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•
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A 21-0
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¥
•

•
PIPERA
AMPI/ AMOXICILLIN
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Vancomycin
↓
.

② resistance

VRsA_
Doc : -

Daptomycin (cell membrane ⊕ )

 .
1

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-2020
'

Old RNTCP

Duration ↓ ( 6- 18m )
•
24 -

30m .

↓ 6- 9
#
drugs moinj
• •

PO
drugs C. 30
.si/AminoglyeideD
•

/
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# Lsoniazind ( H )
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Pyraiginamide (2)
1
sensitive
Drug Drug resistance .

I
6m
MDRTB
/\
'
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Elhanbutol .

(E)
I
'
C. F- 4m Resistance
'
I. F- 2m l
Multidrug resistance c-
-

I
I

"
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i
H H Resistance I +
-

c-

R
I ☒ / #
i IFQ
I
+
I
E ,
1- 2ⁿᵈ line injectable
2 I , Regimen !
'

/ -

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1 short Long IP
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,

ageeogr
•

Prey Pt .
•

•
swerentra E- Ethionamide
/ 9- 12m Blinking cavitation
6¥
•

tlighdosl
- •
has taken tY2
I -

INH -

Regimen
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BPAL Regimen I OPD
?

] }
isonizine -

←
4- 6m CP=4 -6m
BedaquilinealwBT↑ / IP C- clofazimine
-

Puetomanid } -

I G-
cintenciue) continuous?

drug ) (
sedrug) L -

Leuofloxaein
Linrezolid I
' E- Elhambutol
for in-patient for OPD
-
-
-

p-pynaginami.de
-
-
-
-
- -

ECA Electrolyte imbalance ?

-

Ino : -

,
 Long
/ -
CP -12m
IP 6m
Csedaugjg
-

cat A
↓
hinezolid
.
:

Leoofloxoein
→
BDQ *
- -
- - - - - - -
-

cat B :
cyclo serine
}
.

anyone
.

CAYDceofazime.me

5-
streptomycin .

highest
2- dose -

MI

cell wall made

is
apof my
colic acid /
aeeavinoglgcin .

↳ CIDAL
effect .
↓
IWM ,ÉP¥Ye
Kat-
G
Active .

th
Eez same reaction but difference is 2 →
works

from inside the cell .

tuberculostatie
P -

PAS

E- Ethambwtol

E- Ethionamide
C-
Cycloserine
T -

thia
 acid synth -0 a. dal
} my colic
→
→

granite ⊖
ATP synthase
fly perfusion .

⑧mmHg BP : E-

42%0
<80- =
?
Elevated BP
120<-81,21 mmHg
:

and

HTN
:oy13 ÷ mmHg
I .

MTN
≥a!ʰ÷ mmHg
#
:*
.

Drugs
1-
in-line 2ⁿᵈtine_
Blocker
ACE ⊖ / ARB a-

B- Blocker
'

CCB clonidine a- Methyldona

,
Lt , -
Blocker)
* Diuretics

☆ Thiazide Dilators -

Nitrates
Kt channel opener
-
-
 NICE Guideline
Age
- -
< >
55gr 55yr .

A / A CID
steps : -

voices '¥nse Caftoe Trying [aroudoe -12m] )

→
.
.

steps Atc or Atd Dose

opimization
: -

IN .R

step 3 : -

At C + D

↓NR
Resistance HTN

Steph : -

Doc :
Spironolactone
↳
Add others :& # 1ps # / Dilators
→ .

ACE -0 ( Pret ) ARB ( Sartan) CCB

@ Heart
/ \NonDµpi ,
.

Capt pail Losautan

@
↳HP 's Verapamil -
-

Doc SVT
Lisino Telmi "
canine
Diltiazen
'
i

Rami Val "

i.
Amlodipine ,

c. Emo ' '

Niefidinine
i. '
Nicardipine Doc HTN
emergency
-
-

i. Nimodipine -
Doc -
SAH

Diuretics (Thiazide) Na ce -0
-

eotrampalin
-
-

part Det
@
early of
Hydro chlorothiazide
Chlorthalidone
Indapamide
Metolazone .
 di -

Blocker : PRA eosin

Tera -

Blocker Metro 101

B -
:

Ateneo 101 .

MTN in
Dreg
-
used
- Avoid .
ACE -0 / ARB
D
Lady Labetalol Diuretics
Non Dtepb
-

N Nat Nitropuusside
Hardinge thgdralazine
Med d-
Methyl dopa , Clonidine B B#
-

Non-selective B #
" "

College CCB -

DHP 's _ Dipine .

Cardio select:-B #

When to Start ?

Pté CVD Risk Pt -e without CVD risk .

or

Stant :
-

2130/380 mmHg
- -
71401%90
- - - - - -
-
- - -
- -
-
-

¥- mmHg
Maintain :
< .
 Tot
PUD .

a.a. Peptic Ulcer ¥[PUD).j

↓ NSAIDs
Ñ↑t* PGE, pp -0
PGEz-N§•*
_

Ttecoj secretion
_

PP .

¥ vD→ washout

"→ʰ3¥É mock og
-

Ach inge
Him
{⊕ ↑
Gastrin .

Histamine

Prolongs NSAIDs % NSAIDs induced PUD .

•
Rx : -

Proton pump inhibitor

Omepeeazok Specified
Pantopragole Misoprostol
( PGE ⊕)
Esomepragole (NSAID indued
,

Rabe
prazole P
not
Lansoprazole in
preganey
dominance
Dexlansoprazole
DOC : -
GERD

NSAID induced PUD

ZES /Gastrinoma
PUD
?⃝
 60 mins
OD
before 30 -
-

Mi
antagonist
-

Pirenzepine
Telemzepine .

H2 blocker -

Ranitidine
Famotidine ( most potent)
Nigatidine
Loxatidine .

Constipation)
Almy dioxide
Other : -

Antacids f
↓ Mg Hydroxide
C diarrhea)

fastest pain reliving

drug in PUD .

BISMUTH compound .

-
ulcer protector .

CBS -

colloidal Bismuth Sub salicylate

BSP-B-ismulhsulseitratekt.IM
Pylori therapy
H .

she :
Tongue Blackening
-

" :
stool
Therapies : -

1-
Triple Quadruple

AÑᵗp.pt#e
{ Clauilhromycin
Amoxicillin
M
PPI
Tetracycline
•

+
+

¥0s -0
Metronidazole
+ CBS
" "
CAMP
Duration :-10 -

KD .

continue PPI
wks
after 4-6
after
therapy .

FMG solution (Boob)