Oral drug delivery technologies

DuoCoat®
A superior gastro-resistant coating for rapid release in the
ileocolonic region

DuoCoat®: An Innovative EUDRAGIT® based system What makes DuoCoat® unique?

DuoCoat® is a cutting-edge enteric technology that targets
drug release in the ileocolonic region for accelerated Reliable gastric protection

concentration onset and minimal exposure to efflux

­transporters and gut microbiota. This unique dual-layer Accelerated release in the ileocolonic region
system achieves significantly faster release compared to
conventional polymer coatings. Minimise exposure to efflux transporters and
gut microbiota
The gastro-resistant formulation remains intact through
Target optimal absorption windows
the stomach. Influx of fluid in the small intestine causes the
inner layer to swell and rapidly dissolve the polymer coating.
Reduced inter- and intra-subject variability
The increased buffer capacity, pH and
Outer layer: ionic strength of the inner layer causes swelling
EUDRAGIT® coating and rapid dissolution of the coating
Suitable for various drugs and dosage forms

Conventional manufacturing
Core Core

Clinically proven

Inner layer: Partially neutralized

EUDRAGIT® polymer with buffer Patent protected technology

Rapid and consistent results in humans

In vivo gamma scintigraphy study In vitro release in bio-relevant dynamic

in 8 human subjects dissolution model
100 100
Disintegration time post
gastric emptying [min]

80 80
Drug release [%]

60 60

40 40
Time [min];
20 20 post 2 hrs
acid stage
0 0
DuoCoat® EUDRAGIT® L 30 D-55 0 30 60 90 120

Source: Liu F, Basit AW. J. Control Release. 147 (2010), 242-5 Source: Merchant et al. Int. J. of Pharm. 475 (2014) 585–591

In both studies, DuoCoat® released over twice as fast as the conventional enteric polymer and demonstrated less variable
results. DuoCoat® is a proprietary enteric technology to target drug release in the ilecolonic region.
DuoCoat® offers a unique opportunity for product differentiation, life-cycle management or patent protection.

Evonik
L+L 20-01-108 Operations
vNd GmbH |A4.indd
Datenblatt Doucoat Nutrition & Care
––– 18. | DuoCoat®
Sept. 2020; 14:59 Uhr| September 2020
 DuoCoat® is a proprietary technology from Intract Pharma Ltd

This information and all further technical advice are based on our present knowledge and experience. How- Evonik Operations GmbH
ever, it implies no liability or other legal responsibility on our part, including with regard to existing third party Health Care Business Line
intellectual property rights, especially patent rights. In particular, no warranty, whether express or implied, Pharma Polymers & Services
or guarantee of product properties in the legal sense is intended or implied. We reserve the right to make any
changes according to technological progress or further developments. The customer is not released from the
obligation to conduct careful inspection and testing of incoming goods. Performance of the product described
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herein should be verified by testing, which should be carried out only by qualified experts in the sole responsi- www.evonik.com/oraldrugdelivery
bility of a customer. Reference to trade names used by other companies is neither a recommendation, nor does
202009-DDE-V3

it imply that similar products could not be used.

EUDRAGIT® - reg. trademark of Evonik Industries AG and its subsidiaries
EUDRATEC® - reg. trademark of Evonik Industries AG and its subsidiaries

Evonik Operations GmbH | Nutrition & Care | DuoCoat® | September 2020