MCQs on Pharmaceutics (VI)

1. Concerning respiratory drug delivery,

a) Delivery of therapeutic agents to the respiratory tract is primarily for the treatment of local conditions
b) The treatment of asthma involves the deposition of the therapeutic agent at the alveoli.
c) Systemic absorption of certain therapeutic agents occurs following respiratory delivery.
d) Respiratory drug delivery is associated with a slow onset of drug action.
e) The diameters of the conducting airways decrease towards the alveoli.
f) Drug absorption from the respiratory tract occurs at the alveoli.

2. Factors influence the deposition of particles within the respiratory tract?

a) The size of the inspired droplets:
b) Humidity.
c) The vapour pressure of the propellant.
d) The patient’s inhaler technique.
e) Breath holding time

3. Concerning the formulation and use of metered-dose inhalers,

a) Oxidation of drugs is minimised.
b) The drug is soluble within the propellant system.
c) Metered-dose inhalers always require the inclusion of a preservative.
d) The vapour pressure remains constant throughout the lifetime of use of the inhaler.
e) The propellant type used is HFA.
f) The volume of propellant released upon actuation is controlled by a metering valve.
g) All metered-dose inhalers are filled under atmospheric conditions.

4. The following excipients are included in metered-dose inhalers for the following reasons:
a) Ethanol – to increase the vapour pressure of the propellant.
b) Tween 80 – to enhance the solubility of the therapeutic agent within the propellant.
c) Oleic acid – to stabilise the suspended drug in the propellant.
d) Antioxidants – to inhibit oxidative degradation of the therapeutic agent.
e) Water – as the solvent

5. Concerning the formulation of dry-powder inhalers?

a) Known as insufflations
b) Liquid propellants are not required.
c) Lactose is commonly used to improve the flow properties of the powdered drug.
d) Following inspiration, both lactose and the powdered drug reach the site of action.
e) Required low dose for the response when compared with MDIs

6. The advantages of metered-dose inhalers include:

a) Administration of high doses of therapeutic agent.
b) Convenience for the patient.
c) Ability to be used with a spacer
d) Requirement for patient’s ability to coordinate actuation and inhalation.
e) Greater efficiency than nebulisers.

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7. Concerning nebulisers,
a) Nebulisers require either a compressed-gas source or an ultrasonic device.
b) Nebulsiers are portable and convenient to use.
c) They require patient coordination.
d) They are suitable for the delivery of all drugs.
e) Nebulizer solutions are respiratory solutions

8. Regarding the formulation of solutions for nebulisation,

a) Sterile
b) The pH of nebuliser solutions is always greater than 5.
c) Propylene glycol may be employed as a co-solvent in nebuliser solutions.
d) Nebuliser solutions should be hypertonic.
e) In general, preservatives are not required in nebulizer solutions.

9. Regarding Enemas
a) Liquids for rectal administration
b) Large volume enemas need warming before use
c) Large volume enemas may contain systemic drugs
d) Retention enemas are small volume enemas
e) Volume of small volume enema is less than 100mL

10. True or false;

a) A secondary covering is needed for hydrogel dressing
b) Foam dressings are suitable for heavily exuding wounds
c) Hydrocolloid dressings contain an absorbent layer on a vapour-permeable film
d) Crepe bandages are supporting bandages
e) Cohesive bandages adhere to themselves, but not to the skin

11. In preparation of water for injection, following procedures are involved;

a) Chemical softening
b) Filtration
c) De-ionization
d) Tonicity adjustment
e) PH adjustment

12. True or false about moist heat sterilization

a) can be applied in sterilization of anhydrous materials
b) Autoclaves are used to provide the moist heat sterilization
c) BP recommends 121oC for 15 minutes as the proffered time –temperature combination
d) 121oC can be achieved at 15lb/in2.
e) Surgical dressings can be sterilized by this method.

13. True of false about sterilization

a) Fixed oils & fats can be sterilized using dry heat method

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 MCQs on Pharmaceutics (VI)
b) In heating with bactericide method product should be stable at 98 – 100oC for 60 minutes
c) Ehylene oxide gas can be used for sterilization of plastic materials
d) Eye drops are sterilized after filling and sealing the container.
e) Formaldehyde solution BP is 37% formaldehyde solution

14. Label of a product is labeled as “store below 250C”; Shelf-life is 3 years.

a) It can be stored at “room temperature” of Sri Lanka
b) If it is stored at room temperature, 3 year shelf-life is not valid.
c) It could be stored in a refrigerator.
d) If the container is changed and stored at the same condition, same shelf-life can be claimed.
e) If the storage temperature is changed from 25 to 30, shelf-life should be shortened.

15. True of false;

a) In the BP, Storing in a cool place means below 250C
b) In the BP, Storing in a refrigirator means 2-80C
c) Freshly prepared is defined as “prepared no more than 24hrs
d) Preparations made with chloroform water have a shelf-life of 2 weeks
e) 2 week shelf-life is used for diluted creams

16. True or false about Dialysis;

a) Heamodialysis (HD) solutions should always be sterile.
b) HD is carried out in renal failure
c) In PD, dialyser is not necessary
d) Peritoneal Dialysis solutions contain more glucose compared to HD solutions.
e) Ultrafiltration is the mechanism of dialysis.

17. True or false about Pyrogen;

a) Should be free in all sterile pharmaceuticals
b) Can be removed using bacteria proof filters
c) Exotoxins of G – bacteria are a major source
d) All forms of Pyrogen can be detected using LAL test.
e) LAL test is a limit test

18. True or false;

a) Multiple dose injections should include a preservative
b) Tonicity of onjections are adjusted using sodium chloride
c) Mixing an injection to an infusion is termed “Admixing”
d) Irrigation solutions used to bathe wounds and body cavities
e) Irrigation solutions are hypertonic

19. True or false about containers / materials;

a) The closure in child resistance containers are termed “snap shut”
b) Tamper-evident closures indicate unlawful access to the medicine
c) Blister packs & strip packs can be named as unit dosage packages

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d) The main plastic used in blister packs is PVC
e) Coated Al is used in strip packages
20. Pharmacopoeia standards for containers
a) Hermetically sealed container" means a container that is designed and intended to be secure against
the entry of microorganisms
b) Hermetically sealed container hold the product which is intended for single use for injection.
c) Hermetically sealed container is an air tight container
d) Tamper-evident containers are closed containers fitted with a device that irreversibly indicates if the
container has been opened.
e) Securely closed container is an airtight container in which the closure is fitted in such a way not to
displace it from the container.
21. About cat-gut
a) Absorbable suture
b) Sterile
c) Contain collagen
d) Sterilized by autoclaving
e) Chromium is used to increase the hardness
22. True or false
a) Draughts are single dose liquid preparations.
b) Maximum dose of a draught is 100ml.
c) Separate labeling of more than one dose of a draught is necessary.
d) Individual powder is not official in BP as a dosage form
e) Drugs supplied as stocks solutions should be freely soluble in the solvent
23. Reconstitute syrups,
a) Drugs unstable in liquid form are formulated as reconstituted syrups
b) They should be prepared at the time of dispensing.
c) The powder form is stored below 25oC.
d) Reconstituted syrup can be stored in room temperature for 7 days.
e) Final volume is always a mark given in the label.
24. Precipitation may result in if the following substances are dissolved with tap water; True or false;
a) Potassium permanganate
b) Silver nitrate
c) Copper sulfate
d) Liquid led subacetate
e) Iodine
25. In compounding of liquid external extemporaneous preparations. True or false ;
a) All preparations should be packed and supplied in flutted bottles.
b) White flutted bottles are used for mouthwashes.
c) Coloured flutted bottles are used for throat paints.
d) Label “Not to be taken” indicates that the preparations could be taken to mouth but not to be
swallowed.
e) Red labels should be used.

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