Name:Tal

haObai
d

Emai
l:t
alhaubai
d111@gmai
l.
com

Phonenumber
:+923075969489

Educat
ion:Bachel
or'
sinMi
crobi
ology

Ti
tl
e:

Engineer
ingBroad-
Spect
rum Anti
vi
ralPepti
dest
hroughRat
ional
Desi
gn:APr omisi
ngStr
ategyforCombatingEmergi
ng
I
nfecti
ousDiseases

I
ntr
oduct
ion:
 Emergi
ngi nfect
iousdi seases(EIDs)poseaser i
oust hr eattoglobal publichealt
h,
asevi
dencedbyr ecentout br
eaksofZi kav i
rus,Ebolav irus,andCOVI D-19.
Despi
teadv ancesinv accineanddr ugdev el
opment ,ther apidemer genceand
evol
uti
onoft hesev i
rusesmakei tchallengi
ngt odev elopef fecti
vetherapies.The
useofbroad-spectrum ant i
vi
ralpeptidescouldpr ovi
deapr omisingstrategyf or
combati
ngEI Ds,ast heyhav ethepot enti
altotargetmul ti
plev i
ruseswi thhigh
speci
fi
cit
yandpot ency .However,t
hedev el
opmentofsuchpept i
desislimitedby
thedi
ffi
cul
t yofdesigningpept i
dest hatareeffectiv
eagai nstdiversev i
raltarget
s.

Obj
ect
ives:

 Themainobj ect
iveofthi
sresearchproposali
stoengineerbr
oad-spect
rum
ant
ivi
ral
peptidesthroughrat
ionaldesi
gnstrat
egies,wi
ththeaim ofdev
elopi
nga
novel
therapeuti
capproachtocombatEI Ds.Specif
icobj
ecti
vesincl
ude:

 Toi
dent
if
yconser
vedr
egi
onsi
nvi
ral
prot
einst
hatcoul
dbet
arget
edbybr
oad-
 spect
rum ant
ivi
ral
pept
ides

 Todesignandsy
nthesi
zenov
elpept
idesequencesusi
ngcomput
ati
onal
and
exper
imental
methods

 Toeval
uat
etheanti
v i
ral
act
ivi
tyoft
hedesi
gnedpept
idesagai
nstapanel
of
cl
i
nical
l
yrel
evantv
iruses

 Toopt
imi
zet
hepept
idesequencesf
ori
mpr
ovedant
ivi
ral
pot
encyandsel
ect
ivi
ty

 Toi
nvest
igat
ethemechani
smsofact
ionoft
hedesi
gnedpept
ides

Met
hodol
ogy
:
Thepr oposedr esearchwi ll
useacombi nationofcomput ati
onalandexper imental
met hodst oengi neerbr oad-spect r
um antivi
ralpeptidest hroughr at
ional design
strategies.Int hef ir
stphase, conservedregionsi nviralproteinswillbeident i
fi
edusi ng
bioinformat icst ools,andpot ent i
alpepti
desequenceswi llbegener atedusi ng
comput ational met hods.I nthesecondphase, thedesi gnedpept ideswi l
l besy nthesized
usingsol id-phasepept i
desy nthesisandev aluatedf orantivi
ralacti
vityagainstapanel
ofcl i
nicall
yr elev antvirusesusi ngstandardv i
rologicalassay s.Themostpr omising
pept i
deswi l
l t
henbeopt i
mizedf orimprovedpot encyandsel ecti
v i
tythroughst ructure-
activit
yr el
at i
onshi pst udies.Fi nall
y,themechani sm ofact i
onoft heopt i
mi zedpept ides
willbei nvest i
gat edusi ngmol ecularbiol
ogyt echniques.

Expect
edOut
comes:
Thisresearchproposalai
mst odevel
opanovelt
herapeut
icapproacht
ocombatEI Dsby
engineeri
ngbroad-spectr
um ant
ivi
ral
pept
idest
hroughrat
ionaldesi
gnstr
ategi
es.The
expectedoutcomesoft hisr
esearchi
ncl
ude:

 Ident
if
icat
ionofconser
v edr
egi
onsi
nvi
ral
prot
einst
hatcanbet
arget
edbybr
oad-
spectr
um anti
vi
ralpept
ides

 Desi
gnandsy
nthesi
sofnov
elpept
idesequenceswi
thbr
oad-
spect
rum ant
ivi
ral
act
ivi
ty

 Eval
uat
ionoftheanti
vi
ral
act
ivi
tyoft
hedesi
gnedpept
idesagai
nstapanel
of
cl
i
nical
l
yrelev
antvir
uses

 Opti
mizat
ionoft
hepept
idesequencesf
ori
mpr
ovedant
ivi
ral
pot
encyand
sel
ecti
vi
ty
  I
nvest
igat
ionoft
hemechani
smsofact
ionoft
hedesi
gnedpept
ides

Concl
usi
on:
Thedev el
opmentofef fecti
vether
apiesforemer gi
nginfectiousdiseasesi scri
ti
calto
globalpubli
chealt
h.Thepr oposedresear chaimst oengineerbr oad-spectr
um antivi
ral
peptidesthr
oughr ationaldesi
gnstrategies,whichcouldpr ovideapr omi si
ng
therapeut
icapproachf orcombat i
ngEI Ds.Thisresearchhast hepotentialtoadvance
ourunderstandi
ngofpept ide-
basedant i
viral
therapeuti
csandt ocont ri
butetothe
developmentofeff ecti
vetreatmentsforawi der angeofv i
ralinfecti
ons.