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  • Breast 5

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    Ramez Antakia
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    The document outlines treatment guidelines for locally advanced or large triple-negative or HER2-positive breast cancers. It recommends neoadjuvant chemotherapy, including anti-HER2 drugs like trastuzumab and pertuzumab for HER2-positive cancers, to shrink the tumor and make it amenable to surgery. If cardiac issues emerge, further chemotherapy is given without surgery. Otherwise, surgery is performed after chemotherapy, followed by additional targeted anti-HER2 treatment for 12 months.

    Original Description:

    HER2 status

    Original Title

    Breast5

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    The document outlines treatment guidelines for locally advanced or large triple-negative or HER2-positive breast cancers. It recommends neoadjuvant chemotherapy, including anti-HER2 drugs like trastuzumab and pertuzumab for HER2-positive cancers, to shrink the tumor and make it amenable to surgery. If cardiac issues emerge, further chemotherapy is given without surgery. Otherwise, surgery is performed after chemotherapy, followed by additional targeted anti-HER2 treatment for 12 months.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    6 views1 page

    Breast 5

    Uploaded by

    Ramez Antakia
    The document outlines treatment guidelines for locally advanced or large triple-negative or HER2-positive breast cancers. It recommends neoadjuvant chemotherapy, including anti-HER2 drugs like trastuzumab and pertuzumab for HER2-positive cancers, to shrink the tumor and make it amenable to surgery. If cardiac issues emerge, further chemotherapy is given without surgery. Otherwise, surgery is performed after chemotherapy, followed by additional targeted anti-HER2 treatment for 12 months.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    B

    Locally
    advanced

    Triple -ve HER2+ &


    ER/PR/HER2 >15/20mm

    Neoadjuvant Neoadjuvant Chemotherapy


    Chemotherapy (2m Varies but concurrent with
    anti-HER2) & concurrent
    Trastuzumab & Pertuzumab

    Cardiac
    Issues
    Reassess
    for surgery

    No Yes

    Anthracycline, Post operative Trastuzumab (+/-)


    Cyclophosphamide, Pertuzumab complete 12m (If
    Cyclophosphamide,
    Taxane 2m given before surgery then
    Taxane
    give 10m after surgery)

    Reassess for
    surgery

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