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pharmalcodynemics

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anspeptidase pigs J

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nicillin

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protein

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an staph aurious boy

a E coli in

a pseudomonas

a streptococcus

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of
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meningitis s is aE a

tone 46110.41186269 tight

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AT Benzylpenicillin penicillin G
It i ta streptococcus

pneumococcus staphcoccus nonpenicillinare producing

ifb Gonococcus treponema palidum t.ajl.ms

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not givin orally just by injection

short half life 2

11

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narrow spectrum

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duration

halflife Dj
ink

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prophylax s

route of administration

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n
o flucloxacillin

unafcillin

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salmotieha

shigilla D d't extendedspectrum

Ampicillin Amoxicillin
taken orally

orbtion or

strib a

B lactamase J IgG gtld
Émigiforam

B lactamaseinhibitors b 244 NVM'T

clavulanicAcid sulbacterm tazobactam Augmantine

DJ Antipseudomonal penicilline II IIIin
pipracillin

broadspectrum for pseudmoms o Anairobic bacteria

of a
qt

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pseudomonas

or

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611 61

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pneumococcus pneumonia

Gonococcus Gonorrhea

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AAllergic reaction

TW W 5 10
im is 4 skinrash 625

1 10000 im anaphylactic shock

maybe immediate 12min Type I hypersensitivity anaphylacticsh

Kday Type 3 hypersensitivity

maybe delayed
hypersensitivity is not related for penicillin it's self

but it is related for metabolicproduct of penicillin

of inputs.im fqIwl c.viz

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intrathecal penicillin gprocainbw.IN

Nafcillin b k Bone marrow deprition

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not recommended t bacteriocida

to comb in bacteriostatic

owlspenicillin Erythromycin

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oral

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injection

BBB 1 66 08

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renal hepatic

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classification

5J Therapeutic

uses

M Meningitis 3rd44th

o ostiolitis
S skin infection

g Typhoid fever Biliary infection

U UTI E coli

R R TI

G Gonorrhea

E ENT infection E air nose Tonsill

Intestinal infection

0 Topical skin kream eardrop

Addverse effect

All Allergy

Nephrotoxic Nephrotoxicisty first Ed

254,66514in

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metronedazol orally

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or

vancomycin
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interaction

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cetoperazone ceftriaxone

Disulfiram like reaction

tYa 12hr 24hr

BBB No yes

Hypoprothrombinemia
t t t
cathinteraction

No yes


Monobactam Aztreonam
has B lactam ring

highly resistance for B lactamas enzyme

G DUS
CimIFx

No cross Allergy

Imepened

Carbapenem meropenem

as

has B lactam ring

highly resistance for B lactamas engine

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swift nephrotonicIB

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Vancomycin Teicoplanin

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it's molecular weigh 1460 dad not absorped orally

have 1064J group water soluble x x x

kinatics

ab so orally
not

distribution c Not cross BBB

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t inhibits aHiya

ipw g Mj i peptidoglycan Iifa
aw di di É

GI

coccus

spectrum

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MRSA or subacute infective endocarditis not as 1stchoice

clostridium difficill collitis pseudomembranus collitis

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A infusion D

Allergy by releasing Histamine

syndrome

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is Ii stink im

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Aminoglycoside

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Chemistry
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pharmacokineticsor

absorption Mdot absoped orally duoto NHat

duo to on

distribution Mdot cross BBB jars

can cross placenta

did A
diffness I

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alkaline J Hobyo unchanged aw 2

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staph SE
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for
G infection UTI like E coli
RTI
septecemia
menenjtis intrathecal05115181 ww

TB
w by streptomycin
plague 8
Brucella

neomycin im.bg 3MW1 Goraiyp

paromycin mgyggyq.ca protozoa 2d crypt
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Addverse effect on

N Nephrotoxicity reversable cephalosporin

q.WJE.gl
N Nervetoxic for 8thnerve time diffness N

N Neuromuscular Block muscle weekniss

contraindication with
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Renal fainter
auditory problems
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myasthenia gravis
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Roxithromycin
a

pharmacokinetics Et Data
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distributions poor cross to BBB a cross placenta not teratogenic

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spread verry well to tissues

neutrophils macrophage É5 É55

has long the

metabolism liver Dea

Excreations
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bile Ipfw 365153 t.IM
shot

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spectrum mainly G o o s
intracellular Atypicalorganism like amid.tt
myiipPas Liguniller

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resestemseo binding site on 501lb _É
misogyny
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Gt infection but not as 1st choice eye intetion
infection clamidia g
Atypical Like genital
mycoplasma to pneumonia
RIJL.gs tE
I4egunuaoopneumonia
 Fate H pylori by clarithromycin

Toxoplasmosis

Addverse effect
cholestatiThedpaititis
A wi epigastric pain copay
z g even
I inhibit Cyp 450

heart increase QTinterval Arrythemia

interaction
Drug
Penicillin
A macrolide t bacteriostatic tcidal a
cephalosporin

macrolide statins
6.3
1541110501 ID 344 Cyp450 Dad a
metabolism I

i Toxic 2mi pal 6531 statins I ww

myopathy
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4 40 9 08 É
neomycin

t I Eam

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Absorption complete oral absorption food t.gg
Distribution A cross BBB 811410504566 a'osmacrolidssink
D d ET
infection

Idt body fluid Da

A bone sjoeintsJL.FI KmacrolideDGyE I 1D

A teratogenic w placenta side

Mtabolisma liver III j
Excreation UTI z4iw.b't bile s Ite

MOA 1304in 51s Jim Da macrolides

clindamycin
digamy macrolideshresestance 4151
spectrums Gt airobic like staph strep pneuma

in 5 20 G ahoy
protozoal butnot as 1stchoice
Therapeutic use for
Dental infection s t got of dental infection is anairob
bonedjoints I I 4 I

Bone joints infections

 Toxins
Lab 21.0 toxins w Staph 1 a
Toxic shock syndrome
IFTU toxins I is is clinamycin 1 7
inhibitor for proteinsynthesis pin
Anaerobic infection
Acne aime

Add verse effects

anairobicot Taclostredium diffecill colitis Gibb aw Sai

tryin
oral metronidazole 0494 I

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doxycycline p's

chemistry giopb minobdoxysiw.wybiwb ottl.io

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kinetics
Absorption incomplete oral absorption 6
619204611668Njpw
2611230 w ow own said I idiot
Distribution poor cross to BBB
reach Body fluid very well

A cross placent buy Teratogenic Bone defect

in Baby
Metabolism extensively metabolised in liver

Excreation 801 by renal Can not treat UTI because

exereated
they metabolised then
201 by bile

1156 is
doxycycline
Éptiora I
Excreation o 501 renal Dual rout blip 61in
50 bile renalimpairment

MOA weak 111308J

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reversable Aminoglycosides i
highconsentrations yt.ba
bactw 3
Spectrum Most Gt staph Sismi
Must G pseudmonus Ils't
Most Anairobic C difficil Is Y
A typical calm.my leg
B R S
d
Borrelia tricketised
coxeilla
a It
Lymedisease to
Fighter a fever
18 doxycycline 16.2062
sized
8 od doxycycline
JL a It in.nodoxycycline
protozoal malaria 4405 JIE
toxoplasma
E histoletica
Therapeutic use for
I calm my leg as 2nd choice after macrolides

B R C C as 1st choice then come macrolides

October doxycycline od 4.4 thbbaminoglysidesalmid

Acne doxycycline
4 clindamycin
5 8525
infection
TT Ed
y
SIADH syndrome
of inaproprient ADA secreation by
Mbta.d1 wid demeclocycline
 Addverse effect C I
gastricpain distress a peptic ulcer
GIT abye
Is super infection
É 830W
Win
teeth 8s yellow staining
bone abnormal of teeth ING ES A
cholestatic hepatitis y y
liverylivercell fainter
t.SI I6oiW
Kidney nephro DI
fancony syndrome Of It
win

photosensitivity
 protein ink

Chlorampheniate stick w 1651in Leffew

Kinatics
Absorption absorped orally j'm
Distribution BBB V
Body fluid
placenta W
Metabolism in liver GrayBabysydrorimmnhyy
bygluconnyleansferasemmy

AExcreation aoi in
it 50481

renal as metabolite
3L Cann't cure UTI

MOA8 bacteriostatic revers able weak 505 JI KI

Transfer GIIUL.mil
loramphenicol acetyle eased yj.ow E
CAT
135,416235 8410 way im ix t.w.ww.mx
BonemarrowsuppritionbyepHidWPj 3 y 861

spectrum A Gt G a anaerobic Atypical bacteria

Uses 8 3rd
never come 1stchoice
choice 8 at atypical
II ÉÉ tetracycline
p'wenica

pass meningitis typhoidfever

I Ilm
cephalospor

Adverse effect I bone marrow supprition

S
severe aplastic anemia

8Mbikowsff
Blood Transfusion Acellular
Dose dependant Not dose dependant
2 Bonemarrowstimulanteffector as No prediction
Corticosteroide take place after cure
Gray Baby syndrome imam II
inhibite CYP 450

pal classes toxic mist

cell wall inhibitor
protein synthesis inhibitor

I 49 class II It
I D 10641,8
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DNAimbitorfufrnorfloxacin generation
Lelomy
Fluorquinocons f1Y ncint
tk Gemifconaein
y Levofloxalin 3rd generation
4th generation

of burin I Is at da I Nalditic Acid is limit a

s 2469 od fidelity talk E e's ow 6 Da

ciprofloxacin Db abt Norfloxacin ot wimp la
JC sb I bid 156 t.z.WS I'm 2 Lets k
8612 b A typical6 GT Gt tip Levofloaacin a

6 6 0 Atypical anaerobic Wibw pH EIJI

Kinatics
Absorbtioner orally absorb tion 4711 t.IN d1owlda
A Distribution BBB Vr
Body fluid VA macrolides EID Dj
placenta Vr teratogenic
Metabolismon 2 Why
A Ex creation aoi by renal as unchanged treate UTI
moxifloxacin s'LL
MOA 8 wiw.mg l I Topoisomerase 21 106GHz
fluoroquinolones i Transcription s I DNA I relaxation m

bacterocidal to It Iwl É
d
in Gtmostly it G mostly
spectrum T.at O if

Resistance I t
 USES ET OUTI E 490 48
RTI y neutrophils
4866 EH
Osteomilitis Bone

Menenjitis
Atypical bacteria

Addverse affect musciloskeletalgi

Arthropathy
y
06400116,4 pinyin
a t.sn i8ia8b6Al Rupture Achilles tendon

idgaf off
Sofi If Ilysm
CNS siejures
inhibitory transmeter GABA A inhibited D
QT interval 1113
inhibit Cyp 450
35 Is ok it

owidwio.non
s bIjoI it I b

9.61 of
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m
bsulfonamidesmm

A Chemistry kinetics BTW opera HE

A bacteriostatic w
airobic Ah ja

Kinatics
Absorption 06 0 Sulfadiasine good absorption notaffectedby
food
Distribution A BBB IN C
Tisuefluied 2 12 5
placenta W teratogenic
Metabolism in liver
them
Encreation by kidney as Asylated form still active
get Jodie treat UTI

Utsa
j
MO A 15 A
E
bxria fmgi ywo.im
protoa
metabolic pathway

OMORI Timme in wed

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paraAminoBenzoicAcid pABA
Dihydro synthase DAFA DAFReductas
DAFS
y
Miomdet active form
TetrahydrofolicAcid

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she DHS y
competitive inhibition I presestancents's
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Co
Trimonders MID C id.IM
A spectrum A Gt a toxoplasma
d G A malaria
narrow
Atypical shoe fungus

uses A UTI
Tonsillitis
pneumocystis jirovecii pneumonia PCP joke
toxoplasmosis

Note silver sulfadiazine 53161 in

pg combination

Note sulfadonine pyrimethamin 1111244 combination

Addverse effect
Allergy 3 skin rash Stevensjohnson midi's
syndrome

sulfonamides
izz
crestalurin 5,1 alkalination WINE
Kernectirus wjijyt.gs w bilirubin 0643
it Albumin I
II MI
y BBB Dms bilirubin side
Anemia Hemolytic Anemia in children withdbbGGPI
folicAcid swam Megaloblastic Anemia folicAcid4 swab it
BY 56 III IN

neural tubulardeflect spinaBifida

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kinetics
Absorption W a pw.IE
Distribution
EEfluid wrnot
1Bbody safe
Metabolisms small in liver
Excreationg by renal as unchanged UTI I 248

BKrin.de an airbic DUI metronedzole Dot

MOA
Bacteria
metronidazole
P FOR
iMPD rate Ferdinandoreductase I 111231
2 1501 D
J
reductions
notAneaobicbacteria
a Idk
crypscycle it
DNA III TE
tea symATP 165 01 34
t.MIL a
Bacteriocidal s

a Himba of 6 M A 1 to
Resistance 11.56.4250 Hol b to swig 6516

spectrum A11 Anaerobic bacteria ftp.wmjiwip

protozoa Antameba hystoletica
 Tracomotus vaginalis
Mi 1 A

Giardia
i
antiprotozoal Antibiotics
Addverse effect common GIT abset I metalic test
neurologicaltoxicity Ed ok
GBP 1
rare stevinjonsonsyndrome I 24 WE
antiparasite
mebendazole
a
Bone marrow supprition

Antibiotics D 046 im if I
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Done 🫡 ✅
Waleed Ziad alshurafat