UNIVERSITY OF HARGEISA

FACULTY OF MEDICINE AND SURGERY

COURSE: INFECTIOUS DISEASE

MCQS WITH THEIR ANSWERS

DR.M.A.HERGEYE

MULTILPLE CHOICE QUESTIONS

1. Regarding the infection which of the following is false:

a. Subclinical infection is an infection with few or no obvious symptoms

b. Opportunistic infection is an infection caused by organisms in the normal flora
c. Localized infection is an infection that is restricted to a specific location or region within the body
of the host
d. Systemic infection is an infection that has spread to several regions or areas in the body of the host
e. Primary infection is an infection that develops in an individual who is already infected with a
different pathogen
1. The role of bacterial capsules as virulence factors is usually related to their ability to interfere with
a. Antibody binding
b. B lymphocyte activation
c. Antibacterial penetration of bacterial cells
d. Phagocytosis
e. The release of interferon gamma and other macrophage activating cytokines
2. Which of the following is true about igM antibodies?
a. Cross the placenta
b. Are characteristically produced in a secondary immune response
c. Cannot activate complement
d. Are usually found lining mucosal surfaces

1|Page
 e. Are usually pentameric
3. Normal flora is present in the following organs/regions except
a. Skin
b. Lower respiratory tract
c. Oral cavity
d. Intestine especially large intestine
e. Vaginal tract
4. Exotoxin is a type of bacterial toxin with the following properties except
a. May be produced by either gram-positive or gram-negative
b. Is secreted by the bacteria
c. The action of the exotoxin does necessarily require the presence of the bacteria in the host
d. Most exotoxins are peptide or protein
e. Most exotoxins are heat sensitive
5. Which of the following statement regarding amoebiasis is correct?
a. Excystation takes place in the large bowel
b. E.dispar is nonpathogenic strain of E.histolytica
c. Hepatic infection occur if cyst enter mesenteric venules
d. Entamoeba coli have larger cyst with 4 nuclei
e. Entamoeba histolytica trophozoite have unidirectional motility
6. About the igA all are true except:
a. It has five subclasses
b. It is the first antibody that appears in fetus life
c. It is a poor activator of the complement system
d. Plays a critical role in mucosal immunity
e. Is the main immunoglobulin found in mucous secretions
7. In a chronic carriers of hepatitis B virus which of the following markers may not be present in the
patient’s serum?
a. Antibody to hepatitis B core antigen
b. Antibody to hepatitis B antigen
c. Antibody to hepatitis B surface antigen
d. Hepatitis B surface antigen
e. HBV DNA
8. Which of the following statements relating to the HIV replication cycle is correct?
a. Reverse transcription results in production of a double stranded DNA copy of the virus
b. The RNA genome of HIV can exist in a latent state inside infected cells
c. The translation occurs in the host cytoplasm
d. The virus requires the availability of cellular enzymes to integrate its genome into host cell
chromosomes
e. Maturation of viral particles does not require the presence of viral protease enzyme
9. In hepatitis A infection, all are true except:

2|Page
 a. HAV is a single stranded RNA picornavirus
b. One stable serotype only
c. Difficult to grow in cell culture
d. Viral antigen is found in serum, stool and liver only during acute infection
e. IgG antibody appears early in the disease but diminishes within several weeks then disappears
because there is no chronic stages
10. Which of the following statements relating to hepatitis viruses is false:
a. The risk of transmission of hepatitis B virus from mother to baby is greater than that of hepatitis C
virus
b. The chances of an adult becoming a chronic carrier are greater following infection with hepatitis B
virus than with hepatitis C virus
c. The risk of acute liver failure(fulminant hepatitis)is greater for infections with hepatitis B virus
than it is for hepatitis A virus
d. The mortality associated with acute hepatitis E virus infection is greater than that with acute
hepatitis A infection
e. Hepatitis D virus can only replicate in cells already infected with hepatitis B virus
11. Following statements regarding Giardia Lambia are correct except:
a. Trophozoites are the infective form of the parasite
b. Trophozoites are pear shaped
c. Cysts are present in the formed stool
d. Trophozoites are motile and non-infectious
e. Cysts are non-motile and egg shaped
12. Regarding ART, following statements are correct except:
a. Nelfinavir is protease inhibitors
b. Efavicenz is non-necleoside reverse transcriptase inhibitors
c. Didanocaine is nucleoside transcriptase inhibitor
d. Stavudine is nucleoside transcriptase inhibitor
e. Nevirapine is avoided first trimester
13. Following are clinical features of mumps except
a. Moderate fever
b. Malaise
c. Pain on chewing or swallowing
d. Cough
e. Swelling in front of the ear
14. The following are clinical features of measles except
a. Maculopapular rash
b. Cough
c. Conjunctivitis
d. Koplik spots(rash on mucous membranes)
e. Subacute sclerosing panencephalitis

3|Page
 15. Concerning the giardiasis which of these is true
a. It is treated by metronidazole
b. Its commonly transmitted by direct contact
c. Both trophozoite and cyst are infectious
d. It has no complications because it is commonly self –limiting infection
e. Giardia prevalence is about 2% in developing country
16. A nosocomial infection comes from:
a. Insect
b. rodent
c. Tropical region
d. Medical facility
e. Swine
17. Following are differential diagnosis of amoebiasis except
a. Inflammatory bowel disease
b. Tuberculosis peritonitis
c. Gall bladder disease
d. Bacillary dysentery
e. Schistosoma mansoni
18. Each of the following statements concerning human immunodeficiency virus is correct except
a. The CD4 protein on the lymphocyte surface is the receptor for the virus
b. Transmission of the HIV occurs primarily by the transfer of blood or semen in adults but neonates
are primarily infected perinatally
c. Most people can tell when they initially become infected with the virus
d. The current HIV antibody tests will tell a person what their HIV status was as of 6 months prior to
the test.
e. HIV belongs to the subclass of retroviruses
19. Best indicator of progression to AIDS with HIV positivity
a. CD4 count
b. Serum HIV antibody titer
c. B2{beta}..microglobulin
d. CD8 count
e. HIV viral load
20. The measles vaccine is made up of
a. Live attenuated virus
b. Inactivated(killed) virus
c. Purified toxoid
d. Polysaccharide antigen
e. Measles virus surface antigen
21. Following are clinical features of Giardiasis except
a. Tenesmus

4|Page
 b. Weight loss
c. Foul-smelling
d. Asymptomatic
e. Stomach cramps
22. Following are clinical features of amoebiasis except
a. Abdominal pain
b. Diarrhea with blood
c. Tenesmus
d. Vomiting
e. Fever
23. In hepatitis infection:
a. Jaundice is commonly seen in the pre-school age
b. Virus is present in stool before the onset of clinical illness
c. Mode of transmission is mainly perinatal transmission
d. Development of IgA antibodies is indication of the chronic infection
e. Sickle cell anaemia is a recognizable complication
24. Which of the following test is the best indicator for active viral replications in hepatitis B
a. Hepatitis B surface antigen
b. Hepatitis B surface antibody
c. Total hepatitis B core antibody
d. Hepatitis B e antigen
e. Hepatitis B e antibody
25. Measles infection
a. Causes a vesicular rash
b. May respond to acyclovir
c. May be prevented by antiviral therapy
d. Koplik spots are diagnostic sign
e. Is caused by a zoonotic RNA virus
26. Following statements regarding Giardia Lambia are correct except
a. Cysts are the infective form of the parasite
b. Trophozoites are pear shaped
c. Cysts are present in the formed stool
d. Trophozoites are motile and infectious
e. Cysts are non-motile and egg shaped
27. Which of the following is clinical feature of bacillary dysentery
a. Tenesmus
b. Weight loss
c. Foul-smelling stool
d. Asymptomatic
e. Stomach cramps

5|Page
 28. Regarding the rheumatic fever which of the following statement is true
a. Children below 5 years carditis usually mild but arthritis more prominent
b. Carditis is the only manifestation of rheumatic fever that leaves a sequelae and permanent damage
to the organ
c. Acute rheumatic fever is a systemic disease of childhood often recurrent that follows group B beta
hemolytic streptococcal infection
d. Erythema marginatum often associated with acute carditis
29. Regarding poliomyelitis infection which of the following is correct?
a. It is caused by bacteria
b. Can be effectively treated by oral vaccine
c. It is transmitted through oral-fecal route
30. Which of the following infections is zoonoses
a. Brucellosis
b. Leprosy
c. Tuberculosis
d. Meningitis
e. Cholera
31. Rheumatic fever which of the following is false:
a. Is the most common in the first decade
b. Is more common in areas of social deprivation
c. Causes erosive arthritis
d. Relapse rate may be reduced by prophylactic antibiotics
e. Is more common following streptococcal pharyngitis than streptococcal cellulitis
32. The paralysis of polio virus infection all are true except:
a. Is upper motor neuron type
b. Is asymmetrical
c. Usually affects the lower limbs more severely than the upper limbs
d. Is more severe if strenuous physical exercise occurred in the incubation period
e. May be caused by polio vaccination

Matching
Options:

a. Hepatitis B
b. Oral hairy leokoplekia
c. Measles
d. Mumps

6|Page
 e. Amoebic liver abscess

1. A 55 year old woman with fever and abdominal swelling. On examination she has
hepatosplenomegaly and hyperpigmentation of the skin……………..
2. A 20 year old man present with to the tip of the shoulder. On
examination he has jaundice on sclera and tenderness of right upper abdomen
3. A 3 year old girl in pediatric ward of the Hargeisa hospital present with high grade fever, dry
cough, conjunctivitis and maculopapular rash…….
4. A 5 year old boy present with swelling in the front of the ear, moderate fever, malaise and pain
chewing or swallowing particularly acidic liquids….
5. A 30 year old lady present with a white patch on the side of the tongue with a corrugated
appearance. She is HIV positive…….
6. A 45 year old male is referred to the Hargeisa TB hospital by Jilib general hospital(south
Somalia). He has been complaining of peripheral nerve lesions, plantar ulcers and diffuse skin
nodules and plaques……….

Column A Column B

1 A

2 F

3 D

4 E

5 C

7|Page