INSTITUTE OF PATHOLOGY, MADRAS MEDICAL COLLEGE, CHENNAI - 3.

INTERNAL ASSESSMENT- MBBS (UG) (2023-24 BATCH)

Topic :CELL ASAUNIT OF HEALTH& DISEASE,CELL INJURY,DEATH, ADAPTATION,
INFLAMMATION & REPAIR
Date : 23.03.2023 Total : 100 Marks
Time :1.30 pm - 4.30 pm (Theory = 80 + MCQ = 20)

)ESSAY 2x15=3O Marks

(1) Following aroad traffic accident, a young man visits the OPD with swollen painfuÍ wounds
with intact skin & areas of laceration. At the OPD, the wounds are cleaned and dressing
done. He is given anti inflammatory drugs and antibiotics for 5 days.
a) What is the reason behind the swollen painful wounds? (2)
b) What is the role of the anti-inflammatory medication? Elaborate with respect to
the inflammatory mediators? (3)
c) This is a lacerated wound, what is the mechanism of healing of this wound? (3)
d) List the 6 factors that will help in early healing. (1%)
e) What complication do you anticipate if the tissue repair abnormally,
if the wound does not heal on time? (1)
f) Writea note on fracture healing? (2)
g) Elaborate on the role of complement activity in this healing process. (14)
h) What are NET? (1)

(2) (a) Match the Following (1)

Psammoma Bodies
Lipofuscin
Hemosiderin Old Age
Calcium Xanthoma
Cholesterol Blood Transfusion
b) Write about any 1 intracellular accumulation & its effects (12)
c) List the 5 mechanism of cell death. (1) Define Apoptosis (½) (34)
Compare any "2UNCOMMON MECHANISM". (2)
d) Elaborate on the role of mitochondria in apoptosis. (4)
e) Morphologicalchanges in apoptosis. (2)
f) Misfolded Proteins. (2)
g) List the causes for cell injury. (1)

10x5-50 Marks
(W) SHORT NOTES
(1) a) Draw & Describe cellcycle events and Genes controlling the events (3)

b) Match the following (2)

Cyclin A Cyclin B
G1S Cyclin D
G2M CDK2
P21 CDK2
 I N S T

..2.

(S)
(2) REGENERATIVE MEDICINE
(1)
(3) a) Match the following
BCL 2
Pro Apoptotic
BAD
Anti Apoptotic
Initiates Apoptosis
BAX
SMAC Anti Apoptotic (3)
b) Types of necrosis with example. (1)
c) Morphologica lly how does Necrosis differs from Apoptosis.
(5)
(4) OXIDATIVE STRESS
(5)
(5) Find the odd one and write about the correct Genes.
-GATA4 - MEF2 - aACTIN - IGF1

(6) PHAGOCYTOSIS
(5)

(7) a) Match the following:

(1)
Cytokines Cells
|L 12 Macrophage
IL 1 T.Lymphocyte
Chemokines Dendritic Cells
IL 17 Mast Cells

b) Write about the role of macrophages in inflammation. (4)

(8) Draw a Granuloma, Name 5 diseases with Granuloma. (5)

Write about the pathogenesis of Granulomatous inflammation.
(9) SNPs and CNVS - and their application in diseases (5)

(10) List the components of ECM & Elaborate on each of them. (5)
 INSTITUTE OF PATHOLOGY, MADRAS MEDICAL COLLEGE, CHENNAI -3.
(5) INTERNAL ASSESSMENT-2 II MBBS (UG) (2023-24)
Topic:HEMODYNAMIC DISORDERS, DISEASE OF IMMUNE SYSTEM, GENETICS-I
Date:20.04.2023 Total : 100 Marks
Time :1.30 pm -4.30 pm (Theory=80 + McQ =20)

(OESSAY 2x15=30 Marks

(1)
a) Aneurysms,Atherosclerotic plaque, myocarditis. (1)
What is the outcome that is common to these conditions.
b) Match the following (1)
PGI Thrombomodulin
Protein -C Nitric Oxide
Heparin Fibrinogen
Gpllb Antithrombin IIl
c Elaborate on the role of platelets in maintaining hemostasis. (3)
d) Elaborate on the pathogenesis of your answer in question. (a) (5)
e) HIT Syndrome (3)
f) Pulmonary Embolism. (2)

(2) (a) Explain with example: (6)

(i) Co-dominance (ii) Mosaicism
(ii) Genetic Heterogeneity (iv) Incomplete Penetrance
(v) Non conservative missense mutation (vi) Polymorphisms
b) Find the Right combination. (2)
Protein type/ function Example Disease
Transmembrane Familial
Receptor conductance regulator Hypercholesterolemia
ii) lon Channels LDL Cystic Fibrosis
ii)Cell Membrane Hb Hereditary Spherocytosis
Protein 4.1 aThalassemia
iv) Transport Oxygen
Ataxia, (3)
c) (i)Pick the odd one and reason: Duchenne Muscular Dystrophy, Friedreich
Hemophilia, G6PD deficiency.
(iü)List the features of the mode of inheritance for your answer.
d) Write on the structural abnormalities of chromosomes. (2)
Pathogenesisof familial hypercholesterolemia. (2)
e)
10x5=50Marks
(D) SHORT NOTES
(1) Classify amyloidosis based on associated disease and the major fibrillar protein. (5)
() PeripheralTolerance (5)
category (5)
(3) List the pathophysiological categories of odema with 2examples in each
(5)
A) Hyperinflammatory state - discuss.
(5)
(5) Explain the mechanism underlying anasarca.
(6) Infarct- Discuss. (5)
(5)
(7) List 5 antibody mediated diseases, their target antigen, mechanism of disease,
Bothclinical &pathological presentation. (5)
(8) Pathogenesis of SLE.
(9) Pathogenesis of Acute Rejection. (5)
(5)
(10) Type-l Hypersensitivity Reaction - Etiology, pathogenesis.
 INSTITUTE OF PATHOLOGY, MADRAS MEDICAL COLLEGE, CHENNAI -3.
INTERNAL ASSESSMENT-3- II MBBS (UG) (2023-24 BATCH)
Topic : NEOPLASIA, INFECTIOUS DISEASE, GENETICS-|
Date : 18.05.2023 Total: 100 Marks
Time :1.30 pm-4.30 pm (Theory= 80+ MCQ =20)
(DESSAY 2x15-30 Marks
(1) 40/M presents with dizziness, headache &hematuria of two weeks duration. Complete workup
was done & a mass in the abdomen was identified. Followinga nephrectomy the specimen was
sent for Histopathological examination. It had characteristic gross findings fitting into a malignant
lesion.
a) What would that gross finding be? &the microscopic features? (%+)
b) Name the lesion ()
c) What is the cause of his presenting complaint? (1)
d) Name 4 tumors & related conditions based on your answer to Q (c). (2)
e) HPV & Cellcycle (3)
f) Match the following (1)
RAS BREAST
BRAF COLON
ERB2 RET
MEN MELANOMA
g) Write in detail about carcinogenesis due to the last correct match elaborating
on the structure, types of geneticdamage & tumor (4)
h) What is Genomic instability & its cause? (1)
i Match the following (12)
CEA PANCREAS
CA19.9 LUNG
PSA OVARY

CA125 PROSTATE
What are these and their significance?
(3)
(2) (a) List the 5 Phenotypic Hallmarks of Cancer & the corresponding genes
(3)
b) Warburg effect (5)
c) Significance of G1S Checkpoint
d) Match the following
Uniparental disomy Mitochondria
FXS
Angelman syndrome
Mental retardation
Heteroplasmy (3)
Write about pathogenesisof anyone correct pair (1)
e) Classify oncogenes.
10x5=5O Marks
B) SHORT NOTES (5)
in Tumor
( 1 Outline Immune surveillance (5)
NGS-Principle & Application (5)
Velastasis (5)
Plasmodium falciparum
(4) Clinicopathological features of (5)
(5) The Spectrum of Tuberculosis. (5)
( FNAC (5)
(n Chemical Carcinogens (5)
(8 Dysplasia. cycle inhibitors, 4 Tumor suppressor
(9) Name 4 signal transducing proteins, 4 cell (5)
Genes, Write an DNA Repair gene. (5)
(104 Epigenetic changes causing cancer.
 INSTITUTEOF PATHOLOGY
MADRAS MEDICAL COLLEGE, CHENNAI -3.
INTERNAL ASSESSMENT- 5 -II MBBS (UG) (2023-24)
Topic: HEART, BLOOD VESSEL, ENVIRONMENTAL PATHOLOGY, NUTRITIONAL DISORDERS
Date: 24.07.2023 Total: 50 Marks
Time :11.30am 1.00 pm (Theory = 40 + MCQ = 10)

(0)ESSAY 1x15=15 Marks

(1) 55 years old male presented to emergency ward with stabbing chest pain, profuse
sweating and was found on examination to have rapid, weak pulse.
a) What is your diagnosis? (2)
b) What are the etiologic factors and describe the pathogenesis (5)
c) Classify the condition based on the pattern. (1)
d) List thelaboratory investigations required for this condition. (2)
e) Describe the morphology of the above disease. (4)
f) What are the complications? (2)
() SHORT NOTES 5x5=25 Marks
(1)Adverse effects of lonising radiation (5)
(2) Anorexia Nervosa (5)
(3) Vasculitis (5)
(4) Protein energy malnutrition (5)
(5) Aneurysm (5)

**** **
 INSTITUTE OF PATHOLOGY
MADRAS MEDICAL COLLEGE, CHENNAl-3.
INTERNAL ASSESSMENT- 6 -II MBBS (UG) (2023-24)
Topic : Head &Neck, Diseases of Infancy &Childhood, Respiratory System,
GIT (Oral Cavity, Oesophagus, Stomach) Total: 50 Marks
Date: 21.08.2023
Time: 11.30 am -1.00 pm (Theory= 40 + MCQ =10)
1x15=15 MarkS
(QESSAY
abdominal pain
2. 50 year male patient presented with complaints of satiety, nausea, vomiting, antropyloric
and weight loss.endoscopic examination showed ulcer with heaped up margins in the
region.
(1)
a) What is your diagnosis?
(3)
b) What are the predisposing risk factors of the disease?
c) Classification of the disease and write briefly about the morphology (2+4)
d) What are the serum markers and prognostic factors of the disease? (2)
e) What is Blumer's shelf and krukenberg tumour? (1)
) Types of gastric polyps. (2)
(u) SHORT NOTES 5x5=25 Marks
(1) Precancerous lesions of oral cavity
(2) NUT midline carcinoma
(3) Pathogenesis of cystic fibrosis
(4) Pneumoconiosis
(5) Miliary TB
**** **
 INSTITUTE OF PATHOLOGY
MADRAS MEDICAL COLLEGE, CHENNAI -3.
INTERNAL ASSESSMENT- 7 -II MBBS
Topic: GIT (Excluding oral cavity, oesophagus, stomach),(UG) (2023-24)
Date: 07.10.2023 hepatobiiiary &Pancreas
Total:50 Marks
Time :1.30 pm -3.00 pm (Theory = 40 + MCQ = 10)
(0) ESSAY 1x15=15 Marks
1. 56 year old male patient, chronic alcoholic, presented with hematemesis. Clinicalexamination
revealed splenomegaly, caput medusae and gynaecomastia.
a) What is your diagnosis? (1)
b) Pathogenesis of the disease diagnosed in (a) (3)
c) Spectrum of the disease associated with the etiology of above diagnosis(a) (1)
d) Morphologyof each disease in the spectrum? (6)
e) 4 risk factors for hepatocellular carcinoma (1)
f) Name 2 enzymes which are markers of hepatocellular injury and 2enzymes which are
markers of cholestasis. (2)
g) Normal histology of classical hepatic lobule. (1)
(0) SHORT NOTES 5x5=25 Marks
(1) Intestinal polyp
(2)Cholelithiasis
(3) Pathogenesis of colorectalcarcinoma /
(4) Pathogenesis of Acute pancreatitis
Difference between Ulcerative colitis&crohns disease
* * ****
 INSTITUTE OF PATHOLOGY
MADRAS MEDICAL COLLEGE, CHENNAI -3.
INTERNAL ASSESSMENT- 8 -II MBBS (UG) (2023-24)
Topic: KIDNEY,FGT, MGT,BREAST
Date: 19.10.2023
Total : 50 Marks
Time : 1.00 pm - 2.30 pm
(Theory=40 + MCQ =10)
()ESSAY lx15=15 Marks
1. 50 female presenting with painless breast lump for 3 months. On examination hard in
consistency.
a) What is your probable diagnosis? (4)
b) What are the diagnostic modalities available? (2)
c) Discuss in detail the etiopathogenesis of this disease. (4)
d) Pathological features observed in the diagnosis. (5)
e) Prognostic and predictive markers for the same. (24)
f) Cytological features for your diagnosis (1)

(1)SHORT NOTES 5x5=25 Marks

(1) Endometriosis
(2) Pathology of lgA nephropathy
(3) Enumerate the types of renal calculi. Add anote on ADPCKD
(4) Carcinoma penis
(5) Elaborate clinical features, investigations, histopathological scoring, grading and treatment
of prostate carcinoma
**** **
toma(5) (4) (3) Meningioma(2)a) SHORT(1NOTES
) (0) 25.11.2023
1.
ESSAY TimeDate:
(O
Write
Pathogenesis c) b) b) a) d)
mellitus. Write c)
in b) a)
Match CSF
Pathogenesis Elaborate List
Classify :11.30
Alzheimers
Parkinsons i ) i) Microscopy
iv) iii) Prion
inFronto findings out
Topic:
detail the the
detailDiabetes am
on -1.00
ENDOCRINE,
of
temporal following: diagnostic INTERNAL
about in of the
bacterial acutePapillary and about
Morphology Mellitus pm
etiology,
(ea) morphological the
lobar bacterial criteria BONE,MADRAS
osteomyelitis carcinoma pathogenesis ASSESSMENT-
PATHOLOGY
INSTITUTEOF
degeneration
types, and for JOINTS,
meningitis
features clinicaldiabetes MEDICAL
spread thyroid SKIN,
Adda of
***
Type SOFT
and note of features mellitus COLLEGE,
9
plaque
Kuru bòdy body
Pi-ck Lewy
- - Hashimoto 2 TISSUE, -II
amyloid
-Aß Diabetes
diagnosis on of MBBS
chronic CHENNAI
Gout. SKELETAL
of thyroiditis mellitus (UG)
melanoma complications -3.
MUSCLE,
(2023-24)
(Theory=

Total: CNS,
Marks50
5x5=25
Marks of 1x15-15
Marks
40 PNS,
Diabetes +
MCQ EYE

(5) (2) (2) 10) =

(6)
(1) (1) (3) (2) (3)
(5) (5)(2+3)