Drug Study

Name of Student: Jhon Kurt Monibet Section and Group Number: BSN2F, Group 3
Name of CI: Anne Jillian Singson Area of Exposure: OPD Area

Name of Drug Mechanism of Action Indication Contraindication Adverse Effect Nursing Responsibilities

Generic Name: Cyclophosphamide works by three Cyclophosphamide is Cyclophosphamide is Adverse effects are : 1. Observe the patient for
Cyclophosphamide ways by targeting and cross-linking indicated for treatment contraindicated to  Vomiting adverse reactions during
with the strands of RNA and DNA to of malignant patients with  Diarrhea and after the preparation
hypersensitivity,
Brand Name: inhibit protein synthesis, by lymphomas, multiple  Weight Loss and administration of drug.
urinary outflow
Cytoxan fragmenting repair enzymes, and by myeloma, leukemias, obstruction, bacterial  Headache Inform attending physician
inducting the mispairing of nucleotides mycosis fungoides infection, chickenpox,  Dizziness of any adverse reactions
Classification: that lead to mutations. (advanced disease), shingles, opportunistic  Hair Loss exhibited immediately.
Alkylating neuroblastoma fungal infection, an  Stomach Pain
Reference: (disseminated disease), infection due to a  Loss of Appetite 2. Assess CBC differential,
Route: adenocarcinoma of the protozoa organism, an  Changes in Skin and platelet count weekly.
Cyclophosphamide. (2022, July). NIH- National infection due to a
Intravenous Library of Medicine. Retrieved February ovary, retinoblastoma, Color Withheld drug if RBC,
parasite,
1, 2023, from and carcinoma of the myeloproliferative  Missed WBC, or platelet counts
Dosage: https://www.ncbi.nlm.nih.gov/books/NB breast. It is also Menstrual drop below predetermined
K553087/ neoplasm, low amount
300 mg/m2 indicated for the of sodium in the blood, Periods levels.
treatment of biopsy- dehydration, anemia,  Changes in Nails
proven minimal decreased blood  Wounds That 3. Explain side effects of
change nephrotic platelets, low levels of Would Not heal drug to reassure the patient
white blood cells,
syndrome in pediatric when side effects occur,
neutrophils, heart
patients. muscle disease caused
by the medication 4. If side effects such as
doxorubicin, liver diarrhea accompanied by
problems, uric acid colicky pain, nausea,
kidney stones, bradycardia, and skeletal
inflammation of the muscle weakness occur. It
bladder with, bloody
may be a onset of
urine, high amount of
uric acid in the blood, hyperkalemia. Inform the
and pregnancy. physician immediately.
 5. Record body weight
twice per week. Alert
attending physician to
sudden or slow weight gain
or loss.

6. Monitor Input and Output

ratio and patterns.

Drug Study

Name of Drug Mechanism of Action Indication Contraindication Adverse Effect Nursing Responsibilities
Generic Name: Rituximab suppresses the immune Indicated for patients Contraindicated to CNS: Headache, Fever,  Provide the patient
Rituximab system by triggering and tricking cells with low-grade or patients with Dizziness, Fatigue with a medication
of the immune system in picking out follicular, CD20- hypersensitivity to guide to read before
positive, B-cell non- rituximab, and to
Brand Name: marked cells and destroy them. It does RESP: Bronchospasm, each treatment
Hodgkin's lymphoma any of its
Mabthera this by attaching itself to the CD20 alone, with, or excipients or to Cough, Dyspnea appointment.
antigen on the surface of B- following treatment murine proteins
Classification: lymphocytes cells or white blood cells, with severe, active CV: Arrythmias,  Express the urgency
Monoclonal preventing the activation process for cyclophosphamide, infection, severe Hypotension, Peripheral to the patient to report
Antibodies cell-cycle initiation and differentiation. vincristine, and heart failure, Edema for hypersensitivity
prednisolone (CVP). uncontrolled reactions such as
Reference: Moderately to severely cardiac disease,
Route: GI: Abdominal Pain, itching, rash, chills,or
active rheumatoid and pregnancy.
Intravenous arthritis with Altered Taste, rigor, during and after
Rituximab treatment in autoimmune disorders.
(2020, April 19). Cambridge University methotrexate in Dyspepsia the infusion.
Dosage: Hospitals. Retrieved February 1, 2023, patients who have had
10mg/mL IV from https://www.cuh.nhs.uk/patient- an inadequate response DERM:  Instruct the patient to
information/rituximab-treatment-in-
autoimmune-disorders/
to one of more TNF Mucocutaneous Skin report any adverse
antagonist therapies. Reactions, Flushing, reactions and effects
Urticaria such as and including
fever, sore throat,
ENDO: Hyperglycemia lethargy, easy
bruising, nosebleeds,
F and E: Hypocalcemia bleeding gums,
stomach discomfort,
or tarry stools, and to
HEMAT: Anemia, monitor his or her
Neutropenia, temperature regularly
Thrombocytopenia for any abnormalities.

MS: Arthralgia, Back

Pain

MISC: Allergic
reactions, Anaphylaxis,
Angioedema,
 Infections, Infusion
Reactions, Tumor Lysis
Syndrome, Fever, Chill,
Rigors

References:
Cyclophosphamide. (2022, July). NIH- National Library of Medicine. Retrieved February 1, 2023, from https://www.ncbi.nlm.nih.gov/books/NBK553087/

Cyclophosphamide: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. Retrieved February 1, 2023, from https://go.drugbank.com/drugs/DB00531

Cytoxan (Cyclophosphamide): Uses, Dosage, Side Effects, Interactions, Warning. (2020, August 19). RxList. Retrieved February 1, 2023, from https://www.rxlist.com/cytoxan-

drug.htm

Mabthera Adverse Reactions | MIMS Philippines. (2021, February 17). MIMS. Retrieved February 1, 2023, from https://www.mims.com/philippines/drug/info/mabthera/adverse-

reactions

NHS website. (2021, November 18). Treatment. nhs.uk. Retrieved February 1, 2023, from https://www.nhs.uk/conditions/glomerulonephritis/treatment/

Rituximab treatment in autoimmune disorders. (2020, April 19). Cambridge University Hospitals. Retrieved February 1, 2023, from

https://www.cuh.nhs.uk/patient-information/rituximab-treatment-in-autoimmune-disorders/