GOVERNMENT MEDICAL COLLEGE, ARIYALUR

DEPARTMENT OF PATHOLOGY

INTERNAL ASSESSMENT – 3

Essay: (1x15=15 marks)

1.a) What is angiogenesis? (2 marks)

b) Discuss the mechanism of angiogenesis in tumors. (7 marks)

c) What is genomic instability? Discuss with examples. (6 marks)

Short Notes: (5x5=25 marks)

1. Chemical carcinogenesis
2. Enumerate the difference between Marasmus and Kwashiorkor
3. Paraneoplastic syndrome
4. 25 year/ F presented with hypopigmented anesthetic macules over hands and face for 3
months. O/E – peripheral nerves were palpable and tender.
Slit skin smear shows Acid fast bacilli.
a) What is your diagnosis? (1 mark)
b) Describe the etiopathogenesis of the disease. (4 marks)
5. a) Justify the statement “Leptin plays a central role in energy homeostasis”. (2 marks)
b) Discuss the etiopathogenesis of obesity. (3 marks)

GOVERNMENT MEDICAL COLLEGE, ARIYALUR

DEPARTMENT OF PATHOLOGY

INTERNAL ASSESSMENT – 3

Essay: (1x15=15 marks)

1.a) What is angiogenesis? (2 marks)

b) Discuss the mechanism of angiogenesis in tumors. (7 marks)

c) What is genomic instability? Discuss with examples. (6 marks)

Short Notes: (5x5=25 marks)

1. Chemical carcinogenesis
2. Enumerate the difference between Marasmus and Kwashiorkor
3. Paraneoplastic syndrome
4. 25 year/ F presented with hypopigmented anesthetic macules over hands and face for 3
months. O/E – peripheral nerves were palpable and tender.
Slit skin smear shows Acid fast bacilli.
c) What is your diagnosis? (1 mark)
d) Describe the etiopathogenesis of the disease. (4 marks)
5. a) Justify the statement “Leptin plays a central role in energy homeostasis”. (2 marks)
b) Discuss the etiopathogenesis of obesity. (3 marks)
 GOVERNMENT MEDICAL COLLEGE, ARIYALUR

DEPARTMENT OF PATHOLOGY

INTERNAL ASSESSMENT – 3

MCQs: (10x1=10 marks)

1. Radiation exposure during infancy has been linked to which one of the following carcinoma?
a) Breast b) GIT c) Thyroid d) Lung
2. H.Pylori is associated with development of
a) Gastric adenocarcinoma
b) Gastric fundal polyp
c) GIST
d) Gastric sarcoma
3. ALK is a
a) Cyclin receptor b) Tyrosine kinase receptor c) CDK receptor d) RB receptor
4. 65 / M diagnosed by biopsy as a case of lung carcinoma with paraneoplastic syndrome and
increased calcium. Probable cause is
a) PTH b) PTH related peptide c) Calcitonin d) Calcitonin related peptide
5. The following characteristics are used for cytomorphological recognition of cancer except
a) Cytoplasmic contents b) Nuclear size c) Nuclear Cytoplasmic ratio d) Mitosis
6. Chancre is seen in
a) Primary syphilis b) Secondary syphilis c) Tertiary syphilis d) Congenital syphilis
7. Virchow cells are seen in
a) Tuberculosis b) syphilis c) leprosy d) AIDS
8. Which of the following is not true 00about kwashiorkor?
a) Generalized edema or dependent edema.
b) Weight of the children is 60 – 80 % of normal.
c) Severe loss of somatic protein component.
d) Relative sparing of subcutaneous fat and muscle mass.
9. The human virus that has been associated with Burkitt’s lymphoma is
a) Cytomegalovirus
b) Human papilloma virus (HPV)
c) Retrovirus
d) Ebstein-Barr virus
10. Which of the malaria species has longest incubation period?
a) P.falciparum b) P.malariae c) P.ovale d) P.vivax