DEVELOPMENT OF

SPINAL CORD

from candal part neural plate

s caudal to form neural tube
-Develops of eminence .

caudal
-
to 4th pair of somites
-
the lat walls thicken to form central canal (@9-10 weeks)
-
Neural tube -

thick pseudostratified
, ,
columnar neuroepthelium

-
Neuroepithelium
1) Ventricular zone > Neurons

(exendymal layer) >

Macroglial cells -

astrocytes &
oligodendrocytes
white matter cord cell bodies
of spinal
>

Marginal
nerve in
2) >
-

zone
,

Spinal cord I brain

,
ganglia .

Ventricular zone

some cells form primordial neurons (neurobla > form intermediate layer
>
They form neurons
forming cytoplasmic processes
.

form
Some cells
glioblasts ongioblasts)> also migrates to intermediate layer

> forms astroblasts >

-

astrocytes
> ~
oligodendroblast >
-

oligodendrocytes
Remaining neuroepithelial cells
ependymal cells
ependyma dining central canal
-
·

>
-

Microglia
-

scattered
through s
grey
white matter
.

·
derived from mesenchymal cells

·
invades CNS after it is
penetrated by vessel

originate from bone marrow