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VIRAL ZOONOTIC DISEASES

Name of Other Causative Disease in
Distribution Reservoir Transmission Disease in Humans Diagnosis Treatment Prophylaxis
disease names agent Animals
Incubation period is 1-3 days Direct culture and RT-
with the following stages of PCR.
clinical signs
1. Early signs: Vesicular The source of samples:
rash/ulcers Buccal mucosa, ✓ Acyclovir
Bites & scratches macaques remain
(pain/pruritus, conjunctiva, urogenital (12.5-
from macaques, asymptomatic but
influenza-like illness, area and 15mg/kg
direct or indirect oral herpetic
Macacine regional lymph node decontaminated cage. every 8 h
Herpes B Natural contact of broken lesions such as ✓ Acyclovir
herpesvirus enlargement for 6-12
virus, host - skin or mucous gingivostomatitis, (800mg
Herpes B (Cercopithecine Worldwide 2. Intermediate signs: mo.)
Herpesvirus Macaques membrane (Saliva, oral and lingual 5x/d for
herpesvirus 1 – - Fever and Numbness ✓ Ganciclovir
simiae feces, urine, or ulcers, and 14 days)
CHV -1) 3. Late signs: (5mg/kg
Bustasa mouthanidea nervous tissue) conjunctivitis
Meningismus, every 12 h
and contaminated have been
nausea/vomiting, for 6-12
syringe. reported.
headache/stiff neck, mo.)
dysphagia, ataxia,
cranial nerve palsies,
retinitis. Encephalitis
and coma
✓ Physical removal-
skin lesions Cryotherapy, curettage and
hand
parang laser therapy .
Direct: person-
The IP is 2-7 weeks to 6 ✓ Oral therapy- Cimetidine.
person physical
Molluscum Pigeons, months. The presence of ✓ Topical therapy-
Molluscum contact, Skin biopsy and clinical
contagiosum Worldwide chicken, mollusca – small, raised, Podophyllotoxin cream
contagiosum fomites,auto- signs
virus (Poxvirus) dogs, horse flesh-colored w/ pit in center is ,Iodine, Salicylic acid,
inoculation and
seen potassium hydroxide,
sexual contact
Tretinoin , Cantharidin,
Imiquimod
✓
Name of Other Causative Disease in
Distribution Reservoir Transmission Disease in Humans Diagnosis Treatment
disease names agent Animals
endemic African Animal-human: Fever, cough, IP is 7-14 days / 5-21 days culture, polymerase ✓ Smallpox vaccine
malalang trangkaso countries are: rodents Bite/scratch, bush discharge from with fever, chills, headache, chain reaction (PCR), ✓ Antivirals
Benin, meat preparation, eyes, swollen muscle aches, back ache immunohistochemistry, ✓ vaccinia Immune globulin
Cameroon, direct contact with lymph nodes, ,exhaustion and swollen or electron microscopy (VIG)
Monkeypox the Central body fluids and lesions lymph nodes. The various
Monkeypox
virus African indirect contact stages of lesions are:
Republic, the with bedding Macules-Papules- Vesicles-
Democratic Pustules- Scabs
Republic of Human-human:
the Congo, Large respiratory
 Gabon, droplets, direct
Ghana contact with body
(identified in fluids and indirect
animals only), contact w/ clothing
Ivory Coast,
Liberia,
Nigeria, the
Republic of
the Congo,
Sierra Leone,
and South
Sudan.
Animal-animal:
Cuts/skin
abrasions and
direct contact
between animals
Scabby Lesions on lips &
mouth, Sheep, Animal-human: muzzle and sores Presenting clinical signs
Sore mouth Orf virus Worldwide Pain, Fever and lesions ✓ Orf vaccine
contagious Goats Bites/broken skin, on lower legs & and history
lesions ecthyma bottle feeding of teats
lips
sheep/goats,
parang malalang casual contact,
singaw
handling
contaminated
equipment
Name of Causative
Distribution Reservoir Transmission Disease in Humans Diagnosis Treatment
disease agent
Direct & IP is 10-14 d with the following stages of disease: Clinical signs –
prolonged face • Initial symptoms:2-4 days with high differential ✓ Tecovirimat
to face contact, fever,head & body aches and vomiting diagnosis with ✓ Cidofovir
cough/sneeze chicken pox ✓ Brincidofivir
• Early rash: 4 days with skin sores
Small pox Variola virus Globally eradicated Human droplets and • Pustular rash & scabs: 10 days with sores
fomites Prevention
become pustules then after 5 days ,
✓ Smallpox
becomes scab
vaccine
• Scabs fall off: 6 days
• No scabs in 4 weeks
Name of Causative
Distribution Reservoir Transmission Disease in Humans Disease in Animals Diagnosis Treatment
Disease agent
Bite, direct Agitation, confusion, Two forms: In humans
contact of hallucinations, • Furious type - wild History &
infected saliva aggressiveness, vicious behavior, Clinical signs
into open bizarre, abnormal whining,foaming of S, RT-PCR,
wounds/ posture, muscle mouth, difficulty in Skin biopsies
mucous spasm, seizures, eating &
membranes , weakness or breathing,restlessness In animals
All continents blood paralysis, extreme ,runs aimlessly and Presence of Rabies immune
Raccoon, skunk,
except Antarctica, transfusion and sensitivity to lights, bites anyone Negri bodies globulin,
foxes, organ sounds, or touch, via direct
with over 95% of • Dumb type - Rabies
Rabies Lyssa Virus coyotes,bats
human deaths transplant increased salivation lethargic, depressed, microscopy of vaccines and
cats,cows,dogs,
occurring in Asia and difficulty hides in dark areas, amons horn of anti-tetanus
ferrets,goats
and Africa speaking. Initially, refuses to eat, staring hippocampus. toxin
irritability and at a distant object,
excessive movements salivates continuously,
difficulty in
swallowing, difficulty
in breathing,
lameness then dies
w/o signs
Name of Disease Causative Agent Distribution Reservoir Transmission Disease in Animals Disease in Humans Diagnosis Treatment

• Ebola • Ebola virus Equatorial African green IP is 2-21 days (Ebola)

hemorrhagic (Zaire e- Africa- monkey 3-10 days (Marburg)
fever virus) Democratic (Cercopithecus with the following clinical
• Ebola virus • Reston v. Republic of the aethiops), symptoms: fever,
disease • Sudan v. Congo, Gabon, Chimpanzees, Fever, anorexia, vomiting, headache, sore
Guinea, Gorillas, Rhesus throat, weakness, Virus isolation, ELISA, Transfusion of
• Marburg • Tai Forest v. Direct contact vomiting,
Liberia, monkeys, Vervet maculopapular rash, red PCR, serology for IgG fresh-frozen
hemorrhagic • Bundibugyo w/ infected splenomegaly, skin
Republic of the monkeys, eyes, hiccups, internal & antibodies, plasma,
fever v. blood, feces rash, bleeding from
Congo, Sierra Cynomologous external bleeding, immunohistochemistry vaccine-rVSB-
• Marburg virus • Marburg and vomit puncture wounds &
Leone, Sudan monkeys, hemorrhages and bloody - necropsy ZEBOV
disease Marburgvirus mucous membranes
and Uganda Newborn mice & diarrhea.
guinea pigs,
bats, snakes
and spiders
Name of Disease Causative agent Distribution Reservoir Transmission Disease in Humans Diagnosis Treatment
Arenavirus confined to Main host &
Africa- vector: Short-
Venezuela, tailed cane
Portuguesa mouse
Inhalation of
and Barinas (Zygodontomys Hemorrhages, fever, malaise, headache,
Venezuelan droplets of
0 Guanarito virus state, its brevicauda) arthralgia, sore throat, abdominal pain/diarrhea, RT-PCR
hemorrhagic fever saliva, urine,
distribution convulsions
blood.
being
dependent on
the ecology of
reservoir hosts
Argentine confined to Rodents Direct contact IP: 10-12 d with initial symptoms of fever, Ribavirin
hemorrhagic fever Africa, (Calomys w/ urine & weakness, headache and inappetence. Later ,
Other names distribution musculinus & saliva, hemorrhagic & neurologic symptoms follow Virus isolation,RT-PCR
O’Higgins disease O Junin virus being Calomys Inhalation, confusion, convulsion, hemorrhage from orifice ,ELISA, IHC, IFA and
,Mal de los dependent on laucha) mucous the coma other serological tests
rastrojos the ecology of membrane/
reservoir hosts. skin.
Bolivian endemic within Vesper mouse Direct contact Vomiting w/ blood, bloody nose/gums,
hemorrhagic fever only a small (Calomys w/ urine & headache, inappetence, dehydration, blood in
⑧ Machupo virus ELISA (IgM) and Triton
Other names geographic callosus) feces, urine, muscle pain, and reduce heart rate.
(MACV) X-100 (reagent)
Dog fever, black region of Inhalation of Subconjuntival hemorrhage and erythematous
typhus Bolivia sprayed urine rashes in some cases
 Name of Causative Distribution Reservoir Transmission Disease in Humans Diagnosis Treatment
Disease agent
Inhalation of virus Fever, headache, myalgia, Antigen-capture ELISA
Sabia
Brazilian 0
particles, close contact nausea/vomiting, weakness, sore throat Avoid rodents and
mammarena
hemorrhagic Brazil, Sao Paulo Rodents w/ reservoir & infected ticks, vaccine, no
virus
fever individual and lab- cure, Ribavirin
(arenaviridae)
related infection
Animal-human-Direct Hemorrhages, dyspnea dysphagia, Definitive-RT-PCR,ELISA,
West Africa contact w/ blood, urine, cough, swollen airways, hepatitis, chest Antigen detection tests and
including Sierra Multimammate rat feces of infected pain, shock, hearing loss, abnormal virus isolation
0 Lassa virus
Lassa fever Leone, Liberia, (Mastomys rodents. Human- heart rate, hypo/hypertension, Ribavirin
(Arenavirus)
Guinea and natalensis) human-contaminated pericarditis, tremors, encephalitis,
Nigeria. medical equipment, meningitis, seizures.
sexual transmission.
potential for Primary host Animal-human with IP: 8-13 days with the initial phase
worldwide Common house direct contact w/ urine, (fever, malaise, Inappetence, muscle
0 distribution; mouse (Mus droppings, saliva of ache, headache, nausea/vomiting Blood test- Leukopenia
Lymphocytic Ribavirin and Anti-
Lymphocytic however, human musculus) infected rodents,broken followed by second phase (meningitis, and thrombocytopenia,
choriomeningitis inflammatory drugs
choriomeningitis cases have been Natural host skin, eyes, nose, encephalitis, meningoencephalitis, acute virus isolation,RT-PCR,
virus (corticosteroids)
documented only rodents, hamsters mouth. Human-human: hydrocephalus and myelitis ELISA (IgG & IgM)
in the Americans Mother to fetus and
and Europe organ transplant
In Humans Bats-pigs (Pasture/feed Disease in Disease in
Nipah virus contaminated by Animals Humans
encephalitis urine/feces) Mild to severe IP is 14 days with
Human-human coughing, headache,
In pigs (Hospital workers and dyspnea, dizziness,
Porcine Natural reservoir patients) convulsions, drowsiness ,loss of
Bangladesh,
respiratory & Fruit bats Farm-farm (Fomites) coma, death within muscle tone,
India, Philippines, Virus isolation from blood & Supportive (Aspirin
neurologic Nipah virus few hours muscle spasm,
Malaysia and CSF and Theophyllines)
syndrome Host seizures,
Singapore
(PRNS) Pigs and dogs spastictity,sensory
& cerebral
dysfunction,
progressive
disorientation and
encephalitis
Name of Disease Causative agent Distribution Reservoir Transmission Disease in Disease in Humans Diagnosis Treatment
Animals
Hantaan Asia and Europe- Striped-field IP: 3-60 days (Ave: 14-
virus,Seoul v., China, Korea, mouse,brown 30 d) with different
Hemorrhagic fever Dobrava-Belgrada and Russia. rat,yellow-necked phases under HFRS &
Animal-human-
v., Puumula v.,
⑧ ⑧

China is the most mouse,bank NE:

w/ renal syndrome Inhalation of
Andes v., Bayou v., severely vole,long-tailed ➢ Febrile (3-5 days)
(HFRS) contaminated
Black creek canal impacted country pygmy rice rat, ➢ Hypotensive (hours -
rodent urine, History & Clinical
Other names v., Sin nombre v., and accounting rice rat,cotton days)
feces, or saliva. sign,
New York v for around more rat,deer ➢ Oliguric (3-7 days)
• Nephropathia
⑧
Ingestion of Not pathogenic immunohistochemical Ribavirin
than 90% of all mouse,white- ➢ Diuretic(days-week)
epidemica (NE) ⑧
contaminated staining, microscope
HFRS cases footed mouse ➢ Convalescent (2-3
• Hantavirus worldwide in the
food and bites.
mo)
examination
cardiopulmonary Human-human:
last few decades Different phases of
syndrome Exposure to
HCPS
(HCPS) blood
1. Prodromal (3-5 d)
2. Cardiopulmonary
3. Convalescent (w-m)
With 79% mortality
rate and acute
onset of disease,
Natural reservoir
Ingestion of increased body
Black flying fox,
contaminates temp. increased
Spectacled flying With 57% mortality rate,
pasture, feed, respiratory rate, Virus Isolation from
Hendra virus fox, Grey-headed rare, fever, sore throat
water shifting of weight CSF or throat swabs, Vaccine -Equivac
Hendra Virus (Equine fox, Little red fox lethargy, headaches,
between legs, ELISA (IgG & IgM), HeV
morbillivirus) high fever, drowsiness,
Animal-human: depression, nasal RT-PCR
Host convulsions and coma
Direct contact to discharge, head
Racehorse Fox-
infected horse tilting/circling,
horse
muscle twitching,
urinary
incontinence
Name of Causative agent Distribution Reservoir Transmission Disease in Animals Disease in Diagnosis Treatment

sige
Disease Humans
Animal-human: In horse & sheep with CA: Variegated ELISA (blood Amantadine sulfate-2-

·melordeis
Infected incubation period of 4 weeks. squirrel bornavirus sample),Screen 4mg/day/kg bw for 3
-

d secretions It has 80-100% mortality in 1 (VSBV-1), test: Bornavirus- months and Ara-C (1-
(nasal, horses while 50% mortality in fever/shivers, specific circulating beta-
Barie conjunctival,
saliva)
sheep. It can be a chronic
disease & asymptomatic. The
unsteady gait,
myoclonus/ocular
immune
complexes (CICs)
arabinofuranosylcytosine)

cocomotion animals are excited or with

depressed behavior, shows
paresis,
progressive
CNS ataxia, ocular disorders, psychomotor
Germany, in other abnormal posture & slowing, confusion
European Horses, sheep, movement with immune- and coma
Borna Borna disease
countries, and in cattle, cats, dogs , mediated meningitis,
disease virus
North America ostriches, shrew encephalomyelitis
and Japan. In cats: the IP is 1-6 weeks
with increased vocalization,
ataxia, anorexia, lethargy,
fever, hypersalivation,
seizures, posterior paresis
and inability to retract claws

In dogs: Lethargy, tremor,

salivation, mydriasis,
seizures, circling
Direct contact w/ IP: 5 d with 100% mortality
infected/carrier rate. Signs include greenish
birds, contact w/ white diarrhea, ruffled
Newcastle
secretion, feathers, depression, Hyperimmune serum,
disease Avian
Africa, Asia and Chickens, ducks, airborne and torticollis, paralysis, death Transitory Virus isolation, RT- Vaccine: Heat-tolerant V4
Exotic paramyxovirus
South America geese mechanical within 2-3 days conjunctivitis PCR,ELISA, HI strain, Hitchner B1 La
Newcastle type 1
transmission Sota
disease
from infected
feces via fleas,
rodent, dog
Endemic in Cattle,pigs, Direct contact w/ IP of 2-14 days with blisters
several parts of sheep,goats,feral infected on nose, tongue, lips, hooves,
Foot and Asia and in most pigs, african animals, direct teats, fever followed by Vesicular eruptions
Vaccine for animals but in
Mouth animal:Aphthovirus of Africa and the buffaloes and Wild contact w/ depression salivation, on hand, mouth PCR, ELISA , CFT
humans no vaccine
Disease Middle East. In deer. contaminated inappetence, drop in milk and feet
Latin America, the Foodstuffs,infected materials, production then recovery
majority of carcasses,soil ingestion of within 7 day
and ruminants
pigs
 countries apply infected animal
zoning and are products and
recognised as inhalation of
FMD-free, either virus particles
with or without
vaccination

Disease in
Name of Diseases Causative agent Distribution Reservoir Transmission Disease in Animals Diagnosis Treatment
Human
In horse- IP: 8-10 In swine -
d, 5% mortality rateCNS tentative: Based
which shows on history- high %
IP: 6-8 days with
subclinical signs- of weak and
5-35% mortality
fever, Impaired stillborn piglets
rate.
locomotion, stupor, Definitive: virus
It can be
teeth grinding, isolation
Japanese asymptomatic.
Japanese encephalitis Asia and Oceania, blindness, coma In horse - Vaccine: JE-
encephalitis virus Pigs, egrets, mosquitoes (Culex Affected individual
from Japan to and death Tentative: rise in VAX(formalin
with subtypes: heron, bats, tritaeniorhychus- suffers with high
Other name India, Pakistan and titer; Definitive - inactivated
Nakayama , JaGar snakes, frogs primary vector) fever, stiff neck,
Summer encephalitis Australia. In swine: Close to neutralization, HI, vaccine)
01 headache, stupor,
0% mortality with IF, CF and ELISA
acute encephalitis,
Stillborn / In human: 4-fold
paralysis, seizures,
mummified fetuses, rise titer, HI, IFA
convulsion, coma
tremors, CF and IgG ELISA
and death
convulsions, swollen
testicles, decreased
fertility
West Nile fever
(WNF) Signs
West Nile meningitis high fever,
(WNM) Vector: mosquitoes excessive sweating,
thru bites, blood fatigue, swollen
Africa, Europe, the No symptoms in
Other name transfusion, organ lymph nodes,
Middle East, North most, febrile in
West Nile West Nile virus Birds transplant, drowsiness, joint Pain relievers
America and West some and severe
meningoencephalitis, exposure in lab, pain and GI
Asia in few.
West Nile poliomyelitis from mother to symptoms
(WNP), West Nile fetus
reversible paralysis West Nile
neuroinvasive
(WNND) Signs
 Meningitis,
encephalitis,
meningoencephalitis
and poliomyelitis-
like syndrome

West Nile virus

encephalitis (WNE)
Sign
Fever, headache,
altered mental
status.

No symptoms in
most,febrile in some
and severe in few.

Disease in
Name of disease Causative Agent Distribution Reservoir Transmission Disease in Animals Diagnosis Treatment
Humans
IP of 2-6 days .
Cattle, sheep, Asymptomatic to
southern Africa, Direct contact w/ Systemic disease -
goats, buffalo, inflammation of
but also in most blood, fluids from hepatitis, abortion,
camels retina, fever, liver Virus isolation, RT-
RVF virus (RVFV) countries of sub- infected animals, nasal discharge,
abnormalities, PCR, Antigen- Vaccines, MP-12 and
Rift Valley fever (Phlebovirus) Saharan Africa, inhalation of excess salivation,
Vector: back pain, capture ELISA and Clone 13
(Bunyaviridae) Madagascar, droplets and bites inappetence,
Mosquitoes dizziness, ocular ELISA (IgG & IgM)
Saudi Arabia and from infected weakness and
(Aedes spp. & dss, encephalitis,
Yemen mosquito diarrhea
Culex spp.) coma and
seizures.
Hemorrhagic fever
Endemic in all of Cattle, sheep, Virus isolation, RT-
CCHF virus Africa, the goats, ostriches, PCR, ELISA,
Other name
(Nairovirus) Balkans, the tick bites Principal serum Ribavirin
Crimean-Congo
(Bunyaviridae) Middle East and in vector: Hyalomma neutralization and
Hemorrhagic fever
Asia spp. antigen detection
(CCHF)
Main vector: IP: 4-7 days with
Chikungunya Green monkeys In human-
Mosquitoes the following signs: Virus Isolation,
CHIK virus (Cercopithecus Acetaminophen,
Chikungunya (Aedes aegypti)(A. cephalagia, serologic
(Alphavirus) aethiops) Baboons Paracetamol and
africanus)(A. anorexia, lower diagnosis
(Togaviridae) (Papio ursanus) Fluids
furcifer-taylori) back pain,
 conjunctivitis,
adenopathy,
morbilliform rash &
purpura on trunk.

Name of disease Causative Agent Reservoir Transmission Disease in Animals Disease in Humans Diagnosis Treatment
Wild birds, Biphasic: Depression, IP: 7-10 d , 65% Virus Isolation from
pheasants, Horse legs apart, flaccid mortality rate, brain, serologic
Eastern Equine Vectors: Mosquitoes lips, easily excited, biphasic, cephalagia, diagnosis In animal-Monovalent
Alphavirus (Togaviridae) Bite of mosquitoes
Encephalitis (Aedes solicitans) walk in circles, conjunctivitis, & bivalent vaccine
(Culiseta melanura) stumble and death lethargy, neck
within 5-10 days stiffness, convulsions
Natural reservoir: IP: 1-3 weeks with IP: 5-10 days, 3-14% Virus isolation from
Wild birds, domestic signs of fever, mortality rate, brain, serologic
fowl Main vector- lethargic phase, experience diagnosis
Western Equine Important amplifier: Mosquito (Culex paralytic phase and cephalagia, lethargy,
Alphavirus (Togaviridae)
Encephalitis Horse tarsalis) (Culiseta death within 1-2 d neck stiffness, mental
melanura) confusion,
convulsions, flaccid &
spastic paralysis
Vectors: Mosquitoes Subclinical Cephalagia, articular Hemagglutination
(Culex univittatus) pain/arthritis, mild inhibition test
Bridge vector –
Sindbis disease Natural host: Wild birds (Culex annulirostris) jaundice
Aedes cinereus
(Culicoides
pseudovishnui)
Amplifying host: Frontal cephalagia,
Marmosets (Callithrix Conjunctival
Main vector:
argentata) conjunction,
MAY virus (Alphavirus) Mosquito No specific treatment,
Mayaro fever Maintenance host: arthralgias, joint
(Togaviridae) (Haemagogus Virus isolation from symptomatic only
Birds,rodents edema, macropapular
janthinomys) blood,
cutaneous eruption,
hemagglutination
leukopenia
inhibition and
Ross River virus Competent host- Main vector: IP: 3-7 days then
complement fixation
(Alphavirus) large marsupials, Mosquito (Aedes shows fever,
Epidemic Polyarthritis Subclinical (Arthritis Paracetamol and
(Togaviridae) local mouse spp polynesiensis) (A. cutaneous eruption,
or Ross River Fever and muscular illness) Aspirin
Amplifying host: vigilax) (Culex arthritis and
lambs annulirostris) polyarthritis
Subtypes: Main reservoir: Main vector: In horse: IP: 1-3 days IP: 2-5 days. In human-Virus
Venezuelan Equine Subtype I (AB, C, D, E, Marsupials, horse, Mosquito (Culex with signs of Chills, malaise, isolation from Vaccine:TC-83
Encephalitis F) birds, rodents aikenii) (C. depression, anorexia, myalgia, cephalagia, nasopharyngeal
(Sigmodon spp) encephalomyelitis, nausea/vomiting, exudates,
 Subtype II (Everglades), (Peromyscus spp) opisthopus) (C. leukopenia and diarrhea, encephalitis hemagglutination
Subtype III (Mucambo), (Proechimys spp) portesi) grinding of teeth and leukopenia inhibition,
Subtype IV (Pixuna) , (Oryzomys spp) complement fixation
Alphavirus (Togaviridae) and neutralization
test

Name of Disease Causative Agent Reservoir Transmission Disease in Human Diagnosis Treatment
IP of 3-12 days, asymptomatic, fever, red flat
Bite from infected
rash,joint pain, red itchy eyes ,miscarriage,
mosquito, mother to
birth defects.
fetus and sexual
↳ microcephaly babies PCR, RT-PCR,ELISA Anti-pyretics and
Zika fever Zika virus (Flavivirus) Rhesus monkey transmission Vectors: sa
mga (IgG & IgM) analgesics
Mosquitoes (Aedes
aegypti & Aedes
albopictus)
Disease in Animals Disease in Humans
Initial phase: 3-4 d, IP: 3-6 days,
fever/chills, flu-like hemorrhagic fever
symptoms (fever, muscle pain,
Second phase: 48 h, backache, headache, Vaccine, avoidance of
Vector: Mosquitoes - Remission inappetence, mosquitoes and
Yellow fever virus Primary reservoir:
Yellow fever (Aedes aegypti & Third phase: nausea/vomiting. PCR, ELISA symptomatic
(Flavivirus) Human, monkeys
Haemagogus spp.) Jaundice, hepatitis, Recovery within 3-4 treatment-fluids and
internal bleeding, d. Jaundice, dark rest
vomiting blood, urine, abdominal
shock, multisystem pain, bleeding then
organ failure then death within 7-10
death days