GTS 161 - TUTORIAL 5 ASSIGNMENT - 2020

SU 5: PIERCE: CHAPTER 6 P 168 – 171.

6.3 Pedigree of a person with Waardenburg syndrome. The proband (P) is the person from whom
this pedigree is initiated. (In this pedigree) Waardenburg syndrome is inherited as an autosomal
dominant trait. The syndrome is characterized by deafness, fair skin, visual problems, and a white
forelock.

20. Consider the pedigree shown in Figure 6.3.

a. If individual IV-7 married a person who was unaffected with Waardenburg syndrome, what is the
probability that their first child would have Waardenburg syndrome? Explain your reasoning.

ADDITIONAL QUESTIONS

i. Provide genotypes for individuals III-4 and IV-4 in this pedigree. Use A/a to represent the alleles
of the gene that causes Waardenburg syndrome.
ii. The father of two children has Waardenburg syndrome. The son has fair skin and a white forelock
but is otherwise phenotypically normal. The daughter is completely deaf and blind. Assuming that
the Waardenburg allele inherited by the daughter is the same allele as was inherited by the son,
what is the correct term for this phenomenon?

23. A man with a specific unusual genetic trait marries an unaffected woman and they have four
children. Pedigrees of this family are shown below, but the presence or absence of the trait in the
children is not indicated. For each type of inheritance redraw the pedigree below, and indicate how
many children of each sex are expected to express the trait by filling in the appropriate circles and
squares. Assume that the trait is rare and fully penetrant.

a. Autosomal recessive trait

b. Autosomal dominant trait
c. X-linked recessive trait
d. X-linked dominant trait
e. Y-linked trait

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25. The trait represented in the following pedigree is expressed only in the males of the family. Is the
trait Y-linked? Why or why not? If you believe that the trait is not Y-linked, propose an alternative
explanation for its inheritance.

27. The following pedigree illustrates the inheritance of ringed hair, a condition in which each hair is
differentiated into light and dark zones. What mode or modes of inheritance are possible for the
ringed hair trait in this family? Please answer in the format specified under Additional questions
below.

ADDITIONAL QUESTIONS

i. For each of the following modes of inheritance, determine whether it is a possible mode of
inheritance and give a reason for your answer.

a. Autosomal recessive trait

b. Autosomal dominant trait
c. X-linked recessive trait
d. X-linked dominant trait

31. On the basis of concordance shown in Table 6.2, is variation in rheumatoid arthritis influenced by
genetic factors, environmental factors, or both? Explain your answer.

Additional questions:
i. Answer the question above (31) for cancer based on concordance in Table 6.2.

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SU 6: PIERCE CHAPTER 7 p 209 – 211.

2. In a testcross for two genes, what types of gametes are produced with (a) complete linkage, (b)
independent assortment, and (c) incomplete linkage?

3. What effect does crossing over have on linkage?

4. Why is the frequency of recombinant gametes always half the frequency of crossing over?

19. Alleles A and a occur at a locus that is located on the same chromosome as a locus with alleles B
and b. Aa Bb is crossed with aa bb, and the following progeny are produced:

Aa Bb 5
Aa bb 45
aa Bb 45
aa bb 5

What conclusions can be made about the arrangement of the genes on the chromosome in the Aa
Bb parent?

22. In tomatoes, dwarf (d) is recessive to tall (D) and opaque (light green) leaves (op) is recessive to
green leaves (Op). The loci that determine the height and leaf color are linked and separated by a
distance of 7 m.u. For each of the following crosses, determine the phenotypes and proportions of
progeny produced.

23. In German cockroaches, bulging eyes (bu) are recessive to normal eyes (bu+) and curved wings
(cv) are recessive to straight wings (cv+). Both traits are encoded by autosomal genes that are
linked. A cockroach has genotype bu+bu cv+cv and the genes are in repulsion. Which of the
following sets of genes will be found in the most common gametes produced by this cockroach?

a. bu+cv+
b. bu cv
c. bu+bu
d. cv+cv
e. bu cv+

Explain your answer.