 Muscle transduces chemical energy

into mechanical energy.

 TheSarcomere is the functional unit

of muscle.
(1) In the relaxation phase of muscle
contraction;
 the S-1 head of myosin hydrolyzes
ATP to ADP and Pi,
 but these products remain bound. The
resultant ADP and Pi-
 myosin complex has been energized
and is in a so called high-energy
conformation.
(2) When contraction of muscle is
stimulated via;
 events involving Ca2+, troponin,
tropomyosin, and actin, which are
described below), actin becomes
accessible
 and the S-1 head of myosin finds it,
binds it, and
 forms the actin-myosin-ADP-Pi complex
indicated.
(3) Formation of this complex promotes the
release of Pi, which initiates the power
stroke. This is followed by release of ADP
and is accompanied by a large
conformational change in the head of
myosin in relation to its tail , pulling actin
about 10 nm toward the center of the
sarcomere.
 This is the power stroke.
 The myosin is now in a so-called low-energy
state, indicated as actin-myosin.
(4) Another molecule of ATP binds to
the S-1 head, forming an actin-
myosin-ATP complex.
(5) Myosin-ATP has a low affinity for
actin, and actin is thus released.
 This last step is a key component of
relaxation and is dependent upon the
binding of ATP to the actin-myosin
complex.
 Tropomyosin and the Troponin
Complex

 Presentin Thin Filaments Perform

Key Functions in Striated Muscle.