Ryan Monago Aug 15 The dose-volume parameters withinthis chapter should be used only as a guide. Forinstance, there are clinical scenarMore The author brings up an interesting point here. Toxicity in different tissues are not all equivalent. The risk of a specific toxicity may be ‘of more concern to the physician than others. Therefore, we have priority to reach certain constraints over others. The goal of dosimetrists should always be to create the most effective plan while limiting dose to the OAR. However, conversations with the physician about a specific case may result in them not wanting to compromise PTV coverage for a constraint. There are acceptable variations with higher toxicity rates that may need to be considered.