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2 Basic Chemistry
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1 Slide Deck Presentation Prepared By

Mr. Niño A. Cabatingan


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Outcomes
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l • Differentiate matter from energy;


• List four major energy forms, and provide one example of
how each is used in the body; ___________________________________
i • Define radioisotope, and describe its application to diagnosing
and treating disease;
• Define molecule, and explain how molecules are related to
d compound; ___________________________________
• Differentiate between ionic, polar covalent, and nonpolar
covalent bonds, and describe the importance
e of hydrogen bonds;
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Readings
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l Marieb, E. N. & Keller, S. H. (2018). Essentials of anatomy and


physiology 12th Edition. England: Pearson Education Ltd. pp. 50-
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Checklist
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• Read course and unit objectives; ___________________________________
i • Ready study guide prior to class attendance;
• Read required learning resources; refer to unit terminologies
for jargons;
d • Proactively participate in discussions; ___________________________________
• Participate in weekly discussion board (Canvas);
e • Answer and submit course unit tasks.
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Watch Videos
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Cobeng, A. (2020, August 12). Anatomy and Physiology - Chapter
2 Chemical Basis of Life (Online Video) Retrieved from ___________________________________
i https://www.youtube.com/watch?v=ieUzS8pjsBI

d mrbiology15. (2014, July 25). Basic Chemistry Part 1(Online ___________________________________


Video) Retrieved from
https://www.youtube.com/watch?v=vI3dPWq6OoY
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Introduction
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l • Cells, tissues and organs composed of chemicals


• Chemical reactions important for function ___________________________________
i • Chemistry is the study of:
• Elements, compounds, chemical reactions, molecular
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Matter and Energy
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Matter ___________________________________
i • Anything that occupies space and has
mass.
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• Generally exists in three states: gas,
e liquid, and solid.
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Matter and Energy
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Energy ___________________________________
i The capacity to do work or to move matter.
Energy has kinetic (active) and potential
d (stored) energy capacities. ___________________________________
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Matter and Energy
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Energy ___________________________________
i Energy forms that are important in
the body function include:
d • Chemical • Electrical ___________________________________
• Mechanical • Radiant
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Matter and Energy
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Energy ___________________________________
i Energy forms that are important in
the body function include:
d • Chemical • Electrical ___________________________________
• Mechanical • Radiant
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Composition of Matter
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• Elements
• Fundamental units of matter
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i • 96% of the body is made from four elements
• Carbon (C)
Oxygen (O)
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• Hydrogen (H)
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• Nitrogen (N)
e • Atoms – composed of three subatomic
particles: proton, electron, and neutron.
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S Components of the Atom


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• Protons – positive charge ___________________________________
i • Neutrons – negative charge
• Electrons – negative charge
• Protons & Neutrons join
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nucleus
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Atomic Structure
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l • Nucleus
• Protons (p+) ___________________________________
i • Neutrons (n0)

• Outside nucleus
d • Electrons (e-)
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Identifying Elements
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• Atomic number
• Equal to the number of protons that ___________________________________
i the atoms contain
• Atomic mass number
• Sum of the protons and neutrons
d • Atomic weight ___________________________________
• basically the mass number of all
isotopes of an element.
e • Isotopes and Atomic Weight
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Atomic mass = the number of protons plus neutrons.
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Atoms want Stability
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l The defining
characteristic of stable ___________________________________
i elements is the maximum
number of electrons in its
valence (outer) shell.
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Isotopes and Atomic Weight
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d Isotopes ___________________________________
• Have the same number of protons
e • Vary in number of neutrons
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Isotopes
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l • Oxygen often forms isotopes (O16, O17, and O18)


• Radioactive isotopes are unstable, releasing ___________________________________
i energy or pieces of themselves (atomic radiation)

For an element, the atomic weight is often


d considered the average of the atomic weights of its
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isotopes.
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Radioactivity
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• Radioisotope ___________________________________
i • Heavy isotope
• Tends to be unstable
d • Radioactivity - process of spontaneous ___________________________________
atomic decay
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Molecule and Compound
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Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
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Molecule and Compound
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Molecule – particle formed when two or more ___________________________________
i atoms chemically combine

d Compound – particle formed when two or more ___________________________________


atoms of different elements chemically combine
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Molecular Formulas
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i Depict the elements present and the number of
each atom present in the molecule
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H2 C6H12O6 H 2O
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Molecules and Compounds
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• Atoms are united by chemical bonds ___________________________________
i • Atoms dissociate from other atoms
when chemical bonds are broken
d • Chemical bonds: ionic, covalent, ___________________________________
hydrogen bonds
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Bonding of Atoms
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l • Bonds form when atoms combine with other atoms.


• Electrons of an atom occupy regions of space called ___________________________________
i electron shells which circle the nucleus.
• For atoms with atomic numbers of 18 or less, the
following rules apply:
d • The first shell can hold up to 2 electrons ___________________________________
• The second shell can hold up to 8 electrons
e • The third shell can hold up to 8 electrons
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S Lower shells are filled first ___________________________________


• If the outermost shell is full, the atom is stable
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- - -
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+ 0
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+ -
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Hydrogen (H) Helium (He) Lithium (Li)

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Ionic Bonds
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• An attraction between a + 11p+
12n0
17p+
18n0
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cation and an anion
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• Formed when electrons Sodium ion (Na+) Chloride ion (Cl–)

Sodium chloride

d are transferred from one ___________________________________


atom to another atom Na+
Cl–

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d ionic bond A chemical bond in
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which atoms of opposite charge

e are held together by electrostatic


attraction.

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Ion
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• An atom that gains or loses electrons to become stable


l • An electrically charged atom
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i Cation 11p+
12n0
17p+
18n0

• A positively charged ion


• Formed when an atom loses electrons
d Anion
Sodium atom (Na) Chlorine atom (Cl) ___________________________________
• A negatively charged ion
e • Formed when an atom gains electrons
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Covalent Bonds
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l H
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H
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H2

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Formed when ___________________________________
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atoms share
electrons
Hydrogen atom + Hydrogen atom Hydrogen molecule

d • Hydrogen atoms form single H―H


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bonds O=O
e • Oxygen atoms form two bonds
• Nitrogen atoms form three bonds
N≡N
O=C=O
• Carbon atoms form four bonds ___________________________________

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S Polar Molecules ___________________________________


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l • Molecule with a slightly negative end and a slightly positive end


• Results when electrons are not shared equally in covalent bonds
• Water is an important polar molecule
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i Slightly negative ends

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Slightly positive ends ___________________________________
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Hydrogen Bonds
H H
O
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l H

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Hydrogen bonds
A weak attraction between the positive O
H
O
H

end of one polar molecule and the


i
H
H O

H H

negative end of another polar molecule O


H

• Formed between water molecules


d • Important for protein and nucleic ___________________________________
acid structure
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Chemical Reaction
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Chemical Reaction NaCl Na+ + Cl- ___________________________________
i Reactant Products

Reactants are the starting materials of the


reaction - the atoms, ions, or molecules
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Products are substances formed at the end of the
chemical reaction
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Synthesis Reaction – more complex chemical structure is formed


l A+B AB
Decomposition Reaction – chemical bonds are broken to form ___________________________________
i a simpler chemical structure
AB A+B

Exchange Reaction – chemical bonds are broken and new bonds


d are formed ___________________________________
AB + CD AD + CB
Reversible Reaction – the products can change back to the
e reactants
A + B 🡘 AB ___________________________________
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Figure 2.9a–b

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Straight chain of
glucose molecules,
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l some are branched,

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PART
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i 2 Basic Chemistry
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Slide Deck Presentation Prepared By

Mr. Niño A. Cabatingan


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Objectives
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l • Distinguish organic from inorganic compounds;


• Explain the importance of water to the body homeostasis;
• List several salts (or their ions) vitally important to body
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i functioning;
• Differentiate salt, acid, and base;
d • Explain the concept of pH, and the state of the pH of the ___________________________________
blood.

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Biochemistry: Essentials for Life
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• Organic compounds
• Contain carbon
• Inorganic compounds ___________________________________
i • Lack carbon
• Most are covalently • Tend to be simpler
bonded compounds
d • Example: C6H12O6 • Example: H2O (water) ___________________________________
(glucose)
• Water, salts, acids-bases
• Carbohydrates, proteins,
e fats, sugars & starches
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Important Inorganic Compounds
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l • Water
• Most abundant inorganic compounds ___________________________________
i • Vital properties
• High heat capacity – prevents sudden changes in body
temperature.

d • Polarity/solvent properties – dissolve or suspend.


Nutrients, resp. gases, waste, carbon dioxide.
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• Chemical reactivity – uses water as a reactant, (hydrolysis), to
digest foods.
e • Cushioning – cerebrospinal fluid, amniotic fluid.

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Water and Living Things
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Characteristics of water polarity: ___________________________________
1. Liquid – remains liquid in our bodies.
i 2. Universal solvent – facilitate chemical
reactions in/out of our bodies
d 3. Cohesive properties – helps water base- solutions fill blood ___________________________________
vessels

e Without hydrogen bonding between water


molecules, body fluids would be a gaseous form
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Water and Living Things
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Characteristics of water polarity ___________________________________
i 4. Ability to change temperature slowly – prevents drastic
changes
5. Vaporization – keeping body temperature from overheating
d 6. Ability to freeze – becomes less dense and in weight.
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Important Inorganic Compounds
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l • Salts
• Easily dissociate into ions in the presence of water ___________________________________
i • Vital to many body functions
• Include electrolytes which conduct electrical currents ( Na, K, Cl, Ca,
Phos.) in the body
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Important Inorganic Compounds
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• Acids & Bases = another form of electrolytes; they are ionize
and dissociate in water causing electrical conduction.
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i Acids - release Hydrogen ions. Sour
or sharp taste, tomato juice, coffee, vinegar
• Bases - Proton acceptors – gain Hydrogen ions Bitter taste,
d become slippery when wet, MOM, ammonia, household ___________________________________
cleaners & detergents
• Neutralization reaction
e • Acids and bases react to form water and a salt
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pH
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l • Measures relative concentration of


hydrogen ions ___________________________________
i • pH 7.0 = neutral
• pH below 7.0 = acidic
• pH above 7.0 = basic
d • Buffers: chemicals that regulate pH ___________________________________
change
e • pH needs to be maintain in humans in
order to maintain homeostasis
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Objectives
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l • Explain the function of hydration synthesis and hydrolysis in


formation and breakdown of organic molecules;
• Compare and contrast carbohydrates and lipids in terms of
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i their building blocks, structures, and functions in the body;
• Differentiate fibrous proteins from globular proteins;
d • Define enzyme, and explain the role of enzyme. ___________________________________
• Compare and contrast the structures and functions of DNA
and RNA.
e • Explain the importance of ATP in the body.
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Organic Molecules & Compounds
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Important Organic Compounds
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• Carbohydrates
• Contain carbon, hydrogen, and oxygen
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i • Include sugars and starches
• Classified according to size
• Monosaccharides – simple sugars
d • Disaccharides – two simple sugars joined by dehydration
synthesis
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• Polysaccharides – long branching chains of linked simple
sugars
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Carbohydrates
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l Monomer Polymers

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Important Organic Compounds
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• Lipids ___________________________________
• Contain carbon, hydrogen, and oxygen
i • Carbon and hydrogen outnumber oxygen
• Insoluble in water
d • Neutral fats (triglycerides)
• Found in fat deposits, solid, animal fat
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• Composed of fatty acids and glycerol

e • Source of stored energy


• Saturated vs. Unsaturated fats
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Slide 53 Lipids - Emulsification ___________________________________


Emulsifiers
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• Fats are nonpolar; they do not dissolve in water


and tend to form “globules” (oil and vinegar
dressing)
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• Emulsifier breaks down the globules of fat into
smaller droplets
• detergens, bile
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Lipids – other forms
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• Common lipids in the human body ___________________________________
• Phospholipids
i • Form cell membranes – cell wall, electrical charge which
allows selective permeability of the cell wall.
• Steroids
d • Include cholesterol, bile salts, vitamin D, and some
hormones (corticosteriods, sexual hormones
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Important Organic Compounds
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• Proteins ___________________________________
• Made of amino acids
i • Contain carbon, oxygen, hydrogen, nitrogen, and sometimes sulfur
• Meats, meat products, milks, beans, nuts.
• Fibrous proteins – collegen, keratin
d • Globular proteins – gentic material, DNA ___________________________________
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Proteins
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• Account for over half of the body’s organic matter
• Provides for construction materials for body tissues
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i • Plays a vital role in cell function
• Act as enzymes, hormones, and antibodies
d • Proteins molecules can easily denatured (deformed) by heat
and enzyme reactions.
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Enzymes
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• Act as biological catalysts ___________________________________
i • Increase the rate of chemical reactions

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Figure 2.17

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