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2ND PU CHEMISTRY IMPORTANT CONCEPTS
Potassium dichromate (K2Cr2O7) :
preparation of potassium dichromate is a three step process
Step 1: The chromite ore (FeCr2O4) is fused with sodium carbonate in free access of air to obtain yellow
solution of sodium chromate
4 FeCr2O4 + 8 Na2CO3 + 7 O2 → 8 Na2CrO4 + 2 Fe2O3 + 8 CO2
step 2: The yellow solution of sodium chromate is filtered and acidified with sulphuric acid to obtain orange
sodium dichromate, Na2Cr2O7. 2H2O can be crystallised.
2Na2CrO4 + 2 H+ → Na2Cr2O7 + 2 Na+ + H2O
Step 3: Sodium dichromate is more soluble than potassium dichromate. Potassium dichromate is prepared by
treating the orange solution of sodium dichromate with potassium chloride.
Na2Cr2O7 + 2 KCl → K2Cr2O7 + 2 NaCl
Orange crystals of potassium dichromate crystallise out.
Potassium permanganate(KMnO4) :
Preparation of potassium permanganate is a two steps process
Step 1: fusion of MnO2 with KOH and an oxidising agent like KNO3 it produces the dark green K2MnO4 solution
2MnO2 + 4KOH + O2 → 2K2MnO4 + 2H2O
Step 2: dark K2MnO4 disproportionates in a neutral or acidic solution to give purple colour of permanganate.
3 MnO42- + 4 H+ → 2 MnO4 - + MnO2 + 2 H2O
(3K2MnO4 + 2H2SO4 → 2KMnO4 + MnO2 + 2H2O + 2K2SO4)
Valence bond theory:
1) [Co(NH3)6]3+complex:
Co( Z= 27) electronic configuration is -[Ar] 3d7 4s2 and
Co3+ electronic configuration is –[Ar] 3d6 4s0
↑↓ ↑ ↑ ↑ ↑
in this coordination complexes NH3 ligand can act as strong ligand. It causes the pairing of the unpaired 3d
electrons
Co3+ electronic configuration is –[Ar] 3d6 4s0 4p0
↑↓ ↑↓ ↑↓
To form complex with NH3 molecules Co3+ participate in d2sp3 hybridization form six d2sp3 hybrid orbitals.
d2sp3 hybrid orbitals of Co3+ electronic configuration is –
[Ar] 3d 6 d2sp3 hybrid orbitals
↑↓ ↑↓ ↑↓
Six pairs of electrons, one from each NH3 molecule, occupy the six hybrid orbitals..
[Co(NH3)6]3+ 3d6 d2sp3 hybrid orbitals
↑↓ ↑↓ ↑↓ ↑↓ ↑↓ ↑↓ ↑↓ ↑↓ ↑↓
2 3
Hybridization: d sp
Shape: Octahedral
Magnetic character: diamagnetic
Structure:
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2)[CoF6]3- complex:
Co( Z= 27) electronic configuration is -[Ar] 3d7 4s2 and
Co3+ electronic configuration is – [Ar] 3d6 4s0
↑↓ ↑ ↑ ↑ ↑
in this coordination complexes fluoride ligand can act as weak ligand. Hence 3d electrons are not paired
Co3+ electronic configuration is – [Ar] 3d6 4s0 4p0 4d0
↑↓ ↑ ↑ ↑ ↑
To form complex with F ion, Co participate in sp3d2 hybridization by using 4s, 4p and 4d orbitals and form
- 3+
3)[Ni(CN)4]2- complex:
Ni( Z= 28) electronic configuration is -[Ar] 3d8 4s2 and
Ni2+ electronic configuration is –[Ar] 3d8 4s0
↑↓ ↑↓ ↑↓ ↑ ↑
-
in this coordination complexes CN ligand can act as strong ligand. It causes the pairing of the unpaired 3d
electrons
Ni2+ electronic configuration is –[Ar] 3d 8 4s0 4p0
↑↓ ↑↓ ↑↓ ↑↓
To form complex with CN- ions Ni participate in dsp2 hybridization form four dsp2 hybrid orbital’s.
2+
Structure:
Magnetic character: diamagnetic).
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4)[NiCl4]2-complex:
Ni( Z= 28) electronic configuration is -[Ar] 3d8 4s2 and
Ni2+ electronic configuration is –[Ar] 3d8 4s0
↑↓ ↑↓ ↑↓ ↑ ↑
in this coordination complexes chloride ligand can act as weak ligand. Hence 3d electrons are not paired
sp3hybrid orbital’s.
Sp3 hybrid orbital’s of Ni2+ electronic configuration is –
[Ar] 3d 8 sp3 hybrid orbitals
↑↓ ↑↓ ↑↓ ↑ ↑
Four pairs of electrons, one from each Cl- ion, occupy the four hybrid orbitals.
Structure:
Units: Sec-1
SN2 mechanism:
The reaction between CH3Cl and sodium hydroxide yields methanol . It is second order reaction. The rate
depends on the concentration of both chloro methane and sodium hydroxide.
Rate = K [(CH3)3CBr]
so it is first order kinetics.
Reactivity order : 3o > 2o > 1o alkyl halides
Solutions Q.No; 1 (mcq) + 16 (fib) + 21 (2m) +33 (3m) + 44,45 (NP-3m) = 13M
Binary solution: The solution consisting of two components only (solute & solvent).
Types of Solutions:
Type of Solution Solute Solvent Common Examples
Gaseous Solutions Gas Gas Mixture of oxygen& nitrogen gases
Liquid Gas Chloroform with nitrogen gas
Solid Gas Camphor in nitrogen gas
Liquid Solutions Gas Liquid Oxygen dissolved in water
Liquid Liquid Ethanol dissolved in water
Solid Liquid Glucose dissolved in water
Solid Solutions Gas Solid Solution of hydrogen in palladium
Liquid Solid Amalgam of mercury with sodium
Solid Solid Copper dissolved in gold
35% (v/v) Ethylene glycol solution can act as antifreeze. It lowers the freezing point of water to 255.4K
(-17.6oC)
(1) Mole fraction(X):
Mole fraction of a component is defined as the ratio of number of moles of one component to the total
number of moles of the solution.
Molefraction not depends on temperature If temperature increases molefraction of the solution not change.
(2) Molality: Molality (m) is defined as the number of moles of the solute per kilogram (kg) of the solvent
units: mol/kg
Molality not depends on temperature If temperature increases molality of the solution not change.
(3) Molarity: Molarity (M) is defined as number of moles of solute dissolved in one litre of solution
Units:mol/lit
Molarity is a function of temperature and it is inversely proportional to temperature.
If temperature increases molarity of the solution decreases because volume of solution increases.
Solubility of a gas in liquids:
The solubility of a gas in liquid depends on low temperature and high pressure
If temperature increases solubility of a gas in liquid decreases. Because it is an exothermic process.
Henry’s law.
The solubility of a gas in a liquid is directly proportional to the partial pressure of the gas present above the
surface of liquid or solution
p = KH S (Or)
The partial pressure of the gas in vapour phase is proportional to the mole fraction of the gas in the solution
Mathematically p = KH x
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Different gases have different KH value. This suggest K H is a function of nature of the gas
Higher the value of KH at a given pressure, the lower is the solubility of the gas in the liquid.
Henry’s law applications :
1) To increase the solubility of CO2 in soft drinks and soda water, the bottle is sealed under high pressure.
2) Scuba divers are suffers from bends disease so scuba divers carry diluted air with composition
11.7% helium, 56.2% nitrogen and 32.1% oxygen.
3) At high altitudes peoples are suffers from anoxia disease.
4) Aquatic species are more comfortable in cold waters rather than in warm waters due to high solubility of
Oxygen gas in cold water.
Raoult’s law: (SOLUTION = Solvent (A) + solute (B))
The partial vapour pressure of each component of the solution is directly proportional to its mole fraction in
the solution. Mathematically
PA ∝ xA or PA = pA0 xA and pB ∝ xB or pB = pB0 xB
Difference between ideal and non ideal solution:
Ideal solution Non ideal solution
1. The solution obeys raoult’s law 1. The solution donot obeys raoult’s law
2. For ideal solution ∆Hmix = 0; 2. For ideal solution ∆Hmix ≠ 0;
3. for ideal solution ∆Vmix= 0 3. for ideal solution ∆Vmix ≠ 0
4. They donot form Azeotropes. 4. They form Azeotropes.
5. The interaction between solute and solvent is 5. The interaction between solute and solvent is
always equal to solute – solute and solvent – solvent not equal to solute – solute and solvent – solvent
interactions. interactions.
Ex: n-hexane and n – heptane, bromoethane and Ex: Ethanol and acetone, chloroform and acetone
chloroethane, benzene nd toluene.
Due to weaker interactions between Solvent and solute, solution show positive deviation from raoult’s law
Due to stronger interactions between Solvent and solute, solution show negative deviation from raoult’s law
Difference between non ideal with positive and negative solution: (depending on interaction)
Non ideal solution with positive deviation Non ideal solution with negative deviation
1)for this solution ∆Hmix > 0; 1) for this solution ∆Hmix < 0;
2) for this solution ∆Vmix> 0 2) for this solution ∆Vmix< 0
3) Ptotal > pA + pB 3) Ptotal < pA + pB
4) solvent-solute interactions are weaker than 4) solvent-solute interactions are higher than
solvent-solvent, solute-solute interactions. solvent-solvent, solute-solute interactions.
5) The solutions can form minimum boiling 5) The solutions can form maximum boiling
Azeotropes. Azeotropes.
Ex: Ethanol and acetone, ethanol and water, CS2 and Ex: phenol and aniline, chloroform and acetone and
acetone Nitric acid and water
Azeotropes: The solutions which are binary mixtures having the same composition in liquid and vapour phase
and boil at a constant temperature. It is not possible to separate the components by fractional distillation..
Ex: Maximum boiling azeotrope: 95% by volume of aq.ethanol solution ( B.p is 351.3K)
Minimum boiling azeotrope: 68% by volume of aq.nitric acid solution (B.p is 393.5K)
Colligative Properties:
“The properties which depend on the number of solute particles but not nature of solute particles present in
the solution are called colligative properties”. These are
(1) relative lowering of vapour pressure of the solvent
(2) elevation of boiling point of the solvent
(3) depression of freezing point of the solvent
(4) osmotic pressure of the solution.
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When non volatile solute is added to pure solvent then vapor pressure of solution decreases, boiling point of
solution increases, freezing point of solution decreases and osmotic pressure increases.
Osmosis:
The flow of solvent molecules from low concentration solution to high concentration solution through semi
permeable membrane is called osmosis.
Ex: raw mangoes shrivel in brine solution, wilted of flowers in fresh water,
Reverse Osmosis and Water Purification:
At high pressure than osmotic pressure the flow of solvent molecules from high concentration solution to low
concentration solution through semi permeable membrane is called reverse osmosis.
Ex: Desalination of sea water
Osmotic pressure:
The pressure that just stops the flow of solvent in osmosis is called osmotic pressure. Or the pressure required
to stop the osmosis is called osmotic pressure.
Osmotic pressure depends on concentration of solution and temperature
Semi permeable membrane is a membrane which allows only solvent particles but not solute particles.
Ex: pig’s bladder, parchment (natural), cellophane (synthetic)
Isotonic solutions: Two solutions having same osmotic pressure or same concentration
Hypertonic solutions: in two solutions the solution having higher osmotic pressure or higher concentration
Hypotonic solutions: in two solutions the solution having lower osmotic pressure or lower concentration
Vanthoff factor (i): It is defined as the ratio of normal molar mass to abnormal moalr mass.
van’t Hoff factor(i) = Normal molar mass
Abnormal molar mass
i < 1 indicates solute participate in association
i >1 indicates solute participate in dissociation.
Compound Van’t hoff factor I for complete dissociation/association
NaCl, KCl, MgSO4 2
BaCl2, MgCl2, ZnCl2, K2SO4 3
CH3COOH in benzene 1/2
C6H12O6, Urea, Sucrose 1
van’t Hoff factor(i) is required when the solute is participate in association or dissociation.
The Standard electrode potential of hydrogen electrode is assume to be 0 V. so it can act as reference
electrode.
Inert electrodes: The electrodes which not participate in chemical reaction but provide their surface for
oxidation or reduction reactions and for the conduction of electrons.
Ex: platinum electrode, gold electrode
Electro chemical cell applications:
To determine the pH of solutions, solubility product, equilibrium constant, other thermodynamic properties,
and for potentiometric titrations.
Difference between Electronic & Electrolytic conductors:
Electronic (metallic) conductors Electrolytic (ionic) conductors
1)Electrical current flows by movement of electrons 1)Electrical current flows by movement of ions
2) no chemical change occurs 2) chemical change occurs
3) it does not involve the transfer of any matter 3) it involves the transfer of matter in the form of
4) Resistance increases with increase of temperature ions
5) Faraday’s law is not followed 4) Resistance decreases with increase of
Ex: Metal(Cu,Ag,Al…), non metal(graphite), alloys temperature
5) Faraday’s law is followed
Ex: Acids, bases and salt solutions (electrolytes)
Wheatstone bridge:
The electrical resistance can be measured with the help of a wheatstone bridge. It consists of two resistaces R3
and R4, a variable resistance R1 and the conductivity cell having the unknown resistance R2. The wheatstone
bridge is fed by an oscillator O and suitable detector P. the bridge is balanced when no current passes though
the detector. Under these conditions
Unknown resistance R2 = R1R4/R3
Cell constant of the conductivity cell = R2k
The conductivity cell is now filled with given electrolytic solution. It is connected to wheat stone bridge and
the experiment is repeated. The resistance R2 of the electrolytic solution is determined.
Specific conductance of the electrolytic solution k = cell constant/R2
Molar conductivity( m): The conductance of all the ions present in one molar solution is called molar
conductivity.
Conductivity(k)
Molar conductivity ( m) = Concentration(C)
Corrosion:
Corrosion is a process in which a purified metal converts to its oxide, hydroxide, or sulfide when metal contact
with moisture.
Example: The rusting of iron.
During rusting of iron iron oxidation changes to +3
Prevention techniques:
Covering the surface with paint
Covering the surface with some chemicals like bisphenol
Covering the surface with other metals (Sn, Zn, etc.)
Chemical Kinetics Q.No; 4 (mcq) +17 (fib) +22 (2M) + 36 (3m) + 46,47 (NP-3m) = 13M
Rate of a Chemical Reaction:
The rate of a reaction can be defined as the change in concentration of a reactant or product in unit time.
A) For a reaction R → P
−Δ[R] +Δ[P] −d[R] +d[P]
Average rate of a reaction = Δt = Δt differential rate of a reaction = dt = dt
Rate expression = K[R]
B) For a reaction aA + bB → cC + dD
−1 Δ[A] −1 Δ[B] +1 Δ[C] +1 Δ[D]
Average rate of a reaction = = = =
𝑎 Δt 𝑏 Δt 𝑐 Δt 𝑑 Δt
−1 d[A] −1 d[B] +1 d[C] +1 d[D]
differential rate of a reaction = = = =
𝑎 dt 𝑏 dt 𝑐 dt 𝑑 dt
Rate expression = K[A]a[B]b
Units of rate of a reaction: mol L-1s–1 or atm.s-1 (for gaseous reactions)
Units of rate constant:
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Zero order reaction: mol. L-1.Sec-1;
First order reaction: Sec-1;
Second order reaction: mol-1.L.Sec-1
Units of rate of a chemical reaction are similar to zero order reaction.
First order reaction units are not depends on concentration it depends on only time
Difference between order and molecularity:
Order Moleculairy
1) It is defined as the sum of powers of the 1)It is defined as The number of reacting species
concentration of the reactants in the rate law (atoms, ions or molecules) taking part in an
2)It is applicable to elementary as well as complex elementary reaction
reactions 2) It is applicable to elementary reactions
3) order can be zero 3) molecularity never not be zero
4) order values are positive, negative and fraction also 4) molecularity values are 1,2,3.
Example for molecularity of a reaction:
NH4NO2 → N2 + 2H2O molecularity = 1 (unimolecular reaction)
2HI → H2 + I2 molecularity = 2 (bi molecular reaction)
2NO + O2 → 2NO2 molecularity = 3 (tri molecular reaction)
Factors effect on rate of a reaction:
concentration of reactants (pressure in case of gases), temperature and catalyst
Zero order reaction: The reactions in which rate of reaction depends on zero power of concentration of
reactants.
Ex: some enzyme catalysed reactions, decomposition of ammonia gas on platinum surface, decomposition of
HI on gold surface.
First order reaction: The reactions in which rate of reaction depends on first power of concentration of
reactants.
Ex: All natural and artificial radio active decay of unstable nuclei, hydrogenation of ethane
Effect of catalyst:
A catalyst is a substance which increases the rate of a reaction without undergoing any chemical change.
𝑀𝑛𝑂2
Ex: 2KClO3 > 2 KCl + 3O2; MnO2 can act as catalyst.
Catalyst can increase the rate of reaction by decrease the activation energy. It can show an alternate path to
the chemical reaction.
The reduction half reaction of potassium dichromate is Cr 2O72- + 14H+ + 6e- → 2Cr3+ +7H2O
Acidified potassium dichromate can convert ferrous to ferric, iodides to iodine, sulphides to sulphur, tin(ii) to
tin(iv). 6Fe2+ → 6Fe3+ + 6e-; 6I- → 3I2 + 6e-; 3H2S → 6H+ + 3S + 6e-; 3Sn2+ → 3Sn4+ + 6e-
Potassium permanganate:
Lab preparation: 2Mn2+ + 5S2O82- + 8H2O → 2MnO4- + 10 SO42- + 16H+
Potassium permanganate on heating it form potassium manganate. 2KMnO4 → K2MnO4 + MnO2 + O2
Optical isomerism:
The bond between metal and CO can possess both sigma and pi character. The sigma bond is formed by the
donation of lone pair of electrons on the carbonyl carbon. The pi bond is formed by the donation of a pair of
electrons from a filled d orbital of metal into the vacant anti bonding π* orbital of CO. such type of bond is
called synergic bod and this effect is called synergic effect.
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Halo alkanes and Haloarenes 7 (mcq) +19 (fib) +24 (2m) +37 (5m) = 9M
In allyl halide and benzyl halide the halogen attached to sp3 hybrisised carbon.
In vinyl halide the halogen attached to sp2 hybrisised carbon.
CH3-CHCl2 Ethylidine chloride(geminal) ClCH2-CH2Cl Ethylene dichloride(vicinal)
Alkyl chloride have high dipole moments
Alkyl halides are slightly soluble in water.
Due to symmetry para isomers fits in crystal lattice and have high melting points than ortho and meta isomers.
𝑅𝑒𝑑 𝑃
1. CH3OH + Cl2 > CH3Cl
𝑆𝑂𝐶𝑙2
2. CH3OH > CH3Cl(pure) + SO2 + HCl
SOCl2 is best reagent to prepare pure alkyl chloride because the bi products are escapable gases.
48% HBr and KI in 95% H3PO4 required for preparation of alkyl bromides and iodides from alcohols.
Halo arenes are not prepared from phenol, because in phenol the bond between C-OH group is partial double
bond.
Finkelstein reaction:
Alkyl chlorides react with sodium iodide in presence of dry acetone form alkyl iodides. NaCl or NaBr form
precipitate in drycetone and forward reaction mainly takes place.
𝐷𝑟𝑦 𝑎𝑐𝑒𝑡𝑜𝑛𝑒
Ex: CH3Cl + NaI > CH3I + NaCl
Swart’s reaction:
Alkyl chlorides react with silver fluoride form alkyl fluorides
Ex: CH3Cl + AgF > CH3F + AgCl
R-X + KCN → R-CN + KX, R-X + AgCN → R-NC + AgX
R-X + KNO2 → R-ONO + KX, R-X + AgNO2 → R-NO2 + AgX,
Chloro benzene react with NaOH followed by acid hydrolysis form phenol
Esterification:
Carboxylic acids react with alcohols in presence of dehydrating agent conc. H 2SO4 form fruity odour ester is
called esterification.
Ex: CH3COOH + C2H5OH → CH3COOC2H5 (ESTER)
Distinguish between 1o, 2o & 3o alcohols:
Conc. HCl and an hydrous ZnCl2 is called Lucas reagent
1o alcohol donot form turbidity but it form turbidity on heating
2o alcohol form turbidity ofter some time
3o alcohol form turbidity immediately
𝐶𝑢 𝐶𝑢 𝐶𝑢
CH3 – CH2 – OH 573𝐾 > CH3 – CHO; CH3–CHOH–CH3 573𝐾 > CH3 – CO – CH3; (CH3)3COH 573𝐾 > (CH3)2C=CH2
Phenol on nitration with dilute nitric acid for o-nitrophenol (intra molecular hydrogen bonding-low boliling
point, steam volatile) and p-nitrophenol (inter molecular hydrogen bonding- high boliling point, steam non
volatile) which are separated by steam distillation
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Phenol on nitration with concentrated HNO3 it form an yellow ppt is called 2,4,6 – trinitrophenol (picric acid).
Kolbe’s reaction:
Sodium phenoxide react with carbon dioxide followed by acid hydrolysis form 2 – hydroxybenzoic acid
(salicylic acid)
Phenol on oxidation with chromic acid in presence of sulphuric acid form benzoquinone.
Phenols are strong acids than alcohols because phenols form resonancely more stable phenoxide ion.
Phenol is less stable than phenoxide ion due to charge separation.
If electron donating groups ( -CH3) are increases acidic character decreases
If electron drawing groups ( -NO2) are increases acidic character increases
Acidic character of phenols is
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ETHERS
𝐻2𝑆𝑂4
2 C2H5OH 413𝐾 > CH3CH2OCH2CH3 (SN2 process)
Ethanol Ethoxyetane
Williamson synthesis of ethers: (SN2 process)
sodium alkoxide react with alkyl halide form either symmetrical or unsymmetrical ethers
R – ONa + R – X → R – O – R + NaX
Ex: a) CH3 – CH2 – ONa + CH3 – Cl → CH3 – CH2 – O – CH3
(Sodium ethoxide) (Methoxy ethane)
b) CH3 – CH2 – ONa + CH3 – CH2 – Cl → CH3 – CH2 – O – CH2 – CH3
(Sodium ethoxide) (Ethoxy ethane)
When tertiary alkyl halide react with sodium methoxide it form an alkene
Lower ethers are soluble in water due to formation of inter molecular hydrogen bonding with water. Ethers
have low boiling points than alcohols due to absence of inter molecular hydrogen bonding between ethers.
CH3 – O – CH3 + HI → CH3OH + CH3I CH3CH2 – O –CH3 + HI → CH3CH2OH + CH3I
(Sn1 mechanism)
Bromination of anisole:
Anisole react with bromine in ethanoic acid form 2- bromo anisole and 4 - bromoanisole.
Nitration of anisole:
Anisole react with conc. HNO3 and Con. H2SO4 form 2 – nitroanisole and 4 – nitroanisole .
s
Friedal - crafts acylation:
Anisole react with acetyul chloride in presence of an hydrous AlCl3 form 2 – methoxyacetophenone and 4 –
methoxyacetophenone.
Aldehydes, ketones & carboxylic acids Q.No: 10,11 (mcq) + 25 (2M) + 40,41 (5m) = 14M
In aldehydes ketones and carboxylic acids carbon undergo SP 2 hybridisation
Rosenmund reduction:
Acyl chloride undergo reduction inpresence of Pd and BaSO4 form aldehydes
Stephen reduction:
Niriles undergo reduction in presence of stannous chloride and HCl form aldehydes
𝐷𝐼𝐵𝐴𝑙−𝐻 𝐷𝐼𝐵𝐴𝑙−𝐻
RCN 𝐻3𝑂+ > RCHO; RCOOR 𝐻3𝑂+ > RCHO (DIBAl-H; diisobutylaluminiumhydride)
Etard reaction:
Toluene on oxidation with chromyl chloride followed by acid hydrolysis form benzaldehyde
Due to moecular association aldehydes and ketones have high boiling points than ethers. Lower aldehydes and
ketones are solble in water due to formation of inter molecular hydrogen bonding.
Ketones are less reactive towards nucleopillic addition reactions due to steric reasos and electronic reasons.
aldehydes and ketones give orange red crystalline ppt with 2,4-DNP. It is the identification test for aldehydes
and ketones.
Clemmensen reduction:
Aldehydes/ketones react with Zinc amalgam and conc.HCl form corresponding alkanes
Tollens reagent: Ammonical silver nitrate. Aldehydes form silver ppt with tollens reagent but not ketones.
Fehiling solution: it is combination of Fehiling A and Fehiling B solution.
Fehiling A solution: aqueous copper sulphate solution
Fehiling B solution: alkaline sodium potassium tartarate solution. Aldehydes form red brown ppt with fehiling
solution.
Aromatic aldehydes not react with fehiling solution due to absence of α-hydrogen.
Aldol condensation:
Aldehydes/ketones containg alpha hydrogens are participate in aldol condensation.
Aldehydes/ketones containing alpha hydrogen undergo self condensation form beta hydroxy
aldehyde/ketone. On dehydration form α,β – unsaturated aldehydes/ketones.
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Cannizaro reaction:
Aldehydes/ketones not containg alpha hydrogens are participate in cannizaro reaction.
Aldehydes with out alpha hydrogen undergoes reduction and oxidation with NaOH form alcohol and
carboxylate
Nitration of benzaldehyde:
Carboxylic acids:
In carboxylic acids the Carbon undergo sp2 hybridisation and less electrophilic in nature.
From oxidaton:
𝑎𝑙𝑘.𝐾𝑀𝑛𝑂4/𝐻3𝑂+ 𝑚𝑖𝑙𝑑 𝑜𝑥𝑖𝑑𝑎𝑡𝑖𝑜𝑛
RCH2OH 𝑜𝑟 𝐽𝑜𝑛𝑒𝑠 𝑟𝑒𝑎𝑔𝑒𝑛𝑡 > RCOOH; RCHO 𝑠𝑡𝑟𝑜𝑛𝑔 𝑜𝑥𝑖𝑑𝑎𝑡𝑖𝑜𝑛> RCOOH
Jones reagent: Cromium trioxide(CrO3) In H2SO4
From hydrolysis:
𝐻+/𝑂𝐻− 𝐻+/𝑂𝐻− 𝐻+/𝑂𝐻−
RCN > RCONH2 ℎ𝑒𝑎𝑡 > RCOOH + NH3 RCOCl > RCOOH + HCl
(Nitriles) (amide) (carboxylic acid) (acid chloride) (carboxylic acid)
𝐻+/𝑂𝐻− 𝐻+/𝑂𝐻−
RCOOR > RCOOH + ROH RCOOCOR > 2 RCOOH
(Ester) (carboxylic acid) (alcohol) (acid anhydride) (carboxylic acid)
From grignards reagent:
Grignard reagent react with CO2 followed by acid hydrolysis form carboxylic acid
𝑑𝑟𝑦 𝑒𝑡ℎ𝑒𝑟 𝐻3𝑂+
RMgBr + CO2 > RCOOMgBr > RCOOH
𝑑𝑟𝑦 𝑒𝑡ℎ𝑒𝑟 𝐻3𝑂+
CH3MgBr + CO2 > CH3COOMgBr > CH3COOH
Due to molecular association through intermolecular hydrogen bonding Carboxylic acids exist as dimers even
in vapour state and have very high boiling points.
Due to formation of intermolecular hydrogen bonding with water lower Carboxylic acids are soluble in water.
Carboxylic acid react with ammonia form ammonium carboxylate. It on heating form amide
RCOOH + NH3 → RCOONH4 → RCONH2 + H2O
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𝑐𝑜𝑛𝑐 𝐻2𝑆𝑂4
RCOOH + ROH > RCOOR (ester-Alkylalkanoate)
−𝐻2𝑂
𝑃2𝑂5
2 RCOOH > RCOOCOR (acid anhydride)
𝐻+
𝑃𝐶𝑙3 𝑜𝑟 𝑃𝐶𝑙5
RCOOH > RCOCl (acid chloride)
𝑂𝑟 𝑆𝑂𝐶𝑙2
𝐶𝑎𝑂+𝑁𝑎𝑂𝐻(1:3)
RCOONa > RH + Na2CO3
𝐷𝑒𝑐𝑎𝑟𝑏𝑜𝑥𝑦𝑙𝑎𝑡𝑖𝑜𝑛
𝐿𝑖𝐴𝑙𝐻4 𝑜𝑟 𝐵2𝐻6
RCOOH > RCH2OH
𝐻3𝑂+
Hell volhard zelinsky reaction: (H.V.Z reaction)
carboxylic acids containg alpha hydrogen react with chlorine in presence of Red P form
Carboxylate ion is deactivating and form bond with catalyst AlCl3. Due to this reason benzoic acid nor
participate in friedal craft’s reaction.
Carboxylic acids are strong acids in nature due to formation of stable carboxylate ion.
If electron donating groups ( -CH3) are increases acidic character decreases
If electron drawing groups ( -NO2) are increases acidic character increases
Aniline react with bromine water form a white ppt 2,4,6 – tri bromo aniline.
Aniline undergo nitration form o,m,p-nitro aniline. M-nitroaniline is due to formation of anilinium ion in which
NH3+ act as electron withdrawing group.
Benzene diazonium chloride is a crystalline solid soluble in cold water but reacts with hot water.
Benzene diazonium fluoro borate is water soluble and more stable at room temperature.
gatterman reaction:
Benzene diazonium chloride react with copper in presence of HCl form chloro benzene.
Benzene diazonium chloride undergo reduction with H3PO2/H2O or CH3CH3OH form benzene.
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Maltose: Maltose + H2O → 2 α-D- glucose. It is reducing sugar due to presence of free –CHO group at C1
carbon. It has C1 – C4 glycosidic linkage.
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Lactose (Milk sugar): Lactose + H2O → β-D-galactose + β-D-glucose. It is reducing sugar due to presence of
free –CHO group at C1 carbon of glucose. It has C1 – C4 glycosidic linkage.
Poly sachharides: The carbohydrates produce more no.of mono sachharides on hydrolysis.
Starch: It is a polymer of α-D- glucose units. Its consists of two components.
Amylose: it is long chain molecule and soluble in water. The percentage of amylose in starch is 15-20%. It has
C1 – C4 glycosidic linkage.
Amylopectin: It is branched chain polymer and it is insoluble in water. The percentage of amylopectin in
starch is 15-20%. It has C1 – C4 glycosidic linkage and C1 – C6 glycosidic linkageat branches.
Cellulose: The most abundant organic comound in plant kingdom is starch. It is a polymer of β-D- glucose
units.
Glycogen: it is a plymer of α-D- glucose units an it is also called animal starch. It has C1 – C4 glycosidic linkage
The ether linkage between two carbohydrates is called glycosidic linkage.
α – Amino aicds: if both COOH and NH2 grops are present on same carbon they are called α – Amino aicds.
EX: Glycine, Alanine, Valine, Leucine, Isoleucine, Arginine, Lysine, Glutamic acid and Aspartic acid etc
Enzymes:
Enzymes are complex nitrogeneous organic compounds, they can act as biocatalyst. Almost all enzymes are
globular proteins. The enzyme which can participate In oxidation and reduction is called Oxidoreductase.
𝑀𝑎𝑙𝑡𝑎𝑠𝑒
Ex: C12H22O11 > 2 C6H12O6
Maltose Glucose
vitamins:
Water soluble vitamins:
vitamins which are soluble in water but insoluble in fat. Ex: Vitamin B and Vitamin C.
Fat soluble Vitamins:
Vitamins which are soluble in fat but insoluble in water. They are stored in liver and adipose tissues.
Ex: Vitamin A, Vitamin D, Vitamin E and Vitamin K.
Vitamins Deficiency disease
A Xero phthamia, night blindness
B1(Thiamine) Beri beri
B2 (Riboflavin) Chelosis
B6 (Pyridoxine) Convulsions
B12 Pernicious anemia
C (Ascorbic acid) Scurvy
D Rickets
E Increased fragility of RBCs and muscular weakness
K Increased blood clotting time
Nucleic acids:
Pentose sugar + heterogeneous base → Nucleosides
Nucleosides + Phosphate linkage → Nucleotides
Poly nucleotides are called nucleic acids.
Nucleic acid Pentose sugar Heterogeneous base
DNA β – D – 2 - deoxyribose Adenine, Guanine, Cytosine, Thymine.
RNA β – D – ribose Adenine, Guanine, Cytosine, Uracil.
The nucleic acid participate In genetic information is D.N.A.
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R.N.A molecules are three types. They are messenger RNA(m-RNA), Ribosomal RNA (r-RNA) and transfer RNA
(t-RNA).
Two hydrogen bonds are present between Adenine and Thymine.
Three hydrogen bonds are present between Guanine and Cytosine.
Hormones:
Hormoes are inter cellular messengers produced by endocrine glands and poured into blood stream.
Steroidal hormones: Estogens, Androgens
Poly peptide hormones: Insulin, Endophins
Amino acid derivatives: Epinephrine, norephinephrine, Thyroxine
Thyroxine hormone contains iodine. Low level of Thyroxine causes hypothyroidism and high level of Thyroxine
causes hyperthyroidism and
Insulin and glucagon are two hormones which regulate blood glucose level.
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Numerical formulas:
Solutions:
𝑚𝑎𝑠𝑠 𝑜𝑓 𝑡ℎ𝑒 𝑐𝑜𝑚𝑝𝑜𝑛𝑒𝑛𝑡
Mass percentage of a component = X 100
𝑡𝑜𝑡𝑎𝑙 𝑚𝑎𝑠𝑠 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑖𝑜𝑛
𝑣𝑜𝑙𝑢𝑚𝑒 𝑜𝑓 𝑡ℎ𝑒 𝑐𝑜𝑚𝑝𝑜𝑛𝑒𝑛𝑡
Volume percentage of a component = X 100
𝑡𝑜𝑡𝑎𝑙 𝑣𝑜𝑙𝑢𝑚𝑒𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑖𝑜𝑛
𝑛𝑜.𝑜𝑓 𝑚𝑜𝑙𝑒𝑠 𝑜𝑓 𝑠𝑜𝑙𝑣𝑒𝑛𝑡
Mole fraction of solvent (XA) = 𝑡𝑜𝑡𝑎𝑙 𝑛𝑜.𝑜𝑓 𝑚𝑜𝑙𝑒𝑠 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑖𝑜𝑛 X 100
𝑛𝑜.𝑜𝑓 𝑚𝑜𝑙𝑒𝑠 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑒
Mole fraction of solute (XB) = 𝑡𝑜𝑡𝑎𝑙 𝑛𝑜.𝑜𝑓 𝑚𝑜𝑙𝑒𝑠 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑖𝑜𝑛 X 100
𝑛𝑜.𝑜𝑓 𝑚𝑜𝑙𝑒𝑠 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑒
Molarity = 𝑣𝑜𝑙𝑢𝑚𝑒 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑖𝑜𝑛 𝑖𝑛 𝑙𝑖𝑡𝑟𝑒 Units: mol/lit
𝑛𝑜.𝑜𝑓 𝑚𝑜𝑙𝑒𝑠 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑒
Molality = Units: mol/Kg
𝑚𝑎𝑠𝑠 𝑜𝑓 𝑠𝑜𝑙𝑢𝑡𝑖𝑜𝑛 𝑖𝑛 𝑘𝑔
1000 𝑋 𝑑𝑒𝑛𝑠𝑖𝑡𝑦
Molality = (1000 𝑋 𝑚𝑜𝑙𝑎𝑟𝑖𝑡𝑦)− ( 𝑚𝑜𝑙𝑎𝑟𝑖𝑡𝑦 𝑋 𝑚𝑜𝑙𝑒𝑐𝑢𝑙𝑎𝑟 𝑚𝑎𝑠𝑠)
Henrys law for gas in liquid type of solution: P = kH.X or p = kH.S
Raoult’s law for liquid in liquid type of solution: Ptotal = PA + PB = PA0XA + PB0XB
Relative lowering of vapour pressre = 1 – XA
𝑃𝐴𝑜 −𝑃𝐴 𝑤𝐵 𝑀𝐴
relative lowering of vapour pressure: = 𝑋
𝑃𝐴𝑜 𝑀𝐵 𝑤𝐴
0
PA is vapour pressure of pure solvent
PA is vapour pressure of solution
wA, wB are weight of solvent and solute.
MA, MB are molar mass of solvent and solute
𝑤𝐵 1000
elevation of boiling point : ΔTb = Tb - Tbo ; ΔTb = Kb 𝑋
𝑀𝐵 𝑤𝐴
Tbo, Tb are boiling point of pure solvent and solution
Kb is Ebullioscopic constant or molal elevation constant and it is depends on sovent. Units: K.Kg.mol-1
𝑤 1000
depression of freezing point: ΔTf = Tfo – Tf ; ΔTf = Kf 𝐵 𝑋
𝑀𝐵 𝑤𝐴
o
Tf , Tf are freezing point of pure solvent and solution
Kf is cryoscopic constant or molal depression constant and it is depends on solvent. Units: K.Kg.mol-1
𝑤𝐵 𝑅𝑇
Osmotic pressure of the solution: π V(lit) = 𝑀
𝐵
π is osmotic pressure, V is volume of solution in liter, T is temperature, R is universal gas constant.
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Electro chemistry:
E0cell = E0cathode – E0anode
0.059
Ecell = E0cell – 𝑛 log Qc
0.059
E0cell = 𝑛 log Kc
ΔG0 = -nFE0cell
ΔG0 = -RT ln K
Cell constant (l/A) = Resisatnce/Resistivity = Resistane X conductivity = conductivity/conductance
𝑐𝑜𝑛𝑑𝑢𝑐𝑡𝑖𝑣𝑖𝑡𝑦 𝑋 1000
Molar conductivity (^m) = 𝑀𝑜𝑙𝑎𝑟𝑖𝑡𝑦
For stong elelctrolyte ^m = ^0m – AC ½
For weak electrolyte Degre of ionisation (α) = ^m/^0m
˄mo = V+𝜆+o + V-𝜆-o
W = ZQ or w = ZIt
Chemical kinetics:
−∆[𝑅] [𝑅]2−[𝑅]1
Rate of a reaction = =
∆𝑡 𝑡2−𝑡1
[𝑅𝑜]−[𝑅] [Ro]
For zero order reaction rate constant (k) = and half life time, t1/2 =
𝑡 2𝑘
2.303 [𝑅]0 0.693
For first order reaction rate constant (k) = log and half life time, t1/2 =
𝑡 [𝑅] 𝑘
𝐾2 𝐸𝑎 𝑇2−𝑇1
log (𝐾1) = 2.303𝑅 [ 𝑇1𝑇2 ]