RAJIV GANDHI GOVT.

POST GRADUATE AYURVEDIC COLLEGE AND HOSPITAL,

PAPROLA DISTT. KANGRA (H.P.) 176115

SYNOPSIS FOR
PROPOSED THESIS WORK FOR THE DEGREE OF AYURVEDA VACHASPATI
M.D. (Ayu.) DRAVYAGUNA

TITLE
“Identification of different species used as ‘Chukrika’ & To evaluate the clinical
efficacy of Rumex vasicarius Linn. in Arochak”

Research Scholar
Dr. Kailash rana
B.A.M.S. (H.P.U.)

Guide Dr. Navneet Sharma

M.D.(Ayu.)
Reader
P.G. Deptt. of Dravyaguna
R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Kangra (H.P.) 176115
Co-Guide Co-Guide
Prof. Ashwani Upadhyaya Dr.Rashmi Shrivastava
M.D.(Ayu.) Ph.D. M.D.(Ayu.) Ph.D.
Head of Deptt. Reader
P. G. Deptt. Of Dravyaguna P. G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College & R.G.G.P.G. Ayurvedic College &
Hospital, Paprola, Kangra (H.P.) 176115 Hospital, Paprola, Kangra (H.P.) 176115

Place of Study: P.G. Deptt. of Dravyaguna,

R. G. G. P. G. Ayurvedic College and Hospital, Paprola Distt. Kangra (H.P.)
176115 Drug Testing Laboratory (ISM), Joginder Nagar
Session : 2021-2024
From : Dr. Kailash Rana
M.D. (Ayu.) Dravyaguna, Ist year Research Scholar
R.G.G.P.G. Ayurvedic College and Hospital, Paprola, Kangra (H.P.) 176115
To
The Chairman
Departmental Research Committee
R.G.G.P.G. Ayurvedic College and Hospital, Paprola, Kangra (H.P.) 176115

Sub : Submission of Synopsis for registration of ‘Title of Thesis’ for M.D.

(Ayu.) Dravyaguna.

Respected Sir,

Kindly allow me to submit synopsis for registration of title for the degree of Ayurveda
Vachaspati M.D. (Ayu.) Dravyaguna. Please find enclosed herewith synopsis of my thesis work

entitled “Identification of different species used as ‘Chukrika’ & To evaluate the

clinical efficacy of ‘Rumex vasicarius Linn. in Arochak”. This is the research work I
propose to undertake during Post Graduation. This is being submitted for your kind consideration
and necessary action.

Thanking you,
Date……………. Yours sincerely,

Place : Paprola Dr. Kailash rana

B.A.M.S. (H.P.U.)
M.D. (Ayu.) Research Scholar
P. G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College and Hospital
Paprola, Distt. Kangra, (H.P) -176115
 CERTIFICATE OF SUPERVISION

This is to certify that the plan of the proposed research work entitled “Identification of
different species used as ‘Chukrika’ & To evaluate the clinical efficacy of ‘Rumex
vasicarius Linn. in Arochak” has been prepared by Dr. Kailash rana under our supervision
and further research work will also be carried out during M.D.(Ayu.) course under the guidance
of the undersigned.

Guide Dr. Navneet Sharma -----------------------

M.D.(Ayu.)
Reader
P.G. Deptt. of Dravyaguna
R.G.G.P.G. Ayurvedic College and Hospital,
Paprola, Kangra (H.P.) 176115

Co-Guide
Prof. Ashwani Upadhyaya --------------------------
M.D.(Ayu.) Ph.D.
Head of Deptt.
P. G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College and Hospital,
Paprola, Kangra (H.P.) 176115

Co-Guide Dr. Rashmi Shrivastava ------------------------

M.D.(Ayu.) Ph.D. Reader
P. G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College and Hospital,
Paprola, Kangra (H.P.) 176115
 ETHICAL JUSTIFICATION CERTIFICATE
TO WHOM IT MAY CONCERN
This is certified that clinical study namely “Identification of different species used as
‘Chukrika’ & To evaluate the clinical efficacy of ‘Rumex vasicarius Linn. in Arochak”
being conducted in the P.G. Department Of Dravyaguna under the supervision of
Dr. Navneet Sharma is well defined as per texts of Ayurveda and will not cause any
inconvenience to the patient. The reference of the drug under trial and there
therapeutic indication under taken in the present clinical trial are well explained in
Ayurvedic literature.
The patient and the parents/guardian will be explained about the nature of disease and clinical
trial. They shall be explained the need of relevant investigation required for diagnosis in the
language they understand. They will also be explained about the treatment modality they will
receive and the duration of the treatment. During this trial the patient will not be subjected to any
additional procedure or expenditure and the study will be conducted on only those patients who
will give their consent. The study is purely designed to create the evidence based efficacy of the
trial drug.

Supervisor Scholar

Dr. Navneet Sharma Dr. Kailash rana

Date:

Place:- R.G.G.P.G. Ayurvedic College and Hospital,

Paprola, Kangra (H.P.) 176115
 FORMAT FOR REGISTRATION OF TITLE OF THESIS FOR M.D.
(AYU.) DRAVYAGUNA
1. a) Name of the candidate
b) Name of the course
c) Year and month of registration
d) Year and month of examination
when due to appear
2. Title of proposed thesis
3. Name of the Guide
4. Name of the Co-Guide
5. a) Deptt. Where thesis work will
be carried out
b) Which other department of the
institute will cooperate in the
proposed thesis
6. Any work pertaining to the proposed :
work has been done earlier in this institute
7. Brief resume of intended work
: Dr.Kailash Rana
: M.D. (Ayu.) Dravyaguna
: April 2022
: March 2025
: “ Identification of different species
used as ‘Chukrika’ & To evaluate the
clinical efficacy of ‘Rumex vasicarius
Linn. In Arochak”
: Dr. Navneet Sharma
M.D.(Ayu.), Reader
P.G. Deptt. of Dravyaguna
R.G.G. P. G. Ayu. College and Hospital,
Paprola, Kangra (H.P.) 176115
: Prof. Ashwani Upadhyaya
M.D.(Ayu.) Ph.D, Head of Deptt.
P. G. Deptt. Of Dravyaguna
R.G.G.P.G. Ayurvedic College and Hospital,
Paprola, Kangra (H.P.) 176115
Dr.Rashmi Shrivastav
M.D. (Ayu.) Ph.D.
P.G. Deptt Of Dravyaguna
R.G.G. P. G. Ayu. College and Hospital,
Paprola, Kangra (H.P.) 176115
: P.G.Deptt. of Dravyaguna,
R.G.G.P.G. Ayu. College and Hospital,
Paprola , Kangra (H.P.) 176115
: Ras Shastra & Bhaishajya Kalpana,
Rog nidan evam Vikriti Vigyan
No
7.1 Introduction
Modern days lifestyle &food habits are leading cause to many problem related with the
digestive system.Arochak is such a kind of disorder which has been mentioned separate disease
entity by Acharya Charak, Acharya Shutruta & Varidh Bhoj and as a symptoms in many
diseases where it has been described as ‘Aruchi’.This is a very common problem in the society
where the patient is not willing to eat properly and due to this faces many other problem.
To get rid of this problem the patient approach Ayurvedic system of medicine with a hope
to get a permanent remedy for this disease.
The drug selected for this study is described in Ayurvedic text with the name ‘Chukrika’.
which is used as a folklore medicine in this area.Many Ayurvedic text have praised and mentioned
this drug in the treatment of ‘Arochak’.The drug is widely available in distt. Kangra, hence taken
for study. The reference of the drug used in ‘Arochak’ has been mentioned in Bhavprakash
Nighantu & Priya Nighantu .

“प्रक्षिप्तं तु मुखे चान्नं जन्तोर्न स्वदते मुहः अरोचकः स विज्ञेयो” I

“ वृद्ध भोज”

" चुक्रा त्वम्लतरा स्वादी वातघ्नी कफपितकृ त I

रुच्या लघुतरा पाके वृन्ताके नातिरोचनी II

“भा.प्र”

चुक्रं स्याद् अम्लपत्रं तु लघुउष्णं वातगुल्मनुत I

दीपनं पाचनं रुच्यमीषतपित्तकरं मतम् II

"प्रिय निघन्टु "

7.2 Aims and Objectives

Aim of the study
To identify different species used as Chukrika & to evaluate the clinical efficacy of
Rumex vasicarius Linn.in ‘Arochak’.
Objectives
• To review the classical & modern literature to identify different species used as Chukrika.
• To carry out macroscopic & microscopic study on different species of Chukrika found in
mid hill zone of Distt. Kangra,Teh. Baijnath (H.P.) for its identification.
• To prepare standard quality medicine as per GMP & classical Ayurvedic texts.
• To clinically evaluate the effect of Chukrika (Rumex vasicarius Linn.) in ‘Arochak’.

Review of literature
 A detailed review of different species of Chukrika will be done from Ayurvedic and
Modern literature, journals and recent research works.
 Ayurvedic and modern literature will be reviewed thoroughly to know Arochak in detail
and its treatment, according to Ayurvedic therapeutics.

Previous work done on Chukrika:

No work has been done on pharmacotherapeutics of Rumex vasicarius Linn. in Arochak.

INTRODUCTION OF DRUG
PLANT DESCRIPTION:
Name of Drug - Chukrika
Botanical Name - Rumex vasicarius Linn.
Family - Polygonaceae
PROPERTIES AND ACTIONS:
Rasa - Amal, Madhur

Guna - Laghu

Veerya - Ushna

Vipaka - Amal

Karma - Vaatghani,Dipana, Pachana

Useful part - Leaves

 " चुक्रा त्वम्लतरा स्वादी वातघ्नी कफपितकृ त I

रुच्या लघुतरा पाके वृन्ताके नातिरोचनी II

“भा.प्र”

चुक्रं स्याद् अम्लपत्रं तु लघुउष्णं वातगुल्मनुत I

दीपनं पाचनं रुच्यमीषतपित्तकरं मतम् II

"प्रिय निघन्टु "

On the basis of this reference this drug has been selected for present research work.

Pharmacognostical study:

Detailed macroscopic and microscopic study on different species used as Chukrika of trial drug
will be done in the department of Dravyaguna.

Preparation of drug:

The selected drug will be collected locally and after proper verification by the experts of Deptt. Of
Dravyaguna, the final drug will be prepared under the guidance of Deptt. of Rasa Shastra evum
Bhaishjya Kalpana in the college pharmacy.

Formulation:

Chukrika Patara Churan

Clinical study:

Clinical study will be done on the patients selected from OPD and IPD of R. G. G. P. G.
Ayurvedic College and Hospital, Paprola, Distt. Kangra(H.P.), irrespective of caste and religion.
Complete description regarding the details of each research case will be recorded in a prepared
proforma.
8. Protocol for clinical study >>

8.1. Protocol for Research

• The ethical clearance will be taken for the research from Institutional Ethics Committee
(IEC) before starting the study.

• Consent of patient: Awareness about the duration and nature of the trial and written
informed consent.

• Registration of the patients who fulfill the inclusion criteria.

• Investigation mentioned will be advised to the patient before and after the treatment.

• Data so available and deducted clinically will be statistically analyzed.

8.2. Criteria for selection of patients:

Study will be conducted on 30 patients suffering from Arochak.

1. Inclusion criteria

Patients fulfilling the following criteria will be included in the trial.

a) Patients willing for trial

b) Age - > 18 Years

c) Gender - Either gender

d) Diagnosis - on the basis of following symptoms (as per classical

texts):

 Annaabhilasha ( not willing to eat )

• Kashaya asyata (Bitter taste in mouth)

• Madhur asyata (Sweet taste in mouth)

• Picchilita (Stickiness in Mouth)

• Gourav (Feeling of heaviness)

 Exclusion Criteria
a) Patients not willing for trial.

b) Age - < 18 Years

c) Patient having any known disease of GI Tract and liver disorders.

8.3. Dose of drug and Route of administration, Anupaan

5 gm of Chukrika Patra churan (5gm BID ).

Duration of therapy- 15 days

Anupaan - Samsitoushan Jal

8.4. Follow up

There will be a follow up on 5TH and 10TH days during treatment and one after completion of
trial.

Diagnosis criteria- A proforma will be prepared, incorporating all the signs and symptoms
of disease and other related information regarding the problem.

9. Criteria for assessment

Effect of therapy will be assessed according to improvement in signs and symptom of Arochak.

9.1. INVESTIGATIONS

For general assessment of patients and exclusion of other pathologies, following

investigations will be performed.

Laboratory investigations

 Estimation of CBC will be carried out for general assessment of patients before and after
trial.

• Liver function Test -TSB,DSB,ISB,SGOT,SGPT

9.2. Criteria of Assessment

Criteria of assessment is kept on the basis of relief in the sign and symptoms of the disease
Arochak. All the patients will be examined after three days of treatment and completion of trial.
Assessment will be done on the basis of following criteria.
Grading of assessment criteria
o Annaabhilasha

Grade 0 - No Annaabhilasha

Grade 1 - Sometime not willing to eat, but take food regularly

Grade 2 - Sometime not willing to eat, but don’t take food regularly
Grade 3 - Not willing to eat all.

Kashaya asayata

Grade 0 - No Kashaya asayata

Grade 1 - occasionally feel Kashaya asayata

Grade 2 - Most of times feel Kashaya asayata,but other taste also.

Grade 3 - continuously feel Kashaya asayata

o Madhur asayata

Grade 0 - No Madhur asayata

Grade 1 - Occasionally feel Madhur asayata

Grade 2 - Most of times feel Madhur asayata,but other taste also.

Grade 3 - continuously feel Madhur asayata

o Foul smell of mouth/ Bad breath

Grade 0 - No Bad breath

Grade 1 - occasionally Bad breath

Grade 2 - Bad breath after eating food.

Grade 3 - Continuous bad breath

 o Picchilita / Stickiness in mouth

Grade 0 - No Stickiness in mouth

Grade 1 - Occasionally Stickiness in mouth.

Grade 2 - Stickiness in mouth after eating food

Grade 3 - Continuous Stickiness in mouth

o Gourav (Feeling of heaviness)

Grade 0 - Absent

Grade 1 - Occasional feeling of heaviness

Grade 2 - After eating feeling of heaviness

Grade 3 - Continuous feeling of heaviness

Assessment criteria for overall effect of therapy –

Patients will be assessed before and after the treatment for improvement in symptoms on the
basis of above said scoring pattern and percentage improvement will be calculated.

Statistical Analysis:

The result thus obtained from individual patient will be categorized according to the
following grades:
Cured - 100% relief in symptoms

Markedly improved - 76-99% improvement in symptoms

Moderately improved - 51-75% improvement in symptoms

Mildely improved - 26-50% improvement in symptoms

Unchanged - Below 25% improvement in symptoms

REQUIREMENTS
o Well established library.
 o Raw drug and other equipments for processing of drug.

o GMP approved pharmacy

o Well equipped laboratory

o Drug testing lab

o Latest national and international magazines and research journals

This is expected that the findings obtained through this research trial will certainly prove fruitful
to enrich the present knowledge of subject.

P.G. DEPARTMENT OF DRAVYAGUNA

R.G.G.P.G. Ayu. College and Hospital, Paprola (H.P.)
 CONSENT FORM

Case Sr. No. -

Name of Patient -

Name of Research Scholar - Dr. Kailash Rana

Name of Guide - Dr. Navneet Sharma

I…………………………….. age………………yrs. R/o………………………. have been

informed adequately, about the study “Identification of different species used as Chukrika &
To evaluate the clinical efficacy of Rumex vasicarius Linn. in Arochak”. I have understood
the information sheet for above study i.e. purpose of clinical study, nature of trial and follow up
including lab investigations.

I have been given the opportunity to question Dr. Kailash Rana on all aspects of the study. I
hope to complete the study but I am also aware of my right to withdraw at any time during the
course of study without any reason.

I have been informed to my satisfaction about the trial and agree to take part in clinical trial
for a period of 15 days.

I will not make any claim for compensation for any hazardous effect if it occurs during or
after the treatment.

Name of patient with signature Name of attendant/relative with signature

I confirm that I have explained the nature, purpose and possible hazards of the above
mentioned study to Mr./Mrs………………………….

Date Signature of the Research Scholar

P.G. DEPARTMENT OF DRAVYAGUNA R.G.G.P.G. Ayu. College,

Paprola (H.P.)
 Patient Information Sheet

Study title - “Identification of different species used as Chukrika & To evaluate the
clinical efficacy of Rumex vasicarius Linn. in Arochak”

Invitation – As an ideal candidate for research study conducted by Dr. Kailash

Rana you are being invited to take part in it, but before starting the trial it is necessary to
know about the purpose and nature of trial. Read the following information carefully and
decide whether you will take part in it or not.

Purpose of the study – This is a research study being conducted by research

scholar Dr. Kailash Rana under the guidance of Dr. Navneet Sharma to prove the efficacy
and safety of Ayurvedic drug and assess the effect of the drug on Arochak.

Procedure of the trial – If you are agree to take part in this study, you will be given
Chukrika patar Churan two times orally in 5gms dose for period of 15 days.

You have to undergo investigation before and after the trial for assessment.

Expected untowards effects - The trial drug as such involves no untowards effects
but yet individual specific variations may occur at any time during the course of clinical
trial.

If you want to ask anything about the clinical trial, you are free to ask at any stage of
trial. A copy of the information sheet and signed consent form will also be given to you.

All your information will be kept confidential and the result will be published in
leading medical journals so that other doctors get benefit from the result.

Contact for further information…………………..

Signature Date