Professional Documents
Culture Documents
Appleman,
off medication was similar to that ex- 1. W. E. (E.
Bisochemistrru 7, 4177 (1968).
W. Sutherland, G. A. Robison, R. W.
Bunney, Jr., G. F. Boi-ge, D. L. 11)
creted by an age-matched group of Murphy, F. K. Goodwin, paper presented at
the anntual meeting of the American Psychi-
BLutcher, C irclllation 37.
279 (1968).
11. R. C. Haynes, S. B. Koritz. F. G. Peron,
normal controls. In addition, the mean atric Assoc., Bal Harbour. Fla., 1969; W. E. J. Biol. Chemn. 234, 1421 (1959).
valUes for both the hyperactive patients Btunney. Jr., D. L. NMurphy, F. K. Goodwin, 12. R. V. Farese, L. G. Linarelli, W. H. Glin-
G. F. Borge, Lancet 1970-I, 1022 (1970). mattn, B. R. Ditzion, M. 1. Patul, G. L. Pauk,
and control children were in the sam- 2. H. Cramer and W. Kuhlo, Acta Aeutrol. En doc,ini0ologt,
85. 867 (1969).
range as our aduLlt normal controls. 3.
Ps c/hiat. Belg. 67, 658 (1967).
M. I. Paul, B. R. Ditzion, G. L. PauLk, D. S.
13. P. S. Schonhofer, I. F. Skidatlore,
B. RZ. Ditzioni, G. L. PauLk, G. Krishna, B. B.
NM.
I. Patil,
After pro'onged physical activity (foot- 3a,nowskv. Ainer. J. Psvtchiat. 126. 1493 BI-odie, unpublished data.
ball), there was no significant differ- (1970); iM. I. Pauil, B. R. Ditzion, D. S. 14. R. Strom-Olsen and H. W. Weil-Mallherbe,
JanoxAskv. Lanicet 1970-I, 88 (1970). J. Mesit. Sci. 104. 696 (1958): A. Bergsman.
eince between the pre- and postexercise 4. Y. H. Abdtdllah and K. Hamadah, lancet A ita Pst/vshitt. Neirol. Sc asitl. Stippl. 33,
levels of Urinatry cyclic AMP in seven 1970-I 378 (1971)). S133 (1959); N. Shinfuku, 0. Mlichio, K.
5. HI. t. PaUl, H. C ramner, F. K. Goodswin, ibidl., Nl.>.ao. Yoniago Acta Med. 5, 1(09 (19'll);
normall suibjects. In contrast to our p. 996; Arc/h. Gen1. Pstchiat., in prcss. R. B. Sloane, W. Htughes. NI. I.. HaLuSt, C'ani.
Ps
findings, one study suggested that ex- 6. NI. 1. PauLl. B. R. Ditzion, G. L. PauLk. tc/hiat.
15. J. J.
Ass. J. 11, 6 (1966).
P/iar, uacologv 3, 148 (1971)). Schildkrauit, E. K. Gordotn, J. DLurell,
J. PsYc/ciat. Res. 3, 213 (1965).
crcise maly elevate urinary cyclic AMP 7. G. 1. Gessa, J. Forn, A. Tagliamonte, G.
Krishnia, in Role of Cyclic AM5/P in NAelronal 16. W. E. Btinney. Jr., and J. NI. Davis, Arch.
levels ( 17). Robison et al. also recently Funizctioni, E. Costa and P. Green-ard. Eds. Gen. Psv chiat. 13, 483 (1965).
reported normiial levels of cerebral spinal (Raven, New York, in pi-ess). 17. D. Eccleston. R. Loose, 1. A. Pttllar, R. F.
fluid cyclic AMP in manic patients: 8. W. E. Bunney and D. A. Hambturg. Arc/h. Stigdcn, Lancet 1970-lII 612 (1971)).
18. G. R. Robison et al., ibid., p. 1028.
Ceti. PtYchiat. 9, 280 (1963); A. Beigel, D.
however, they did not study patients at NluLrphy, W. E. BuLnlney, uLnpublished data. 23 July 1970; i-eviscd 14 October 197(1
the time of the swvitch into mania and
thuLs would have missed a transient
mlarked peak at that time (18). In our
stuLdies, cyclic AMP excretion is inde- Speech Perception in Infants
penldent of age anid sex (3).We have re-
viewed the known factors intluencing Abstract. Discriminiationi of synith1etic speechll .SOlunid was stldie(i in 1- anid 4-
cyclic AMP excrction (3, 5), but the mizonith-old infanlts. The speechl soiunds varied i alolig anl (colustic diuICInsionI pie-
relatixe proportion of cyclic AMP com- viously shown'n to cute plionieniiic distiinctions amiiong the voiced an?6d voiceless stop
inig from extrarenal sources remainis to consonants ini adullts. Disciiin?tilability wtas ienas ured by ani increase ii conIdi-
be cletermined. Thus, at this time, one tioiiedl responise rcate to a second speech souiCd a/f/er hiabitutatioln to the first speechi
canniot state wvhether the cyclic AMP sound. Recovery fromiz habituation tas greater for a givcn acoustic dif/ereiice
response is mediated centrally or is a whi en the twvo stimulili were frcomii difJecient adlult ph1ontein ic cate(,tories thlcan wivhen
reflection of peripheral metabolism. De- they were fi-oini the samze caltegory. The discontinuity in discriniiiiacltioni at the
creases in the excretion of urinary cy- regionr of the adirlt pllollenilic boundary t'as teikeii as ev,idence for categorical
clic AMP have been demonstrated in )e-cetption.
patients with pseudohypoparathyroidism.
Thtus, changes in calcium metabolism In this study of speech perception, investigation of this nature (2) revealed
may be associated with alterations in cy- it was founid that 1- and 4-month-old that the perceptioin of this cue was very
clic AMP metabolism (3). Althou,gh the infants were able to discriminate the nearly categorical in the sense that
changes iin urinary cyclic AMP nmax acoustic cue underlying the adult pho- listeners couldl discriminate continuous
be secondary to catecholamine or cal- nemic distinction between the voi-cd variations in the relative onset of the
ciulm chaniges, our evidence docuLmlents and voiceless stop consonants /b/ and first formlant very little better than they
atn alteration in an important process / Mp.loreover, and more important, could identify the sound paltterns abso-
that accomiipanies and, in at least one there was a tendency in these subjects lutely. ThaLt is, listeners could rcadily
instance, preceded gross behavioral toward categorical perception: discrim- discriminate between the voiced and
changes. This further suLggests the im- ination of the same physical difference voiceless stop consonants, just as they
portance of biochemical changes in the was reliably better across the adult would differentially label them, but they
manic-depressive illness. It is of inter- phonemic boundary than within the were virtually unable to hear intra-
est to consider the possibility that the adult phonemic category.
concept of cyclic AMP as a trigger
phonemic differences, despite the faAt
Earlier research using synthetic that the acouLstic varitation xxvas the same
mech'anism for metabolic processes may speech sounds with adult subjects un- in both conditions. The most measur-
be relevant to the switch process from covered a sufficient cue for the per- able indication of this categorical per-
depression to mania. ceived distinction in English between ception was the occurrence of a high
MICHAEL I. PAUL the voiced and voiceless forms of the peak of discriminability at the bouLndary
Neuropsychiatric Institute, Ceiter stop consonants, /b-p/, /d-t/, and Ig- between the voiced and voiceless stops,
for the Health Sciences, University k/. occurring in absolute initial position
of California, Los Anugeles 90024
and a nearly chance level of discrim-
(1). The cue, which is illustratcal in in,ability among stimuli that represented
HINRICH CRAMER the spectrograms displayed in Fig. 1, is acoustic variations of the same pho-
Laboratory of Cheiinical Pharmnacolog, the onset of the first l'ormnant relative to Such
Natio!nal Heart anid Luiil Institlute,
neme. categorical perception is
the second and third formaints. It is pos- not found with nonspeech sounds that
Bethesa., Maryland 20014 sible to construct a series of stimuli that vary continuously along physical con-
WILLIAM E. BUNNEY, JR. vary continuously in the relative onset tinua such as frequency or intensity.
L,abora-'ory of Clinical Scienice, time of the first formant, and to investi-
National Institute of Menttal Healtlh, Typically, listeners are able to discrim-
gate listeners' ability to identify and inate many more stinmuli than they are
Bethesda, Maryland 20014 discriminate these sound patterns. An able to identify absolutely, and the dis-
22 JANTJARY 1971
303
the special processing to which sounds Not all languages studied make use
of speech are subjected and thus to be of the three modal positions. English,
characteristic of perception in the for example, uses only two locations, a
@2 - F -2|
speech or linguistic mode (4). short lag in voicing and a relatively long
Because the voicing dimension in the lag in voicing. Prevoicing or long voic-
F-1 ing lead, found in Thai, for example,
stop consonants is universal, or very
nearly so, it may be thought to be is omitted. Of interest, however, is the
+ 10 msec
fact that all languages use the middle
reasonably close to the biological basis
of speech and hence of special interest location, short voicing lag, which, given
3
E 0
I
_ ,~~~~~~~~~~~~~~~IX
to a positive pressure transducer that
c
C
I provided polygraphic recordings of all
I
responses and a digital record of cri-
15 _ B 54 3 2 1 2 3 4~~~~ terional high-amplitude sucking re-
I sponses. Criterional responses activated
a power supply that increased the in-
I tensity of the auditory feedback. A
I I I ; ! , . I
rate of two responses per sec-
I I
B 5 4 3 2 1 1 2 34
sucking
B5 43 2 1 1 2 34 ond maintained the stimulus at maxi-
Time (min) mum intensity, about 75 db (13 db
Fig. 2. Mean number of sucking responses for the 4-month-old infants, as a function over the background intensity of
of time and experimental condition. The dashed line indicates the occurrence of the 62 db).
stimulus shift, or in the case of the control group the time at which the shift would The presentation of an auditory stim-
have occurred. The letter B stands for the baseline rate. Time is measured with ulus in this manner typically results in
reference to the moment of stimulus shift and indicates the 5 minutes prior to and an increase in the rate of sucking com-
the 4 minutes after shift.
304
SCIENCE, VOL. 171
pared with the baseline rate. With con- ZOD stimulation was made. The control
tinued presentation of the initial stim- group served to counter any argument
ulus, a decrement in the response rate that the increment in response rate as-
occurs, presumably as a consequence of sociated with a change in stimulation
the lessening of the reinforcing prop- was artifactual in that the infants
erties of the initial stimulus. When it 4-
tended to respond in a cyclical manner.
was apparent that attenuation of the Eight infants from each age level were
reinforcing properties of the initial stim- 0