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Introduction t
1. Introduction to Nanotechnology
Introduction
1.1 Nanotechnology –
A biological system can be exceedingly small.
Definition and Examples ....................... 1
Many of the cells are very tiny, but they are
very active; they manufacture various substances; 1.2 Background and Research Expenditures . 4
they walk around; they wiggle; and they do all 1.3 Lessons from Nature (Biomimetics)......... 6
kinds of marvelous things—all on a very small 1.4 Applications in Different Fields .............. 7
scale. Also, they store information. Consider the 1.5 Various Issues ...................................... 8
possibility that we too can make a thing very
1.6 Research Training ................................. 8
small that does what we want—that we can
manufacture an object that maneuvers at that 1.7 Organization of Handbook .................... 9
level. References .................................................. 9
(From the talk “There’s Plenty of Room at the
Bottom,” delivered by Richard P. Feynman at the the California Institute of Technology, Pasadena,
annual meeting of the American Physical Society at CA, on December 29, 1959.)
Human hair
50 – 100 µm
DMD 12 µm
Landing
Yoke tip
Quantum-dot transistor
300 nm Red blood cell
8 µm
Drain
Molecular gear
10 nm – 100 nm
SWCNT transistor
C atom 0.16 nm DNA 2.5 nm 15 nm
changes in properties can occur. If only one length of of less than 100 nm and combine electrical and me-
a three-dimensional nanostructure is of nanodimension, chanical components. In mesoscale devices, if the
the structure is referred to as a quantum well; if two sides functional components are on a micro- or nanoscale,
are of nanometer length, the structure is referred to as they may be referred to as MEMS or NEMS,
a quantum wire. A quantum dot has all three dimensions respectively. These are referred to as intelligent
in the nanorange. The word quantum is associated with miniaturized systems comprising sensing, process-
these three types of nanostructures because changes in ing, and/or actuating functions and combine electrical
properties arise from the quantum-mechanical nature of and mechanical components. The acronym MEMS
physics in the domain of the ultra small. Materials can originated in the USA. The term commonly used
be nanostructured for new properties and novel perfor- in Europe is microsystem technology (MST), and
mance. This field is opening new venues in science and in Japan it is micromachines. Another term gener-
technology. ally used is micro/nanodevices. MEMS/NEMS terms
Micro- and nanosystems include micro/nanoelectro- are also now used in a broad sense and include
mechanical systems. MEMS refers to microscopic electrical, mechanical, fluidic, optical, and/or biolog-
devices that have a characteristic length of less than ical functions. MEMS/NEMS for optical applications
1 mm but more than 100 nm and combine electri- are referred to as micro/nanooptoelectromechanical
cal and mechanical components. NEMS refers to systems (MOEMS/NOEMS). MEMS/NEMS for elec-
nanoscopic devices that have a characteristic length tronic applications are referred to as radio-
Introduction to Nanotechnology 1.1 Nanotechnology – Definition and Examples 3
Introduction
a) Global MEMS market segment
mensions in perspective
US $ (billions)
NEMS characteristic < 100 nm
8 Microbolometers
length RF MEMS
MEMS characteristic length 1 mm and > 100 nm 7 Bio & Microfluidics comp.
DLP (micromirrors)
Molecular gear ≈ 10 nm
MOEMS
Vertical SWCNT transistor ≈ 15 nm 6 Gyroscopes
Quantum-dots transistor 300 nm Accelerometers
5 Pressure sensors
Digital Micromirror 12 000 nm Inkjet head
Individual atoms Typically fraction 4
of a nm in diameter
DNA molecules ≈ 2.5 nm wide 3
Biological cells In the range of thousands 2
of nm in diameter
Human hair ≈ 75 000 nm in diameter 1
frequency-MEMS/NEMS or RF-MEMS/RF-NEMS.
MEMS/NEMS for biological applications are referred 10 Nanomaterials
to as BioMEMS/BioNEMS.
To put the dimensions of MEMS and NEMS in per-
spective, see Fig. 1.1 and Table 1.1. Individual atoms are 0
typically a fraction of a nanometer in diameter, DNA 2002 2003 2004 2005 2006 2007 2008
year
molecules are about 2.5 nm wide, biological cells are in
the rage of thousands of nanometers in diameter, and Fig. 1.2 Global MEMS and nanotechnology market seg-
human hair is about 75 µm in diameter. The NEMS ments
shown in the figure range in size from 15 to 300 nm
and MEMS is 12 000 nm. The mass of a micromachined MEMS may slow down, and nonsilicon MEMS may
silicon structure can be as low as 1 nN, and NEMS can pick up during the next decade. The NEMS industry
be built with a mass as low as 10−20 N with cross sec- was worth about $10 billion dollars in 2004, mostly in
tions of about 10 nm. In comparison, the mass of a drop nanomaterials (Fig. 1.2) [1.7]. It is expected to expand
of water is about 10 µN, and the mass of an eyelash is in this decade, in nanomaterials, biomedical applica-
about 100 nN. tions, and nanoelectronics or molecular electronics. For
MEMS and emerging NEMS are expected to example, miniaturized diagnostics could be implanted
have a major impact on our lives, comparable to for early diagnosis of illness. Targeted drug delivery de-
that of semiconductor technology, information tech- vices are under development. Due to the enabling nature
nology, or cellular and molecular biology [1.4, 5]. of these systems and because of the significant impact
MEMS/NEMS are used in electromechanical, elec- they can have on both commercial and defense applica-
tronics, information/communication, chemical, and tions, industry as well as federal governments have taken
biological applications. The MEMS industry in 2004 a special interest in seeing growth nurtured in this field.
was worth about $4.5 billion and with a projected annual MEMS/NEMS are the next logical step in the “silicon
growth rate of 17% (Fig. 1.2) [1.6]. Growth of Si-based revolution.”
4 Part Introduction
On December 29, 1959 at the California Institute of been testament to his vision. In recognition of this reality,
Technology, Nobel Laureate Richard P. Feynman gave a in 1998 the White House National Science and Technol-
talk at the annual meeting of the American Physical So- ogy Council (NSTC) created the Interagency Working
ciety that has become a classic in 20th-century science Group on Nanoscience, Engineering, and Technology
lectures. The talk was titled “There’s Plenty of Room at (IWGN). In a January 2000 speech at the same institute,
the Bottom” [1.8]. He presented a technological vision of former President Bill Clinton talked about the excit-
extreme miniaturization in 1959, several years before the ing promise of “nanotechnology” and, more broadly,
word “chip” became part of the lexicon. He talked about the importance of expanding research in nanoscale sci-
the problem of manipulating and controlling things on ence and technology. Later that month, he announced
a small scale. Extrapolating from known physical laws, in his State of the Union Address an ambitious $497
Feynman envisioned a technology using the ultimate million federal, multiagency national nanotechnology
toolbox of nature, building nanoobjects atom by atom or initiative (NNI) in the 2001 fiscal year budget and made
molecule by molecule. Since the 1980s, many inventions the NNI a top science and technology priority [1.9, 10].
and discoveries in the fabrication of nanoobjects have The objective of this initiative was to form a broad-based
coalition in which academia, the private sector, and local,
state, and federal governments would work together to
a) Public expenditure in nanotechnology R&D push the envelope of nanoscience and nanoengineering
R&D expenditure (US $ billions) to reap nanotechnology’s potential social and economic
4 benefits.
FP6 Funding for this initiative in the US has continued
(EU) to rise. In January 2003, the US Senate introduced a bill
3
Europe to establish a National Nanotechnology Program. On
2 NNI
(USA) Japan
Public and private expenditure in nanotechnology R&D in 2004
1 USA R&D expenditure (US $ billions)
Others 4 Government/institutional
0 Corporate/private
1997 1998 1999 2000 2001 2002 2003
2004 global total
b) Public and private expenditure in nanotechnology R&D Corporate/private – $ 6.6 billion
in 2004 3 Government/institutional – $ 3.7 billion
R&D expenditure (US $ billions)
3
Private Private 2
1.30 1.70
2 Private
1.40
Member Public
States 1.90 1
states +
1 associated 0.40
1.40 Federal Public
0.99 0.90
EC 0.48
0 0
Europe USA Japan Others
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ce
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Fr
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Introduction
a) Worldwide publications Start-up companies
in nanotechnology in nanotechnology
(1997 – 1999) Europe (1997 – 2002)
34% USA
55 %
Others USA and Asia
5% Canada 4%
28%
Candidate
countries Rest of
and Russia Asia World
8% 25% 11 % Europe
29 %
b) Worldwide patents
in nanotechnology
Europe
39 % Switzerland
Others France
3% 4% 4%
UK
Asia 6%
13 %
Others
USA and 5% Germany
Canada 11 %
45 %
and the US had the largest expenditure, followed by led, followed by Europe and Asia. Figure 1.6 shows
Introduction
Germany, Taiwan, South Korea, UK, Australia, China, the breakdown in startup companies around the world
France, and Italy. Figure 1.5 shows the breakdown of (1997–2002). Entrepreneurship in the USA is clearly
worldwide publications and patents. The US and Canada evident followed by Europe.
Introduction
Science and technology continue to move forward in tape substrates and magnetic particles in magnetic tape
making the fabrication of micro/nanodevices and sys- coatings).
tems possible for a variety of industrial, consumer, and Nanoelectronics can be used to build computer mem-
biomedical applications (see, e.g., [1.19, 20]). A vari- ory using individual molecules or nanotubes to store bits
ety of MEMS devices have been produced, and some of information, molecular switches, molecular or nano-
are commercially used [1.12, 21–29]. Several types of tube transistors, nanotube flat-panel displays, nanotube
sensors are used in industrial, consumer, defense, and integrated circuits, fast logic gates, switches, nanoscopic
biomedical applications. Various micro/nanostructures lasers, and nanotubes as electrodes in fuel cells.
or micro/nanocomponents are used in microinstruments BioMEMS/BioNEMS are increasingly used in com-
and other industrial applications such as micromirror mercial and defense applications; see, e.g., [1.38–44].
arrays. The largest “killer” MEMS applications in- They are used for chemical and biochemical analyses
clude accelerometers (some 90 million units installed (biosensors) in medical diagnostics (e.g., DNA, RNA,
in vehicles in 2004), silicon-based piezoresistive pres- proteins, cells, blood pressure and assays, and toxin
sure sensors for manifold absolute pressure sensing identification) [1.44, 45], tissue engineering [1.46], and
for engines and for disposable blood pressure sensors implantable pharmaceutical drug delivery [1.47, 48].
(about 30 million units and about 25 million units, Biosensors, also referred to as biochips, deal with liquids
respectively), capacitive pressure sensors for tire pres- and gases. There are two types. A large variety of biosen-
sure measurements (about 37 million units in 2005), sors are based on micro/nanofluidics. Micro/nanofluidic
thermal inkjet printheads (about 500 million units in devices offer the ability to work with smaller reagent
2004), and digital micromirror arrays (about $700 mil- volumes and shorter reaction times, and perform analy-
lion in revenue in 2004). Other applications of MEMS ses multiple times at once. The second type of biosensors
devices include chemical/biosensors and gas sensors, includes micro/nanoarrays that perform one type of anal-
microresonators, infrared detectors, and focal plane ar- ysis thousands of times. Micro/nanoarrays are a tool
rays for earth observations, space science, and missile used in biotechnology research to analyze DNA or pro-
defense applications, picosatellites for space applica- teins to diagnose diseases or discover new drugs. Also
tions, fuel cells, and many hydraulic, pneumatic, and called DNA arrays, they can identify thousands of genes
other consumer products. MEMS devices are also be- simultaneously [1.41]. They include a microarray of sil-
ing explored for use in magnetic storage systems icon nanowires, roughly a few nanometers in size, to
(Bhushan [1.30]), where they are being developed for selectively bind and detect even a single biological mol-
supercompact and ultrahigh-recording-density magnetic ecule, such as DNA or protein, using nanoelectronics to
disk drives. detect the slight electrical charge caused by such bind-
NEMS are produced by nanomachining in a typi- ing, or a microarray of carbon nanotubes to electrically
cal top-down and bottom-up approach, largely relying detect glucose.
on nanochemistry [1.31–37]. Examples of NEMS in- After the tragedy of September 11, 2001, concern
clude microcantilevers with integrated sharp nanotips over biological and chemical warfare has led to the de-
for scanning tunneling microscopy (STM) and atomic velopment of handheld units with bio- and chemical
force microscopy (AFM), quantum corral formed us- sensors for the detection of biological germs, chemical
ing STM by placing atoms one by one, AFM cantilever or nerve agents, and mustard agents and to chemical pre-
array (Millipede) for data storage, AFM tips for nano- cursors to protect subways, airports, water supply, and
lithography, dip-pen lithography for printing molecules, the population at large [1.49].
nanowires, carbon nanotubes, quantum wires, quantum BioMEMS/BioNEMS are also being developed
boxes, quantum-dot transistors, nanotube-based sensors, for minimal invasive surgery including endoscopic
biological (DNA) motors, molecular gears by attaching surgery, laser angioplasty, and microscopic surgery.
benzene molecules to the outer walls of carbon nano- Other applications include implantable drug-delivery
tubes, devices incorporating nanometer-thick films (e.g., devices—micro/nanoparticles with drug molecules en-
in giant magnetoresistive or GMR read/write magnetic capsulated in functionalized shells for site-specific
heads and magnetic media) for magnetic rigid disk drives targeting applications and a silicon capsule with
and magnetic tape drives, nanopatterned magnetic rigid a nanoporous membrane filled with drugs for long-term
disks, and nanoparticles (e.g., nanoparticles in magnetic delivery.
8 Part Introduction
There is an increasing need for a multidisciplinary, a particulate dust that lands on one of the electrodes of
system-oriented approach to the manufacture of mi- a comb drive can cause catastrophic failure. There are
cro/nanodevices that function reliably. This can only no MEMS/NEMS fabrication standards, which makes it
be achieved through the cross-fertilization of ideas from difficult to transfer fabrication steps in MEMS/NEMS
different disciplines and the systematic flow of infor- between foundaries.
mation and people among research groups. Common Obviously, studies of determination and suppres-
potential failure mechanisms for MEMS/NEMS requir- sion of active failure mechanisms affecting this new and
ing relative motion that need to be addressed in order promising technology are critical to a high reliability of
to increase their reliability are adhesion, friction, wear, MEMS/NEMS and are determining factors in successful
fracture, fatigue, and contamination [1.50–53]. Surface practical application.
micro/nanomachined structures often include smooth Adhesion between a biological molecular layer and
and chemically active surfaces. Due to a large surface the substrate, referred to as “bioadhesion,” and reduction
area to volume ratio in MEMS/NEMS, they are par- of friction and wear of biological layers, biocompat-
ticularly prone to stiction (high static friction) as part ibility, and biofouling for BioMEMS/BioNEMS are
of normal operation. Fracture occurs when the load on important.
a microdevice is greater than the strength of the material. Mechanical properties are known to exhibit a depen-
Fracture is a serious reliability concern, particularly for dence on specimen size. Mechanical property evaluation
brittle materials used in the construction of these com- of nanometer-scaled structures is carried out to help
ponents, since it can immediately or would eventually design reliable systems since good mechanical prop-
lead to catastrophic failures. Additionally, debris can be erties are of critical importance in such applications.
formed from the fracturing of microstructures, leading Some of the properties of interest are Young’s mod-
to other failure processes. For less brittle materials, re- ulus of elasticity, hardness, bending strength, fracture
peated loading over a long period of time causes fatigue toughness, and fatigue life. Finite element modeling is
that would also lead to the breaking and fracturing of the carried out to study the effects of surface roughness and
device. In principle, this failure mode is relatively easy scratches on stresses in nanostructures. When nanostruc-
to observe and simple to predict. However, the mater- tures are smaller than a fundamental physical length
ial properties of thin films are often not known, making scale, conventional theory may no longer apply, and
fatigue predictions error prone. new phenomena emerge. Molecular mechanics is used
Many MEMS/NEMS devices operate near their ther- to simulate the behavior of a nanoobject.
mal dissipation limit. They may encounter hot spots that The societal, ethical, political, and health/safety im-
may cause failures, particularly in weak structures, such plications are receiving considerable attention [1.11].
as diaphragms or cantilevers. Thermal stressing and re- One of the prime reasons is to avoid some of the pub-
laxation caused by thermal variations can create material lic skepticism that surrounded the debate over biotech
delamination and fatigue in cantilevers. In large temper- advances such as genetically modified foods, while at
ature changes, as experienced in outer space, bimetallic the same time dispelling some of the misconceptions
beams will also experience warping due to mismatched the public may already have about nanotechnology.
coefficients of thermal expansion. Packaging has been Health/safety issues need to be addressed as well. For ex-
a big problem. The contamination, which probably hap- ample, one key question is what happens to nanoparticles
pens in packaging and during storage, also can strongly (such as buckyballs or nanotubes) in the environment
influence the reliability of MEMS/NEMS. For example, and whether they are toxic in the human body if ingested.
academic disciplines into physics, chemistry, biology, To increase the pool of students interested in science
Introduction
and various engineering disciplines meaningful at the and technology, science needs to be projected as excit-
nano level? Generic skills and entrepreneurship are ing at the high school level. Interdisciplinary curricula
needed to translate scientific knowledge into products. relevant for nanoscience and nanotechnology need to
Scientists and engineers in cooperation with relevant ex- be developed. This requires revamping the education,
perts should address the societal, ethical, political, and developing new courses and course materials including
health/safety implications of their work for society at textbooks [1.28, 36, 53, 55–57] and instruction manuals,
large. and training new instructors.
References
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10 Part Introduction
Adhesive Mimicking Gecko Foot-Hair, Nat. Mater. 2, Current Chemistry 194 (Springer, Berlin Heidelberg
Introduction