Uncontrolled AbnestifIF excessive mitotic division

is called cancer
of cells
from crab
cancer
cancer word came
the surrounding tissue
They Invade and di'stoy

cancer Oncology
study of
cancerous cells are abnormal and undifferentiated
 i i a

Increase in number
Aka
cell membrane is abnormal
Nucleus contain more amount of DNA Largenucleo
Nucleus is feyberchromatic strains more darker

Abnormal cytoplasm
Mitochondria are swollen
Proteins of cytoplasm become disorganised

cancer cells compete

Abnermalfunction
with normal cells for nourishment
contact inhibition
Lost the property of

neoplastic
tumor cells
É m

Normal body cells show a property ofcontact

inhibition virtue of which contact with other cells
by
linhibit their uncontrolled growth
Cancer cells appear to have lost this property As a
result cancer cell just continue to divide and give
rise to mass called
 cells to
Metastasis spread of cancerous

distant sites by using blood and lymph system

normal cells oncho present in

In genes
are

inactive form Protoonchogene Growth

which induce cellular proliferation factor

that inhibit cellular proliferation

genes
Tumor supressergenets

Genes that programmedcelldeath

gulate
Suicide genes E

Protoonchogenes

O f normal cells
TumentOsupressorgeneo
88
Gene related to programs cell death
 Proton'Ecogenictransformation

t
oncogene
It
8888
000
00

Remarkably durable and prolific line

of ftp.E nage
I obtained during the treatment of
Henritta Lack's cancer cervical Hela cells were
cancel
cell line to be establised and have
First human
been widely used in laboratory studiesspecially
in research on virus cancer and human genetics
 I

Cervical cancer in females common

male in India
oral cancer in

Breast cancer in female commonincidences in world

Prostate cancer in male
cancer accountsfor 3 y of all cancer death in men finIota
lung
 chronic
myelogenous

leukemia

Fatal cancer occurs mainly

due to reciprocal translocation
btw chromosome 22 and chromosome
which produces abnormal
chromosome 22 Philadelphia
chromosome

Burkitt's
Mutation in
lymphoma soy cancer
Protooncogene
so's Cancer Mutation in TSG
Tumor suppressorgene
viruses
15 20 Cancer Due to on co

Causeof cancer
 cancer
causes
of

N Nitrosodimethyl amine Heavysmokers causes cancer oflarynxand

lungs
bancer
Benzpyrene Present in tobacco smoke causes Lang

Chemicalagents

CytotoxiD
feed as a
chemical
weapon
centres
skin to
blisteranddamages
eyesand difficultyinbreathing

Aspergillus flavus
Grows in cattle
fodder
1
cow milk
Hakan
Pathogen fungus
causes Hepatocarcina
blood flake
Asbestos Naturally occurring
silicate minerals
I ye yn get
1
Diagnosis
 Vita

Taxol
Ia yariatey

combination
It involves treatment by ofsurgery
con therapy
radiation therapy and chemotherapy

Interleukin 2 Interleukin are signaling molerules released

by WBCs They stimulate other wBcs lymphocytes to
kill cancer cells