BIOKIMIA GIZI 2020

ASAM NUKLEAT
DE NOVO PATHWAYS PURIN
1. α-D-Ribosa 5-fosfat (I)
(+) = ATP & Mg2+ + enzim PRPP sintase
(-) = AMP
 PRPP atau Phosphorribosyl pyrophosphate (II)
2. PRPP/Phosphorribosyl pyrophosphate (II)
(+) = Glutamine & H2O + enzim PRPP glutamul amidotransferase
(-) = Glutamate & PP
 5-Phospho-β-D-Ribosylamine (III)
3. 5-Phospho-β-D-Ribosylamine (III)
(+) = ATP & Mg2+ + glycine
(-) = ADP + P
 Glyclnamide ribosyl-5-phosphate (IV)
4. Glyclnamide ribosyl-5-phosphate (IV)
(+) = N5.N10 Methenyl H4 folate + enzim formyltransferase
(-) = H4 folate
 Formylglycinamide ribosyl-5-phosphate (V)
5. Formylglycinamide ribosyl-5-phosphate (V)
(+) = Gln? & ATP & Mg2+ + enzim VI synthetase
(-) = glu
 Formylglycinamidine ribosyl-5-phosphate (VI)
6. Formylglycinamidine ribosyl-5-phosphate (VI)
(+) = ATP & Mg2+ + ring closure + enzim VII synthetase
(-) = H2O
 Formylglycinamidine ribosyl-5-phosphate (VI)
7. Aminoimidazole ribosyl-5-phosphate (VII)
8. Aminoimidazolecarboxylate ribosl-5-phosphate (VIII)
9. Aminoimidazole syccinyl carboxamide ribosyl-5-phosphate (IX)
10. Aminoimidazole carboxamide ribosyl-5-phosphate (X)
11. Formimidoimidazole carboxamide ribosyl-5-phosphate (XI)
12. Inosine monophosphate/IMP (XII)

DE NOVO PATHWAYS PURIN