Professional Documents
Culture Documents
Textbook
• Bioelectromagnetism
: Principles and Application of Bioelectric and
Biomagnetic Field
– Jaakko Malmivuo/Robert Plonsey Jaakko Malmivuo, PhD
Professor, Aalto University
– Oxford University Press/1995 Department of Electronics
AALTO, FINLAND
• Bioelectromagnetism Portal
– http://www.bem.fi/
– Textbook & Related information
Robert Plonsey, Ph. D.
Professor Emeritus,
Duke University
Biomedical Engineering
Bioelectromagnetism
• Discipline examining electric, electromagnetic,
& magnetic phenomena in biological tissues
– Behavior of excitable tissue(the sources)
– Electric currents and potentials in the volume
conductor
– Magnetic field at and beyond the body
– Response of excitable cells to electric and magnetic
field stimulation
– Intrinsic electric and magnetic properties of the
tissue
• cf: medical electronics: actual devices for this
Related Disciplines
• Engineering & Physics Biology & Medicine
• Biophysics: biological problems with physics.
• Bioengineering: biomedical Eng. + biotechnology
• Biotechnology: microbiological process technology for
agriculture, food and drug production.
• Medical electronics: electronic devices and methods
in medicine.
• Medical physics: science based on physical problems
in clinical medicine.
• Biomedical engineering: application of science and
technology to biology and medicine.
BEM & Disciplines
Subdivision
• Maxwell’s equation: electromagnetic connection
– Bioelectric field Biomagnetic field
Magnetic Electric -
Subdivision
• Principle of Reciprocity
– Measurement, Stimulation, Impedance
Measurement of
Source Medium External
Intrinsic Property
Measurement
– Electric sheatfish(catfish)
상형문자
• Egyptian hieroglyph: 4000BC
무덤벽화
• Sepulcher fresco: 1868
• Electric shock: 450V
– 1st medical application
• With torpedo fish: AD46
• Headache and gout arthritis
• Unique way to get electricity until 17th century
History: Amber
• Amber: attract light substance
– Arostotle(384-22BC),
– Thales(625-547BC)
– Smith(1931)
• Electroscope: Gilbert(1600)
– Turn toward the substance
of attracting power
(Electriks)
the Greek name for amber
– Published in “De magnete”
Muscle contraction
• By “animal spirit”, “nervous inflow”?
• Experiments for volume change water
droplet
– Swammerdam(1664)
• No movement of water droplet silver
• No inflow of nervous fluid ! wire
– Kleist: 1745
– Musschenbroek: 1746
• Leyden U. Netherlands
– Ramsden: 1768, 1st practical generator
Benjamin Franklin
• Founding Fathers of the United States,
박식가
• “The 1st American“ & Polymath:
– Author, printer, political theorist, politician,
scientist, postmaster, inventor, civic activist,
statesman, diplomat.
• Concept of +/- electricity
• Atmospheric electricity
– Kite experiment: 1752
• Lightning: electricity
• Collecting into Leyden jar
• Invention of lightning rod
Portraits in US Dollars
George Andrew
Washington Jackson
1st President 7th President
Ulysses S.
Thomas Grant
Jefferson 18th President
3rd President
Abraham Benjamin
Lincoln Franklin
16th 1st US
President Ambassador
to France
1st American
Alexander
Hamilton
1st US
Secretary of
the Treasury
Muscle Stimulation
• Jean Jallabert: 1747
– Prof. in mathematics in Genova
– Electrical stimulation to hand paralyzed patient
• For 3 months & successful
• Beginning of therapeutic stimulation of muscle by
electricity
• Lugi Galvani: Jan. 26. 1781
– Prof. in anatomy, U. of Bologna
• Electrical stimulation of femoral nerve of frog
• Violent muscular contraction
– 1st neuromuscular electric stimulation
Lugi Galvani
• Study with atmospheric electricity zinc
– Frog leg contraction on lightning
• Study on calm weather
– Iron railing in garden cooper
Compass:
1st magnetic field detector
Invented about AD100 in China
Galvanometer
• Instrument detecting weak electric current
– Multiplikator by Schweigger(German, 1821)
• Increased magnetic field with multiple loops
• Astatic galvanometer: Nobili(Italy, 1825)
1 needle for
detecting
2 needles 1 needle for
8-shape coil indicating
Bioelectric Current Measurement
• 1st muscle impulse
– By Matteucci(Italy,1838) in frog muscle
• 1st nerve impulse
– By du Bois-Reymond(German, 1843) in frog
• 1st electric activity of brain
– Caton(British, 1875)
– In rabbit and monkey
du Bois-Reymond’s
• Nerve potential propagation apparatus
– Beck(Polish, 1888)
– Along the nerve without attenuation
EEG
• 1st recording
– By Hans Berger
• German, 1924
– Identified major
rhythms
• rhythms
• rhythms
• In 1829
Berger’s
notebook
ECG
• 1st recording : Waller (British, 1887)
– Using capillary electrometer
• Photographic film + capillary filled with sulfuric acid and
mercury
• Interface move in response to electric field
• 1mV sensitivity, poor time response
Apexcardiogram:
Mechanical movement of apex
ECG
Dipolar Nature
• Cardiac generator has dipolar nature
– Need 5 measurement points
• Hands, legs, mouth
• 10 bipolar leads
– 3 almost orthogonal leads
• Mouth - left arm
• Mouth - left leg
• Back - front
Willem Einthoven
• 1st high quality ECG recorder: 1908
– Based on string galvanometer
– Possible to clinical application
– Summarized results in 1908 & 1913
– Nobel prize in 1924
Vectorcardiography
• Williams: 1914
– Sequence of instantaneous vectors
• Clinical tool: by Mann(1916)
– 2D VCG based on Einthoven triangle
– “Monocardiogram”
• Display in real-time vector form
– Low voltage CRT: Johnson, 1921
– Amplification by electron tube: Forest, 1906
– Transistor: Bardeen & Brattain, 1948
Electrophysiological Studies
• Neuron as functional unit of nervous system
– Forel, His, Cajal in 1871
• Neuron for neural cells: Waldeyer(German, 1891)
• Concept of synapse & reflex arc
– Sherrington (British, 1897)
• All-or-nothing law: Adrian(British, 1912)
– Measurement of single nerve impulse: 1926
– Nobel prize in 1932 with Sherrington
Membrane
• Membrane theory by Berstein(German)
– Membrane potential by ion distribution ratio
– Selective permeability
• Impulse transmission over Axon
– Gasser & Erlanger: 1922 Nobel prize in 1944
– Time course of nerve impulse & thicker fiber
transmit faster
• Accurate mathematical membrane model
– Hodgkin & Huxley: (English,1952)
– Nobel prize in 1963
• Synaptic transmission: Eccles(Australia, 1950)
Retina & Nervous System
• Granit(Finland)
– Inhibitory synapse in retina: 1935
– Color vision experiments: 1937
• With ERG to confirm spectral differentiation
– 3 types of color cells: red, green, blue
• With microelectrode inside the cell
– Nobel prize in 1967
• With H. Keffer, George Wald
Patch Clamp
• Behavior of ion channel in greater detail
– Electric current from single ion channel
– Neher and Sakmann: 1976
– Nobel prize in 1991
• Origin of biomegentism into molecular level
– Useful also for developing new pharmaceuticals
Electricity & Magnetism
• Oersted, Biot, Savart: 1819
– Force btw magnetic pole & current carrying wire
• Ampere: 1820, 1827
– Solenoid behave magnetically like permant magnet
– Mathematical theory of electrodynamics
• Maxwell: 1864, 1865
– Electromagnetic connection
– Equations for time varying electricity & magnetism
• Devices
– Galvanometer, electric generator, electric motor…
Electricity & Magnetism
• Hans Christian Orsted(1819)
– 1st Electric Magnetism connection
• Jean Baptiste Biot & Felix Savart
– Inversely proportional force
• Between helical wire and magnetic pole
• Andre Marie Ampere(1820)
– Magnetically behaving solenoid
• Electric current to produce magnetic field
– Mathematical theory for electrodynamics
• James Clerk Maxwell(1864)
– Theoretical formulation of electromagnetic connection
Biomagnetic Signal
• Not detected for long time by extremely low
amplitude
• Magnetocardiogram(MCG)
– Baule & MacFee: 1963
– Magnetometer: 2M turns of wire around ferrite-core
– 2 detectors
• Opposite sensing
• To cancel noises
– SQUID at working at -269C
• Superconducting QUantum
Interference Device
Magnetoencephalogram
• David Cohen
– 1st alpha rhythm recording with induction coil
magnetometer(1968)
– 1st MEG with SQUID(1970)
• Practical detection only by SQUID