Salient Features

(Patient’s Info) Pathophysiology: WILM’S TUMOR Malignant

• 3y/o Child
Fetal Kidney
• Chief complaint: less Fetal renal tissue Normal renal parenchyma
development
active (past 2
(gestation)
months) gene (11p.13) for genitourinary development

Healthy children (unknown cause) Loss/deletion of WT1, Loss of genomic imprinting of WT2

Nephrogenic rests (Precursor) Immature Fetal renal tissue persists after birth

Wilms Tumor Cells accumulate Cells Grow out of proportion and divide uncontrollably

Abdominal mass & flank mass (Tumor) Triphasic tumor (blastemal, stromal,
epithelial)
Invasion of renal pelvis Haematuria

Haemorrhage in tumor Blood loss

Spread to blood vessels

and other organs Fatigue (Lethargy) or extreme tiredness