Drugs that suppress growth hormone release acromeBally include the followinB except:

[n
9.
A. Bromocriptine
B. Somatostat[n
C. Octreotide
Nafarelin

10. Thyrotropln exerts the following actions on thyroid gland except:

A. Increases V'ascula r[ty
.
Inhibits proteolysis of thyroglobulin
C. Induces hyperplasia and hypertrophy
D. Promotes iodlde trapping

11. Which hormone works antagonistically to parathormone:

A. Triodothyronine
B. Insulin

6=: , (ob h bbb3 a24° pp'"1"Q Q

W 1
C
pTW)

12 . Inthe body both sodium and potassium levels are regulated by

A. Pheromones
@Aldosterone
C. Cortisol
D. Androgens
13. Jim, age 22, develops neurogenic diabetes insipidus after sustaining a head Injury from a rock
climbing fall. The physician prescribes vasopressin 5 units stat. Which of the following
administration routes would render vasopressin ineffective?
A. Intranasal
B. M.. 1.
ssun U. A_Wn
Wpa A\, \H wA SC-
C.S.C. · *

@P.O.
14. Which of the following may be

B.

C.
Oestrogen replacement
Pamidronat
(S 4
H
used for osteoporosis?
W
i4 icAp W h'&Q

D. All

15. Carbimazole acts by:

of the above
\pvu-M· «/F&pMphn«tu (A\eninwb H ¢, M·
Inhibiting the release of thyroid hormone
mMqeh ls mb4
A,.

B. Supplementing endogenous thyroid hormones tb mdhfmQ·

C. Block iodide uptake by the gland
Inhibiting coupling of iodotyrosines Wu n A p° A\dqm fwm
W\»*
a
A U

tfu-. L ru, M. Dn h=3'0b. A->

000
16. Which of the followino ic lpa« t likplv tn cnuse hvoogjvcaemia?
A. Acarbose
B. Insulin
C. Repaglinide
D. Glimepiride

3
 all EXCEPT:
17 . Eisphosphonates are used in
A. Malignancy
Vitamin D excess
C. Post Menopausal Osteoporosis
D. Hypercalcaemia
include:
18. Complications of aerosol steroids
A. Oral candldiasis
B. Cushings syndrome
C. Decreased ACTH
D. Systemic complications
19.0ctreotide is a long acting synthetic analogue of:
A. Prolactin
B. Growth hormone
©Somatostatin
D. Gonadotropin releasing hormone
ls :
for the treatment of peptic ulcer disease due to chronic use of aspirin
2 0. Drug of choice
A. Pirenze pine
B. Loxatldine
C.M isoprostol
Esomeprazole

21. Antacid druB that typically causesdiarrhoea?

A. Sodium bicarbonate
Magnesium hydroxide
C. Calcium bica rbonate
D. Aluminium hydroxide
acid output
The most effica cious drug for Inhibiting round the clock gastric
is:
22.
@Omeprazole
B. Ci metidine
C. Pirenzepine
D. Misoprostol
autocoid/autocoids:
2 3. There are no preformed stores of the following
A. Prostaglandins
B. Leukotrienes
C. Angiotensin II
All of the above

24. Compared to blockers, omeprazole affords the following:

H2

A. Faster relief of ulcer pain

B. Faster healing of duodenal ulcer
C. Higher efficacy In healing reflux oesophagitis
All of the above
fastest symptom relief is obtained with:
25. Among the disease modifying antirheumatic drugs,
A. Auranofin
B. Hydroxychloroquine

0
e -U U U U L'

--f
-\\\\\\\\\.
.
'"""""""""
:
 26., Allopurlnol prevents conversion of:
Hypoxanthine to Xanthlne
8. Xanthlne to uric acid
C. None of the above
All of the above
27. Irreversible inhlbltor of cyclo-oxygenase ls :
@Aspirin V
8. Penylbutazone
C. Indomethacin
D. Piroxicam
28. Which of the following ls a DMARD?
A. Desferrioxamlne (\Ym tino\t\
@Penicillamine
C. Succlmer
D. Dimercaprol
2 9. Which of the following is aspirin?
A. Methyl salicylate
B. Para-aminobenzoic acid
C. Para-amino sallcylic acid
@Acetyl salicylic acid/
30. Which of the following organs is innervated only by parasympathetic nerves?
A. Iris musde
B. Ciliart muscle
C. Sweat glands
D. Splenic capsule
31. Which of the following is always true?
A. drug is more effi cacious
Amore potent
B. Amore potent
drug is safer
C. Amore potent
drug is clinically superior
drug can produce the same response at lower doses
A more potent
orphan' drug?
Which of the following statements best describes
an,'

32.
A. It is a drug which acts on orphanin receptors
B. It is a very cheap drug
C. It is a drug that has no therapeutic use
It is a drug required for treatmentor prevention of a rare disease

33. True statementregarding Inverse aBonist is:

A. Binds to the receptor and causes Intended action
Binds to the receptor and causes opposite action
C. Binds to the receptor and causes no action
D . Binds to the receptor and causes submaximal action

34. Receptor agonist possesses:

A. Affinity but no intrinsic activity

BIntrinsic activity but no affinity

Intr
UAffinity and intrinsic actlvlty with a + sign
D . Affinity and Intrinsic activity with a sign.
 atropine ls :
35, Antagonism between acetylcholine and
@Com petltlve antegonlsm
e. Physlologlcal antagonism
C. Noncompetltlve entagonlsm
O. None
poisoning is:
36. A drug of choice for treatment of acute organophosphate
@Atroplne
B. Pralidoxime
C. Neostlgmlne
D. D-tubocurarine

37 . Which of the following drugs Is useful in prophylaxis of motion sickness!

@Hyosclne
B. Metoclopromlde
C, Prochlorperazine
D. Ondansetron
all
38. In addition to slow intravenous infusion, which of the following routes of administration
for titration of the dose of a drug with the response:
A. Sublingual
B. Transdermal
©Inhalation
D. Nasal Insufflation
39. Which of the following ls a depolarlslng blocking agent:
A. Tubocurarl ne
B. Pancuronlum
C. Atracurlum
©Succinylcholine

"ix
40. The followins ganglion blockers may be used to produce controlled hypotensionin hyper
h. ph"
B. Mecamylamlne
C. NIcotine
D. Carbachol

41. Lethal Dose (LD 50) ls :

A. The maximum dose at which a specified toxic effect is not seen
@The dose that kills approximately 50% of the animals
C The smalle4st dose that is observed to kill any6 experimental animal.
D . None of the above

42. In which of the following conditions is stimulant purgatives contraindicated:

A. Bed ridden patients
B. Before abdominal radlography
C. Subacute intestinal obstruction
D. Allof the above
 colitis Is exertedby:
43. The therapeutic effect of sulfasalazlne In ulcerative
the unabsorbed druB on the abnormal colonlc flora
A, Inhibitory action of
B. Breakdown of the drug in colon
to release 5-aminosalycylic acid which suppresses
Inflammation locally.
C, Release of sulfapyrldine having
antibacterial property
D . Systemic immunomodulatory action of the drug.

44, Bisacodyl is;

A. Bulk formlnB
B. Stool softener
©Stimulant pursative
D . Osmotic purgative

45. An example of an antidote used In polsonings to increase the inactivation rate of a toxic
metabolite is:
A. Ethanol
B. Atropine
C. N-acetylcysteine
D. Naloxone

46. Select thefirst choice drug in acute Bout:

A. Colchicine
@Indomethacin
C. Allopurinol
D. Dexamethasone
is:
47 . The most reliable guide to adjustment of thyroxine dose in a patient of hypothyroidism
A. Pulse rate
B. Body weight
C. Serum thyroxlne levels
D . Serum TSH levels

48. The most prominent action of bromocriptine ls:

@Dopamine D2 agonism
B. Dopamine D 2 antagonism
C. Dopamine D1 antaBonism
D.a adrenergic antagonism
49. Antacld drug that typically causes diarrhoea?
A. Sodium bicarbonate
@M agneslum hydroxide
C Calcium blcarbonate
D . Aluminium hydroxide

Which of the following is NOT an action of the body on

a drug?
50.
A. Absorption
Distribution
k
B.

& : X%
 51. Which of the following G-protein is associated with smooth muscle and glandulartissue,
muscarlnic receptor M3, mobilizinB Internal Ca++ and the DAG cascade?
k Gs
B. Gi

D. Go

52 . Which of the following routes of administration has a bioavailabilityof about 80-100%, is

usually very slow absorbing, and has prolonged duration of action?
A. IV(intravenous)
B. IM (intramuscular)
X:""I
53. What is the common location for the scopolamine motion sickness Transdermal patch?
A. Side of the hip
B. Chest
C. Over the deltoid muscle
@Behind the ear
54. A child on Pz agonists for treatment of bronchial asthma may exhibit allof the following features
Except:
A. Tremors-
B. Hypoglycaemia
©Hypokalaemia
D. Bronchodilatation V
55. Irrespective of the type, alllaxatives exert the following action:
A. Increase the content of solids in the faeces
Increase the water content of the faeces
C. Reduceabsorption of nutrients
D. Increase intestinal motility

56. Aspirin In low doses produces long lasting Inhibition of platelet cyclo-
oxygenase (COX)because:
A. Platelets contain low quantity of COX
B. Platelets cannot syntheslze fresh COX molecules
C. Platelets bind aspirin with high affinity
D . Platelet COX is Inducible

57 . The most prominent action of Leukotriene B4 is:

A. Vasodilatation
B. Uterine contraction
C Platelet asgregation
Chemotaxis of neutrophils and monocytes

58. Long term use of aspirin in children ls associated with:

A. Metabolic acidosis
Reye's syndrome
C. Renal tubular acidosls
D. Fixed drug eruption
 59. Rofieco« ib has been banned due m
@ischaemic heart disease
& Renal comp&imion
C liver
D. Gastric u¢ oer

60 Wnid\of these dngi is usehd for gout?

k Pyrazinamide
& Rifampicin
©Aaopurinol
D. Nalmmne

6L wnich of the fouowing

choi« Je:
disease dbugs(DMARDs» is the dng of tirst
@Methooe« Re
&
C
D.
www
Gold omnpoundb

Makinra

c
m rybutinin ads
O* br
A Nioobne www.orstimulation
& Musrcarinic receptur stimulation
©Muscarinicreceptorinhdbition
D.a reoepoor inhibition
63. Diarrhoea is a side effieG
JA Omeprazole r&=#9
B.Su« ra* fate
JC Metoclopromide V
(W-

ole
V D.
ind
MisopnDSbol

64. Sutfa drug tEed in Inflanwnatorp bowel disesase

C
D. SuKada» cine

65. Fxmn»e aldosterme can Ipad m al of the fouo* ring oonGtions extnpt
A Hypolcataemia
'
B. Hypenmremia·
C HyponatremiaA
D. Hyperl¢ ataeniax

66.0mnic trsp of which of Me Mowing medications is most 6kely to cause

B. Propranold
©Prednisone
D. Wahxin
 67. Bisphosphonates act by:
A., IncreasinB the osteoid formation
B. Increasing the mineralization of osteold
Decreasing the osteoclast mediated resorption of bone
D . DecreasinB the parathyroid hormone secretion

68. Corticosteroid which is given by inhalation route is:

X,"".. Nu.\)
C. Dexamethasone K
D. Hydrocortisone
69. For pneumocystis carinlipneumonia, the drug that can be used as an alternativeto
cotrlmoxazole & pentamidine is:
A. Proguani[
B.M efloquine
Atovaquone
D. Prazlquantel
7 0. The following antibiotic may be used as a luminal amoebicidal drug:
A. Gentamycin
B. Neomyci n
C. Penicillin G
D. Tetyracycline
71. 'Red man syndrome' as an ADR is caused by:
A Metronidazole
Vancomycin
C. Azithromycin
D. Ceftriaxone

72. Gynaecomastia may occur as an ADR with use of:

A Griseofulvin
B, Mebendazole
Ketoconazole '

D. Cotrimoxazole

73. The following drug is used as a topical application preparation for herpes simplex virus infection:
Acyclovir
B, Valacyclovir
C. Lamivudine
D. Trifluridine

7 4. The following antibiotic comes in combination with cilastatin:

@lmipenem
B. Norfloxacin
C. Interferon a
D. Dalfopristln

10
 usefulfor neuro cystlc ercosls :
75. The following drug is
A. Mebendazole
B. piperazlne
Pyrantelpamoate
m
C.
Albendazole
for infection with influenzaA virus:
76. Which of the followinB are effective
A. Adefovir (fr81)
@Amantadine
C. Valacyclovir(m)
D. Stavudine (nQJ*)

77. Which of the following is an anti-pseudomonal

penicillin:
@Ticarclllin
B. Ampicillin
C. aoxacillin
D. Clarithromycin

78. Pharmacodyna mics considers;

A. The way in which the body affects a drug
The effects of the druB on the body and the mode of druB action
C. DruB metabolism
D. Drugexcretion
79. In human adultfemale oxytocin:
Causes strong uterine contractions during parturition
B. Is secreted by anterior pltuitary

C. Stimulates wowth of mammary Blands

D . Stimulates pituitaryto secrete vasopressin

and symptoms, the

Because long-term use of a corticosteroid can produce cushingold signs
during prednisone therapy. Which of
80.
pharmacist assesses a patient regularly for these effects reaction?
the following signs and symptoms suggest this adverse

00
A. Alopicia and dysmenorrhea
B. Hypoglycemia and thrombocytopenia

£ Hyp
O
n s icA, tachycardia and dyspnea
Abdominalgbesity, glycosurla and moon face
SECTION Bz

Answer any two (21 questions

Question 1
of indigestion, bloating and
A malepatlerrt50 years of age presents at a clinic complaininB relieved on eating food. The pat\mt
heartbums. These symptoms are worse on empty stomach and
for which he regularly took NSAIDs. The doctor at the clinic made a
complained of chronic backache,

di
diagnosis of peptic uk)ers.
1. What do you understand by the terms,'Tripletherapy'and'Quadruple
therapy'for peptic
ulcer (4 Marks)
for peptic
2. Describe the rnechanism of action of the druss used as triple or quadrupletherapy
ulcer disease. (8 Marks)

3. Enlist the adverse drug reactions associated with each drug you mmtion. (8 Marlcs)

Question 2
A female comes to your Obs/Gynae clinic, she has been married for 2years and has a child 10
months of age. She consults on methods of contraception and chooses hormonal method.
1. which hormones constitute the c, ombined oral contra ceptlve pius and describe their
mechanism of action for contraception (10 Marks)
2. Enli st their adverse reactions and contraindi cations (10 Marks)

Question 3
Wrfte shrort notes on the pharmac,ologv of any two of the following non-opioid a nalgedcs:
(10 Marks Each)
A. Aspirin
B. Paracetamol
C Celecoxlb
D. Indomethacin

END OF EXAMINAHON