MODULE 6

BIOCHEM

B1. The most commonly mutuated gene gene in human cancer:

A. Rb

B.Tp53

C. Myc

D. Ras

B2. Which one is incorrectly matched

A. VEGF C _ VEGFR 3

B. VEGF B _ VEGFR 1

C. VEGF D _ VEGFR 3

D. VEGF A _ VEGFR 2

E. PIGF _ VEGFR 3

B3. Which enzyme catalizes the conversion of phosphatidylinositol to IP3 and DAG

A. Akt

B. Mapk

C. Erk

D. Plc gamma

B 4. Src is best expressed as

A. Scafolding

B. Tyrosine kinase

C. Adaptor

D. Lipid kinase transcription factor

B5. Which of the following factor is important to recruit and activate STAT?

A. Mapk
B.pi3k

C.jak

D. Akt

B6. Which of the ff is not true abt chronic oncogenic viruses:

A. They transofrm host gene oncogene in cell culture

B. In rare, cases the inserted dna provirus is inserted near a proto oncogene

C. Induces tumor formation through insertional mutagenesis

D. The viruses dont carry viral oncogen

B7. Which of the ff product downregulates EGFR:

A. Myc

B. Cbl

C. Pten

D. Gaps

B8. Which one of the following is epigenetic method of oncogene activation

A. Fusion of genes

B. Insertion of a base pair in the oncogene

C. adding a base pair in the promoter region of the oncogenes

D. amplification of genes

E. oncogene activation by microRNA

B9. Tumor angiogenesis is not important for?

A) Tumor growth

B) Metastasis

C) Invasiveness

D) malignant transformation

E) none
 MICROBIOLOY

M17. Which one of the following is not correctly paired

A. Human T-lymphotrophic virus / T-cell lymphoma

B. Human Papilloma Virus/ Anogenital cancer

C. Kaposi sarcoma virus / Kaposi sarcoma

D. Epstein Bar Virus / Nasopharengeal carcinoma

E. Hepatitis E Virus/ Hepatocellular Carcinoma

M18. All of the following are oncogenic except

A. Hepatitis E virus

B. Kaposi's sarcoma virus

C. Episten Barr virus

D. Human T cell lymphotropic virus

E. Human papilloma virus

Image to Text (OCR) bot:

M20. Which of the following are not recognized by the CD8 +

T lymphocytes

A Mutated tumor Suppressor gene

B. Self-antigens

C. Mutated self-protein

D. Oncogene products

E. Oncogenic viruses

M21. Which one of the following is not true about tumor

evasion mechanism?
A Tumors lose antigen expression that illicit immune

response

B. Tumors induce CTLs by expressing costimulatory

products

C. Regulatory T cells may suppress T cells

D. Tumor antigens may induce specific immunological

responses

E. Tumors may suppress anti-tumor immune response

M22. Not related to infection induced malignancy

A. Acute inflammation due to HCV invariably leads to HCC

B. Viral genome integration to host DNA causes host

genome instability which leads to tumorigenesis

C. Chronic inflammation due to chronic microbial infection

considered as indirect cause of tumorigenesis

D. Host immune suppression due to infection by

pathogens is important mechanism of tumorigenesis

E. Oncogenic proteins like E6 and E7 interfere with tumor

suppression by destroying host tumor suppressor protein

P23. Chronic inflammation that precedes tumor

c development and autoimmunity

A. Inflammatory bowel disease

B. CUSHI Rheumatoid arthritis

C. Cholestasis

D. HPV
E. psoriasis

M24. Biomarkers of tumor of colon

A Common acute lymphoblastic leukemia antigen

B. Carcinoembryonic antigen

C. Human papillomavirus antigen

D. Epstein Barr virus antigen

E. Alpha fetoprotein antigen

M25. Which patr of cancers are involved in skin cancer

A. HPV S Merkel cell polyomavirus

B. Merkel cell S EBV

C. Kaposi's sarcoma & measles

D. EBV & HBV

E human T-iymphotrophic & Merkel cell

M23 .Whtch one of the following agent cause bladder stone

and bladder carcinoma.

A. Schistosoma intercalatum

B. Schistosoma heamatobium

C. S. mansoni

D. S. merkurg

E. S. japonicum

M24. Which of the following is not a direct action of H. pylori

infection in causing adenocarcinoma?

A. Modulation of cellular growth

B. Modulation of cell migration

C. Induction of the hummingbird phenomena

D. Production of reactive oxygen species

M25. Which of the following is true about HPV?

A. It is a large DNA virus

0 B. It is DNA virus that has reverse transcriptase

to integrate into the host genome and cause

tumor

C. Cervical cancer is caused by either of the

papilloma species 16, 18, 31 and 45.

D. HPV is ssRNA that inte rates into the host

genome and cause tumor

M29. Which one is true about role of microbes in cancer?

A disruption in microbiota causes cancer
B. 15% of cancer caused by bacterial pathogen
C. candida albicans produces acid aspartyl for its
oncogenesis
D. Hallmark of cancer is downregulation of proinflammatory cytokinenes
M30. All of the ff have been identified by iarc as a carcinogenic to human except

A. opsthorcis viverini
B. EBV
C. Colonorchis sinesis
D. H.pylori
E. S.mansoni
M32. Correct about cytotoxin associated gene A in H. pylori
A. they are found downstream of Cag pathogenic island
B. enhance cell to cell adhesion
C. it creates elongated shape of epithelial cells
D. it is type 4 secretion pattern
E it is found in all H. pylori stains

PATHOLOGY

P10. Not a feature of ataxia telengiectasia (A-T).

A. Mid face butterfly telengiectatic erythema

B. Sterility

C. T- cell leukemia

D. Cerebellar atrophy

E. Low IgA IgG and lgE

P11. Which one it incorrect

A Multiple endocrine neoplasia 2b and mucosal neuromas

B. Von Hippel Lindau disease and polycythemia

C. Turcot syndrome and brain tumors

D. Central neurofibromatosis and plexiform neurofibromas

E. Lynch syndrome and medullary cancer of the colon

P12. Strong immunogenic tumor appears:

A. Only in experimental animals

B. In immunosuppressed individuals

C. In all cancers

D. Only in leukemia and lymphoma

E. Only in elderly people

P13. Which one is an example of tumor promoter in human?

A. Opposed progesterone

B. Opposed estrogen

C. Unopposed progesterone

D. Unopposed estrogen

E. Unopposed oxytocin

P14. Which one is mismatched

A FNCB and autosomal recessive

B. Ataxia and AFP elevation

C. Fanconi anemia and BCRA2

D. Xeroderma Pigmentosum and melanoma

E. Bloom syndrome and Increased sister chromatin

exchange (SCE)

P15. Which one is incorrect

A) Chronic inflammation is induced by non-infectious

agents and contributes to carcinogenesis

B) Acute rather than chronic inflammation is known to

cause cancer

C) Tumors do co-opt some of the signaling molecules of

the inflammatory response

D) Up to 20% of human malignancies are related to

chronic inflammation and virus and bacterial infection

E) Many environmental causes of cancer and risk factors

are also linked with chronic inflammation

P16. Not associated with Fanconi anemia

A Bird like face

B. Aplastic anemia

C. Absent thumb

D. Long stature

E. Horseshoe kidney

P19. Which show the transformation of normal cells to a

cell with metastatic potential?

A. initiation

B. invasion

C. metastasis

D. promotion

E. progression

P22. Which one of the following is true about

paraneoplastic syndrome?

A. Cushing syndrome in small cell carcinoma

B. Hypercalcemia

C. Hypoglycemia in Beta cell adenoma

D. Anema

E. Disseminated intravascular coagulation

P26. Migratory thrombophylebitis Is known to be mostly

associated which type of cancer?

A. Prostatic adenocarcinoma

B. Colon cancer

C. Pancreatic adenocarcinoma
D. Cervical cancer

P27. All of the following are evidence for immune reactivity

in tumors, EXCEPT
A .The young and the old have increased occurrence of
tumor
B. Detection of antibodies in patients with tumors
C. Some tumors regress spontaneously
D. Tumors rarely infiltrate lymph node
E. Higher incidence of tumor after immunosuppression
P28. Which one is an autosomal dominant disease caused
by germ line mutation of proto-oncogene
A Neurofibromatosis
B. VHL
C. MEN 2
D. Retinoblastoma
E. MEN 1
P31. Which one describes lynch syndrome over FAP
A, > 100 polyps
B, affect the proximal colon
C, affects APC gene
D, CHRPE
E, garden syndrome