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Hiral Hiralot Adrenergic Drugs
Hiral Hiralot Adrenergic Drugs
Beta 1 Selective Agonists Beta 2 Selective Agonists (cont) Adrenergic Drugs (cont)
Located at Myocardium Another Uterine Muscle (When Adrenergic Stimulate activity in tissues that
Stimulation Increased Heart rate and LOCATION stimulated-->cause inhibition or Drugs respond to Epi and NorEpi
relaxation of the uterus) (Adrenergic agonists) OR inhibit
results in increased force of myocardial
epinephrine and norepinephrine
contraction (Increased Cardiac Beta 2 Albuterol (Provventil, Ventolin),
influence (adrenergic
output) Selective Metaproterenol (Alupent,),
Bronchodial Pirbuterol (Maxair), Salmeterol antagonists)
USED FOR To increase cardiac output in
ators (Servent), and Terbutaline From Adrenal gland and reach to
emergency situations such as
(Brethaire, bricanyl). where they Heart, Kidneys, and various other
CVS shock or to treat
release? tissues and organs via systemic
complications in Cardiac what it Bronchodilatation at pulmonary
circulation.
Surgery. causes smooth muscles - Asthma.
also USED To increase cardiac function in Isoproteren can be the same but: less beta 2 Where it is Junction between sympathetic
found postganglionic neurons and
FOR the short-term treatment of ol (Isuprel) selective and affects beta 1
certain type of heart disease, - receptor too. peripheral tissues
Receptor selectivity
MIX ALPHA AND BETA MIX ALPHA AND BETA (cont) MIX ALPHA AND BETA (cont)
Amphatami Drugs:Am Increase Norepi As Narcolepsy treatment Metaramin act like Directly stimulates
nes phetamine release and Bronchod ol Epinephrin alpha 1, 2 and
(generic), decrease NorEpi ilator (aramine) e beta1
dextroamp reuptake and
Epinphrine All Antiasthmatic Treat shock or general
hetamine breakdown at
(Adrenalin, receptors inhalation products. - anasthesia
(Dexedrin adrenergic
Bronkaid are primary stimulate B2 NorEpiNep Stimulates displays little
e) and synapses - so
Mist, stimulate bronchii. hrine : Alpha 1, agonistic activity
methamph Increase activity at Primatene d.
(Levophed) 2 and toward beta2.
atamine synapses with Mist, )
Beta 1.
(Desoxyn) Norepi sesitive
Effect of vasoconstirction and
receptors - Alpha Adm IV Treat: Hypotension
Alpha 1 control of bleeding injection during shock or
1,2 and Beta1)
vascular during minor surgical general
Used to The use to
procedures (sutures). anasthesia.
treat suppress appetite or
Prolongs effects of
attention- to combat normal Adverse Nervousn Prolonged use
the anasthetics
deficit sleepiness is Effect ess, Causes-
B1 effect reestablish normal restlessne hypertension,
disorder discourage- as they
on heart cardiac rhythm during ss, arrhythmias, cardiac
in have high potential
cardiac arrest. anxiety. arrest.
children, of abuse
to Drug of hypersensitive Prolonged Use in
increase choice in allergic reaction inhalation: Cause
mental Anaphyla marked by CVS bronchial irritation.
alertness ctic collapse (decreased
in adults shock cardiac output,
ALPHA 1 SELECTIVE AGONISTS
with hypotension) and
narcoleps severe Alpha 1 or Contraction and
y. bronchoconstriction. alpha 2 VasoConstriction : Increase BP
Ephendrine Stimulate Use: Primarily for why Becase Stimulate heart (b1), Mephenter Maintain/restore BP during
(Generic) Alpha 1, 2 Alpha 1 effects: ability to vasoconstriction mine hypotensive episodes.
and beta treat hypotension. periphery (alpha 1) (Wyamine) Administered: IV or IM
1 and also and Dilate bronchi injections.
stimulate (beta2).
the same
by
increasing
release of
norepi at
synapses
IV ALSO a nasal
injection decongenstant -
stimulate alpha 1:
combined with other
agents
(antitussives,
antihistamines) to
form cough and
cold products
ALPHA 1 SELECTIVE AGONISTS (cont) ALPHA 1 SELECTIVE AGONISTS (cont) ALHA 2 SELECTIVE AGONISTS (cont)
Methoxam Increase and maintain BP in Adverse increased BP, headache, Clonidine Antihypertensive and analgesic,
ine(Vasox severe hypotension- during Effect: abnormally slow heart rate, (Catapres, It does not effect ALONE. so
yl) general anesthesia and spinal sometimes chest pain, difficulty in Duraclon) given with PRAZOSIN (Minipress
anesthesia. Treats: Paroxymal breathing, feelings of nervousness - alpha antagonists). also useful
sypraventricular tachycardia by to treat severe pain in cancer.
causing peripheral ALHA 2 SELECTIVE AGONISTS Guanabenz decrease BP (same as
vasoconstriction, activation of
(Wytensin) Clonidine)
baroreceptor reflex. Adm : IV Primary Hypertension, spasticity..
use Guanfacine similar to Guanabenz
injection
(Tenex)
Midodrine Treat: orthostatic hypotension How Drug stimulate alpha-2 receptors
located at brain and brainstem -- Methyldopa Antihypertensive.
(ProAmati Adm: Orally Also: treat
> cebtral alpha2 exert an (Aldomet)
ne) hypotension in patients who go
under dialysis, offset the inhibitory effect on sympathetic Tizanidine To treat spasticity. Similar to
hypotensive effects of discharge from the vasomotor (Zanaflex) Clonidine but has fewer
psychotropic drugs like center in the brainstem ---> vasomotor effects and less likey
antipsychotic medications diminished sympathetic to cause hypotension and other
discharge results in decreased CVS problems.
Oxymetaz Adm: naslal drops and nasal
BP.
oline sprays. Treat: Decrease nasal Adverse Hypotension, dizziness,
(Afrin, congestion and decrease redness Also Stimulation of Alpha 2 --> causes Effects drowsiness, dry mouth. Difficulty
OcuClear, and minor eye irritation effective interneuron inhibition and a in breathing, slow heart rate,
Many on Spinal subsequent decrease in persistent fainting - overdose of
others) cord excitability of motor neurons drugs.
supplied by interneurons. USE
Phenyleph Treat: hypotension, treat certain
TO normalize the neuronal
rine (Neo- episodes of supraventricular
activity in Spasticity
Synephrin tachycardia. Adm: Orally a lso or
e, Others) nasal spray, or topically as eye Brimonidin Adm: local to eye to treat