One Instrument.

Multiple applications.
Hands-free.

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GeneTitan® Instrument
Less time acquiring data.
More time for science.
 The first and only fully-integrated microarray instrument
for hands-free array processing

GeneTitan Instrument ®

Transform your lab with a GeneTitan Instrument and experience the unparalleled power of streamlining array
processing for discovery, exploration, and screening. Both the GeneTitan Instrument for expression applications
and the GeneTitan® Multi-Channel (MC) Instrument for expression and genotyping seamlessly integrate hybridization,
washing, and imaging in a single instrument to provide hands-free array processing—whether you are performing basic
or applied research.

 Scalable – Meets both medium- and high-throughput needs, provides the fastest time to data, and requires the
fewest resources.

 Efficient – Condenses hands-on processing time to as little as 30 minutes, images an array in less than five minutes,
and operates unattended overnight.

 Flexible – Supports gene expression and genotyping studies on multi-format array plates.

 Accurate – Delivers high-quality, consistent data every time by processing multiple samples under identical conditions.

 Adaptable – Creates flexible workflows and sample registration via the Affymetrix® GeneChip® Command
Console® Software (AGCC).

www.affymetrix.com/genetitan
The flexibility you want—multiple formats and customized solutions
for gene expression and genotyping studies

GeneTitan® Instruments together with industry-recognized Affymetrix® High-Throughput (HT) Array Plates provide the first
hands-free, automated solution for microarray processing. With a broad selection of array plate formats, you can easily transition
from discoveries through genome-wide SNP genotyping, to comprehensive explorations of gene expression profiles relating to
important biological phenotypes, such as disease or drug response.

Pre-designed and customizable array plates, shown in 24- and 96-format,

give you the highest productivity with a scalable throughput

Human Model and applied research organisms

Whole-transcriptome analysis

Gene expression profiling

Genome-wide analysis Marker-assisted breeding

Population genetics

Targeted genotyping

GeneTitan Instruments together with Affymetrix Array Plates enable a

wide menu of applications in gene expression and genotyping studies

Multiple formats Scalable throughput Customized solutions

Affymetrix Expression Array Plates Process between 16 and 192 MyGeneChip™ Expression
Ideal for medium- to high-throughput samples per day Array Plates
labs; available in 16-, 24-, and Lets you scale up throughput without Customized solutions for human and
96-sample formats adding manpower or instrumentation model and applied research organisms

Axiom® Genotyping Array Plates
Available in multiple formats, able
to process 24 to 96 samples per plate
Achieve high productivity
Array plates condense hand-on
processing time, minimize user
intervention, and are processed
unattended overnight
Axiom® myDesign™ Genotyping
Array Plates
Genomic coverage tailored for human
and agricultural populations, focusing
on the SNPs of interest to you

www.affymetrix.com/genetitan
 Automated array processing
for a hands-free workflow

A GeneTitan® Instrument takes your experiments from prepared samples to primary analysis
without user intervention. And unlike any other system currently on the market, the instrument
automates all array processing and plate transfers for a fully hands-free workflow.

Efficient
The instrument condenses eight hours of hands-on time into as
“Hands-free” GeneTitan
little as 30 minutes for any microarray platform, and multiplexes
Instruments deliver
samples with minimal operator intervention, reducing labor needs
 Lower labor and array costs and freeing up skilled lab personnel for other priorities.
 Highest data consistency

 More time with biology— Highest productivity

not the technology The Instrument operates unattended overnight, providing up to
10 times the productivity of other platforms. And, the unique
degree of hands-free automation means superior reproducibility
and increased confidence in your results.

Deliver high-quality, consistent data every time by processing

multiple samples under identical conditions.

Set up – Load – Go

1 Load consumables 2 Press Start 3 View primary analysis

A single operation for hands-free, unattended array Primary analysis can be completed automatically to
processing. The user simply loads the arrays, prepared rapidly assess the quality of each experimental study
samples, and reagents into the instrument

www.affymetrix.com/genetitan
Genotyping solutions
unmatched accuracy, productivity, and customization, with a single assay

The Axiom® Genotyping Solution includes the GeneTitan® MC Instrument and offers a fully
automated workflow for a broad selection of applications including genome-wide association
studies (GWAS), replication studies, candidate-gene association, and targeted genotyping for
human disease research and agricultural genomics.

Reduce complexity
The GeneTitan MC Instrument is the only platform that lets you
Genotyping on the GeneTitan MC
generate robust and reliable genotypes with minimal user interven-
Instrument enables
tion while reducing costs and processing complexity. The Axiom
 Fastest time to data Genotyping Solution includes Affymetrix-supported manual or
 A single scientist to process automated target prep methods and automation-friendly reagent
thousands of samples kits for preparing samples to process in the instrument.
 High control over genotyping production

Scalable and customized solutions

Choose from a suite of pre-designed population-specific Axiom®
Genome-Wide Array Plates for genetic mapping. Or, design your
own custom Axiom® myDesign™ Array Plate with 1,500 to 2.6
million SNPs by choosing from our database of 11 million validated
genomic markers and your own proprietary target markers from
sequencing initiatives.

Target prep Hybridization Ligation Imaging

The GeneTitan MC Instrument enables one bench scientist

to manage a throughput of more than 760 samples per week
with less than 2.5 hours of hands-on time per 96 samples.

Flexible workflow
Integrate Microsoft® Windows GUI-based Genotyping
Console™ Software (GTC) or automation-friendly command
line-based Affymetrix Power Tools (APT) for completing the
primary genotyping analysis. The flexible software work-
flow with simplified data management allows you to easily
share your results and seamlessly integrate with third-party
software packages.

The GeneTitan MC instrument generates robust and

reliable genotypes that can be visualized using the SNP Cluster
graph through a user-friendly graphical interface
Gene expression
discovery, validation, and screening, with a single instrument

With either the GeneTitan® Instrument or the GeneTitan® MC Instrument you will be able to
streamline array processing for whole-transcriptome or 3’ IVT gene expression analysis in human
and model and applied research organisms. Regardless of your throughput requirements, you will
rapidly identify and validate gene expression profiles and discover biologically relevant pathways.

Gene expression on both GeneTitan
Instruments offers
 Consistently reproducible data
 Highest accuracy in expression analysis
 More confidence in your results
Latest content
Choose from the most popular and widely cited microarrays for
whole-transcriptome or classical 3’ based designs in a convenient
medium- to high-throughput format for low-cost expression profil-
ing of human, mouse, and rat. You may also customize your
array content for any available annotated genome, focus region,
or control sequence using our MyGeneChip™ Custom Program.

Ease of use
Automation-friendly reagent kits easily integrate with upfront
Affymetrix-supported automated target prep methods. Alternately,
reagent kits designed for the manual assay give you the flexibility
of preparing samples for lower throughput.

GeneTitan Instruments generate highly reproducible and

concordant data and can detect changes in gene expression
at or above the 1.5 pM concentration.

Automatic answers
Use Expression Console™ Software or any of the GeneChip-
compatible™ Partner Solutions for probe set summarization and
gene-level analysis. Follow up with NetAffx® analysis to correlate
array results with array design and annotation information.
Alternately, you may build automated primary analysis pipelines
for a completely automated workflow, using Affymetrix Power
Tools Software and the data transfer tools provided with the
instrument control software.

Results of the analysis of 3’ IVT expression data demonstrate

the ability to achieve consistently reproducible data

www.affymetrix.com/genetitan
 Streamlined software
and easy-to-interpret results

GeneTitan® Instruments come installed with the popular, file-based Affymetrix® GeneChip®
Command Console® Software (AGCC) for instrument control. The primary analysis can be
completed using the Affymetrix® Expression Console™ Software for gene expression profiling
or the Affymetrix® Genotyping Console™ Software (GTC) for genotyping analysis.

Affymetrix GeneChip Command Console Software (AGCC)

 Enhances hands-free processing with wizard interfaces

and workflow monitoring.
 Easy data sharing and scalable data management with a
convenient file-based format.
 Includes remote notification of instrument status for
walk-away automation.
 Enables seamless integration with other applications for
further quality control, statistical, pattern recognition,
and biological pathway analysis.

Affymetrix Expression Console Software

The AGCC user interface enables you to monitor and
track all instrument activities from a single view
 Customize your data summaries for QC and primary
analysis results.
 Rapidly assess the quality of each experimental study
with tabular and graphical reports.
 Compare data in a statistically significant way with
a comprehensive set of visualization tools.

Affymetrix Genotyping Console Software (GTC)

 Conduct primary data analysis using the new Axiom®

Genotyping Algorithm for automated allele calling and
quality assessment of called genotypes.
 Intuitive and easy to use menu interface for rapid
primary analysis.
 Generate genotyping calls and quality control metrics.

NetAffx® Analysis Center

The SNP cluster graph in Genotyping Console
Software is one of many ways to look at genotyping
calls and quality control metrics
 Securely access information about probe sets of interest
from more than 10 public domain databases.
 Use the Axiom® Design Center to quickly select and
configure a custom Axiom® myDesign™ Array for your
genotyping studies.

www.affymetrix.com/genetitan
Genotyping and expression solutions
available on GeneTitan® Instruments

Applications Products Analysis software

GWAS and replication*  Axiom® Genome-Wide Arrays

 Axiom® myDesign™ Custom Arrays

Fine mapping and candidate genes*  Axiom® myDesign™ Targeted Genotyping Arrays  Genotyping Console™ Software
Haplotype structure*  Axiom® Genomic Screening Service  Affymetrix Power Tools

Agricultural genomics*  Axiom® Genome-Wide Bovine Array

 Axiom® myDesign™ Custom Arrays

3’ IVT expression  PrimeView ™ Human Gene Expression Array

 HT HG-U133+ PM Array Plate
 HT Human Genome U133 Array Plate Set
 HT MG-430 PM Array Plate
 HT Mouse Genome 430 Array Plate Set
 HT RG-230 PM Array Plate
 HT Rat Focus Array Plate  Expression Console™ Software
 Affymetrix Power Tools
 Model and applied research organism array plates
(ordered through the MyGeneChip™ Custom Arrays Program)
 GeneChip-compatible™ Software

 MyGeneChip™ Custom Arrays

Whole-transcriptome expression  Human Gene 1.1 ST Array Plate

 Mouse Gene 1.1 ST Array Plate
 Rat Gene 1.1 ST Array Plate
 Model and applied research organism array plates
 MyGeneChip™ Custom Arrays

*GeneTitan® MC Instrument only

GeneTitan® Instrument
Less time acquiring data. More time for science.
www.affymetrix.com/genetitan
Affymetrix, Inc. Tel: +1-888-362-2447  Affymetrix UK Ltd. Tel: +44-(0)1628-552550  Affymetrix Japan K.K. Tel: +81-(0)3-6430-4020
Panomics Solutions Tel: +1-877-726-6642 www.panomics.com  USB Products Tel: +1-800-321-9322 www.usb.affymetrix.com

www.affymetrix.com Please visit our website for international distributor contact information.
“For Research Use Only. Not for use in diagnostic procedures.”
P/N EXP00259 Rev. 1
©Affymetrix, Inc. All rights reserved. Affymetrix®, Axiom®, Command Console®, CytoScan™, DMET™, GeneAtlas®, GeneChip®, GeneChip-compatible™, GeneTitan®, Genotyping Console™,
myDesign™, NetAffx®, OncoScan™, Powered by Affymetrix™, PrimeView™, Procarta®, and QuantiGene® are trademarks or registered trademarks of Affymetrix, Inc. All other trademarks are the
property of their respective owners.

Products may be covered by one or more of the following patents: U.S. Patent Nos. 5,445,934; 5,744,305; 5,945,334; 6,140,044; 6,399,365; 6,420,169; 6,551,817; 6,733,977; 7,629,164;
7,790,389 and D430,024 and other U.S. or foreign patents. Products are manufactured and sold under license from OGT under 5,700,637 and 6,054,270.