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THE BRAIN FROM TOP TO BOTTOM http://thebrain.mcgill.ca/flash/d/d_03/d_03_cr/d_03_...

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THE PLEASURE CENTRES AFFECTED BY DRUGS

Pleasure-Seeking The brain regions involved in the sensation of pleasure and reward are among
Behaviour
those most affected by drugs.
Pleasure and Drugs
Avoiding Pain The nucleus accumbens, together with the ventral tegmental area, constitutes
the central link in the reward circuit. The nucleus accumbens is also one of the
brain structures that is most closely involved in drug dependency.
The PET-scan images to
the right show the brain’s The nucleus accumbens provides liaison between the limbic system, which is
response to the
avalanche of dopamine the seat of the emotions, and the central grey nuclei, which help in planning
in the nucleus movements and reasoning processes.
accumbens of people
with dependencies. To
relieve the chronic The nucleus accumbens appears
stimulation of its to be involved in controlling our
neurons, the nucleus motivations. Also, the frequent
accumbens simply
reduces the number of consumption of a drug is known to
dopamine receptors that tremendously increase the amount
they have.
of the main neurotransmitter in this
In these images of the part of the brain, dopamine. We
brain, the red areas can therefore better understand
indicate large numbers of
dopamine receptors. the drug addict’s obsessive drive to
These images show that keep seeking more of the drug.
people who are
alcoholic, obese, or
cocaine-dependent have
fewer dopamine But the nucleus accumbens is not
receptors than normal
people do. isolated from the other brain
structures that are also influenced
by drugs.

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