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A 4. Process by which drugs find their way into the urine, EXCEPT:
a. active glomerular filtration d. passive glomerular filtration
b. active tubular secretion e. none
c. passive tubular secretion
B 8. When the dose of the drug is gradually increased and the first noticeable effect is observed, the dose that
produces this effect is called:
a. quantal dose d. a and b
b. threshold dose e. b and c
c. lethal dose
A 10.Inhaled anesthetics are relatively insoluble in blood and brain are eliminated at faster rate than the more
soluble anesthetics:
a. True b. False
C 11. Coordinate body movement and posture to help maintain body equilibrium:
a. cerebrum of the peptide bond c. cerebellum
b. main stem of H-bond d. none
B 13. Used prophylactically in treating manic depressive patients and in the treatment of manic episodes:
a. anti-psychotics b. lithium salts c. anxiolytic drugs d. all
C 16. The most important criterion in determining whether surgical anesthesia has been achieved is:
a. papillary dilation b. respiratory lagging c. absence of eye motion d.
vomiting
B 17. The branch of pharmacology that deals with the study of the action of drug on functions of the body:
a. Toxicology b. Pharmacodynamics c. Pharmaokinetics d.
none
B 20. The branch of pharmacology that deals with disposition and fate of drug is:
a. Pharmacodynamics b. Pharmacokinetics c. both d.
none
A 21. Causes mydriasis by blocking the parasympathetic impulses to the sphincter muscle of the iris:
a. Atropine b. Cocaine c. Lidocaine
d. all
A 31. Which of the ff. agents shows cytotoxicity that is cell cycle specific?
a. Bleomycin b. Dactiomycin c. Lumustine
d. none
D 32. During times of stress, the adrenal gland releases ___ into the blood.
a. epinephrine b. adrenaline c. acetylcholine d. a and b e.
b and c
C 33. Acetylcholine transmits all parasympathetic signals to end organs by binding to:
a. receptor site d. ganglionic receptor
b. cholinergic nervous system e. none
c. muscarinic receptors
B 34. Increase calcium influx into myocardial cells during heart failure:
a. Atenolol d. all
b. Digoxin e. none
c. Streptokinase
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C 35. Draw water into the urine, without interfering with ion secretion or absorption in the kidney:
a. Loop diuretics d. potassium-sparing diuretics
b. Thiazide diuretics e. all
c. Osmotic diuretics
D 36. Arrhythmia occurs because one or more regions of the heart is/are:
a. beating too fast d. all
b. beating too slowly e. none
c. beating automatically without regard for impulses originating from SA node
C 37. Clinically useful agents which enhance neurotransmission include the ff, EXCEPT:
a. receptor agonist
b. drugs which prevent transmitter degradation
c. ganglionic blockers
d. agents which induce neurotransmitter release
e. none
C 40. This may occur when the electrical conduction pathways malfunction:
a. chest pain b. hypertension c. arrhythmias d. MI
e. all
A 43. It refers to the fate of the drug during its sojourn through the body:
a. Pharmacokinetics b. Pharmacodynamics c. Pharmacogenetics d.
Pharmacotherapeutics
D 48. The following situations give rise to excitatory postsynaptic potential (EPSP), EXCEPT:
a. Na+ conductance c. depolarization of the membrane
b. opening of Ca++ion channel d. opening of Cl- ion channel
A 49. The response characterized by increasing magnitude with greater concentration of unbound drug at the
receptor site:
a. “graded” b. quantal c. all-or-none
d. margin of safety
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C 50. It refers to the relative concentration required to produce a given magnitude of effect:
a. affinity b. efficacy c. potency
d. none of these
C 51. Interaction of two drugs whose opposing actions in the body tend to cancel each other’s effect:
a. noncompetitive b. chemical c. physiological d.
pharmacokinetic
A 52. The period from the drug administration to the first visible effect is:
a. onset of action c. ceiling effect
b. duration of action d. peak time
D 54. When MAOi is taken with tyramine containing food it can result to serious consequences such as:
a. hypertensive crisis d. a and b only
b. cerebral stroke e. all
c. insomnia
D 61. All of the ff. statements about the extrapyramidal effects of antipsychotics are correct, EXEPT:
a. these are caused by the blockade of the dopamine receptors on the basal ganglia
b. can be counteracted by the administration of anticholinergic
c. if therapy is stopped, tardive dyskinesia occurs
d. haloperidol does not cause extrapyramidal effects
C 68. It refers to a change of one or more of the pharmacokinetic processes with increasing dose size:
a. disposition b. clinical pharmacokinetics c. dose dependency d.
depot phase
A 69. Cleaning out of stomach by repeated infusion of water using rubber tube:
a. gastric lavage b. emesis c. anaphylaxis d.
hydration
B 70. The process with the slowest rate constant in a system of simultaneous kinetic processes:
a. lag time b. rate limiting step c. bioequivalence
d. accumulation
B 71. The measured preparation devised to make possible the administration of medications in prescribed or
measured amounts:
a. dose size b. dosage form c. dosage regimen
d. drug
D 72. The sum of all body regions in which the drug concentration is an instantaneous equilibrium with that in
blood or plasma:
a. clearance b. accumulation c. depot phase
d. central compartment
C 73. Loss of drug from the central compartment due to transfer to another compartment:
a. apparent partition coefficient c. disposition
b. biliary recycling d. creatinine clearance
C 74. The extent of protein binding is determined in vitro by the ff. mechanisms, EXCEPT:
a. ultracentrifugation c. endocytosis
b. dialysis d. eletrphoresis
C 78. Commonly used spinal anesthetic that is 10 times more potent than procaine:
a. cocaine b. lidocaine c. tetracaine
d. procaine
B 80. Is a potent ultra short-acting non barbiturate hypnotic agent without analgesic properties:
a. diazepam b. etomidate c. morphine
d. cocaine
A 81. It is an important autonomic nervous system center wherein it plays a role in the regulation of body
temperature water balance, and metabolism:
a. hypothalamus b. thalamus c. diencephalons
d. broca’s area
C 82. It triggers the ovulation of an egg from the female ovary and causes the ruptured follicle to be converted to a
corpus luteum:
a. thyrotropic hormone c. luteinizing hormone
b. prolactin d. follicle-stimulating
hormone
A 83. The standard of comparison for potency of general anesthetic agent is:
a. minimum alveolar concentration c. partition coefficient
b. solubility d. maximum vapor
concentration
C 84. Benzodiazepines are used therapeutically for all of the ff. indications, EXCEPT:
a. panic disorder b. schizophrenia c. status epilepticus
d. insomnia
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D 88. This drug has both local anesthetic and antiarrhythmic properties:
a. halothane b. isoflurane c. desflurane
d. lidocaine
A 89. This drug produces rapid analgesia and amnesia while maintaining laryngeal reflexes:
a. dissociative anesthesia b. balanced anesthesia c. neuroleptanesia d.
local anesthesia
A 93. Postulates that the local anesthetic displaces Ca++ from a site near the Na+ channel and blocks the adjacent
Na+ channel:
a. specific receptor theory c. lock and key theory
b. membrane expansion theory d. lidocaine
B 95. The agent which has a parasympathetic effect that can cause bradycardia and hypotension:
a. droperidol b. fentanyl c. alfentanil
d. morphine
D 96. Which of the ff. agents may be considered the drug of choice for the treatment of absence seizures?
a. phenytoin b. phenobarbital c. carbamazepine
d. ethosuximide
C 97. Softening of the bones caused by a deficiency of Vitamin D either from a poor diet or lack of sunshine or
both:
a. osteoporosis b. osteoarthritis c. osteomalacia
d. osteomyelitits
A 98. A stage of anesthesia where there is loss of consciousness and is characterized by irregular respiration and
involuntary activity:
a. delirium b. analgesia c. surgical
d. medullary paralysis
C 101. Which of the ff. agents is the primary drug for treatment of major motor seizures and partial seizures?
a. clonazepam b. ethosuximde c. carbamazepine d.
trimethadione
B 102. A tricyclic antidepressant which is effective in multiple sclerosis patients with pseudobulbar palsy:
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C 103. It potentiates the action of biogenic amines, presumably by blocking the inactivating reuptake of the amines
after release from the presynaptic neuron:
a. MAO inhibitors b. phenothiazines c. tricyclic antidepressants
d. local anesthetics
B 104. Granulocytopenia, GI irritation, gingival hyperplasia and facial hirsutism are all possible side effects of
which of the following anticonvulsant drugs?
a. Phenobarbital b. phenytoin c. valproate
d. dantrolene
C 106. Barbiturates are being replaced by benzodiazepines for use as sedative-hypnotic agents because of the
shortcomings of the barbiturates therapy, which include all of the following, EXCEPT:
a. a narrow therapeutic index
b. suppression of rapid eye movement (REM) sleep
c. induction of seizures
d. high potential for physical dependence
D 107. Chemically it is a trimethylated monocyclic phenylaminoketone used for the treatment of major depression:
a. venlafaxine b. amphetamine c. fluoxetine d.
bupropion
A 108. The brain stem centers affected most strongly by barbiturates are:
a. the respiratory centers c. the cardioinhibitory centers
b. the vasomotor centers d. none of the choices
D 111. Endocrine and metabolic effects of antipsychotic drugs are the following, EXCEPT:
a. hyperprolactinemia c. weight gain
b. galactorrhea d. hypotension
C/A 112. Drugs active by the oral route in the treatment of bronchial asthma, EXCEPT:
a. epinephrine d. corticosteroids
b. terbutaline e. aminophylline
c. theophylline
E 119. All of the following statements concerning antacids are true, EXEPT:
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a. sodium bicarbonate is very effective in neutralizing stomach acid but its use is not recommended because of
the potential for systemic alkalosis and fluid retention
b. antacids only neutralize stomach acids and have no effect on the secretion of pepsin
c. a common side effect of magnesium-based antacids is diarrhea, while aluminum-based antacids tend to
cause constipation
d. milk alkali syndrome is associated with the administration of sodium bicarbonate and calcium
bicarbonate-containing antacids, along with milk or cream
e. magnesium-based antacids, rather than aluminum-based antacids, are preferred for the treatment of patients
with renal dysfunction
D 120. The mechanism of action of the anticoagulant effect of coumarin derivatives involves:
a. a reduction in levels of factors VII, IX and X
b. an action taking place in the bloodstream
c. no effect on vitamin K
d. an action that blocks the release of preformed prothrombin by the liver
e. fibrinolysis
A 122. Antihistamines (H1 antagonists) are useful in treating certain allergic disorders and the mechanism is most
likely the result of:
a. inhibition of histamine release
b. depletion of histamine stores
c. metabolic inactivation of histamines
d. chelation of histamine
A 124. Which of the following agents can produce hearing loss and renal impairment?
a. cisplatin b. melphalan c. mercaptopurine
d. vinblastine
A 127. Which of the following drugs is used to prevent postpartum hemorrhage in patient with blood pressure of
180/100 mmHg?
a. oxytocin b. methylergonovine c. ritodine
d. methysergine
C 129. It is a CNS neurotransmitter with greater inotropic effect, less chronotropic effect and is used primarily for
congestive heart failure:
a. amphetamine b. atropine c. dopamine d.
norepinephrine
D 136. Enzyme/s which break/s down the neurotransmitter of the sympathetic nerve:
a. catechol-o-methyl transferase c. monoamine oxidase
b. acetylcholine esterase d. a and c
B 137. Enzyme/s which break/s down the neurotransmitter of the parasympathetic nerve:
a. catechol-o-methyl transferase c. acetylcholine esterase
b. monoamine oxidase d. a and c
B 142. Dopamine:
a. cholinergic agonist c. antiacetylcholinesterase
agent
b. adrenergic agonist d. anticholinergic agent
C 143. Edrophonium:
a. cholinergic agonist c. antiacetylcholinesterase
agent
b. adrenergic agonist d. anticholinergic agent
B 146. Nifedipine:
a. ACE inhibitor b. calcium channel blocker c. cardiac glycosides
d. alpha blocker
B 147. Nitroglycerine:
a. Anti-arrhythmic agent c. antihypertensive agent
b. Anti-anginal agent d. all of the above
B 149. Aldosterone:
a. glucocorticoid c. anti-estrogen
b. mineralocorticoid d. anti-androgen
C 150. Two drugs have the same pharmacological effects but when given together produced a greater effect than if
each drug was given individually:
a. additive b. potentiation c. synergism
d. antagonism
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A 161. This anti-infective agent has disulfiram-like effect when taken with alcoholic beverages:
a. metronidazole b. griseofulvin c. nystatin d.
amphotericin B
D 162. This drug can be used for both PTB and leprosy:
a. pyrazinamide b. ethambutol c. isoniazid (INH)
d. rifampicin
B 172. Niclosamide:
a. antibiotic b. anthelimintic agent c. antimycotic agent
d. antiviral agent
B 173. Quinine:
a. antituberculotic agent b. antimalarial agent c. antileprotic agent d.
antiprotozoal agent
A 174. A patient is being treated for nighttime sedation. Which alteration in warfarin dosage is indicated?
a. a decrease because its metabolism has been inhibited
b. a decrease because its excretion has been reduced
c. an increase because its GIT absorption has been impaired
d. an increase because its metabolism has been stimulated
B 175. Displacement of a drug from plasma binding sites would usually be expected to:
a. decrease tissue levels of the drug
b. increase tissue levels of the drug
c. decrease the volume of distribution of the drug
d. decrease the metabolism of the drug
C 176. Widely used in cancer management that are classified as steroid hormone:
a. prednisolone b. prednisone c. both d. none of
the above
A 181. Type of epilepsy which involves the spread of electrical firing in a single hemisphere of the brain:
a. partial b. general c. none of the above
d. both a and b
D 183. Which of the following effect/s of histamines are mediated through H2 receptors, EXCEPT:
a. uterine relaxation c. increased gastric secretion
b. cardiac stimulation (in guinea pigs) d. release of catecholamines from adrenal medulla
B 184. Drug used to treat amoebiasis can be categorized as the following, EXCEPT:
a. luminal b. peripheral c. systemic d.
mixed
C 185. An antiviral drug used for parkinsonism which releases dopamine from storage vesicles:
a. chlorpromazine b. phenelzine c. amantidine d. none of the above
C 188. Type of general seizure which involves the abnormal movement of muscles:
a. grand mal b. petit mal c. myoclonic seizures d. status epilepticus
d. none of the above
C 189. ________ is effective in the management of gastric acid hypersecretion and symptoms relief with
Zollinger-Ellison syndrome:
a. misoprostol b. niclosamide c. omeprazole d.
thiabendazole
C 191. Isoniazid may produce peripheral neuropathy and can be prevented by co-administration of:
a. vitamin B6 b. pyridoxine c. both d. none
B 193. A Phenobarbital derivative which is used in combination therapy for types of epilepsy:
a. valproic acid b. primidone c. benzodiazepine
d. ethosuximide
C 197. The H2 histamine receptor lockers are of great value in treating patients with:
a. ulcer b. CHF c. Zollinger-Ellison syndrome d.
duodenal ulcer
C 201. Agent that facilitates the expulsion of gases from the GIT:
a. laxatives b. adsorbents c. anti-flatulents d.
stomachics
C 209. For the treatment of postoperative retention of urine that the patient is likely to e benefited with drug/s
possessing which of the ff. property(ies):
a. diuretic property c. smooth muscle stimulant property
b. antidiuretic property d. smooth muscle relaxant property
D 211. Inhibition of carbonic anhydrase enzyme may be therapeutically useful for which of the ff. purposes,
EXCEPT:
a. to produce diuresis c. to prevent acute mountain sickness
b. to reduce intraocular pressure d. to counter the effects of vasopressin on the kidney
D 215. Which of the following are the main advantages of ranitidine over cimetidine?
a. higher potency c. fewer side effects
b. lack of an antiandrogenic activity d. all of the above
C 216. Among the following, which is the primary action of heparin responsible for its anticoagulant effect?
a. decreased prothrombin formation in the liver
b. decreased formation of fibrinogen
c. activation of plasma antithrombin III
d. decreased aggregation of platelets
D 218. The ff. effect/s of histamine is/are mediated through H1 receptors, EXCEPT:
a. bronchoconstriction c. uterine contraction
b. stimulation of intestinal smooth muscles d. increased gastric secretion
C 220. Which of the following drug/s primarily act on the proximal tubule (site 1) to produce its/ their diuretic
effect, EXCEPT:
a. mannitol b. acetazolamide c. furosemide d.
glycerol
B 221. Also known as absence seizures:
a. grand mal c. status epilepticus
b. petit mal e. none of the above
c. myoclonic seizures
D 222. Agents that facilitate the easy removal of compacted fecal matter:
a. astringent b. styptics c. adsorbents d.
cathartics
B 224. The non-systemic antacids are preferred because of the safety as well as:
a. shorter duration of action c. no action
b. longer duration of action d. none of the above
B 237. A non-selective beta antagonist, it blocks both beta 1 and beta 2 receptors:
a. atenolol b. propranolol c. tinolol d.
atropine
A 238. Each of the following drugs produces a reflex increase in sympathetic activity and tachycardia as side
effects, EXCEPT:
a. clonidine d. hydralazine
b. nitroglycerine e. minoxidil
c. diazoxide
D 239. Which of the following drugs could be used effectively to alleviate postpartum breast engorgement in
patients who are breastfeeding their infants?
a. vasopressin d. oxytocin
b. estrogen e. ergonovine
c. progesterone
C 241. Agents that facilitate the easy removal of compacted fecal matter from the large intestines:
a. anti-diarrheals d. anti-flatulents
b. anti-motility agents e. none of the above
c. laxatives
D 242. Megaloblastic anemia can develop as consequence of prolonged therapy with each of the following,
EXCEPT:
a. phenytoin d. ethosuximide
b. primidone e. amethopterin
c. phenobarbital
D 243. Type of anemia which produces immature RBC decreasing their oxygen carrying capacity (this results due
to the decreased biosynthesis of thymidylate which in turn is utilized in the synthesis of DNA):
a. pernicious b. microcytic c. aplastic d. megaloblastic
e. none of the above
C 244. The side effects of steroids diminish when the drug is given via:
a. IV b. oral c. inhalation d. subcutaneous
e. rectal
A 245. Vitamin used in cancer chemotherapy:
a. cyanocobalamine d. thiamine
b. folic acid e. riboflavin
c. pyridoxine
A 246. In a person with ulcerative colitis and diarrhea, which agent would have the greatest potential for producing
perforation of the intestine?
a. morphine d. methylcellulose
b. kaolin with pectin e. propantheline
c. atropine
E 248. Administration of each of the following drugs during chronic dicumarol therapy may cause an increase in
the anticoagulant effect of dicumarol:
a. clofibrate d. salicylates
b. broad spectrum antibiotics e. Phenobarbital
c. phenylbutazone
C 251. The most specific drug therapy for neostigmine-induced diarrhea would be:
a. methysergide d. calcium carbonate
b. cholestyramine e. kaolin with pectin
c. tincture of belladonna
D 253. Anti-ulcer drug which possesses both anti-secretory and cytoprotective properties:
a. sucralfate d. misoprostol
b. carbenoxolone e. none of the above
c. milk of bismuth
D 255. The development of metabolic acidosis limits the diuretic efficacy of:
a. hydrochlorothiazide d. acetazolamide
b. mannitol e. ethacrynic acid
c. furosemide
C 257. An antihypertensive agent that rarely produces postural hypotension as a troublesome side effect is:
a. guanethidine d. hydralazine
b. methyldopa e. mecamylamine
c. hydrochlorothiazide
E 258. Metabolic alkalosis is likely to enhance digitalis toxicity because it is often associated with:
a. decreased ionized plasma calcium d. increased plasma magnesium
b. decreased plasma volume e. decreased tissue potassium
c. increased ionized plasma magnesium
C 259. For the emergency treatment of anaphylactic shock, one should administer:
a. aminophylline d. disodium chromoglycate
b. diphenhydramine e. isoproterenol
c. epinephrine
D 262. Hemolytic anemia is a recognized danger in the administration of all of the ff., EXCEPT:
a. sulfadiazine d. digitoxin
b. primaquine e. para-aminosalicylic acid
c. menadione
B 263. Chemical compounds that alleviate irritation of mucous membrane or abraded tissue by forming a protective
coating:
a. emollients b. demulcents c. protectives d. astringents
e. none of the above
B 264. The excretion of large volumes of urine isotonic with plasma is most likely to occur after the administration
of:
a. hydrochlorothiazide b. acetazolamide c. amiloride d.
aminophylline
D 267. Common toxic effects of digitoxin include all of the following, EXCEPT:
a. anorexia d. visual disturbance
b. diuresis e. heart rate below 60
beats/minute
c. pulsus bigeminus
B 268. Types of anemia which causes neurological symptoms, achlorhydria, plus the symptoms of megaloblastic
anemia:
a. microcytic b. pernicious c. aplastic d. aggranulocytosis
e. none
D 269. Which of the ff. agents is least likely to produce kidney damage when used to treat a systemic infection?
a. sulfadiazine b. streptomycin c. bacitracin d. erythromycin
e. viomycin
D 270. Agents that lower serum cholesterol by interfering with cholesterol synthesis include:
a. heparin b. cholestyramine c. d-thyroxine
d. clofibrate
Pharmacology Page 17 of 18
A 275. Agents that reduce the number of resident bacteria of the skin and thus inhibit bacterial decomposition of
perspiration:
a. deodorants d. all of the above
b. anti-perspirants e. none of the choices
c. styptics
B 276. Inherent pharmacologic property of iodine ion:
a. mucolytic d. bronchodilator
b. expectorant e. none of the choices
c. anti-tussive
D 277. Pharmacologic actions of calcium channel blockers include:
a. vasodilation due to the blockade of calcium and reduction of intracellular calcium
b. decrease coronary vascular resistance
c. increase coronary blood flow
d. all of the above
A 278. This dusting powder is not used as a lubricant for surgical gloves since it may produce granulomas:
a. talc b. zinc oxide c. starch d. all of the above
e. none of the choices
A 279. Deficiency state of folic acid:
a. megaloblastic anemia c. microcytic anemia
b. pernicious anemia d. sterility
C 280. Anti-nauseant used by patients undergoing cancer chemotherapy:
a. haloperidol b. phenothiazines c. cannabinol d. meclizine
B 281. Oxygen-starved areas of the heart begin to die:
a. arrhythmias d. hypertension
b. myocardial infarction e. angina
c. heart failure
C 282. These are toxic manifestations of atropine poisoning, EXCEPT:
a. increase heart rate b. thirst c. slowing of the heart d. decreased
secretions
B 283. The side effect of magnesium containing antacids:
a. constipation d. systemic alkalosis
b. laxative e. all of the above
c. acid-rebound
A 284. Each of the ff. drugs produces a reflex increase in sympathetic activity and tachycardia as side effects,
EXCEPT:
a. clonidine b. nitroglycerine c. diazoxide
d. hydralazine
E 285. The ff. are the uses of ethyl alcohol:
a. antiseptic d. external antipyretic
b. rubefacient e. all of the above
c. disinfectant
B 286. Which of the ff. anti-emetic compounds is most likely to produce jaundice and parkinsonism when used for
prolonged periods?
a. dimenhydrinate b. chlorpromazine c. meclizine d.
diphenidol
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