4th Floor, Shim’s Building, 314-37,

Chunho-dong, Kangdong-gu,
Seoul, 134-020, Korea

Tel : 82-2-485-4011 Fax : 82-2-470-4013 Email : dwsci@laball.co.kr

MHW-3 Three-axis Water Hydraulic Micromanipulator

Acclaimed water hydraulic manipulator for patch clamping.

This was Narishige's first water hydraulic micromanipulator specially designed for patch clamping. Its
water hydraulic system has a lower coefficient of expansion than an oil hydraulic system, and allows
precise movement. A 1:5 cartridge is incorporated to minimize drifting. The large, rigid driving unit
enables fine movements and coarse manipulations and a sturdy ball joint is also used. Installation is
made more rigid by securing attachments with a double adaptor, eliminating direct attachments to the
bar. The drum type control unit has a large handle for precise operation and high linear repeatability.
Overall, design considerations are focused on precision movement and stability over long periods of time.
This model set the standards for subsequent models of micromanipulator for patch clamping.

*For attachment to the microscope, a suitable adaptor is required (sold separately).

*The micromanipulator can be mounted directly on the isolation table.
*This model can be firmly fixed to any part of the isolation table with GJ-12 thintype magnetic stand
(sold separately).
*AP-12/AP-13-2 patch clamp headstage holders can be attached on the B-9 ball joint, incorporated in
the manipulator .
*Combining the ball joint that attaches the micromanipulator with MHW-4 single-axis water hydraulic
micromanipulator enables four-dimensional remote controlled movement.

Specification

B-9 Ball Joint, H-12 Electrode Holder,

Accessories included
Allen Wrench
X30mm, Y30mm, Z30mm
Coarse
Full rotation of knob: approx. 4mm
Movement range X2mm, Y2mm, Z2mm
Fine Full rotation of knob: 50um
Minimum graduation: 0.2um
Control unit W115 x D115 x H132mm, 1.6kg
Dimensions/Weight
Drive unit W155 x D155 x H100mm, 900g
WR-6 Three-axis Water Hydraulic Micromanipulator

Highly recommended for patch clamping from the microscope stage side.

Employing the water hydraulic system, which has a lower coefficient of expansion due to temperature
changes, this model offers precise movement while minimizing drift by incorporating a 1:5 cartridge. In
addition, it integrates both coarse and fine manipulation capabilities by featuring a manual coarse
manipulator for each axis. The drum type control unit has a large handle for precise operation and high
linear repeatability. Overall, design considerations are focused on precision movement and stability over
long periods of time. The WR-6 is outstandingly versatile: when setting up, it is attached using the bar,
but independent setup using a magnetic stand is also possible, as is attachment to the side of the
microscope stage with an adaptor.

*For attachment to the microscope, P-1A Height Adjustment Plate and a suitable adaptor is required
(sold separately).
*Can be attached directly to the GJ-1 magnetic stand (sold separately).

Specification

B-8D Ball Joint, H-1 Electrode Holder

Accessories included
P-1A Height Adjustment Plate, Allen Wrench
Coarse X18mm, Y18mm, Z18mm

Movement range X2mm, Y2mm, Z2mm

Fine Full rotation of knob 50um
Minimum graduation 0.2um
Control unit W115 x D115 x H132mm, 1.6kg
Dimensions/Weight
Drive unit W110 x D60 x H140mm, 0.4kg
MHW-103 Three-axis Water Hydraulic Micromanipulator

A wide driving range while keeping drift to a minimum.

Liquid hydraulic micromanipulators developed for patch clamping generally use the 1:5 cartridge system
to solve the problem of drifting. Since this can limit their driving range to as little as 2mm, customers who
want a wide driving range are recommended to choose this product, which uses a 1:1 cartridge. The
drum type control unit has a large handle for precise operation and high linear repeatability. The water
hydraulic system is less prone to drift caused by changes in temperature than an oil hydraulic system,
and is thus more suitable for patch clamping. A coarse manipulator is not mounted, so must be
purchased separately.

*For attachment to the microscope, a coarse manipulator and suitable adaptor are required (sold
separately).
*Select Type B adaptor for mounting this manipulator in combination with MMN-1 coarse manipulator.

Specification

Accessories included B-8C Ball Joint, H-7 Pipette Holder

Movement range
Dimensions/Weight
X10mm, Y10mm, Z10mm
Fine Full rotation of knob 250um
Minimum graduation 1um
Control unit W115 x D115 x H132mm, 1.6kg
Drive unit W70 x D50 x H80mm, 150g
MMO-202ND Three-axis Hanging Joystick Oil Hydraulic Micromanipulator

3-D joystick operations while maintaining an easy posture.

The MMO-202 micromanipulator features an oil hydraulic joystick enabling smooth three-dimensional
movement with a single lever. Since the joystick is the hanging type, it can be manipulated with the
user's arms and hands placed comfortably on the table. Operation is therefore done in a natural posture,
and can be maintained for longer periods. Among other features promoting ease of use are the movable
ratio adjustment section located on top of the control unit, and the unit's familiar rounded design instead
of the more angular shape seen on conventional equipment. As one of our most popular
micromanipulators, the MMO-202ND is highly recommended.

*For attachment to the microscope, a coarse manipulator and suitable adaptor are required (sold
separately).
*Select Type B adaptor for mounting this manipulator in combination with MMN-1 coarse manipulator.
*Changing the universal joint that attaches the micromanipulator to such double pipette holder(sold
separately) enables performance of embryo biopsy.
*Changing the universal joint that attaches the micromanipulator to MMO-220 single-axis oil hydraulic
micromanipulator enables four-dimensional remote controlled movement.

Specification

IP Iron Plate, UT-2 Universal Joint,

Accessories included
Allen Wrench
X10mm, Y10mm, Z10mm
Fine Full rotation of knob: 250um
Movement range Minimum graduation: 2.5um
joystick (for maximum movement in X-Y plane) 2mm
Control unit W165 x D80 x H175mm, 1.85kg
Dimensions/Weight
Drive unit W70 x D50 x H80mm, 0.15kg
MO-202U Three-axis Joystick Oil Hydraulic Micromanipulator

Return of an acclaimed design with outstanding ease of use.

This oil hydraulic joystick micromanipulator won considerable attention as an innovative model as soon
as it went on sale, principally because of its smooth three-dimensional operation using a single lever.
Since that time, it has been widely used by many customers, whose requests for restoration of its former
shape and other discontinued features are met in this latest model. Those features include the tall upright
joystick control section with plastic hand-rest and full, 500ƒÊm rotation movement. In addition, a slimmer
driving unit and attachment of the UT-2 as an accessory make this model easier than ever to use.

*For attachment to the microscope, a coarse manipulator and suitable adaptor are required (sold
separately).
*Select Type B adaptor for mounting this manipulator in combination with MMN-1 coarse manipulator.
*Changing the universal joint that attaches the micromanipulator to such double pipette holder(sold
separately) enables performance of embryo biopsy.
*Changing the universal joint that attaches the micromanipulator to MMO-220 single-axis oil hydraulic
micromanipulator enables four-dimensional remote controlled movement.

Specification

Accessories included UT-2 Universal Joint, Allen Wrench

X10mm, Y10mm, Z10mm
Fine Full rotation of knob: 500um
Movement range Minimum graduation: 5um
Joystick (for maximum movement in X-Y plane): 2mm
Control unit W135 x D135 x H210mm, 1.85kg
Dimensions/Weight
Drive unit W40 x D39 x H82mm, 0.17kg
MMO-203 Three-axis Oil Hydraulic Micromanipulator

Original hydraulic model with large handle offering excellent linearity.

This micromanipulator's hydraulic drive system can be remotecontrolled, and provides smooth, vibration-
free movements. As successor to the vernier type, it features a big cylinder control unit which enables
very fine operation. Another key feature is high reproduction of the linear position. Compared with the
currently popular joystick method, this control unit has a long record of use among discerning customers
because of its simple design and outstanding cost-efficiency. For microinjection systems, this model is
recommended for use on the cell holding side, in combination with a joystick type manipulator.

*For attachment to the microscope, a coarse manipulator and suitable adaptor are required (sold
separately).
*Select Type B adaptor for mounting this manipulator in combination with MMN-1 coarse manipulator.
*Changing the universal joint that attaches the micromanipulator to such double pipette holder(sold
separately) enables performance of embryo biopsy.
*Changing the universal joint that attaches the micromanipulator to MMO-220A single-axis oil hydraulic
micromanipulator enables four-dimensional remote controlled movement.

Specification

Accessories included B-8C Ball Joint, H-7 Pipette Holder

Movement range
Dimensions/Weight
X10mm, Y10mm, Z10mm
Fine Full rotation of knob 250um
Minimum graduation 1um
Control unit W115 x D115 x H132mm, 1.6kg
Drive unit W70 x D50 x H80mm, 0.15kg
MMO-220A Single-axis Oil Hydraulic Micromanipulators

MMO-220A Control unit

MMO-220A Drive unit

Three-dimensional manipulator with added movement capability in the same direction as the pipette.

When using this unit to insert a pipette into the cell, operators can make further movement in the same
direction, which minimizes the chance of damaging the cell. This single-axis oil hydraulic manipulator
meets that requirement and can also be used as an add-on manipulator. A compact drive unit is installed
on the tip of the ball joint, giving this model the same high accuracy as a general oil hydraulic
micromanipulator. Using a general drum handle, the MMO-220A can be combined with any kind of
three-dimensional manipulator.

Specification

- MMO-220A
10mm
Movement range Fine Full rotation of knob 250um
Minimum graduation 1um
Control unit W70 x D115 x H100mm, 1.15kg
Dimensions/Weight
Drive unit W52 x D20 x H35mm, 38g
MM-89 Motor-drive Manipulator

Coarse manipulator with most popular motor-drive system.

This motor-driven coarse micromanipulator enables remote controlled movement of a pipette into a
microscope observation field. The bigger the microscope, the more difficult manual control becomes;
remote control is the mainstream alternative. Control is easy, with the joystick right at the operator's hand,
and a return mechanism facilitates pipette exchange.

Specification

Power Cord x 1
Accessories included
Allen Wrench (1.5/3mm) 1 each
Movement range (Coarse) X22mm, Y22mm, Z22mm
When the High Speed Button is in use : 1.4mm/s
Driving Speed
Speed Adjusting Knob (at Maximum) : 0.7mm/s
(in each X-/Y-/Z-axis)
Speed Adjusting Knob (at Minimum): 0.1mm/s
AC100V(±5%), AC120V(±5%),
Power source
AC220V(±5%), AC240V(±5%)
Power consumption Approx. 15W
AC100V/120V : 0.5A 250V 2pieces (φ5 x 20mm /Time-lag Fuse)
Fuse
AC220V/240V : 0.25A 250V 2pieces (φ5 x 20mm /Time-lag Fuse)
Power supply W125 x D105 x H85mm, 1.5kg
Dimensions/Weight Control unit W55 x D75 x H120mm, 0.3kg
Drive unit W63 x D102 x H104mm, 0.5kg
MMN-1 Coarse Manipulator

Manual coarse manipulator suitable for a wide range of applications.

This manual coarse manipulator features a classical, performance-proven design. Different component
combinations enable a variety of installations, ensuring wide applicability for installation of liquid
hydraulic micromanipulators. Responsive manual operation and good economy have made the MMN-1 a
long-term success with pioneering researchers.

Specification

Accessory included Allen Wrench

Movement range Coarse X30mm, Y30mm, Z30mm
Dimensions/Weight W95 x D90 x H110mm, 0.47kg
MN-4 Coarse Manipulator

Manual coarse manipulator with many convenient functions.

This manual coarse manipulator is used in combination with a liquid hydraulic micromanipulator to
transfer the pipette into the microscope view field. Since its operation is manual, this model offers
excellent response and impressive economy. Compared with the MMN-1, setup and installation are
straightforward. Return and rotating mechanisms are included for easy pipette exchange.

Specification

Accessory included Allen Wrench

Movement range Coarse X30mm, Y30mm, Z30mm
Dimensions/Weight W125 x D110 x H135mm, 0.6kg
MWS-1A Micromanipulator (Single-Axis Water Hydraulic System)

Excellent microinjection performance under low magnifications.

Intended for performing microinjections under low magnifications using a stereo microscope, this unit
features a single-axis water hydraulic micromanipulator mounted on the MWS-1. Employment of the 1:1
cartridge system produces a movement range as wide as 10mm, so that the MWS-1A can be used for a
wide variety of applications other than microinjection.

*For attachment to the microscope, a suitable adaptor is required (sold separately).

*AP-14/AP-13-3 patch clamp headstage holders can be attached (sold separately) .

Specification

Accessories included H-1 Electrode Holder, Allen Wrench

Coarse X15mm, Y15mm, Z15mm
Movement range T10mm, Full rotation of knob 250um,
Fine
Minimum graduation 1um
Control unit W70 x D115 x H100mm, 1.15kg
Dimensions/Weight
Drive unit W105 x D115 x H110mm, 370g
MWS-1 Manipulator

Manipulator for experiments using stereo microscopes.

This is a manual manipulator developed for experimental tasks under low magnifications using a stereo
microscope. An adaptor attachment is employed, according to the size of the stand with which the
illumination equipment is integrated. The compact size makes it possible to place the unit closer to the
specimen. A pipette rotation and return mechanism is included to simplify pipette exchange.

*For attachment to the microscope, a suitable adaptor is required (sold separately).

Specification

Accessories included UT-2 Universal Joint, H-7 Pipette Holder, Allen Wrench
Movement range Coarse X15mm, Y15mm, Z15mm
Dimensions/Weight W105 x D115 x H110mm, 300g
MN-151 Joystick Micromanipulator

Light, compact, easy-to-operate manual manipulator with joystick.

Designed to be light and compact for diverse applications, this manual micromanipulator features
joystick control for excellent operability. The joystick enables micro tools to be freely controlled on the X
and Y planes, and coarse movement is provided on the X, Y and Z axes. The Z-axis offers fine
movement as well, making vertical adjustment both easy and accurate: used with the joystick, it also
enables threedimensional fine movement. A ball joint is attached so that approach angles can be set
without interfering with the joystick operation. The model's versatility also extends to installation, with a
bar mount system which allows attachment by either a magnetic stand or mount adaptor.

*For attachment to the microscope, P-1A height adjustment plate and a suitable adaptor is required
(standard accessories).
*The ball joint that attaches the micromanipulator can be replaced by MMO-220A single-axis oil
hydraulic micromanipulator (sold separately).

Specification

B-8B Ball Joint, P-1A Height Adjustment Plate,

Accessories included
H-7 Pipette Holder
Coarse X25mm, Y20mm, Z25mm
Fine movement: Z axis 8mm
Movement range Full rotation of fine knob 500um
Minimum graduation 5um
Joystick control 1:150 - 1:15 (X-Y plane movement ratio)
Dimensions/Weight W95 x D90 x H110mm, 470g
M-152 Manipulator

Three-dimensional coarse manual manipulator with simple design.

This compact, lightweight model offers coarse manipulation only and is very simple to use. A bar mount
is provided to enable installation by either a mount adaptor or magnetic stand. When used in conjunction
with a micromanipulator such as the MMO-220A, quick three-dimensional operation is possible in low
magnification experiments using a stereo microscope.

*For attachment to the microscope, P-1A height adjustment plate and a suitable adaptor is required
(standard accessories).
*The ball joint that attaches the micromanipulator can be replaced by MMO-220A single-axis oil
hydraulic micromanipulator (sold separately).

Specification

B-8B Ball Joint, P-1A Height Adjustment Plate,

Accessories included
H-7 Pipette Holder
Movement range Coarse X25mm, Y20mm, Z25mm
Dimensions/Weight W95 x D90 x H110mm, 320g
MN-153 Micromanipulator

With added single-axis fine movement in the same direction as the pipette.

Based on the M-152, this version adds the capability of fine movement on the X-axis, enabling accurate
linear approach to the cell with no danger of causing it any serious damage. Employment of the bar
mount system provides complete installation flexibility and greatly broadens the range of possible
applications.

*For attachment to the microscope, P-1A height adjustment plate and a suitable adaptor is required
(standard accessories).
*The ball joint that attaches the micromanipulator can be replaced by MMO-220A single-axis oil
hydraulic micromanipulator (sold separately).

Specification

B-8B Ball Joint, P-1A Height Adjustment Plate,

Accessories included
H-7 Pipette Holder
Coarse X25mm, Y20mm, Z25mm

Movement range X8mm

Fine Full rotation of knob 500um
Minimum graduation 5um
Dimensions/Weight W121 x D36 x H145mm, 330g
HD-21 Double Pipette Holder

Lightweight, compact and simple double pipette holder.

This is the simplest and most economical model of double pipette holder, which allows simultaneous use
of two pipettes. Oil hydraulic pressure is not used for the pipette exchange system; instead, the pipette
position is simply set manually. This compact, economical model can be attached to the manipulator
instead of using another joint unit.

Specification

Accessory included Allen Wrench

Dimensions/Weight W127 x D38 x H52mm, 105g
UT-2 Universal Joint

A dual rotation mechanism in the UT-2 enables the pipette holder to be operated freely. This universal
joint can be finely adjusted in both pivot and tilt axes, making it easy to set the holder and lock it in
position.

Specification

Accessory included Allen Wrench

Dimensions/Weight W100 x D22 X x72mm, 72g
IM-9B Microinjector

Incorporating a new mechanism to improve operability.

A new mechanism is incorporated which improves the parallelism of the plunger within the syringe and
prevents the development of any play. Reducing fluctuations of the handle tension, which have many
possible causes, makes control much smoother. The new mechanism and drive sections are built into
the handle, while the handle itself is made larger: however, the overall design is smaller, and operability
is improved, with a higher driving volume facilitating a greater control volume. The syringe is made of
highly durable and precisely processed stainless steel, while the attached glass syringe is accurately
made and allows the operator to choose a preferred type. The specification of this model allows precise
control of both injection and aspiration: we recommend its use at the injection side after it has been filled
with oil.

*O.D.7mm - 14mm commercially available syringes also mountable.

Specification

Injection Holder Assembly (comes pre-assembled with HI-7, CI-1, and CT-
1)

• Injection Holder/ HI-7 1piece

• Tube Connector/CI-1 x 1piece
• Teflon Tube/CT-1 x 1m
Accessories
included
Glass Syringe (1060μl) x 1piece
Three-way Stopcock x 1piece
Silicone Rubber Gasket / HI01PK01 1pack (containing 5 pieces)
O-ring / IM02 x 3pieces
Silicone Grease x 1piece
Allen Wrench (2.5mm) x 1piece
Movement range Plunger 53mm, Full rotation of knob 500um
Control capacity Full volumes 1060ul, Full rotation of knob approx. 10ul
Dimensions/Weight W175 - 228 x D55 x H77mm, 0.65kg
IM-9A Microinjector

New mechanism and efficient control of large volume of liquid.

This model features the same new mechanism as the IM-9B, offering smooth control by reducing
fluctuations of the handle tension. With the new mechanism built into the large handle, the IM-9A is
compact, easy to operate and can control a large volume of fluid. These capabilities, together with the
use of a large-volume syringe, makes this model suitable for large volume liquid injections or placing the
cell holding side.

Specification

Injection Holder Assembly (comes re-assembled with HI-7, CI-1, and CT-1)

• Injection Holder/ HI-7 x 1piece

• Tube Connector/CI-1 x 1piece
• Teflon Tube/CT-1 x 1m
Accessories included

Three-way Stopcock x 1piece

Silicone Rubber Gasket / HI01PK01 x 1pack (containing 5pieces)
O-ring / IMO3 x 3pieces
Silicone Grease x 1piece
Allen Wrench (2.5mm) x 1piece

Movement range Plunger 53mm, Full rotation of knob 500um

Control capacity Total volumes 4240ul, Full rotation of knob approx. 40ul

Dimensions/Weight W175 - 228 x D55 x H77mm, 0.65kg

IM-9C Pneumatic Injector

Pneumatic system brings maintenance-free operation.

This model features the same new mechanism as the IM-9B, offering smooth control by reducing
fluctuations of the handle tension. As well as controlling a large volume of liquid, it can be operated
pneumatically, avoiding maintenance issues like topping up the oil, re-filling or removing air bubbles.
Mainly recommended for use in placing the cell holding side.

*Dedicated large size syringe incorporated.

Specification

HI-7 Injection Holder x 1unit

Tube Connector (with Multipurpose Valve) x 1unit
CT-1 Teflon Tubing x 1m
Accessories included
Silicone Rubber Gasket (for HI-7) x 1pack (containing 5pieces)
O-Ring x 3pieces
Silicone Grease x 1unit

Movement range Plunger 53mm, Full rotation of knob approx. 6mm

Control capacity Total volumes 4240ul, Full rotation of knob approx. 480ul

Dimensions/Weight W136- 189 x D55 x H74mm, 0.64kg

IM-6 Microinjector

Return of popular features promoting ease of use.

In response to user demand, the IM-6 marks the return of a former model which went out of production.
The large, stable body makes operation extremely reliable, while the specifications allow precise control
of injection and aspiration. Recommended for use at the injection side after it has been filled with oil.

*Oil top-up kit (sold separately) is available for easy oil top-up and air bubble removal.
*For details of attaching a commercially available syringe to this model, please contact us.

Specification

HI-7 Injection Holder x 1unit

CI-1 Teflon Tube Connector x 1unit
CT-1 Teflon Tubing x 1m
Accessories included Glass Syringe (3ml) x 2units
Silicone Rubber Gasket (for HI-7) x 1pack (containing 5 pieces)
Three-way Stopcock x 1piece
Plastic syringe x 1piece

Movement range Plunger 40mm, Full rotation of knob: 500um

Control capacity Total volumes 800ul, Full rotation of knob approx. 10ul

Dimensions/Weight W200 x D80 x H130mm, 2kg

IM-5A Injector

Return of a popular model with maintenancefree pneumatic system.

In response to user demand, the IM-5A marks the return of a former model which went out of production.
The large, stable body makes operation extremely reliable. As well as controlling a large volume of liquid,
it can be operated pneumatically, avoiding maintenance issues like topping up the oil, re-filling or
removing air bubbles. Mainly recommended for use in placing on the cell holding side.

*Oil top-up kit (sold separately) is available for easy oil top-up and air bubble removal.
*For details of attaching a commercially available syringe to this model, please contact us.

Specification

HI-7 Injection Holder x 1unit

CI-1 Teflon Tube Connector x 1unit
CT-1 Teflon Tubing x 1m
Accessories included
Glass Syringe (3ml) x 2units
Silicone Rubber Gasket (for HI-7) x 1pack (containing 5pieces)
Three-way Stopcock x 1piece

Movement range Plunger 40mm, Full rotation of knob: approx. 6mm

Control capacity Total volumes 3ml, Full rotation of knob approx. 480ul

Dimensions/Weight W200 x D80 x H130mm, 2kg

IM-5B Microinjector

Acclaimed for ease of use.

In response to user demand, the IM-5B marks the return of a former model which went out of production.
The large, stable body makes operation extremely reliable. The large syringe allows a large volume of
liquid to be contained and accurately controlled. Recommended for large volume injections or for use in
placing on the cell holding side.

Specification

HI-7 Injection Holder x 1unit

CI-1 Teflon Tube Connector x 1unit
CT-1 Teflon Tubing x 1m
Accessories included
Glass Syringe (3ml) x 2units
Silicone Rubber Gasket (for HI-7) x 1pack (containing 5 pieces)
Three-way Stopcock x 1piece

Movement range Plunger 40mm, Full rotation of knob: 500um

Control capacity Total volumes 3ml, Full rotation of knob approx. 40ul

Dimensions/Weight W200 x D80 x H130mm, 2kg

IM-300 Microinjector (Programmable)

Multi-functional, motor-driven injector for precise control of small volumes.

Setting the time and pressure in advance makes it possible to inject very small volumes of liquid with
great precision. This model's numerous capabilities, including injection, filling up and holding, and varied
functions such as foot switching, programming and air distribution, make it suitable for a wide variety of
applications. External pressure sources are used, and should be selected according to the experiment.

Specification

Input Hose, Output Hose, Foot Switch, Silicone Rubber Gasket,

Accessories included
Power Supply Cable, HI-7 Injection Holder
Pressure 7kg/cm^2 maximum
Power cunsumption Approx. 35W
Dimensions/Weight W425 x D205 x H90mm, 3.7kg

*To Use this model, a compressor or compressed gas tank and regulator is required.
IM-31 Electric Microinjector

As a simpler version of the IM-300 Microinjector, the IM-31 Electric Microinjector has been developed
exclusively for injection with less gas consumption.

Using the compressed gas (air, nitrogen, etc.) as the pressure source, the IM-31 is activated by the
supply of a pressure lower than 500kPa (0.5MPa＝5.1kg/㎡＝Approx. 72.5PSI). The IM-31 offers two
operating modes, i.e. a COUNT mode by which the compressed gas is adjusted by time (10ms - 99.99s)
and the number of times (1 - 99 times) for injection, and the other one is a FOOTSWITCH mode by
which the footswitch is operated for injection. You can choose whichever works better for your
experiment. By inputting the TTL signal (negative-true logic) externally into the external signal input
terminal located on the front panel, the IM-31 can be operated remotely in a manner similar to operation
via footswitch.

As the compressed gas is used, there is no need to refill the silicone oil or the like in order to improve
the response. In addition, a balancing function is provided to prevent backflow of the fluid into the
micropipette by capillary action.
Injection Timer Setting Switch
The injection time is configurable from 10ms to 99.99s.
(ON-TIMER):
Interval Timer Setting Switch
The interval time is configurable from 10ms to 99.99s.
(OFF-TIMER):
Injection Count Setting Switch The number of injection times is configurable from 1 to 99
(COUNT): counts.
Pressure Readout: Injection or Balance Pressure is displayed in kPa or kilopascal.
Remote-control Connecting Port By inputting the TTL signal externally into this port, the system
(SYNC): can be operated remotely.
Balance Pressure Adjustment Knob
Used to prevent backward flow by capillary action.
(BALANCE):
Injection Pressure Adjustment Knob
Injection pressure can be adjusted with this knob.
(INJECT):

*To operate this instrument, "a compressor" or "a compressed gas cylinder and a regulator" are
separately required.
PC-10 Puller

Vertical pull type with automated double mode for improved versatility.

The method used by this puller is to pull the glass capillary vertically, using the gravitational force of its
own weight. For more versatility, two modes are provided: a single pull, which pulls at one stretch, and a
double pull in which the setting is change in mid-process. The PC-10 can therefore produce long, thin
microneedles for injection purposes, and firm microelectrodes for patch clamping. The change of setting
in the double pull mode can be preset and then performed automatically, which represents a drastic
saving of labor over conventional methods. Digital values, with the maximum output of the electromagnet
and heater represented as 100, are shown on the display and the heater output is continually increased,
making accurate mass production easier. This puller has several simple features to enhance ease of use,
such as the employment of two weights (light and heavy) for tension adjustment.

Specification

GD-1 Glass Capillary with filament, Spare Heater,

Accessories included
Power Supply Cable
AC100V(±5%), AC120V(±5%),
Power source
AC220V(±5%), AC240V(±5%)
Power consumption Approx. 80W
Heater level 100 = heater voltage 2.5V
Weight Approx. 25g x 2, Approx 100g x 2
Dimensions/Weight W205 x D190 x H185mm, 6.0kg

Consumable

Model Product Description

PC-10H Heater Kanthal wire (x5)
PN-30 Puller

Puller for producing long, thin, sharp microneedles.

This puller uses a pulling method by which a glass capillary is fine-drawn using electromagnetic force.
The long draw-out volume and employment of a strong electromagnetic solenoid enable the production
of long, sharp microneedles. The pulling tension can be adjusted over a wide range, from weak tension
for gradual pulling of the glass capillary at the beginning to strong tension for the single-stretch draw-
out required to make a long, thin microneedle. The heater uses a platinum plate which heats up quickly,
so pulling can begin immediately, with no time-lag. Digital values, with the maximum output of the
electromagnet and heater represented as 100, are shown on the display, making it easier to mass-
produce large quantities of identical microneedles of uniform quality.

Specification

GD-1 Glass Capillary with filament, Spare Heater,

Accessories included Heater Reshaping Tool, Power Supply Cable,
Allen Wrench
AC100V(±5%), AC120V(±5%),
Power source
AC220V(±5%), AC240V(±5%)
Power consumption Approx. 250W
Heater level 100 = heater voltage 1V
Magnet level 100 = magnetic voltage 36V
Dimensions/Weight W300 x D190 x H230mm, 7.7kg

Consumable

Model Product Description

PN-3H Heater for PN-30 Platium board 3mm (x3)
PN-30H Heater for PN-30 Platium board 6mm (x3)
MF-900 Microforge

Multiple functions for making different kinds of microtools.

Reflecting Narishige's long practical experience, the MF-900 offers a wide range of functions for making
many different kinds of microtools by processing microneedle tips. An easyto-use manipulator is
provided for operating the heater and pipette, and the microscope is operated three-dimensionally with
control close to the operator's hand. Separate rotation mechanisms for vertical and horizontal movement
allow the pipette to be approached at any angle, while a special device in the heater section can form it
into any required shape. As well as conventional scales, a protractor to measure angles is provided on
the microscope eyepiece. With the heater turned ON/OFF via a foot switch, and the heater section
integrated into the microscope body, all control actions are performed easily and precisely close to the
operator's hand.
 Specification

MF-900F Foot Switch, Power Supply Cable,

Accessories included Allen Wrench, Spare Heater, Spare Lamp,
Silicone Rubber Gasket

Heater manipulator: X14mm, Y14mm, Z14mm

Movement range Pipette manipulator: X12mm, Z28mm
Microscope: X approx. 7mm, Y30mm, Z approx. 8mm

Magnifications 50x/100x (Eyepiece: 10x, Objective lenses: 5x and 10x)

Glass capillary O.D.1mm

AC100V(±5%), 50/60Hz
AC120V(±5%), 50/60Hz
Power source
AC220V(±5%), 50/60Hz
AC240V(±5%), 50/60Hz

Power consumption Approx. 35W

Dimensions/Weight W200 x D350 x H300mm, 6.1kg

Optional accessories

Model Product Description

MF-OP Optional lens for MF-900 35x objective lens, 15x eyepiece (one pair)

MF-OPA Optional lens for MF-900 35x objective lens

MF-OPB Optional lens for MF-900 15x eyepiece without micrometer

MF-OPC Optional lens for MF-900 15x eyepiece with micrometer

Consumable

Model Product Description

PT-B Platinum heater 150um x 300mm

EG-400 Microgrinder

Mounted microscope to confirm needle contact with grinding plane.

The microscope is mounted on this grinder, which uses a special motor to minimize irregular movements
of the grinding plane: confirmation of contact between the needle and the grinding plane enables
grinding to be performed with greater precision. In addition, this model provides stable performance at all
revolution speeds ? from low for more precision to high for faster grinding. An easily operable coarse and
fine movement coaxial manipulator is equipped for vertical operation of the microneedle, which also
enables very precise grinding. A protractor is mounted on the needle holder fixing section, making it easy
to set the required grinding angle, and an adaptor is attached for vertical grinding. New water filling and
drainage mechanisms are installed to prevent clogging or the accumulation of shavings , making the
apparatus as a whole much easier to use.
 Specification

Adaptor for Vertical Grinding,

Accessories included Diamond Wheel Cleaner, Dedicated Pipette Holder,
Allen Wrench, Spare Lamp, Power Supply Cable

Pipette manipulator: Approx. 47mm

Movement range
Microscope: X approx. 7mm, Y30mm, Z approx. 8mm

Magnifications 30x (eyepiece 10x, objective lens 3x)

Glass capillary O.D.1mm - O.D.1.5mm

AC100V(±5%), 50/60Hz
AC120V(±5%), 50/60Hz
Power source
AC220V(±5%), 50/60Hz
AC240V(±5%), 50/60Hz

Power consumption Approx. 50W

Motor speed Approx. 50 - 2,000rpm

Dimensions/Weight W250 x D450 x H400mm, 6.6kg

EG-44 Microgrinder

Minimizing irregular movements on the grinding plane for greater precision.

This grinder is ideal for grinding micropipette tips, thanks to its employment of a special motor which is
designed to minimize irregular movements of the grinding plane. In addition, this model provides stable
performance at all revolution speeds ? from low for more precision to high for faster grinding. An easily
operable coarse and fine movement coaxial manipulator is equipped for vertical operation of the
microneedle, which also enables very precise grinding. A protractor is mounted on the needle holder
fixing section, making it easy to set the required grinding angle, and an adaptor is attached for vertical
grinding. New water filling and drainage mechanisms are installed to prevent clogging or the
accumulation of shavings, making the apparatus as a whole much easier to use.
 Specification

Dedicated Pipette Holder, Adaptor for Vertical Grinding,

Accessories included
Diamond Wheel Cleaner, Power Supply Cable

Movement range Slider movement approx. 47mm

Glass capillary O.D.1mm - O.D.1.5mm

AC100V(±5%), 50/60Hz
AC120V(±5%), 50/60Hz
Power source
AC220V(±5%), 50/60Hz
AC240V(±5%), 50/60Hz

Power consumption Approx. 10W

Motor speed Approx. 50 - 2,000rpm

Dimensions/Weight W180 x D165 x H310mm, 2.4kg

ITS-N/O/O2/Z/Z2/L Isolation System

This system employs a stable isolation table on which the specimen and the micromanipulators can both
be fixed independently of the microscope. With the microscope firmly fixed in position, the base can
move in both X and Y planes. This allows the operator to change the observation position without moving
either the specimen or the micromanipulators. The table is designed to accommodate any brand of
microscope, so no adjustment mechanism is necessary. Vertical adjustment is easily performed by using
spacers. The stage is supported by four large pillars whose outstanding rigidity and anti-vibration
characteristics are further reinforced by added crossbeams. Holes provided in the wide, thick stainless
steel stage allow the operator to set up several micromanipulators, in any position required, by means of
magnets or screws. The X, Y stage incorporates several large bearings to ensure smooth, stable
movement of even a heavy microscope. Even the heaviest microscopes can be moved smoothly and
easily with the large handles, which are comfortable to operate with just one hand.
 Specification

Nikon Upright Microscope for Patch Clamping/

ITS-N
Physio Station E600FN
ITS-O Olympus fixed stage upright microscope / BX50WI
Compatible ITS-O2 Olympus fixed stage upright microscope / BX51WI
microscopes
ITS-Z Carl Zeiss fixed stage upright microscope / Axioskop FS
ITS-Z2 Carl Zeiss fixed stage upright microscope / Axioskop 2FS
ITS-L Leica fixed stage upright microscope / DMLFS
Accessory included Allen Wrench
X22mm, Y22mm, Full rotation of knob: 500um
Movement range Fine
Minimum graduation: 2um
Dimensions/Weight W650 x D460 x H290mm, 41.7kg
NMN-21 Micromanipulator

Manual operation minimizes jitter for simplicity and high performance.

Drift and electromagnetic disturbance are critical problems in patch clamping work. This mechanical
micromanipulator was developed specifically for patch clamping: it does not employ a liquid hydraulic
system (which is prone to drift caused by temperature changes), has no spring (a common cause of
mechanical drifting), nor a motor (which is a source of noise). Its body is designed to absorb vibrations,
so that even at high magnifications, problems of jittering are virtually non-existent. Based on a drum type
design, which is highly reputed as a liquid hydraulic method, and with a very stable center of gravity, this
model provides exceptionally steady and stable performance. The overall design is compact, so
installation requires a minimum of space. With coarse and fine manipulators integrated in the compact
body, this model handles a full range of required movements, from moving a microelectrode into the
microscope view field to making contact with the cell.

*For attachment to the microscope, a suitable adaptor is required (sold separately).

*The micromanipulator can be mounted directly on the isolation table.
*This model can be firmly fixed to any part of the isolation table with NMN-C magnetic stand (sold
separately).
*AP-14/AP-13-3 patch clamp headstage holders can be attached on the UST-2 solid universal joint,
incorporated in the manipulator .
Achieving low vibration operation

The slider, which is one of the main mechanisms of a micromanipulator, actually consists of two
independent sliders ? one used inside, the other outside. When the operator touches the control knob,
which is connected to one slider, vibrations are caused. To overcome this problem, the control knob is
fixed independently, separate from the slider.
Specification

UST-2 Solid Universal Joint, Fixing Plate,

Accessories included
H-1 Electrode Holder, Allen Wrench
X15mm, Y15mm, Z15mm
Coarse
Full rotation of knob: approx. 4mm
Movement range X6mm, Y6mm, Z6mm
Fine Full rotation of knob: 250um
Minimum graduation: 1um
Dimensions/Weight W110 x D170 x H105mm, 930g
NMN-25 Micromanipulator

Thin body design for multi-channel recording.

The NMN-25 features a thin driving unit for multi-channel recording. In addition, the placement of
handles in one direction instead of three, and the adoption of a simpler holder fixing section, enables
several manipulators to be installed and operated close together without interfering with each other. Use
of an isolation table makes it easy to install multiple manipulators. Like the NMN-21, which was
developed for patch clamping, this manual manipulator integrates coarse and fine movements, and
employs a body design which absorbs vibrations. As a result, operation is precise and stable, free from
concerns about drifting and electromagnetic disturbance.

*For attachment to the microscope, a suitable adaptor is required (sold separately).

*The micromanipulator can be mounted directly on the isolation table.
*AP-14/AP-13-3 patch clamp headstage (sold separately) can be attached.

Specification

Accessories included Universal Joint, Fixing Plate, H-12 Electrode Holder, Allen Wrench
X Coarse15mm, Fine6mm, Full rotation of fine knob: 250um
Coarse and fine total 15mm,
Movement range Y
Full rotation of fine knob: approx. 250um
Z Coarse15mm, Fine6mm, Full rotation of fine knob: 250um
Dimensions/Weight W155 x D60 x H100mm, 600g
SR-5M/6M Stereotaxic Instrument (for Mice)

SR-5M SR-6M

Stereotaxic Instruments for Mice.

These stereotaxic instruments are designed specifically for mice. The mouthpiece, nosepiece, and
auxiliary ear bar are all well thought out for improved ease-of-use. The mouthpiece and nosepiece are
made slimmer and smaller to fit with the tiny mouth of a mouse. The fore-and-aft and up-and-down
adjustments of the mouthpiece/nosepiece have become more sensitive and functional, allowing smooth
and quick setup by one-hand maneuvering. The improved auxiliary ear bar allows you to feel the delicate
holding touch and the built-in spring permits one-hand maneuvering as well as simple one-touch
locking. When not in use, the auxiliary ear bar can be disassembled for cleaning.

Commonly used in conventional models, the 18.70mm AP frame bar permits the use of various
accessories other than the supplied SM-15 stereotaxic micromanipulator.

*The easy-to-replace ear bars (pointed tips) of the auxiliary ear bar are available in different angles and
diameters. Consult us for specific requirements such as requiring secure fixation or preventing the
rupture of an eardrum.

Specification

SM-15 Stereotaxic Micromanipulator,

Accessories
EB-5N Auxiliary Mouse Ear Bar

SR-5M: W400 x D300 x H110mm, 8.75kg

Dimension, Weight
SR-6M: W400 x D300 x H110mm, 9.2kg
SR-5R/6R Stereotaxic Instrument (for Rats)

SR-5R SR-6R

Stereotaxic Instruments for Rats

These stereotaxic instruments are designed specifically for rats. The mouthpiece, nosepiece, and
auxiliary ear bar are all well thought out for improved ease-of-use. The mouthpiece and nosepiece are
appropriately shaped to fit with the mouth of a rat. The fore-and-aft and up-and-down adjustments of
the mouthpiece/nosepiece have become more sensitive and functional, allowing smooth and quick setup
by one-hand maneuvering. The improved auxiliary ear bar allows you to feel the delicate holding touch
and the built-in spring permits one-hand maneuvering as well as simple one-touch locking. When not in
use, the auxiliary ear bar can be disassembled for cleaning.

Commonly used in conventional models, the 18.70mm AP frame bar permits the use of various
accessories other than the supplied SM-15 stereotaxic micromanipulator.

*The easy-to-replace ear bars (pointed tips) of the auxiliary ear bar are available in different angles and
diameters. Consult us for specific requirements such as requiring secure fixation or preventing the
rupture of an eardrum.

Specification

SM-15 Stereotaxic Micromanipulator,

Accessories
EB-4N Auxiliary Rat Ear Bar

SR-5R: W400 x D300 x H110mm, 8.75kg

Dimension, Weight
SR-6R: W400 x D300 x H110mm, 9.2kg
SG-3N Head Holding Adaptor (for Rats)
SG-4N Head Holding Adaptor (for Mice)

SG-3N SG-4N

Being capable of use in different variations, these mouse/rat head holding devices offer wide applicability.

Three-point clamping arrangement on a single bar, comprised of a mouthpiece, a nosepiece and ear
bars, ensures secure fixation of the head of a mouse/rat. Dovetail type sliders incorporated into the
mouthpiece/nosepiece are smooth and wobble-free. The simple one-touch locking system permits easy
fixation of the head. The head-rotatable design allows flexible 360-degree head angle adjustment. The
easy-to-detach head clamp unit facilitates fixing the head in an easy-to-operate position.

When used in combination with an optionally available mounting adaptor, the low-center-of-gravity
design enables the detachable head clamp unit to be installed on a microscope stage allowing the
securely fixed head of a mouse/rat to be observed under a microscope.

Example for Mounting on a microscope stage.

Head rotatable design.
Olympus BX51WI & Arm adjust adaptor.

Specification

SG-3N: W140-180 x D60 x H50mm, 510g

Dimension, Weight
SG-4N: W120-165 x D60 x H45mm, 470g
SRP-AM Head Holding Device (for MRI / Mouse)
SRP-AR Head Holding Device (for MRI / Rat)

Head Holding device for mouse and rat, with MRI measurement compatibility.

This MRI measurement-compatible head holding device can be attached to SR series fixing devices.
Such attachment ensures extremely stable fixation of the head. When the instrument is detached for MRI
measurement, 100% of the instrument becomes plastic to make the procedure easier.
Markers can be inserted into the mechanism, so that operators can perform MRI measurement simply by
aligning measurement points to the object.
Once MRI measurements are completed, the instrument can easily revert to its function as a fixing
instrument, while keeping the animals fixed. Two types are available: SRP-AM for mouse, and SRP-AR
for rat.

Specification

SRP-AM: W300 x D120 x H80mm, 410g

Dimension, Weight
SRP-AR: W300 x D120 x H80mm, 410g
SRS-A Compact Head Holding Device

Used in conjunction with a stereotaxic instrument (Models SR-5R/5M or SR-6R/6M) you already have,
the Model SRS-A allows you to clamp the head of a knockout mouse or newborn rat and serves as a
stereotaxic instrument. The SRS-A is configured so as to hold the tiny head of a small mouse or rat in
position with its head clamp unit (mouthpiece and nosepiece) and auxiliary ear bars provided with fine
adjustment functions. When used singly, it serves as a head holding device. The point of an auxiliary ear
bar is available in varying sizes and easy to replace according to the intended use (e.g. to avoid the
rupture of tympanic membrane or to fix the ears securely).

Specifications

Dimensions W300 x D120 x H77mm

Total Weight 2.1kg

SM-25A Stereotaxic Micromanipulator (Thin-type, Coarse/Fine Drive)

Thin micromanipulator which can place several microelectrodes close together.

This micromanipulator is for multi-channel recording with stereotaxic instruments, and is designed to be
as thin as possible without compromising its stability. A fixing holder is employed to fix the
microelectrodes, in the same way as thin plates hold the microelectrodes. Rotation mechanisms are
equipped for all three planes, and the horizontal plane can be rotated with the operating handle. This
makes it possible to set the microelectrode angles and easily position the microelectrodes close together.
There are three types (A, B and C) in this series, differentiated by the arrangement of their Z-axis
movement unit. The A-type includes a fine movement unit for precise adjustments.

Specification

Coarse X40mm, Z30mm

Z10mm, Full rotation of knob 250um,
Movement range Fine
Minimum graduation 10um
Pivot angle adjustment
Dimensions/Weight W125 x D28 x H172mm, 350g
SM-25B Stereotaxic Manipulator (Thin-type, Coarse Drive)

Thin micromanipulator which can place several microelectrodes close together.

This micromanipulator is for multi-channel recording with stereotaxic instruments, and is designed to be
as thin as possible without compromising its stability. A fixing holder is employed to fix the
microelectrodes, in the same way as thin plates hold the microelectrodes. Rotation mechanisms are
equipped for all three planes, and the horizontal plane can be rotated with the operating handle. This
makes it possible to set the microelectrode angles and easily position the microelectrodes close together.
There are three types (A, B and C) in this series, differentiated by the arrangement of their Z-axis
movement unit. The B-type provides a simple coarse movement unit.

Specification

Coarse X40mm, Z40mm

Movement range
Pivot angle adjustment
Dimensions/Weight W125 x D28 x H157mm, 330g
SM-25C Stereotaxic Micromanipulator (Thin-type, Single Axis, Oil Hydraulic System)

Thin micromanipulator which can place several microelectrodes close together.

This micromanipulator is for multi-channel recording with stereotaxic instruments, and is designed to be
as thin as possible without compromising its stability. A fixing holder is employed to fix the
microelectrodes, in the same way as thin plates hold the microelectrodes. Rotation mechanisms are
equipped for all three planes, and the horizontal plane can be rotated with the operating handle. This
makes it possible to set the microelectrode angles and easily position the microelectrodes close together.
There are three types (A, B and C) in this series, differentiated by the arrangement of their Z-axis
movement unit. The C-type features an oil hydraulic, remote controlled movement for stable, accurate
operation.

Specification

Coarse X40mm, Z40mm

Movement range Z10mm(oil), Full rotation of knob 250um,
Fine
Minimum graduation 1um
Control unit W70 x D115 x H100mm, 1.15kg
Dimensions/Weight
Drive unit W125 x D28 x H157mm, 380g
SM-11 Stereotaxic Micromanipulator

Versatile micromanipulator with multiple movable sections.

This is the most popular micromanipulator for stereotaxic instruments, and is attached to AP frame bar of
the instrument when in use. A coarse movement unit with a long working range is attached to the Z-axis,
while units for fine movement adjustment are mounted on each individual axis. These fine movement
units have scales with minimum increment of 10um (i.e. the total of a single rotation, 500um, divided by
50), so that precise adjustments of only 10um are possible. In addition, the Z-axis fine movement unit
has a sliding mechanism, which enables approximate positioning of the X-axis. A rotation mechanism is
equipped for each of the XY, XZ and YZ planes, which allows approach from any required tilting angle.
Easy-to-use scales are provided wherever necessary, for operations following a brain chart. Overall, this
micromanipulator is simple to use and meets a wide variety of applications.

*Dedicated attachment SM-11A is

required when attaching MO-10/8/81.
SM-11A sold separately.

SM-11A

Specification

Accessories included Special Screwdriver, Ornamental Screw, Allen Wrench

Coarse Z60mm

Movement range X30mm, Y30mm, Z30mm,

Fine Full rotation of knob: 500um,
Minimum graduation: 10um
Dimensions/Weight W150 x D104 x H225mm, 1.75kg
SM-12 Stereotaxic Manipulator

Simplest micromanipulator for stereotaxic instruments.

This is very simple, economical manipulator for stereotaxic instruments and can be mounted by various
methods. A coarse movement unit is provided for the most important movement (vertical), while position
adjustment for the others can be done with sliders. Rotation mechanisms are employed for the vertical
and horizontal directions, enabling easy approach from any required tilting angle.

*Dedicated attachment SM-12A is

required when attaching MO-10/8/81.
SM-12A sold separately.

SM-12A : I.D. 8mm

Specification

Accessories included Screw, Allem Wrench

Movement range Coarse Z65mm
Dimensions/Weight W140 x D47 x H220mm, 900g
SM-15 Stereotaxic Micromanipulator

Compact, versatile and popular micromanipulator.

This is the most popular micromanipulator for stereotaxic instruments, and is attached to AP bar of the
instrument when in use. Coarse movement units with a long working range is attached to both the X-axis
and the Z-axis; the latter also has fine movement units attached. The fine movement handle is positioned
for ease of use, and jitters from handle operations are not transmitted to the microelectrode tips. Vertical
and horizontal rotation mechanisms are both equipped, enabling approaches from any required tilting
angle. Easy-to-use scales are provided wherever necessary, for operations following a brain chart. This
manipulator has a compact yet rigid design, and can be operated with excellent stability in confined
spaces.

*Dedicated attachment SM-15A is required when attaching MO-10/8/81. SM-15A sold separately.

SM-15A SM-15 + MO-10

Specification
Accessory included Allen Wrench
Coarse X60, Z50mm
Movement range Z8mm, Full rotation of knob: 500um,
Fine
Minimum graduation: 10um
Dimensions/Weight W120 x D75 x H180mm, 1.25kg