PMID- 24418963

OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR - 20211021
IS - 1473-1150 (Electronic)
IS - 1470-269X (Print)
IS - 1470-269X (Linking)
VI - 14
IP - 4
DP - 2014 Aug
TI - Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor
of
inhaled short-acting beta-agonist response in multiple population groups.
PG - 365-71
LID - 10.1038/tpj.2013.49 [doi]
AB - Inhaled short-acting beta-agonist (SABA) medication is commonly used in
asthma
patients to rapidly reverse airway obstruction and improve acute symptoms. We

performed a genome-wide association study of SABA medication response using

gene-based association tests. A linear mixed model approach was first used
for
single-nucleotide polymorphism associations, and the results were later
combined
using GATES to generate gene-based associations. Our results identified
SPATA13-AS1 as being significantly associated with SABA bronchodilator
response
in 328 healthy African Americans. In replication, this gene was associated
with
SABA response among the two separate groups of African Americans with asthma
(n=1073, P=0.011 and n=1968, P=0.014), 149 healthy African Americans
(P=0.003)
and 556 European Americans with asthma (P=0.041). SPATA13-AS1 was also
associated
with longitudinal SABA medication usage in the two separate groups of African

Americans with asthma (n=658, P=0.047 and n=1968, P=0.025). Future studies
are
needed to delineate the precise mechanism by which SPATA13-AS1 may influence
SABA
response.
FAU - Padhukasahasram, B
AU - Padhukasahasram B
AD - Center for Health Policy and Health Services Research, Henry Ford Health
System,
Detroit, MI, USA.
FAU - Yang, J J
AU - Yang JJ
AD - Department of Public Health Sciences, Henry Ford Health System, Detroit, MI,
USA.
FAU - Levin, A M
AU - Levin AM
AD - Department of Public Health Sciences, Henry Ford Health System, Detroit, MI,
USA.
FAU - Yang, M
AU - Yang M
AD - Center for Health Policy and Health Services Research, Henry Ford Health
System,
 Detroit, MI, USA.
FAU - Burchard, E G
AU - Burchard EG
AD - 1] Department of Medicine, University of California San Francisco, San
Francisco,
CA, USA [2] Department of Bioengineering and Therapeutic Sciences, University
of
California San Francisco, San Francisco, CA, USA.
FAU - Kumar, R
AU - Kumar R
AD - Department of Pediatrics, The Ann and Robert H. Lurie Children's Hospital of
Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL,
USA.
FAU - Kwok, P-Y
AU - Kwok PY
AD - 1] Department of Dermatology, University of California San Francisco, San
Francisco, CA, USA [2] Cardiovascular Research Institute, University of
California San Francisco, San Francisco, CA, USA.
FAU - Seibold, M A
AU - Seibold MA
AD - 1] Integrated Center for Genes, Environment, and Health, National Jewish
Health,
Denver, CO, Colorado, USA [2] Department of Pediatrics, National Jewish
Health,
Denver, CO, USA [3] Division of Pulmonary Sciences and Critical Care
Medicine,
Department of Medicine, University of Colorado Denver, Denver, CO, USA.
FAU - Lanfear, D E
AU - Lanfear DE
AD - 1] Center for Health Policy and Health Services Research, Henry Ford Health
System, Detroit, MI, USA [2] Department of Medicine, Henry Ford Health
System,
Detroit, MI, USA.
FAU - Williams, L K
AU - Williams LK
AD - 1] Center for Health Policy and Health Services Research, Henry Ford Health
System, Detroit, MI, USA [2] Department of Medicine, Henry Ford Health
System,
Detroit, MI, USA.
LA - eng
GR - AI077439/AI/NIAID NIH HHS/United States
GR - ES015794/ES/NIEHS NIH HHS/United States
GR - R01 HL078885/HL/NHLBI NIH HHS/United States
GR - K23HL093023/HL/NHLBI NIH HHS/United States
GR - HL078885/HL/NHLBI NIH HHS/United States
GR - U19 AI077439/AI/NIAID NIH HHS/United States
GR - R01 DK064695/DK/NIDDK NIH HHS/United States
GR - HL079055/HL/NHLBI NIH HHS/United States
GR - R01 HL088133/HL/NHLBI NIH HHS/United States
GR - HL088133/HL/NHLBI NIH HHS/United States
GR - R01 ES015794/ES/NIEHS NIH HHS/United States
GR - R01 AI061774/AI/NIAID NIH HHS/United States
GR - R01 HL103871/HL/NHLBI NIH HHS/United States
GR - R01 AI079139/AI/NIAID NIH HHS/United States
GR - RC2 HL101651/HL/NHLBI NIH HHS/United States
GR - K23 HL093023/HL/NHLBI NIH HHS/United States
GR - AI061774/AI/NIAID NIH HHS/United States
GR - DK064695/DK/NIDDK NIH HHS/United States
GR - R01 HL079055/HL/NHLBI NIH HHS/United States
GR - AI079139/AI/NIAID NIH HHS/United States
GR - 5RC2HL101651/HL/NHLBI NIH HHS/United States
PT - Journal Article
PT - Research Support, N.I.H., Extramural
PT - Research Support, Non-U.S. Gov't
DEP - 20140114
TA - Pharmacogenomics J
JT - The pharmacogenomics journal
JID - 101083949
RN - 0 (Adrenergic beta-Agonists)
RN - 0 (Guanine Nucleotide Exchange Factors)
RN - 0 (SPATA13 protein, human)
SB - IM
MH - Administration, Inhalation
MH - Adrenergic beta-Agonists/*administration & dosage
MH - Adult
MH - African Americans
MH - Asthma/*drug therapy/genetics
MH - Female
MH - *Genome-Wide Association Study
MH - Guanine Nucleotide Exchange Factors/*genetics
MH - Humans
MH - Male
MH - Middle Aged
MH - *Pharmacogenetics
MH - *Polymorphism, Single Nucleotide
MH - Population Groups
PMC - PMC4098013
MID - NIHMS560159
COIS- CONFLICT OF INTEREST Authors declare no conflict of interest.
EDAT- 2014/01/15 06:00
MHDA- 2015/10/09 06:00
CRDT- 2014/01/15 06:00
PHST- 2013/09/25 00:00 [received]
PHST- 2013/11/19 00:00 [revised]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2014/01/15 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - tpj201349 [pii]
AID - 10.1038/tpj.2013.49 [doi]
PST - ppublish
SO - Pharmacogenomics J. 2014 Aug;14(4):365-71. doi: 10.1038/tpj.2013.49. Epub
2014
Jan 14.