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  • Retinoids

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    rroshan251003
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    This document discusses vitamin A, including its natural and synthetic forms called retinoids. The three main vitamers of vitamin A are retinol, retinal, and retinoic acid. Provitamin A includes beta-carotene found in plant foods. Retinol is converted to retinal and then retinoic acid. Vitamin A sources include liver, fish, milk, eggs and plants like carrots. It plays roles in vision, epithelial tissue health, reproduction, immunity and preventing infections. Deficiency can cause night blindness and dry eye disease. Therapeutic uses include treating deficiency with high dose supplements or acne with lower doses. Interactions with vitamins E and K and some drugs can affect its absorption and storage

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    This document discusses vitamin A, including its natural and synthetic forms called retinoids. The three main vitamers of vitamin A are retinol, retinal, and retinoic acid. Provitamin A includes beta-carotene found in plant foods. Retinol is converted to retinal and then retinoic acid. Vitamin A sources include liver, fish, milk, eggs and plants like carrots. It plays roles in vision, epithelial tissue health, reproduction, immunity and preventing infections. Deficiency can cause night blindness and dry eye disease. Therapeutic uses include treating deficiency with high dose supplements or acne with lower doses. Interactions with vitamins E and K and some drugs can affect its absorption and storage

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    © All Rights Reserved
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    2 views17 pages

    Retinoids

    Uploaded by

    rroshan251003
    This document discusses vitamin A, including its natural and synthetic forms called retinoids. The three main vitamers of vitamin A are retinol, retinal, and retinoic acid. Provitamin A includes beta-carotene found in plant foods. Retinol is converted to retinal and then retinoic acid. Vitamin A sources include liver, fish, milk, eggs and plants like carrots. It plays roles in vision, epithelial tissue health, reproduction, immunity and preventing infections. Deficiency can cause night blindness and dry eye disease. Therapeutic uses include treating deficiency with high dose supplements or acne with lower doses. Interactions with vitamins E and K and some drugs can affect its absorption and storage

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 17

    VITAMIN A

    ABINAYA S
    RETINOIDS

    Natural Synthetic
    Vitamers of A
    Retinol
    Retinal
    Retinoic acid

    Provitamin A
    B-carotene(plant foods)
    B-carotene

    2 Retinal
    Retinol (Vit A Alcohol) Alcohol
    Oxidation Oxidation

    Retinal (Vit A Aldehyde) Aldehyde


    Oxidation
    Oxidation

    Retinoic (Vit A acid) acid


    Source
    Liver oils
    Marine Fish
    Milk
    Butter
    Egg Yolk
    carrot,Turnip,Spinach
    Physiological role of Vit A
    A) Wald’s Visual cycle
    B) To Maintain helathy epithelial tissue

    Prevents keratin Synthesis (Horny Surface)


    To treat acne
    prevent wrinkles
    signs of aging
    C) Reproduction
    spermatogenesis

    D) Immunity

    Increased Susceptibility to Infection

    vitamin A deficiency
    Deficiency Symptoms
    1. Night Blindness (Nyctalopia)
    2. xeropthalmia-Bitot’s Spots

    Dryness of conjuctiva cornea


    +
    keratinization of epithelial cells
    Xeropthalmia
    Persists

    Corneal ulceration and


    degeneration
    Progress
    Keratomalacia —> Total blindness
    Therapeutic Uses

    Vitamin A deficiency

    Rx Prophylaxis

    50,000 - 100,000 IU 3000 - 5000 IU/day


    i.m or orally for 1 -3 days

    Skin diseases like acne and psoriasis.


    Drug Interactions
    1.Vitamin E
    Increased storage Decreased toxicity
    Increased utilization of retinol

    2.Regular use of liquid paraffin


    Vitamin A deficiency

    3.Long term oral Neomycin


    steatorrhoea
    Interferes with vitamin A
    absorption
    HyperVitaminosis A
    Regular ingestion of gross excess of retinol
    (100,000 IU) daily for months

    Manifestations
    Dermatitis, increased intracranial tension,
    enlargement of liver,loss of weight and nails,etc
    Retinoic Acid
    Activity Epithelial Tissues ✔️ Rapidly metabolised
    Eye & Reproducive organs ❌ Excretion
    Bile and urine
    Retinoic Acid

    All trans Retinoic acid 13 Cis Retinoic acid

    Acne
    Retinoid Receptors
    —-> Nuclear Receptors
    (similar to steroid hormones recpetors)

    RAR RxR
    RECEPTORS RECEPTORS
    Thank you

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