Estrogen dominance

Why is it so important if we going to maintain health, especially to day in our toxic world where
we live eat and breath in an estrogen soup

Dr Anthony de Pontes @ www.drdepontes.com

PART 2: ESTROGEN DOMINANCE
Today’s program
RECAP
1. How to use homeopathy clinically to rebalance OAT axis
2. Liver detox and importance of P450 detox pathways.
What does liver detox mean? homeopaths always are talking about detox, but what does it mean.

3. Interactions of hormones and homeopathics to balance estrogen dominance.

4. Clinical estrogen dominant questionnaire you can use on your patients
5. Lab testing options- best tests.

Dr Anthony de Pontes @ www.drdepontes.com

 ESTROGEN DOMINANCE
What is Estrogen dominance- RELATIVE difference between estrogen and progesterone in the body

Analogy of girls and boys in classroom

Dr Anthony de Pontes @ www.drdepontes.com

Dr Anthony de Pontes @ www.drdepontes.com
 FACTS ABOUT ESTROGEN
DOMINANCE
1. Estrogen Dominance is the result of excessive estrogen and progesterone deficiency.
2. Epidemic, affecting about 50% of the population in western world.
3. Caused by excessive environmental estrogen
4. Estrogen dominant disease occur due to obesity, stress, poor diet,  lack of exercise, and unopposed
estrogen given as part of a hormone replacement.
5. Root cause of many female diseases.

Dr Anthony de Pontes @ www.drdepontes.com

 GLANDULAR PLAYERS- HORMONAL
INTERACTION
1. Need to address 3 glands
2. Adrenal, thyroid ovaries or OAT axis
3. Excessive  estrogen affects both thyroid and adrenal function,
4. Dysfunctional thyroid and adrenal fatigue makes estrogen dominance worse. These glands control the majority of
hormones in the body
5. Conventional medicine looks at symptoms to control the problems instead of root cause.

ADRENA
LS

HYPOTHALA PITUAT THYRO

MUS RY ID

HPG axis OVARI

OAT axis ES
Dr Anthony de Pontes @ www.drdepontes.com
HPA axis
INTERACTION BETWEEN ESTROGEN
AND PROGESTERONE
Day 14-15 OVULATION
The key factor that determines how long it will take before you
ovulate is how soon your body reaches its estrogen threshold.
The high levels of estrogen will trigger an abrupt surge of
Luteinizing Hormone (LH). It's this LH surge that causes the
egg to literally burst through the ovarian wall, usually within a
day or so of the occurrence that we called ovulation. After
ovulation, the egg tumbles out into the pelvic cavity, where it is
quickly transported into the fallopian tubes. The remainder of
the ruptured follicle (called the corpus luteum) recedes back to
the ovary and begins an important task of secreting
progesterone.
Day 15-30
Progesterone level reaches its peak on day 19-22, after which
the level starts to fall if no fertilization.

Dr Anthony de Pontes @ www.drdepontes.com

OVULATION IS IMPERATIVE
If not enough estrogen at the right time then no LH surge
No LH surge, no ovulation
No ovulation no corpus luteum to produce progesterone
No progesterone – bigger chance of ESTROGEN DOMINANCE
Birth control pills force your body into menstruation without ovulation therefore little progesterone.
Increased anxiety, insomnia, skin dryness.

Dr Anthony de Pontes @ www.drdepontes.com

A SMOOTH MENOPAUSE OR NOT
cholesterol

Dr Anthony de Pontes @ www.drdepontes.com

PREGNELONE STEAL SYNDROME

Dr Anthony de Pontes @ www.drdepontes.com

 LIVER IMPORTANCE
The liver has to clear and detox all the hormones and neurochemicals so that estrogen dominance is not
stimulated
HRT- still getting flushes, water retention, etc
Liver detoxification through sulfation, glucuronidation and methylation is important to ensure proper
hormonal function.

Dr Anthony de Pontes @ www.drdepontes.com

TYPES OF ESTROGEN DOMINANCE
1. IF OVERWEIGHT (High serum estrogen with normal serum progesterone) Check the liver.
2. Women 5-6 Kg overweight, often with thyroid dysfunction.
Normal serum estrogen with low serum progesterone) 

Pregnenalone steal syndrome

No ovulation
3. Normal serum estrogen levels and normal serum progesterone levels but with excessive
exposure to endocrine disrupting chemicals. 

Check the liver and environment

4. Progesterone resistance syndromes (such as PCOS and endometriosis)
Rx progesterone, GABA

Dr Anthony de Pontes @ www.drdepontes.com

PART 2: ESTROGEN DOMINANCE
most important axis to assess when striving for balanced hormones
Common Symptoms of OAT Dysfunction. Fatigue. Depression or Anxiety. Irregular or heavy periods.
Hypoglycaemia. Tender breasts. Hair loss. Dry skin.

It’s just adrenal fatigue.”

“It’s just hypothyroidism.”
“It’s just estrogen dominance.”

Dr Anthony de Pontes @ www.drdepontes.com

The Ovarian-Adrenal-Thyroid Axis
most important axis to assess when striving for balanced hormones
Common Symptoms of OAT Dysfunction. Fatigue. Depression or Anxiety. Irregular or heavy periods.
Hypoglycaemia. Tender breasts. Hair loss. Dry skin.

It’s just adrenal fatigue.”

“It’s just hypothyroidism.”
“It’s just estrogen dominance.”

Dr Anthony de Pontes @ www.drdepontes.com

 The Ovarian-Adrenal-Thyroid
Axis
Adrenal Fatigue Symptoms A, T
Depression or Anxiety OAT
Irregular or heavy periods OAT
Hypoglycaemia A
Tender breasts O
Hair loss T
Dry skin T
Mood swings OA
Sugar and caffeine cravings A
Headaches OAT

Irritability between meals A

Difficulty falling asleep, staying asleep and not waking feeling rested AT
Catching every cold or feeling sick often AT
Lightheaded or dizziness from changing positions AT
Water retention OAT
Weight gaindeorPontes
Dr Anthony www.drdepontes.com
difficulty
@ losing weight OAT
START WITH THE ADRENAL
PART OF OAT AXIS.
Rhodiola.- Reduces stress, improves resilience
Support with thyroid
Contra indicated if hx bipolar
Rx 200mg daily

Eleuthero coccus.- increase energy, concentration

Insomnia
Contra indicated with high BP.
Ashwagandha (Withania).- calming, anxiety, energy, libido, oxidative stress
200mg daily

Cortisol 30 daily
Cortisol 4x4
Adrenal gland 6x / 6c tds
ACTH 4x4
Dr Anthony de Pontes @ www.drdepontes.com
GABA 30
APPROPRIATE LAB TESTING
Application in clinical practice
Estradiol, FSH, LH (Best tested on Day 3 of your menstrual cycle)
Progesterone (Best tested on Day 19-22 of your menstrual cycle)
Adrenal Stress Index test
Dutch Complete with Cycle Mapping
Thyroid panel: TSH, Free T4, Free T3, Reverse T3, Anti-TPO, Anti-thyroglobulin
Free Testosterone
Sex Hormone Binding Globulin
Additional testing may be necessary

Dr Anthony de Pontes @ www.drdepontes.com

 ESTROGEN DOMINANCE-
Hormonal minefield
Application in clinical practice
1. MANY HORMONAL PRODUCTS CONTAIN SYNTHETIC HORMONES, not bioidentical
2. Progestins damage cardiovascular system, increase breast ca risk
3. Many different types of ‘natural’ or bioidentical estrogens’ with differing strengths
4. Bad metabolites 4OH and 16OH (hydroxy estrone) P450 DETOX
5. These metabolites rise when liver function is
compromised-
US HOMEOPATHS WILL SUGGEST A LIVER DETOX

Dr Anthony de Pontes @ www.drdepontes.com

 HORMONAL
MINEFIELD- menopause
Application in clinical practice
1. OESTROGEN DOES NOT DROP TO ZERO AT MENOPAUSE. IN A HEALTHY PERSON IT CAN STAY AT
30%-
BUT:- be concerned for the following patients
2. Women without ovaries and who have taken hormonal contraception for many years.
3. Women with insufficient adrenal hormones
Look to increase the DHEA as it converts to oestrdial

Dr Anthony de Pontes @ www.drdepontes.com

A SMOOTH MENOPAUSE OR
NOT
Cholesterol

Dr Anthony de Pontes @ www.drdepontes.com

 IF YOU NEED
SUPPLEMENTATION.
Application in clinical practice
1. BEFORE HORMONES ARE SUPPLEMENTED TRY DIET AND LIFESTYLE
REDUCE ALCOHOL, SUGAR CLUE OAT
IMPROVE SLEEP CLUE CORTISOL AND AUTOPHAGY
SUFFIEIENT VEGGIES, PROTEIN AND FAT- CLUE SUPPORTS LIVER DETOX, STABALIZES BLOOD
SUGAR
BLUE LIGHT EXPOSURE CLUE CORTISOL, MELATONIN DISRUPTION.
B-complex, Ashwagandha

Dr Anthony de Pontes @ www.drdepontes.com

‘ I don’t like progesterone
supplementation’
Application in clinical practice
Low progesterone is due to:
1. INABILITY TO OVULATE
2. PREGNELELONE STEAL SYNDROME- Progesterone is converted to cortisol in order to survive cope
Look at what is stressing the patient- causative factor in order to bring production of cortisol down
Reduced inflammation via diet, exercise, light exposure
Coping strategies for worry
Sufficient sleep
Appropriate homeopathic remedy-

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR
HIGH CORTISOL
Cortisol, ascending potencies,
Causative factor prescription: worry, supressed anger, neglect
Carsinosin, Staphasagria, Sepia, Aconite, Nux Vom,
Adrenal 6x or 6c
B-complex

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen
dominance HORMONAL CASCADE
LH
HYPOLUTEMIA-(SMALL DEFICIT) 5C ON DAY 18 CYCLE (j. Jouanny)
FSH-
15C daily once menopause set in, stops flushes
HYPERFOLLICULEMIA- contributes to osteoporosis and CVD, PREMATURE MENOPAUSE((Premature
ovarian failure)
(INHIBITS 30C 7th day of cycle to regulate PMS

PROGESTERONE
4x4 course,
DHEA- Balance pituitary, hypertrophy of ovaries, ovulation issues, sexual abuse
Can be affected by xenoestrogens

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen dominance
FOLLICULINUM

Often feel cold,(down regulates thyroid)

Balances menstrual cycle and hormones
Menopausal
Help a women to feel feminine again
Infertility, endometriosis, Migraine around ovulation
Ovulation dysfunction
POTENTIAL OTHER ASPECTS OF PRESCRIPTION
Sepia, cimicifuga,

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen dominance
PROGESTERONE

PRECURSOR OF ALL STEROID HORMONES

CHOLESTEROL –PREGNELELONE-PROGESTERONE
Balances the excess estrogens, but can be used up converting to cortisol
Prepares endometrium for implantation of fertilized egg
Endometriosis
Headaches and migraines
Menses every 2 weeks (metrorrhagia)
Myomas/ fibroma
PROGESTERONE 4X4
Rx GABA 30 especially if anxiety symptoms

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen
dominance MIASMIC APPROACH
Carsinosin- passionate, intense emotions, aggravated by heat flushes), craves chocolate,
dysmenorrhea >bending forward>pressure, swelling and tenderness of breasts prior to
menses, ovarian cysts, acne on face, back and chest, PMS

Medorrhinum- Ovarian pains, high sex drive, intense emotions,

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen
dominance – a proper liver detox

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen
dominance – a proper liver detox

Phase 1 creates free radicles (ROS) – lead to inflammation and tissue damage
PROBLEM: Push phase 1 before phase 2
Phase 2 Conjugation where liver attaches another molecule to toxin

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen
dominance detox phases
Phase 1 liver detox uses oxygen to form a reactive site on a toxin- oxidation

Phase 2 liver detox adds a water-soluble group to the reactive site on a toxin
Toxic fat soluble toxin moves to less toxic substance that is water soluble and able to be
eliminated

Phase 3 liver detox eliminates the water-soluble toxins through the bile and out of the
gallbladder. Alkalinity promotes phase 3 detox, so alkaline-forming fruits and
vegetables are fantastic foods for liver detox.
Toxins will be reabsorbed into the bloodstream if they can’t get out via the bile and
eliminated through the faeces.

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen
dominance detox phase 2
PHASE 2 LIVER DETOX
6 detoxification pathways to further conjugate toxins.
Glutathione conjugation- against free radicals produced through phase 1 detox and oxidative stress.
detox environmental toxins versatile in conjugating and binding many different types of toxins.
Sulfation -elimination of steroid and thyroid hormones, neurotransmitters and estrogens .  It also
detoxifies food additives, toxins from intestinal bacteria, and the environment.
Amino acid conjugation uses amino acids to combine with toxins to neutralize them. Glycine, taurine,
glutamine, arginine, and ornithine.
Glucuronidation-metabolizing drugs, estrogens and also conjugates bilirubin.
Acetylation-histamine, caffeine, choline, and tyramine.
• Methylation pathway is responsible for methylating histamine.  symptoms of histamine
intolerance. Methylation used in process neurotransmitters such as dopamine, epinephrine, and
norepinephrine.

Dr Anthony de Pontes @ www.drdepontes.com

HOMEOPATHY FOR oestrogen
dominance detox liver detox

If phase 3 is blocked, then when you detox, you can feel worse
Toxins get reabsorbed in the bloodstream, instead of exiting the liver
Toxins coming out of phase 1 can be more toxic then the original and so phase 1
and 2 must be functioning at same speed

Dr Anthony de Pontes @ www.drdepontes.com

ESTROGEN DOMINANCE
QUESTIONAIRE
Would you like an ESTROGEN DOMINANCE questionnaire for
your patients, and yourself

Dr Anthony de Pontes @ www.drdepontes.com

Dr Anthony de Pontes @ www.drdepontes.com