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KEYWORDS Summary The severe acute respiratory syndrome (SARS) crisis led to the
Operating theatre; construction of a negative pressure operating theatre at a hospital in Hong
Airflow performance; Kong. It is currently used for treatment of suspected or confirmed airborne
Airborne infection
infection cases, and was built in anticipation of a return of SARS, an out-
break of avian influenza or other respiratory epidemics. This article de-
scribes the physical conversion of a standard positive pressure operating
theatre into a negative pressure environment, problems encountered, air-
flow design, and evaluation of performance. Since entering regular service,
routine measurements and observations have indicated that the airflow
performance has been satisfactory. This has also been confirmed by regular
air sampling checks. Computational fluid dynamics, a computer modelling
technique, was used to compare the distribution of room air before and
after the design changes from positive to negative pressure. The simulation
results show that the physical environment and the dispersion pattern of
bacteria in the negative pressure theatre were as good as, if not better
than, those in the original positive pressure design.
ª 2006 The Hospital Infection Society. Published by Elsevier Ltd. All rights
reserved.
Introduction
pressure theatre was considered to be more This paper presents the process of converting
suitable than a positive pressure environment. In a positive pressure theatre into a negative pres-
principle, a positive pressure operating theatre sure theatre, and the subsequent performance
with adequate air changes could quickly eliminate evaluation.
the virus from the environment, and it has been
shown that the risk of cross-contamination from
airborne infection is low if staff are adequately Methods
protected with appropriate personal protective
equipment (PPE).1 However, a negative pressure Routine monitoring of airflow performance
operating theatre offers optimal protection to
personnel working in adjacent areas. The airflow system performance of an operating
Most SARS patients admitted to the United theatre in the hospital was monitored regularly
Christian Hospital during the crisis were residents through observations and/or measurements of
of Amoy Gardens, where the largest transmission of pressure gradient, flow pattern, temperature and
community-acquired SARS occurred. Over a short humidity levels. To ensure sterility in the operating
period, one of the 11 operating theatres in the main theatre, routine bacterial sampling using two
operating suite of the hospital was converted types of plates [tryptone soy agar (TSA) and
temporarily into a negative pressure theatre. This Sabouraud agar] was performed after each air
was achieved by incorporating two strong exhaust duct cleansing and filter replacement. The plates
fans next to the original exhaust system. The were placed in three positions (i.e. high, low and
pressure differential was maintained by sealing at the air exhaust). The high position was located
the entrance doors with disposable sticky tape by the anaesthesia apparatus near the operating
after the patient was transported into the room. table, 2 m above floor level; the low position was
This temporary negative pressure theatre worked located near the operating table, 1 m above floor
well during the SARS crisis.2 Afterwards, the hospi- level; and the air exhaust position was in front of
tal management decided that a permanent nega- either of the exhaust grilles. The SAS Super 100
tive pressure operating theatre was necessary, in Air Sampler (International Pbi, Milano, Italy) was
anticipation of SARS returning and for those pa- used to obtain volumes of 500 L into two separate
tients contracting similar infectious airborne dis- 55-mm culture plates of TSA (Oxoid, Basingstoke,
eases such as tuberculosis and severe influenza. UK) and Sabouraud agar (bioMérieux, Marcy
The construction of this permanent negative pres- I’ Etoile, France). The plates were incubated at
sure operating theatre was completed in June 2004. 37 C and 30 C for two days and five days for bacte-
The original operating theatre suite in this rial and fungal counts, respectively. A colony count
hospital was built in 1994. Similar to all other of less than 30 colony-forming units (CFU)/m3 for
operating theatres in Hong Kong around that the TSA agar and 3 CFU/m3 for the Sabouraud agar
period and up to the present day, the operating was adopted as the acceptable standard in all oper-
theatres were maintained at a positive pressure. ating theatres, but a more stringent standard was
Specifications such as the floor area, airflow applied to the theatre using laminar airflow.5
quantity and pressure gradient were designed to
meet the requirements of the British operating Theatre selection for negative
theatre standards, which have been commonly pressure conversion
used as reference in Hong Kong.3,4 The room pres-
sure was maintained at þ25 Pa. Areas around the Theatre 1 (OT-1) of the main operating suite was
operating theatre were also under positive pres- chosen for pressure conversion for two main rea-
sure. By controlling the supply and extract airflow sons. Firstly, OT-1 was the furthest away from the
rates of each room in accordance with the design other operating theatres, making isolation easier to
data given in Figure 1, a pressure gradient was de- accomplish. It minimized the risk of air from the
veloped in continuous progression through zones corridor being contaminated as a result of traffic
with increasing sterility. Outside air was intro- flow and then being drawn into the negative
duced to the operating theatre through a perfo- pressure operating theatre, which could be a risk
rated diffuser at ceiling level, directly above the for wound infection. Secondly, it had two free
surgical area. This led to a downward displace- sidewalls that could accommodate the addition of
ment of air above the operating table. Room air a separate exhaust system, and had its own scrub
was extracted through a low-level exhaust grill area and a separate induction room that could be
located next to the back door and an embedded converted into a room for removal of contaminated
exhaust duct in the sidewall. clothing. The main feature of the negative pressure
Conversion of operating theatre from positive to negative pressure environment 373
Recovery bay
150 150
150 150
Stabilizer Stabilizer
2 1
AC plant
Dirty corridor
room Preparation
850
850
200
OT-1
210 210
360
E.D.
150 Sluice 150
Figure 1 Floor plan of operating theatre suite before pressure conversion. E.D., exhaust duct; OT-1, Operating
Theatre 1; AC, air conditioning.
design, compared with the positive pressure design, the supply diffuser and exhaust grilles were
was the incorporation of a much stronger low-level checked by vane anemometer measurements. The
exhaust system. The exhaust air passed through airflow pattern was examined carefully using smoke
a two-stage filtration system (prefilter plus High tests. In order to gather more technical information
Efficiency Particulate Air (HEPA) filter) before its for assessing the effectiveness of the present
final disposal via an exhaust air fan. In order to airflow system, the room air distribution before
achieve the designated airflow criteria, an ante- and after the conversion was examined through
room was constructed at the front end of the scrub computer analysis.
and induction rooms leading to OT-1. All doors
leading to these negative pressure rooms were Airflow evaluation by CFD technique
made airtight and interlocking. The physical layout
and the airflow specification of the negative pres- Computational fluid dynamics (CFD) analysis pro-
sure operating theatre suite are shown in Figure 2. vides comprehensive data on airflows within
As OT-1 and OT-2 originally shared the same air con- a room. It demonstrates any deficiencies in air
ditioning system, a separate air conditioning system distribution and in contaminant removal. It has
had to be built for OT-2 before the necessary been applied to the study of airflows and contam-
changes were made to OT-1. inant distribution patterns in various operating
Static pressure heads in OT-1 and in the adjacent theatre applications.6e10
rooms were monitored by differential pressure In this study, the computation models of Cases
gauge measurements. Correct airflow velocities at A and B, i.e. before and after the pressure
374 T.T. Chow et al.
Automatic Automatic
sliding door Anteroom 150 sliding door
100 180
125 150
AC plant
room
Stabilizer 2 Stabilizer 1
E.D. Automatic
850 sliding door
Preparation
Dirty corridor
1000
OT-1 OT-2
E.D. Control
panel
Sluice
300
Figure 2 Floor plan of operating theatre suite after pressure conversion. E.D., exhaust duct; OT-1, Operating The-
atre 1; OT-2, Operating Theatre 2; AC, air conditioning.
conversion, are shown in Figure 3 (a) and (b), re- For Case A (positive pressure), the exhaust
spectively. The room dimensions were 6.3 m airflow at the exhaust grille was 0.21 m3/s and
(length) 5.9 m (width) 3.1 m (height). In the the balance airflow of 0.64 m3/s was a combination
computer model, the seven surgical staff standing of discharge from the two pressure stabilizers and
upright and the patient lying on the operating ta- the gaps between the doors and the floor. For Case
ble were represented as rectangular solid boxes. B (negative pressure), the total air extraction rate
In the analysis, it was assumed that each staff through the two exhaust grilles was 1 m3/s. The
member released infectious particles at a rate of balance airflow of 0.15 m3/s entered the room
100 CFU/min from the body surface that faced through the two pressure stabilizers. A deflector
the patient. Also, an assumption was made that plate was positioned 0.15 m in front of Stabilizer
an infectious particle release rate of 400 CFU/ 2 to divert the incoming flow upwards. These con-
min occurred from the surgical incision site at stituted the only differences between the two
the waist position and from the patient’s upper cases, and hence the simulation results can be
surfaces. The main and satellite medical lamps readily compared.
were 350 W and 200 W, respectively, and produced Numerical simulations were performed with the
heat fluxes from their downward surfaces. Each of commercial CFD software FLUENT.11 The standard
the eight fluorescent lighting panels surrounding empirical model was adopted to simulate the
the perforated supply diffuser released a heat flow turbulence. Only steady-state conditions
flux of 70 W. The flow of fresh air was 0.85 m3/s. were considered.
Conversion of operating theatre from positive to negative pressure environment 375
(a) Perforated
supply diffuser
Staff 6 Fluorescent
Stabilizer 1 lighting
Stabilizer 2
Oxygen supply
Staff 7
Staff 4
Equipment
table
Exhaust grille
Anaesthesia apparatus
Staff 1
Staff 2 Staff 3
Exhaust 1 Staff 4
Staff 3
Staff 2
Exhaust 2 Staff 1
Figure 3 Computation models of Operating Theatre 1 before and after the pressure conversion. (a) Positive pres-
sure, (b) negative pressure.
14
9
was found to be generally consistent with the 16 18
smoke dispersion pattern as visualized through 14
20
16
7
the smoke tests during the commissioning period. >20 5
The results showed that the airflow systems 12 9 18
14 7 3
performed reasonably well both before and after 9 1
5
13 5
conversion from positive pressure to negative 1
pressure.
16
2
3 9
3
7 12
4 45
Medical lamp Back door
5 7
5 89 (main) 5
5 7
7
4 (b)
8
2 4 5
1
3 21 1 2
3 4
3
9 4
3 3
3
2 4
4 2 7
Staff 4 Equipment 7
4
table 9 9
11 >20 2
11
18 11
(b) >20 >20 16
9 13 16
8 1 1 10 9 8 4 7 9
7 2 2 7
2 2 4 18
18
6 3 11
6 4
4 3
>20 >20 16
5 5 6
11
20
6 13
13
5 8 7
7 7
16
6 11
45 42 3
3 6
2
5 5
4 4 5
4 3
3
3 4
3 9
Figure 4 Contours of temperature rise in degrees Cel- Figure 5 Comparison of concentration distribution of
sius (above temperature of air supply) at mid-width bacteria (released from staff) at operating plane, 1.1 m
cross-section of theatre. (a) Case A, positive pressure; from floor level (unit: colony-forming units/m 3 ). (a)
(b) Case B, negative pressure. Case A, positive pressure; (b) Case B, negative pressure.
Conversion of operating theatre from positive to negative pressure environment 377
(a) (a)
1
4 7
Stabilizer 2
14
Staff 6
Staff 2
>30
11 Staff 1 Staff 7
4 7 30 >30 7
14
27
17
(b)
(b)
14 4
1 1
11
4
4
4
7
>30
>30 Figure 7 Comparison of velocity vector at one-third
4 length of theatre, vertical plane cutting across the
4 24
4
and flow rates can be maintained. In the present 3. Essex-Lopresti M. Operating theatre design. Lancet 1999;
case, repeated testing and the results of periodical 353:1007e1010.
4. National Health Service Estates. Health Technical Memo-
air sampling checks confirmed the quality of the randum 2025. Ventilation in healthcare premises. London:
completed work. Moreover, the steady-state sim- HMSO; 1994.
ulation results showed that the level of thermal 5. Friberg B, Friberg S, Burman LG. Inconsistent correction be-
comfort as well as the dispersion behaviour of the tween aerobic bacterial surface and air counts in operating
bacteria in the negative pressure theatre were as rooms with ultra clean laminar air flows: proposal of a new
bacteriological standard for surface contamination. J Hosp
good as, if not better than, those in the original Infect 1999;42:287e293.
positive pressure design. 6. Chen Q, Zheng J, Moser A. Control of airborne particle
concentration and draught risk in an operating room. Indoor
Air 1992;2:154e167.
Acknowledgements 7. Colquhoun J, Partridge L. Computational fluid dynamics
applications in hospital ventilation design. Indoor Built
Environ 2003;12:81e88.
The work described in this article was supported 8. Chow TT, Yang XY. Performance of ventilation system in
by a strategic research grant from the City Uni- a non-standard operating room. Build Environ 2003;38:
versity of Hong Kong (project no. 7001609). 1401e1411.
9. Chow TT, Yang XY. Ventilation performance in the operating
theatre against airborne infection: numerical study on an
ultra-clean system. J Hosp Infect 2005;59:138e147.
References 10. Woloszyn M, Virgone J, Melen S. Diagonal air-distribution
system for operating rooms: experiment and modeling.
1. Seto WH, Tsang D, Yung TY, et al. Effectiveness of precau- Build Environ 2004;39:1171e1178.
tions against droplets and contact in prevention of nosoco- 11. Fluent Inc. User’s guide for Fluent 6.1. Lebanon: Fluent Inc;
mial transmission of severe acute respiratory syndrome 2003.
(SARS). Lancet 2003;361:1519e1520. 12. ISO Standard 7730. Moderate thermal environment e de-
2. Kwan A, Fok WG, Law KI, Lam SH. Tracheostomy in a patient termination of the PMV and PPD indices and specification
with severe acute respiratory syndrome. Br J Anaesth 2004; of the conditions for thermal comfort. Geneva: Interna-
92:280e282. tional Standard Organization; 1990.