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General Biology 1
Quarter 3 – Module 5:
Transport Mechanisms
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Team Leaders:
School Head : Reynaldo B. Visda
LRMDS Coordinator : Melbourne L. Salonga
General Biology 1
Quarter 3 – Module 5:
Transport Mechanisms
Introductory Message
This Self-Learning Module (SLM) is prepared so that you, our dear learners,
can continue your studies and learn while at home. Activities, questions, directions,
exercises, and discussions are carefully stated for you to understand each lesson.
Each SLM is composed of different parts. Each part shall guide you step-by-
step as you discover and understand the lesson prepared for you.
In addition to the material in the main text, Notes to the Teacher are also
provided to our facilitators and parents for strategies and reminders on how they can
best help you on your home-based learning.
Please use this module with care. Do not put unnecessary marks on any part
of this SLM. Use a separate sheet of paper in answering the exercises and tests. And
read the instructions carefully before performing each task.
If you have any questions in using this SLM or any difficulty in answering the
tasks in this module, do not hesitate to consult your teacher or facilitator.
Thank you.
This module is designed for you to define and describe the process of homeostasis
and how it relates to the cell and its environment. You will relate the structure of the
cell membrane in maintaining homeostasis. You will also dwell and study the
different mechanisms that transport materials across the plasma membrane and
how these processes account for the passage of molecules or substances in and out
of the cell. In this module, you will also have to reflect on the importance of cell
transport in the freshness of food and farm products.
What I Know
Recall from Module 1 that cell membrane, sometimes called as plasma membrane,
is the part of a eukaryotic cell that separates the cell from its external environment.
It functions as a selectively permeable membrane that regulates the entrance and
exit of substances into the cell. Cell membranes and other biological membranes are
composed of phospholipids and proteins. These components enable the cell
membrane to provide shape and flexibility to the cell, to maintain its integrity and
fluidity, and to transmit signals for cell– cell recognition.
Like other biological membranes, cell membranes are commonly described as fluid
mosaic. The word <mosaic= entails that the cell membrane has a surface made of
small pieces. These pieces refer to the diverse protein molecules embedded in a
framework of phospholipids. Most of these molecules can drift about in any direction,
describing the cell membrane as <fluid=.
Since the main focus of this module is the cell membrane and its job in allowing
some materials to freely enter or leave the cell while others cannot, it is very
important for you to review first the structures and functions of the cell membrane.
To test your prior knowledge about the structures of the cell membrane, the activity
below is provided for you. All you have to do is to label the structures in this fluid
mosaic model of the cell membrane. Also, review the roles of each of these structures
by picking their functions inside the box located below the model which may be used
more than once.
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2 5
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Lesson
Transport Mechanisms
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Most living cells exist in a liquid environment. Liquids that surround the cells may
be the organisms’ habitat, like that of freshwater or seawater organisms. Liquids for
land dwellers like you may be in the form of blood. The blood bathes most of your
body cells in liquid. Generally, the cytoplasm of a cell is composed mostly of water.
It comes in the form of a dissolving medium for many substances, or as a solution
where various substances are suspended.
If the cell has to remain alive, it must maintain its interaction with the liquid
environment, a give-and-take that never ceases. For cells to function, some
substances, like food, water, and oxygen, must be allowed to enter the cell; while
other substances, like the waste products of metabolism, must be moved out. With
these, the cell will keep themselves in equilibrium with their external environment.
This state of equilibrium is called homeostasis, from the Greek words homoi, which
means <like= or <same=, and stasis, which means <standing=. Homeostasis must be
achieved in order for the cell to survive and build new parts.
Scientists and researchers have been very busy for many years just to study the most
sophisticated and important function of a cell: its ability to exchange materials with
the external environment. How do gases, nutrients, and other substances enter and
leave the cell? Let’s find out as you dig in more to this module.
What’s In
Let us first have a short recap of the two major processes involved in the movement
of materials into and out of the cell so you can understand that this passage of
materials is made possible at different rates and energy input.
Below is a simple activity that can lead you to differentiate passive transport and
active transport. You need to identify which of the following pictures depicts passive
transport and which one portrays active transport. Also, you have to interpret each
picture, so you can identify the distinct feature of the two major transport
mechanisms.
What’s New
The existence of the cell membrane was discovered in the 1890s. Knowledge of the
structure of the cell membrane stems from the century-long studies of scientists,
which began when lipids and proteins were recognized as components of the cell
membrane until all of its chemical components were determined in 1915. From their
studies, they described the cell membrane and its minute components through
models. These models have evolved over time, until the best model that provides a
good description not only for the principal components and functions of the cell
membrane but also the behavior of the cell membrane was made. Do you know what
model of cell membrane it is? To know the name of this model, you have to do the
activity given on the next page.
Identify the term that is being described in each statement and write your answer on
the numbered line given above the statements. As you finish answering the
questions, try to guess the missing concept to complete the sentence using your
answers which correspond to the syllables and words of the missing concept.
__________ __________ __________ __________ __________
1 2 3 4 5
What is It
It has already said that among a cell’s most important activities are its interactions
with the environment. Without it, life could not persist. Living cells are enclosed in a
phospholipid membrane through which few water-soluble substances can pass
through; but at the same time, the membrane contains proteins which serve as
passageways that permit specific substances to enter and leave the cell and allow
the cell to transmit and recognize signals with its environment. We call the delicate
membrane of phospholipid and protein molecules that encase the cell a cell
membrane and in this module, we will start by considering the theories that have
been advanced about membrane structure.
What are the different models that account for the principal components and
functions of the cell membrane?
For many years, scientists and researchers have been very busy just to study not
only the structure and functions of the cell membrane but also the fluidity of cell
membrane. They proposed different models that best describe as to how the fluid
character of the cell membrane works with its minute components while performing
their functions. For you to know and understand the different models of cell
membrane, study the table given below. The table on the next page shows the names
of cell membrane models, their proponents, pictures of how these models look like, and
as to how they describe the cell membrane.
hydrophilic (water
– loving)
Davson – 1935 Hugh The cell membrane
Danielli Davson and is described as a
Model James phospholipid
Danielli bilayer
sandwiched by a
coat of protein on
either surface.
What are the two major types of cell transport? How do they differ from each other?
Phospholipid bilayer
Intracellular space
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Osmosis
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Extracellular space
Na+ K+
ATP
Pi (inorganic
ADP (adenosine phosphate)
Phospholipid bilayer diphosphate)
Intracellular space
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Vesicle
Cytoplasm
Types of endocytosis
Phagocytosis (cellular eating) The process whereby a cell ingests or
engulfs large particles, such as
undissolved materials, cells, and large
Solid particle food molecules, using its cell membrane
Cell membrane
Pseudopodium
Phagosome (food
vacuole)
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Extracellular space
Cell membrane
Vesicle
Cytoplasm
Receptor
Clathrin
Coated vesicle
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What’s More
Since you have already learned the principal components and functions of the cell
membrane, the activity below is provided for you.
The table below consists of three columns with the pictures found in the first column.
Then, on the second column, you have to write the component of the cell membrane
which is analogous to the presented pictures/illustrations. You can choose between
PHOSPHOLIPID, CARBOHYDRATE, CHOLESTEROL, INTEGRAL PROTEINS, and
PERIPHERAL PROTEINS which may be used more than once. Lastly, on the third
column, you have to write the SPECIFIC FUNCTION of the component of the cell
membrane that is depicted by each picture/illustration.
PHOTO – COGNITION
Component of the cell Function being portrayed
Picture
membrane being described
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Now it’s your turn! Try to picture out the structure and functions of the cell
membrane close – up by completing the following story.
Your first mission as a Bionaut requires you to enter a blood vessel and observe the
structure and functions of the cell membranes. You step into the water – filled
chamber of the microtron, which quickly shrinks you to a size much smaller than a
red blood cell.
Through the tunnel – like needle of a syringe, you fall suddenly and uncontrollably
enter in a blood vessel in the arm of a volunteer. You continuously float together with
large, bouncy, and elastic red blood cells until you notice that the liquid turns to
yellow in color. You know that you have reached already the blood plasma, so you
switch on your headlamp and observe the cells of the epithelial tissues that line the
wall of the blood vessel. Their cell membranes seem to be made of millions of small
balloons. These are the hydrophilic heads of the (1) __________ molecules that make
up most of the membrane surface. Through the transparent surface, you can see
their flexible, (2)__________ tails projecting inward toward the interior of the cell
membrane, and beyond them an inner layer of (3)__________ molecules with their
tails pointing toward you. Here, there are (4)__________ proteins embedded on the cell
membrane; some rest lightly on the surface, but most project all the way into the
interior of the cell. The cell membrane is indeed a (5)__________ mosaic, the proteins
are embedded like the pieces of a picture, but you can see that they are free to move
around. You push on one of the proteins, and it bobs like an iceberg. Some of the
phospholipids and proteins have (6)__________ attached to them which serve as an
effective interaction with the aqueous environment that surrounds the cell. You
notice that one of the proteins has a dimple in its surface. Just then a minute, plump
molecule floating in the blood plasma installs in a depression of a protein. The
molecule is a hormone, a chemical signal, and the dimpled protein is the
(7)__________ that enables the cell to respond to it.
In your light beam, you can see the sparkle and shimmer of many molecules, large
and small, in the blood and pass through the cell membrane. You see that the
transparent gas of oxygen is moving from the plasma and enters the cell interior.
This movement is (8)__________; which it occurs through biological membrane, it is
called (9)__________ transport. Similarly, carbon dioxide is flowing out of the cell,
down its (10)__________ gradient, from the cell interior, where it is (11)__________
concentrated, to the blood, where it is (12)__________ concentrated.
You note that water molecules are passing through the cell membrane equally in
both directions. The total concentration of solutes in the cell and in the blood must
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be equal; the solution must be (13)__________. You signal the control team to inject a
small amount of concentrated salt solution into the blood, making the blood slightly
(14)__________ relative to the cell contents. This causes water to flow (15)__________
the cell, until the two solutions are again in equilibrium. This diffusion of water
through a (16)__________ permeable membrane is called (17)__________.
Some sugar molecules floating in the blood are simply too large to pass easily through
gaps in the cell membrane like the much smaller water molecules can. These sugar
molecules slowly glide past on the cell membrane and pass through pores in special
(18)__________ proteins. This is a type of passive transport, because the molecules
move down a concentration gradient without the expenditure of (19)__________.
Because transport proteins help out, it is called (20)__________ diffusion.
Your chemscanner detects that the cell interior is concentrated with potassium ions.
Transport proteins here and there in the membrane are able to move potassium ions
into the cell against the concentration gradient. This must be (21)__________
transport; the cell expends (22)__________ to provide energy to <pump= the potassium
ions into the cell.
Suddenly there is a tug at your foot. You look down to see your flipper engulfed by a
rippling membrane. A leukocyte the size of a building quickly holds you against the
wall of the blood vessel. The phospholipids of its cell membrane are pressed against
your face mask. The cell is engulfing you, protecting the body from a foreign invader!
Taking in a substance in this way is called (23)__________, more specifically
(24)__________, if the substance is a solid particle. Suddenly the pressure diminishes,
and you are inside the leukocyte, floating free in a membrane – enclosed bag, or
(25)__________. Another sac is approaching; it is a (26)__________, full of digestive
enzymes. You manage to get your legs outside of the vacuole and move it back toward
the inner surface of the cell membrane. As the vacuole joins with the cell membrane,
you pull your feet freely and you glide away from the impatient cell, realizing
that(27)__________ released you as fast as endocytosis engulfed you!
You swim to the exit point, and the control team removes you by syringe. This is
quite enough adventure for one day.
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What I Can Do
Cells are highly organized structures with parts that perform specific functions.
Starting from the cell membrane with its incomparable abilities not only to provide
shape and flexibility to the cell but also to determine the nature of its interaction with
its environment. For you to recognize these functions, make an illustration (with a title)
that shows a place which resembles a cell membrane. Also, write the things that you
think they are similar. Your product will be assessed based on the following criteria:
organization and content accuracy, appropriateness of elements, creativity, and
appearance. The actual rubric to be used in assessing your product will be found on
page 21.
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Assessment
Let’s see how well you have enjoyed the amazing world of cell cycle and mitosis by
answering the following questions. Choose and encircle the letter of the best answer.
_____1. Which of the following contributes to the fluidity of the plasma membrane?
a. Hydrophilic heads of phospholipid bilayer
b. Integral and peripheral proteins
c. Lipids and carbohydrates
d. Cholesterol
_____5. Which transport mechanism can bring whole cells into a cell?
a. Pinocytosis c. Facilitated diffusion
b. Phagocytosis d. Osmosis
_____6. In what important way does receptor – mediated endocytosis differ from
phagocytosis?
a. It does not involve the pinching off of membrane.
b. It brings substances into the cell.
c. It brings in only a specifically targeted substance.
d. It transports only small amounts of fluid.
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_____11. A liver cell is placed in a solution whose osmolarity is twice as great as the
solute concentration of the cell cytoplasm. The cell membrane is selectively
permeable, allowing water but not the solutes to pass through. What will
happen to the cell?
a. No change will occur because it is an animal cell.
b. The cell will shrivel because of osmosis.
c. The cell will swell because of diffusion.
d. The cell will shrink because of active transport.
_____13. Which cell membrane component can be either found on its surface or
embedded in the membrane structure?
a. Protein c. Carbohydrate
b. Cholesterol d. Phospholipid
_____14. A nursing infant is able to obtain disease – fighting antibodies, which are
large protein molecules, from its mother’s milk. These molecules probably
enter the cells lining the baby’s digestive tract via _____.
a. osmosis c. pinocytosis
b. potocytosis d. phagocytosis
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_____15. A doctor injects a patient with what the doctor thinks is an isotonic saline
solution (Normal Saline Solution). The patient dies, and an autopsy reveals
that many red blood cells have been destroyed. Do you think the solution
the doctor injected was really isotonic?
a. No. The solution and the RBCs are of the same osmolarity and so, the RBCs
will eventually burst.
b. No. The solution and the RBCs are of the same solvent concentration but
the RBCs have higher osmolarity and so, the water will enter the RBCs.
c. No. The solution and the RBCs are of the same solute concentration but the
RBCs have lower osmolarity and so, the water will leave the RBCs.
d. No. The solution is hypertonic in nature and has lower osmolarity than
inside the RBCs and so, the RBCs will eventually burst.
Additional Activities
You did a great job on reaching at this far end of this module! Let’s wrap up this
brilliant learning experience with another exciting activity.
As you have gone through the lesson, most cells exist in an aqueous environment.
Their cell membranes selectively obtain certain materials from this liquid
environment for them to remain alive and prevent some harmful materials from
entering. Also, their cell membranes expel out harmful substances, like the waste
products of cellular activities, and prevent essential substances from leaving. But
what do you think would happen to a cell if its cell membrane lost its selectivity?
Make an illustration (with a title) that shows your response to this question. Your
product will be assessed based on the following criteria: organization and content
accuracy, appropriateness of elements, creativity, and appearance. The actual rubric
to be used in assessing your product will be found on page 21.
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References
Belardo, Gisselle Millete M., et al. (2016). General Biology 1. Quezon City, Philippines:
Vibal Group, Inc. Pp. 77 – 103.
Calsado, Chuckie Fer, et al. (2016). Teaching Guide for Senior High School: General
Biology 1. Quezon City, Philippines: Commission on Higher Education.
Pp. 46 – 56.
Campbell, Neil A., et al. (2009). Biology: Concepts and Connections. Sixth Edition.
Jurong, Singapore: Pearson Education Asia Pte Ltd. Pp. 73 – 87.
Capco, Carmelita M., et al. (2000). Biology. Second Edition. Quezon City, Philippines:
Phoenix Publishing House, Inc. Pp. 68 – 83.
Evangelista, Luisito T. (2017). General Biology 1 for Senior High School. Quezon City,
Philippines: C & E Publishing, Inc. Pp. 23 – 31.
Hadsall, Annalee S., et al. (2008). Exploring Science and Technology: Biology. Makati
City, Philippines: DIWA Scholastic Press, Inc. Pp. 136 – 143.
Losos, Jonathan B., et al. (2008). Selected Chapters from Biology. Eighth Edition.
United States of America. The McGraw – Hill Companies, Inc. Pp. 85 -
104.
Strauss, Eric, et al. (2003). Biology: The Web of Life. Second Edition. Jurong,
Singapore: Pearson Education Asia Pte Ltd. Pp. 72 – 76.
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