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  • 2. იმუნოპათოლოგიური პროცესები I

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    eliko toloraia
    58 views30 pages
    - The document summarizes the major histocompatibility complex (MHC), which plays a key role in the immune system by helping the body distinguish self from non-self. - MHC consists of MHC class I and MHC class II molecules. MHC class I molecules are expressed on all nucleated cells and present antigens to cytotoxic T cells. MHC class II molecules are expressed primarily on antigen-presenting cells and present antigens to helper T cells. - The MHC gene family is highly polymorphic between individuals, allowing the immune system to recognize a wide range of foreign antigens.

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    - The document summarizes the major histocompatibility complex (MHC), which plays a key role in the immune system by helping the body distinguish self from non-self. - MHC consists of MHC class I and MHC class II molecules. MHC class I molecules are expressed on all nucleated cells and present antigens to cytotoxic T cells. MHC class II molecules are expressed primarily on antigen-presenting cells and present antigens to helper T cells. - The MHC gene family is highly polymorphic between individuals, allowing the immune system to recognize a wide range of foreign antigens.

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    © All Rights Reserved
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    58 views30 pages

    2. იმუნოპათოლოგიური პროცესები I

    Uploaded by

    eliko toloraia
    - The document summarizes the major histocompatibility complex (MHC), which plays a key role in the immune system by helping the body distinguish self from non-self. - MHC consists of MHC class I and MHC class II molecules. MHC class I molecules are expressed on all nucleated cells and present antigens to cytotoxic T cells. MHC class II molecules are expressed primarily on antigen-presenting cells and present antigens to helper T cells. - The MHC gene family is highly polymorphic between individuals, allowing the immune system to recognize a wide range of foreign antigens.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    5o6cpe,06r)a: 303©ncgoau uja38n6cgoaa cD8+ T
    ciated invariant peptide) dgr]S )rl agmgrt MHC
    -]3€F:13g?3bn (u36. 6~6)`
    JJ jTDbrib 8mc"uc?.3..fro„ i.I ,jcpal:oU 8m-
    D8tJmao6t)fin t6©n80606n o6©o806nu 6afi- a:Ojucroanu 66©nao6cgL`85,.3br`!B!"a,j6ic¥,i f'.`3,:!if68a-
    :a?8060C? U3€60C90aEo b|Tlgo3u @6Qmon©rT`%rtb (f6o-
    3oanu 6mc?rlo6n Qabt)6icrn ``6') u`rf;ti'`!, r';"iL 8t>-
    j]j©m6oaoon 86t}uacroauc?o) a6 3n6rvioo©m%nu 6mc} 303©nq?06o Bbc:68a3Liaolu a/' \`:`T".yj.ial.I Lionc?-

    =`JEULic?oaooi, f6nu t)08q?08dc} oBcpoa6 303©nq?a- cgo6a, aouoaaanuaq?, nlio6o ur.?3¢" Lr.!:J\,o`.'!i-.?I" (15
    :3c9. oa%mao6url 303©ocgo6U uja3anrtiQ?oat o.5.
    J6n6rTl8t]J3a8cgo) (lJu6. 6-7). 7)(|Hq`.I,, iJLLt``'L(±J t}m8-
    190 w07j3O n@96fT]33OinE:fTi3n3fin 3r4nL)3L13an

    cell recert[or) cgJja3t3o6oaolj I)08cg()e„ 8Je,f6a8 I)u-

    c}oc?]6ocTno olJ6au©o8t)c?aooac3, 6m8oc?8r)G am-


    6bgncrom6l} oib6blj©o8t)cTb©m6n 8mc?ojucToan:
    JCAivf-J (inlercellular adhesion molecule-1) bf6r]lj
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    ~*_8:8:3;;;3:30 c:oG 3cTn6cgoaa J6©o8066af68cg806oc?a u3€f6o-

    MHC I jcpDl)ol} Q?oanu %ocgJ3nf6%o cga uj68Bnf6cgoaa LFA-I-I T u3€-


    8mc:aeoc=b fioQoaou %ocgJ3nf6%o; LFA-3 (leukocyle function
    associated) 3c?rj6c9oab b6©r)a,06nu 5D66q3806oc=n
    --:=iri,!,?en=,.---mf--S--ty-,1``f=-:---,bS?063a®6:;#m
    U3£f60cgoanu %oc9a3nf6%o Q. uja3t)of6q?06a cD2 8m-
    rJru gap+ -...:, ts` c?ojt)a:ab T u3eff)ocgo8nl) 8ocg.3officbo; 87-I (CD80)
    /.r., „,^`,,
    @c> 87-2 (CD86) g3oc?Dcbo dcpno6o ou6Dl}©r)8u-
    bae!0
    I?b©mf6oan`>, S®6abcg 3cpo6cgo6b n6©of6q!riao©b-
    C:Uf6 Q30696o©UC? U3€f60QO6%0, gDf68macg806l>
    I:rJe,a6cgoau T u3€6ocgril) I)oQa3rtf6Cbo af6Uoauc:o
    8mc?ojuc:06oU: CD28 a?a CTLA-4-cr)3oU (cytoto-
    xic T cell activation-4) 8rt8t>f6oi. CD28-oiti6 87-1-olj
    a?a 87-2-oU cgaja3Boff)06oU Eo8q}oa, T u3E6o-
    a:@aBrt dc:oof6cgoaD CTLA-4 (cytotoxic T-lympho-
    cyte-associated protein 4), IL-2-olJ a?6 ltb3a c3o©m-
    jn6oanl> gDf68md86b, fibo buor]croaoc?ot 8Dcrtn
    36mc?o886aonolJaco3nlJ. CTLA-4-olt)6 87-1 cga
    87~2-riu cgaja38o6oa6 o6303l> Tu3£f6ocgoaolJ od©n-
    3aor)olj q3aoi6e,€636lj, ff)6lJao 608o©ou6rl 608t]-
    Crbor)b ogmq?obb.
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    oinf6rr)%n6e3rTil}8mfn`noc?n606nu 36moouo: SRc m3eDb-
    t}o i)08636c:n lck cnof6m%n6jo66%a uja3t)r)f6cpoaa
    CDS+ T TCR jma3c:odl!t)n t)08a3ac: CD4 8mc?ojcc?au. ob
    o8C6oQr,
    i TCR 3o&- C`D3 jn6b%06n bd©n8q?oaD cgo3mlj3m6oc?n606r)lj bb-
    8nc?oafl o6fT)@o@06o one?a6o
    t)utc?06non. t)o@cgoa CD3 8mc?ojuc?rJ13 y, 3€ad306-
    t)o lck obcgo6U ITAM (immunoreceptor tyrozine-ba-
    l}t}6. 6-6. ]6cgmao6uf6n b6©r)806d6nL 5b6cge,06b sed activation motifs -o8u6fnffooo3©m6ol! oio6m-
    MHC I jc¥.l)r)l) 8mc:iojuc:ioacr7J5 jrrH33c=lcdl)t)o %o6rlu t)08C330c?rl ad©o3aGnrll) on68n8q?03ff)m606o)
    CD8+ T c=cl8gLm(3_nc9j]3]nuacg8n. (Robbills and Cotran ro`m8n§n§rtl) cJ2uml)o?umf6`icrn`nfin§bu. , 6r>l> €1§co`nae/i
    Pathologic Basis of Disease, 2005.) ol>o6rl uja3Bo6cgoE>` lJb3a jn66So6l!: Fyn-13 q3:
    ZAP-70-li. Fyn atd©n )al> C q3ml!q3mc?r>3dcbal>, fin-
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    MHC jtyia3c:odl)r)Q.6 t)bq306U CLIP-riu cgrjljmoo- r>830L|U U3ertlocgancga j6c:oou8riu 8d8mchJ3ouug3-
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    L3c:iJl}r)l) 8rr)c=ojocTL|ar)co 6a(i qi)a,06oc=i 303©ncgoau


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    5o68cg806oc=in u3€ff)oQ3rju b:)cp63nrv=vit]`i MHC` am- ©o``}:)t],`U L3IJC|nonU8%O QJ8mjoQ{)aT)c= (i Sam(5{inF:`-
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    n@]Gm3]mnc=manofin 3fiiTiu@Ii@an w07j3O 191

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    f6rvi6uc::in gD68marviartbDD, 8b8DCTncobQ, aDd©o-
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    `a 3a®38n $ 8abd8n
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    a?o8mujrtcE}oaoc?n a6©nao606rib6cg8n 3nf68ocrdcgn
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    `` ~\,,.` 8{v`j®q3oatog=® `go®c,ogo2nl`.`q]flA a],` .oiBffim ,`Qfio
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    b6 CD86 oaoc:a D6©n806oartb 8n8D6co 8b68mod86oaD dn-


    fincr)bcgacg IgM. T-cgaamjncgoauc?a a6©oe,06oan-
    l)ocp8n 8om6aq?n f606dooa o8f6m dc=oof6oa cga
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    b6®Oan6Ob T-cgD8mjnc3oaucrn d6©n806oanltbbb6 8D6ljb3b3o-
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    bo86®cpo I
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    'FQb8nv3nQoboe a68o80606cnb6 o8v6v6o 6@-
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    lit}6. 6-7. 08%m806t)fin d6©ne,06oaob 6a6cg806a
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    CD4+ T c¥r)88moo©06r>bocg8o. (Robbins and Cotl.an
    ujocgo6oc:o a6©o806oao o53o306 8.j6me3J8oaou
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