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600, 5301832^03 oc?6o’9 6 o3b bo3bo36,g 6 o *33563-
21360b 503633c?3& 0b 233680b 2?o3<3*36 802^36-
”3 o. 6 0 15 0 16 3 63bo, 050 boboooico36o o 6 goc?( 5)-
6 o 0 o ,3c?o ^6(0001 coo 302^030003 0 6 obo63536o,
$3300038003 $3od2?36o 8ofi63,3c?o oj63b 060336003
<3 6 o)0 3 boco.
0^30001023 bo6d333 35o6j3c?ob 3063060180 32^0-
621360, 60)2)0)513 33(8job(&)Otbo oc?2?oob c^oScg^-
6 0 33o6d’9o 06 ’9o)63,0c?o 33(8)ob(8)Ocbo,. 306332^0-
qoo bo8bo363 30 8 3 0 6 3 ‘bmSoboo 06 c?6 3 oqo 8(03-
6063016b.
b*36. 7- 11. 6‘oc?03ob in situ 3063060180. (Robbins
and Cotran Pathologic Basis o f D isease, 2005.)
d3dnu b3bd3bn bribasanb waincinano
bo6dggg 3 5 0 6 3 32 ^ o 6 3 0 % o ,j j 6 o 3 0 6 3 0 6 0 18 0 b
3ob§o>c«rnaox36o $odg&jnd (365102^0 7- 2):
o6 ob3a 3 ooc»,g ^ 0 <$o3ob o630(b o ,3 6 o 3 0 6 3 0 -
6 0 18 0 (b o c Q o 6 6 o b o 6 3 0 % o ,q 6 o 3 0 6 3 0 6 0 18 0 ) $3000-
536b b o 3 6 c n n $330^3330010 70- 80%-b, 8036010301-
^ c j o c o o ^ b 3yo6 o 3oi6bob(8)363oob, o 6 o b 6 o i6 -
3oi6(8),3 6 g 6 o o 6 o 6o68oi6o(j86ob bobg, 3g6(9)6$o
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6003, *£>0153536 3oe?3oogo30(8)3&oa). o$3pooioco 3 0 6 -
3060180 3065050 $38oibocb c ? g 6 ,32?o o qoo o ^ b
6 6 0 2 ^ 0 06 8 3 0 6 0 3o>6bob(8)363oo. o 6 o b 3 g 0 o o -
63(8)- c ^ '3 6 0 (8jo 3ob 3 0 6 3 0 6 0 1 8 0 b 3ob(B)0)c?oi5o,3 6 o
b*36ooio 8 6 0 3 0 ^0 3 3 6 0 1 3 0 6 0 0 . 30^02^(50133636-
30(c)g6,3c? bo3bo36gg6$o oc?o6o$6g6o ( J 'S ^ ti^ 'S "
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J 3ob 6o)63oc?,3 6 o 33ooi3cn,3 6 o ■335632336001, 3o-
010 5068330 33oioc?oi3ob3& oo6o 3ob32?36oi'?i363-
c?o c^otboo63&obo5o6 d6gcjoo. 3 o i6 3 o i6 ,32?o 6 3 -
333(B>0i6g2)0 , 6 0 1 5 0 1 6 3 6"gbo, 3oi(bo(8)o '3 6 o o , boi-
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6gcb,3 c ? 0 bo3bog6g3oo 33(05360 3o>c?n3oi6 i3 '3 c?n
■322^0^0^°^ 3foo6ob(8)Oi3oitb3 255’3g3& obo5o6, 6018-
CJ3&03 3o)6 3 oi6'3 c? 63333(B)oi6 g6tb3 635o(8)o ,3 -
6 0 0 , b n c^ro HER2/neu-3oi^iO(8)o '3 6 o o ( b ^ ^ . 7- 12).
bo 3bo 363oio ,336 o3c? 3boi&o'9o oc^o6o'36356 08
0 )6 (8jo 3b "3oi6 o b 5 0 6 ^ 0 3 0 3 0 2 ^ 0 b,3 6 o a io . 32^06-
£5360 <go66oi‘b ,3C?o, c53b3oi3c?o‘b o ,3 6 o b(8)6 oi3o,
6 0 3 bo3bo36gb odc?33b 3yo6 3o)6bob(8)360oob
3 i2 ? 3 o 3 o o o i, boi2?oi 80801560(30001 oc^o6o‘8635o
50833603360. (b 3 o 6 o itb'32?o 3063060180).
o 6 o b 3 3 3 o o 2 ? '3 6 o (8,o 3ob 3063060180b b'9o 6 oco
0106 obc?03b bocoo 6 6 o b in situ 3063060180, 6018-
2?ob o30igob3<ioo6o)5ob b o 6 o b b o 3 o i6 3c?03oo'9 oo
o6go‘feo,0 6 o 3 0 6 3 0 6 0 1 8 0 b O30i3ob3&oo6oi6ob bo-
6obbcno6. 8o502?ooioco, 30183^01 (8)o3ob in situ
3b 6 o 2?o 7-2. bo6d333 35o6332?ob 3o6 0 o 6n 3ob
3ob^)Oic?fY>50,3 6 o (8)o33&ob
bob”9o 63
3063060180 %
In situ jdfnQn6mdd 15-30
bocoo65iob in situ 30513060)80 80
6nc?^3ob in situ carcinoma 20
n6gd<bng{ 6n go(nQo6cndc> 70-85
ofnob-SgQnoc^foo (8jo3nb (bocon65inb) 30513060)80 79
C?oi6*32?‘35) o 30513060180 10
(§)‘36 ,3 c?‘35io/35in65io(3m5)3,3c?o 30513060180 6
3‘3 3 o6,3 6 o (3oi2^oio(5‘3 6 o ) 30533060180 2
^Q^'3C?‘C]6o 30513060180 2
3o3oc?,35io 30513060080 1
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b '3 6 . 7- 12. 1. o 6 o b 3 3 0 o o c ? * 3 6 o 0 o 3ob (bocoo66ob) 063 0 ^0 * 3 6 0 3060060080. 1. 30C?050>(00(33636-

0 0 6 3 6 * 3 ^ 0 ; 2. (5060(^500(3363600636*35^0. (Robbins and Cotran Pathologic Basis o f Disease, 2005.)

3060060080b, 60050060 G gho, 0006 0 b c ?0 3 b 550- fro c o ^ o b 30(505^500^363600636*35^0 500 ‘fcro-

605^500(3363600636*35^0 3060060080, booe^oo 5Q<i- 8036050 (50(3363600636*3(^0 0630^0*360 3 0 6 0 0 -
6oc?o bo6obbob ogcogobgiooBm iob bocoo66ob in 6oo3d, 6 0 1 5 0 0 6 0 B^bo, (003(^00050*3600, 3oritbo-
situ 3 0 6 0 0 6 0 0 8 0 b 3 0 3 o c ? o c ic q o o 3 q 6 q 6 0 o 6 q 5 '3 c ? o 0 0 * 3 6 0 0 3oo63ro6*3c? 6 3 0 3 ^ 0 0 0 6 3 6 ^ 3 500 ^ S c n -
3060060080. b3330coo *336o3c?3bor)6o^o 0006 0be?03b &oc?03ob
G 'o cn o jo b o B g o ^ o 'g r to 3063060080 35^ 0 6 5 0 36 0 in situ 3060060080. HER2/neu-ob 3^j3b63boo do-
3oe?3o6g6o5oo 3obob 06 SoSn^^ogo^c^o 5083- C?oo6 oc^oocooo. £oc?03ob 500605^500^36360063-
3603360b boboco. cn*330O, "BqS00b3 3 3 0 coo 3 6 C 0 3 g- 6*350*0 3060060080, 6 0 0 5 0 0 6 0 6 ^ 0 , 635000*3600
rocobgco’So O (?o6o’3 6 3 6 o 500(3*3^*360 0630^00, 6o0 3oo63oo6*35^ 6 3 0 3 ^ 0 0 0 6 3 6 ^ 3 500 ^0052236 HER2/
06333b jb m 3 o c ? o b b 0 6 '3 ,'j0 * 3 6 o b *336o’9 36 3 c?ro neu-3co‘fco0o*36oo. 36010 coo 08033 ^3oi3ob36oo-
0 3C ?o c?Q & o b. 6 "o c?03o b 3 0 6 0 0 6 0 0 8 0 b"3 o 6 oco 0 0 6 -
3b6o3oo coo 30010650360 *33o6o(8)3boco 3 mb(8j 3 Q-
6ro3o*3tfe*36 obogcJo.
dmtitQcnencoftoci. 8036(^3003*35010(5 bo 3bo 36Qb
°d3^ ^ 3360 30 3m6bob(Bj360oo coo o6ob6oo6o 3006-
0 * 3 6 3 6 0 . o'93ooct)Oco O55o 6 o ’9 6 g 6 o jb m g o c ^ o b 500-
^ ■3^ -36 0 aob^Qc?36o 550 bo3bo36*36o 6’o6 3 m6 o J-
36 o 0 6 35^0655360. 30^0005^^50*36050 cooSobo-
boocnQ6g5r?oo 5o60oe?333g6*3C!?o bo3bo36*36o *335-
635036000 o6go5r^>06o0oo, 60085^3600 5065^053-
6*35^00 36000 8 6 36 0 3 0 b 06 8 3 0 6 3
boboco. b0 6 ro3 ob 5ogb3oo350?ocbo‘3 6 o 6 30 ^ 0 0 0 8o-
60805^*3600 06 0 6 ocoo6o'96 g 6 o. *32263(5000 0o0oo-
5^0050*360 3oboboocr,Q6 g c ig 6 o 050330, 6 0 0 6’o5^o-
30b in situ 3060060080b 55600b. 0*36*35^360 06
3o3oco>36o 0 6 050060C36360 (b‘3 6 . 7- 13). b'3 o 6 oo
63^0^36*360 ^6b36oo6o. ^ 0 0 5 2 2 36 b o 3 -
bo36*36o 50638000*35^00 600680-
5^* 36 0 b o co o 6 6 g 6 o . *^0052236 35^0655360 *322 ^ 0 £5 - b '3 6 . 7- 13. Soc^ogob o63o'feo*36o 3060060080.
coo 550500 2&5‘3 '3 3 ^ )0 C?** 8 ( ^ 0 3 6 0 30 0 5 ^ 0 8 0 0 6 (30 ^ 8 0 . (Robbins and Cotran Pathologic Basis o f D isease, 2005.)
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6 6 0 c? 0 1 5 0 -3 6 0 0 .
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3 g * o 6 ”3 o 3 m 6 o 6‘o c ? g 5 0 6 3 6 b l^ 0301 c )o i6 o b , E 3 6 C 5 -
3 3 6 0 6 b 506 (3 30(8)36n6b). 8 3 0 1 6 3 J 6 n 3 n b m 3 o'9 o E
3655336060b 5 3 6 0 o66j(8)O 360O 6b 5 6 6 0 0 5 5 0 b 3 6 o i-
3 oi(8)Oi6 ob S ^ O Q o n b , 8 3 0 io c ^ o 6 3 6 o b 06 (8 )6 o 6 b -
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60b b o 'a ^ o c^ s& o c n . 6 6 6 5 ^ 0 1 5 0 -3 6 0 035^05^36360
35^0650366 & o c ? 6 jo b in situ 3 6 6 0 0 6 0 1 8 0 b c ° 6 o ib .
& o c ?6 g o b 0 6 3 0 * 0 -3 6 0 go60o6m 3o, bo6dg33 * .\ \ j .» i H u A ftULc a It S&
« ^ o 6 j3 c ? n b b b30 (8)o 3 o b g o 6 0 o 6 m 8 g & o b o 2 )o6 506- b-36. 7- 14. 83(5-35^-360 3660060186. 1Robbins and
b b 3 0 3 3 & o cr), boboocnco3&o 33 (8) 6 b(8)6 * o 6 3 6 o b b 3 3 0 o - Cotran Pathologic Basis o f D isease, 2005.)
< 3 0 3 -3 6 0 5 * 0 0 1 . 33(8)ob(8)0*o 3 0 0 1 6 6 C 5 36 6 3 o 6 o(8jo i-
6 3 '3 3 ’9 o , 6 3 (8 )6 m 3 3 6 o (8 )m 6 3 '3 3 $ o , 01630b (8)3o6ob
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3660060186 Q3* 66 c?CQo>o3g 6 g 6 0 o 6 g 6 ,3 e?o 6 . bo>coo6- 30336830102^06366.
6 0 b in situ 3660060180b -366360 3 0 o 6 g * o i 3 ob 66 ^ j'3 6 '3 c? ‘3 6 o 3 6 6 3 0 6 0 1 8 6 8 6 3 0 156 6 0 3 0 -3 2 ? b g 6 o -
66 6 6 6(^060^6366, c?o3<g-36o 66 bobbc? 3 oc?g- 6 0 6 5 6 8 (0 3 $ 3 6 (5 5 3 6 (5 6 b 6 3 6 o io i $ 3 8 o ib 3 3 3 6 o i6
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b*36. 7- 16. (8)’3 6 ,3 c ? ‘3 6 o 3 o 6 0 o6o)9o. (Robbins and

lygfn. 7- 15. 9*3006*360 (jnc^oonco^fon) 3o6 0 o 6co9o. Cotran Pathologic B asis o f D isease, 2005.)
(Robbins and Cotran Pathologic Basis o f Disease, 2005.)

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CIN II, bolero) 9do93 coob3c?ocboob 30 CIN III.
09033 co6o)b, CIN I-b 3&mco36o coo6oc?o b o 6 o b b -
ob 06(8)603300)3^*360 ^0^006360 (LSIL - low
grade intraepithelial lesion), bo)c?oo CIN II coo CIN III
5036ct)oo636‘3 c?oo 9oc?oc?o b o 6 o b b o b o 6(8)6 og3o-
0 )3 ^* 3 6 0 , cooJboo636ob bob3c?6'o)G336ocr> (HSIL -
high grade intraepithelial lesion). QDob3c?ocb o o b 36o)-
563boo bo9bo36gc)o o6coo3oco*3oc?‘36 o o , 33ode?3-
60 5056d3c?c03b 6 0 9 ^ 3 6 0 9 3 0)30(006 20 B'c?o9co3.
GIN I CIN II
7-31. bo’93oc?fT)b6o)b 3 3 c ?°b 06(8)603300)3^*360 630)3c?otbo36ob bb3ocoobb30 b o 6 o b b o . (Robbins
Cotran Pathologic Basis o f Disease, 2005.)
wlowo 311
9o)6<gnejo350o. coob3c?otboob c)godc?g6o 3jo>6-
oagb 9ob3oc?G'3Q0oo6o 06 66(8)ggc?o go)6cooe?o)9ob
5063560)60. (feQcoo3o 6 ,3c? *33s6gco36,3 o 6 0 6 0 )3 3 6 0
5 0 ^ 0 ^ 3 6 * 3 ^ 0 qdo 3 o 3 g 6 j6 o )9 * 3 c n o o , 6 0 3 obo-
bogb 3o6*3bob 30(8,0)30010*36 gggjj^b, b‘9o 6 oQ3
oc?o6o'96g6o 3g6o6*3ge?g*36o b o 3 o 6 o g e ? 3 (go)o-
C?0)30(8jO)cbo). 9obgoc?G'33(8)Oo6o coob3e?o‘boo b'So-
6oco 3 3 0 3 0 3 b cqo6oc^o, 66(8jy3c?o coob3c?otboo
30 9ocnoc?o 6 o b 3 o b 3o6*3bob d 30(!)o ^3^b- 0(Bjo-
^■36 ,33e6gcQQ6'3o 6o6a)3-30(8jo>3c«ocb3*36o 06-
cog^jbo coo6c?33*3c?oo, 6 o 6 c n 3 g 6 o b ^ 0)90 3 3 0 ^ 3 -
6ocooo (o6otbo)6,33c?goi‘bo), 3o3g6£j6o)9*3£?oo, 3o)-
C ?o6o)6o (0 0 3 0 6 5 * 3 ^ 0 0 , 9o(8)0)tb*36o *3256gcQ36ob
600155360)60 9oe?oc?oo, oc?o6o'3636o o6o)9oc?*36o
90(8,0)^*360 *3356303360. CIN I-o b co6o)b 0 ^ ^ 3 6 0 -
E?o 3 3 ^ 0 ^ 3 6 3 6 0 3C?o6d9g6o g3oo)ge?o*39ob J33-
coo 9gbo3gco'9o, C JN ,II-ob co6o)b d33CQO 0 )6 9gbo-
93C5^p; CINDI-ob cg^oib 30 0(8,03*36 ^ s ^ c ^ b *330-
300/{j^ocogeio^So^ 9cngc?o bob jg (b*g6. 7 - 31 , 7 - 32 ).
6 6 < § > a 0 c r a 3S 6 0 C R n 3660 <3 6 6 ( 306 n 96 3 0 0 0 6 -
C 0360 20 6 c ? o b ”3 3 9 ^ 3 5 636 o b 9 o 3 6 obogclo. 0 6 3 0 -
^ 0 * 3 6 0 3 0 6 3 0 6 0 ) 0 0 aggc^o'bg b‘9 o 6 oo 40-45 E>e?ob
obog'So, bo)c?oo 3 oc?o e ?o b o 6 o b b o b c ? o b 3 c ? o <b o 3 6 o
30 B"c?ob obogcDo.
B o ir t ^ m c j n g o o . bo"3 g o c ? o )b 6 o ib g g c ^ o b 0 6 3 0 % -
0 * 3 6 0 3 0 6 3 0 6 0 1 9 0 g c?o 6 c o g 6 o b o 9 o bobocn: 3 5 ^ 0 ) -
,go(8)’3 6 o , CQo6gc?'3C?36ocQo cs^ 06(300^(8)6030*3-
C?o. 3 o) 6 b 6ob*3c? '930cob33336‘9 o b o 9 b o 3 6 g 3 6 3 3 c ? -
CIN III
312 vii com Mrid333 senrtJ3c:nui sa dacinb babdsbn bnbaaanb woincinana
b’gfn. 7 - 3 2 . bo”3 g o c in b 6n b ygcjo b o 6 <3)6 o33 ooi32*'3 6 o 63oo3 cjo £boob 00(8)012*00500. 1. 6oo68o2?-36o
tb3(oo3o6-32?o •33263(0360; 2. CIN I; 3. C\N II; 4. CIN III. (Dr. Edm und S. C ibas, Brigham and W omen’s Hospital,
Boston, MA.)
<5360 3Q6o(8)m6Q'33’9o, 3 o 6 (oob 6-33(8)3o, 3 o6 (o-
bo6'3go)‘9 o, b£oo6 6062*0330, bo3 ro3 o. 3g(8|0b(8}0tb0
300)0)6(0360 6350016-32* (50 3 0 16 3-32 * 2*0303*36
330683630, e?3odc?3o, 030^(8,33630, d32?ob (8)306-
bo (50 bb30 b(8,6,3j(B)^)6363o. 3ob(8,oi2*co50*36o(5
6 6 (8)y 3c*’332^ 0^ fv,3c,^n jo60 o 6co3ob 9 5 % 33(55360
(00(00 cboi8ob *33263(5g6obo5o6 coo ,606801(553-
602*00 506^)03360(50 (3ocpoe*CQocg36g60o6g6,3 -
2?o) 06 50'36(jo336oc5o bobocn. 5 %-3 o 32*06(53-
60 coo6ocjcooo33636(3o636,3c^o 30063-33263(500-
3060 66(8,332*0 06 060(5003363600636-32*0 30 6 -
0o6ro3o (63060)36(5003606*32*0, 06*3 fr36o2**332-
63(0003060 3060060080) ^ - 3 6 . 7 - 3 3 ). o3 -33060b-
j6 3c*o b (5600b 36 o i5 6 o i(bo doc*oo6 0*3(500, ^ $ 6
(Qojo3'3o 636'3 e?oo b6"6oo3 33(8)ob(8,o£bo 636obCTio6.
3b bo3bog6336o b 3o 6 o (5 50800633*32*00 80(502*0
6 o b jo b (83-18) H PV-ooi.
b o 3 3 o c * ro b 6 m b 332*ob 306006018360b 2 5 % -b
0053601,3060060080, oc5g6oib'j3o8o)%,g 6 o
3060060180, o6os> oq3g6‘)6 0 o 6 g & ,g c ? o 3060060180
(oo b b 3 0 0 ^ 3 0 0 0 1 0 3ob (8 ,ro cjro g )0 ,3 6 o (8 ,0336 0. 0 (5 3 -
6013060060180 300)06(0360 36(i3ro0363ojjbob 3206-
332*360(506, b3 o 6 o(Q 8ob 6‘o6 •3b6'6g6b 06(8,60-
3300132**360 3206332*003060 bo8bo363, 0(53600306-
0o6ro3o in situ, 32*06 03-360 S 6 (^33c*<3 ^ -
63(5003060 3060060180b 3b503boo. ocjgBrobjgoSoo-
‘6*360 3060060180b (5601b 0(506036360 3363*32*0
3206332*013060 (50 66(8,332* *3 3^63(5 003060 3008-
301636(8,360. bo3o6o*3(ooio, 6018 ob 300106(5360
3,3c*(8)o3ro(8,36(8,'36 o
63^363-3(^0 *33263(536obo5o6.
3 obo 360)5601*60 ■303600 0*32500, 30 (5 6 3 o6ocjpo-
50*360 b ^ o ^ o o b 66(8)332**33263(5013060 3 0 6 0 0 -
60080b (0600b. 3 -3 0 2 *O£5 yoQ<g6 ob 336000(530 (50-
3coo2*b(8,oc*63b(8,6oocjob 8ooj8g(Q36obob 300106(53-
60 3.61. 600132**33263(5003060 3060060080, 600832*00
bo3 oib 0602*0050*360 3060060080b 3b503boo.
b o3302 ?o o b 6 o o b 3 3 2 * o b 3 0 6 0 0 6 0 0 8 0 b 3 2 ^ 0 6 0 3 -3 -
60 b (8,o (5036 oo : b(8,o(ooo 0 - 3 0 6 0 0 6 0 0 8 0 in situ
(CIN III), b(8,0(ooo 1 - 3 0 6 0 0 6 0 1 8 0 3 3 8 0 0 0 0 3 0 6 5 2 ^ 3 6 0
b o 3 30 (^ o o b 6 o o b 332 ^ 0 0 1, la - 3 6 3 3 2 ^ 0 6 0 3 - 3 6 0 3 0 6 -
0o 6o o8o , 600832^00 (5 0 0 5 6 0 0 ‘6 (0 3 6 0 3boo2?oo(5
3o36oob3co3-32^0(5, lal - b(8,6oo3-32^o o630c6oob
b o c? 6 3 g 0 6 0(^380(8)360 3 83 -b , b o 5 o 6 3 3 0 7 33 -b
 W6d330 ?enriJ3E:nba 5a dacinb uaudsun unuasanu wmnEjnana vi/crmo 313

7-33. 1. 66(8)332^*3526303003060 3O>60o6m8o; 2. 02336003060060080 in situ coo CIN III; 3. 0033600306-

0o6m 3o; 4. 63o6on36coool3 6 o 6 ,3 c ? o 3060060080. (Robbins and C otran Pathologic Basis o f Disease, 2005.)

(g.6-. 8 0 3 6 ( ^ 0 6 3 0 ) 3 0 6 0 0 6 0 0 8 0 ) (b,g 6 . 7-34), (0 0 b 6 '3$ (8 )o b 06 bE)oo6o 6ofo2?03ob c?<'r’ 6 6 'm 3 o 6

Ia2 - b(8)6 o o 3 ‘3 c ^ n o6go)(b o o b 3 o (jb o 8 o 2 ^ ,3 6 o b o c o 6 - 5 o 6 b b , 06 0 00 06 036 36 0 83(8^(8)0*6*360 coo b30o6o 0oo .
9 g 3 3 3 - ^ 3 33(8)00), 8 0 5 6 0 8 Q ^ o c n g c jo ^ S o b 6 0 ^ 0 - bo$3ocjoob6oob ygc?ob 3060060000b 363336000
2 ^ * 36 0 3 6 ocqo 6 5 S S -^ g 6032^3600, 30060*6006- 0000003b bo0 3(8)o3b: 1. 00(8) 002? 0050*3 6 0 b 36 o -
(8)o c ? ‘3 6 o 0630^00 7 3 3 -*b3 6 0 3 2 ^ 3 6 0 0 , lb - 0 6 3 0 - 60650 3030603002^0^ 03cnoocoocn (PAP (8)gb(8)o);
*60*360 3 0 6 0 0 6 0 0 8 0 $ 3 8 0 1 0 0 3 0 6 0 ,^ 0 6 0 ) bo)$3oc^or)b - 2. b o 0 b o 3 6 o b & o 6 o 6 g 3 6 oo0 3 b g 6 ob 3 ob( 8)m 2 ?oo 5 0 -
600b 33C?nco coo> Ia2 b ^ o c o o o ^ 03(8)00, b ^ o co o o II - *360 2500560^(8)030 cqo g«jb0o‘feoo; 2. o6(8>o-HPV
3o)60o6oo0o) 36032^00360 b o 3 m 3 o, 3 c)g,6 o>0 060 30^0060000, 6 0 0 cQC?3obocr)3ob 33£?33ob 3 6 m-
0o b ^33000 03bo)03cobo coo 836520b 3 3 (Q 3 2 ? 3 o , b ^ o - 03b$oo. 33*366 o2*on6ob 30600636^0 5-£c?oo 6o
cooo III - 3 0 6 0 0 6 0 0 8 0 3603^03360 836 520b 33- bo0oo0bcjob bo656d2Ijo3oo6o 33000536b 9 5 %-b la
co g c jb o coo bo 3 m b ^ 33 ^ 03bo03co3o. 6 3^ (8 )0 - b^ocQoo^g, 8 0 - 90 %-b lb b ^ o c o o o ^ , 7 5 %-b II b(8)0-
C?‘C )6 o 5 0 8 0 0 33 2 ^ 3 30 0 ) b o 8 b o 3 6 3 b o coo 836520b 3 3 - 0000*63 CQO) 5 0 % -cb 3 6 o 3 2 ? 3 6 b III cqo IV b ^ o c o o o ^ g .
CQ3C?b 3 oo6 ob b o 3 b o 36 o b o 5 o 6 o ^ o b ^ g o c ^ o bo3-
603 06 0^06036360, b^ocooo IV - 3 0 6 0 0 6 0 0 8 0
b 6 3 3 0 e ? n b 6 n b 3 6 0 K l) E ? C r) a 0 6
3 6 0 3 C JC 5 3 6 O 836520b (^>6*30006 06 8 0 0 0 0 0 3 b 3 o 6 -

j 6 g ? n a Q (§ > 6 0 ? ) a 0 b 3 6 m n g ? n a o 6 __________

n B r o m S n ^ ^ o 'g S o b ^ o b ^ ro e ^ ro g o d
o g 6 l3(8)(ln «£)d(m,£ jfn o 0O 3c?ob c o f^ rn b

0 3 6 b ^ )6 ,g o 0 o o b cQ6oob 8 0 8 0 0 0 ^ 0 ^ 3 6 3 6 0 36000083(8)-
6 o'j) 3 o l. *63800 0 0 6 0 3 gbo 3 gcQo, 6o*6o2?*36o 0 gbo03
cqo b o j 3 3 6 0 b o b b (8)g6oooeog6ob 3 o 3 o 6 cn 8 5 6 0 6 0 0 -
60063 06 060b qoo ,3 c6 6 ,3 6 3 3 2 * y o o g b 5 2 0 6 3 3 2 ^ 3 -
6obo CQO) b( 8) 6 oo3 o b ocjcQ 5o6ob ( 3 6 o)e*o<g[]6 o 0 o -
ob 330*60). 36200003(8)6*32*0 3206332*360 b£m 6o,
8 0 2* 0300306 0 b(8)6*3(J(8)*3636oo>, 6oo02*o6o0 o0oo-
<33602*00 3 ocnOCJO, 0 6 * 3 3 6 0 3 0 2 * 3 6 0 0 6 0 0 O 2 ?OO-
(0 6 * 3 2 * 0 3 3 0 0 3 2 * 0 * 3 8 0 0 1 , 0 0 0 0 6 0 3 6 3 6 0 CQOCQO 6 0 -
oocQ36oo6ocn 3o(8)0otb ,3 6 o ’352^3£Q 06o, 2*oi66Y ob b 3 j-
63300b 06 303*300 2* o*6o 0 o o b 506333. b(8) 6 oo3 o
b>06. 7-34. bo$3oc?cob6oob 332?ob 8036000630- 3 3 (0 5 3 6 0 8 ^ ocq 6 oocq 5 0 6 2 * 0 5 36 * 3 2 * 0 a)o co o b (8)o 6 o
*60360 3060060080. (Robbins and Cotran Pathologic Basis '3 ft6 3 C Q 3 6 o b o 5 o 6 ; 60080*3600 330003b 8 0 0 6 3 (0
o f Disease, 2005.) 5 0 8 m b0(8)*32^ 0 o (8 )m 32 * ocboob cqo boboocncQSOO) 80 -
314 vii cnxo bdrfd 333 5en 6 J 3 c ;n b 3 d ^ n b b^bdSbn bn u asan b « m n c : n a n a

c?oc?o 9o(B)Ot6*36o 0^(8)030600. o3*3C?^Gr,0k c$>6ob 3 6 on5 gb( 8)g 6 m 6 *3 C?o ^ o 'b o b 2)o 6 g ’9g. on g *3c?o 0oo b
g6c§o3g(8)6 *3e?o Sc°6 jg c ;‘35nb 36oeM'><8g6 o0oo ^jgg- o 6 o 6 b g & m 6 o b o ^ g o o c n o 80*63*63600: i . 3 6 ^ 0 3 6 0 -
ooQDg6o, 9o(8)o ‘6*36o ^ S ^ g c o g & o b 6 o o c g g 6 o 6 o 6*32*0 0 3 0 0 3 0 2 )3 6 3 6 0 (<3 o 6 o b g 5 6 o coo 0 0 6 3 8 3 2 * -
90o6cog6o, cn3^Jc?O0opb 3g3c5g5 oc?o6o36g 6o b-g6- Cbgcoo 3 5 0 6 3 3 2 ^ CQ603OCQ36360, 3 o 3 o<go* 6 ob b o 9 -
^‘OJCQ’O^o 6o<6oe?,3 6 o bg36 g(8)fo6 '3 c?o 3*ij ’3 fT1" b og6gg2io); 2. b o 3 3 g 6 0 b o b 3 o 6 ggc?o coo 036*60063-
c?0a ° (b jw rtg ^ o o b «gd%a). b g j^ g Q o o y ^Q C J^g 50- 60, 6 0 0 5 0 6 0 0 0 0 3 o < 3 * 3 6 ;j0 o g b o 3 b o g 6 g (5 6 0 6 * 3 -
3obo(8)*3c?oo 3g6b(8>6*3oc?'36o 0 o jc ? n b 8gbo9g 2 * 0* 6 * 36 0 550 0 3 3 0 * 3256 g c3g6 o b b o 3 b o g 6 g g 2io ) 06
33060*63. ^ g Q ^ g a b g jfn g ^ o 5oeoocoob 5 5 0 6 3 3 ^,3 - 3ooCn o 0 o b (8)* 3 6 o bo33g 6 0 b g g 6 o ; 3. 5 g 6 g 6 o c ? o cbg-
6 0 b b o 6 o o * 3 6 3 o , 6 o 9 g c ? o 0 5o6o0coob e°oe?a- 6*32*0 3g0o6o2**36o 0 30 6 (^ * 33336 0, 6005060000
(8)o>0nob. Bgoobg 33066*63 550633^360 cq-^C ^B o- bo8b*3«j6g, 0 * 3 ^ 0 3 3 3 6 0 , 4 6 0 6 0 3 * 3 2 * 0 b o b 0 g 3 * 3 6 o
C?oo, b(B)6 o 3o 3g3'33g6*3c?o o J 5o6o0CQob 36gcog- C00030Q 336360. 8 6 0 3 0 c ? 3 o 0 og 6 0 3 o o 6 o 3*3 2 ,6 0 o*3 -
00^*3*36 03c?oc?g&g&b, 3 g o 0 o g b b 3 o 6 o c ? ,3 6 0 6 - 60 0o3c?ob 80*63*60 * 3 0 6 0 6 0 0 . 0603*32*000*360
0 3 6 0 3 6 b , 0 0 o 6 g 6 o o c o g 6 o 6 o o 6gO (8)6ncgoc^'36 0O 3c?o 3332? *^3 b 3 o 6 oo 3 g 6o 6 j g b 030 3 g 6 o 3 g-
coo c?o9<go0o(8)g6b, 6 o 0 o6og6ob 6030*3*6*36 3 g 6 o o ( ^ ’9 o. o 3 * 3 c ? O 0 o o b o 6 o 6 b g 6 o -
0 6 6o36ogb. "9g9c5g5 <3'0^dG o,3 6 o 3 6 3 6 0 800030- 60 o& 333b g b (8 )6 o 5 g 6 g 6 o b 3og6 g6coo3g(8J6 o * 3 -
^36360 too o6yg6o 3g6b(8)6 ,gdQoo (b*36. 7-35). 3 ob ^066 b(8)o 3 *3 c ? 6 0 oo b, 60b 3 g c o g 5 o (o o 0 30-
oo6cog6o g 6 co o 3g (8 )6 ‘3 c ,o 5 5 o 6 3 3 c g 6 o b b (B )6 * 3j-

gG com Bg^foo^Bob g ^ d O 0 ? ) ^ 0 fi?*^ C J 30- c?),C )6 ’3 C ? o G 3 C ? o C ? 0 ^ 0 ^ n > 3 o o 3 0 6 0 b , 0 o b (8 j* 36 o

3 3 6 0 (c o n b g ^ B d ^ n ^ fo n bnbbcicoaBo) COOC?O(8)O0OO (b * 36 . 7- 36). 3 g o d c ? g 6 o 5 0 8 0 3 ( ^ 0 6 -
C03b b( 8) 6 o 3 ob coo 3 c?o (0 6 0 3 * 3 ^ 0 0 0 * 3 6 0 3 g 6 b(8j-
6 '3 O 0 o o ) , g 6 Co o 9 g (8) 6 o * 3 9 o b b g 3 6 g 0 o * 3 c ? o 03C ?o -
6d ^ )n vD6 6 g 3 6 oco* 3 d G n<3 C? 3 g 6 o o c o 3 o g 6 c o o 3 g( 8)-
C ?g 6 g 6 o b 5o6g3g.
6 o * 3 8 o b R o0m cg0jj36 ob coo *66c§ob c > 3 o 6 (8 )6 o c ? 3 6 b
o6 oo(5 gjg0(8)‘3 6 o bg3 6 g0 oob 030*60 oc?6o36ogb
3 o 3 o a jo * 6 ob coo b o j 3 g 6 0 b o b 3 m 6 3 n 6 g 6 o. 3 o 6 -
y 3 o o g c ? o b bg*3c?o b o 6 o o co g jg 0 (8 )* 36 ^ '3 6 ^ 0 0 0 6 0 -
3 o 6 *3 c ? n co o b 6 o c?o 6 b n oG ^ggb gB com Sg^^n^Sob
6 g 6 o b coo 3 6 o 5 gb 0 g 6 o 6 ob coo6oc? coo6gb, 6 0 -
0 0 6 0 0 3 0 0 b , 0 6 0 3 0 2 * * 3 6 3 6 o c ? o c g g 6 o 0 oo b, b g j6 g -
bo0 0 0 6 obc?ogb o 6 o 6 g 5 * 3 c ? o 6 ‘3 c io 0 3 * 3 ^ * 0 0 0 -
0oob 06 3 o 3 g 6 3 c*o*6 oo b. 3 C ? n 6og*36oco 3332*0*63
•3 6 0 0 o 3 c ? o . 3 2 ^ 0 6 0 3 * 3 6 0 ^ 0 ^ 0 6 0 3 6 3 6 0 *36 0 30 -
b 3 o 6 oo <Jo6 6 o b n b b c ico g 6 o 9g6b(&)6,0 O ^ n n b c o 6 o b go6o, 30336- 06 oco5o9g6o6go. g 6 co o 3 g(8)-
06 3 g 6 (8 )6 '3o 0 n o cn o 3 o 6 o b . 9 o b n 5 0 8 0 18 6 3 33 0 8o - 6 o*39ob 6o o 30o0 g63o 3c?o6cog6o bg36g0o*3c?o
*63*6360 ^gndc^gfto o g o b 06506*32*0 (^ 0 0 6 0 3 * 3 ^ 0 G3C?°C?g6g6o.
g 6 cQoo3 g(8) 6 o(8)n , b*363*33o*6*36o 2 l3 o o 3 o o 3 o, 3 6 - o 6 o c ?-36 o 3o 6(8j 6 o0 g3(8jogg 6o o S^BoSgggc^o
Cooo9g(B)6*3c?n 3 m c?o«Jo, 3 6 c o o 3 g 0 6 o * 3 3 o b b o S b o g - G 3C ?o c?g 6 g 6 o . oc?o 6 o 3 6 g 6 o 3 5 o 6 3 3 c ? 3 6 b o coo b 0 6 o -
6 g g 6 o ) 06 9 3* 36 ^00* 36 0 (co o b c g * 36 j0 o * 3 6 o b o b b c?- 3 ob 3 o 6 o b c o o b 3 o o 6 c o o 6 o 0 o o , 6 0 5 0 6 0 G gbo,
cog6o). ^ '3 6 ^ 0 0 * 3 6 0 coo6c?3g3g&ob So'bg'bg&oo: 06 0 0 ^ (8 )0 * 36 0 5 5 0 6 3 3 ^ * 3 6 0 coo b(8)6 o 3 ob cog0oco*3-
o 6 n 3 * 3 c ? 6 0 o ,3 6 o 3 0 3 2 ^ 0 5 0 3o 6 33 * 32 * 0 6 gb(9) 6 oo- * 3 6 0 0 3 C ? o C ? 3 6 g 6 o . o c? 6 o 3 6 *3 c ? o b * 3 6 o o o 3 g j 0 g -
5363600 $0660 coo b o 6 2 ,6 d c ? 0 3 0 b 0 o 3*3 2 ,o 0 o o o , 30C000.

b '3 6 . 7-35. 3g6b(8)6*3oc?,3 6 o 0 o g c ? o b 3ob(8)oc?ro5oo. 1. 0 ^ 6 3 * 3 ^ 0 b g 3 6 g 0 o o b 030*60 b*366*33cg‘3 6 o

3C»3'3rnc,nC6 o 0 o o o ; 2. 530060 b g 3 6 g 0 o o b go'bo; 3. 36gcog0oco*3*36o 0 3 C o c ? g 6 g 6 o ; 4. 3g6b(8)6 '3 o 0 o -
ob 030*60; 5. b(8)6o3*3c?o 56o6*3c?o0o(8)g6o; 6. b(8)6 o 3ob cogb(8)6*3^0oo. (Robbins and Cotran Pathologic
Basis o f Disease, 2005.)
 bd6iJ033 5enrtJ3dnu^ ^ d^nu babdSbn bnbssanb tomndnana viimxo 315

7-36. 1. o6ro3*3c?o0o‘3 6 o 36(50083(8)60*330; 2. j f n m 6 n 36(50083(8)60(8)0. (Robbins and Cotran

Basis o f D isease, 2005.)

3 £)6 m 3 c>,g <b ,£)6 o (5 0 3 n b ( 8j 9 a 6 m 3 o,g (b ,g 6 o 0 3 2 * 0 - ^02^60 $6obo5o6 (5 0 $ 0 0 6 3 6 3 2 ? 0 0 2 -3 3 3 -ocr).

2*36 36 0. 5 2 36 o c?o 6 o $ 6 36 o S b ^ ^ o 3033632^0^00 ^ 0 0 5 3 2 3 6 3 3 6 b (8 )6 * 3 o 0 o o b (0 6 0 0 b b(53& o 08 36(500-
coo x of;\33C ?D & n ^ Q o b ^ ^ ^ o ( d o c jo ^ o q o o , $ 3 8 ( 5 3 5 3 3 (8 )6 o ,0 3 o b 8 0 8 0 0 130 ^ 36 0 , 600 o6 ’3 3 3 b 8360060-
3 0 g3ocr}g2?o,g 9 o b (50 b(8)6 oo3 o b 0(8)600(300. ^ 0 0 5 - 5 0 0 b , 8(5 )30 36 3,£)2* (5 o b 3 3 6 o o 6 3 o b , (5 o b 3 o 6 3 * 3 6 o o b
3236 o ^ )6 m cg o o b $ 3 8 (0 3 5 (OO2^O(8)O0OO $ 3 6 0 6 8 * 3 - (3(8)30363-32^o b j3 b o o 6 6 o 3 o 0 ^ 0 ) , 836320b o 6 3 $ o
63632^00, 6 o b o 0 0ob(8)’^ 6 o 0(8)6001300 36“n (0 3 & o . (8)3°3n2nb, 5o6bo3,3a)6g6ocn 363836b(B)6 *302?‘3 6
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