IMMUNOLOGY AND SEROLOGY (WEEK 5)

CASE ANALYSIS SGD 2

Each group will make a PPT presentation for this case. There will be a case presentation next meeting. A random
representative from each group will present their answers to the whole class. Additional questions will be asked
during the presentation. All group members must be prepared before class.

CASE STUDY:
Patient X, 3-year-old female came in because of difficulty of breathing.
Condition started 4 days prior to admission when periorbital edema was noted
which progressed and became generalized. Condition was associated with non-
productive cough & low-grade fever, relieved by Paracetamol. Three days prior
to admission, tea colored urine was noted. There was neither dysuria nor
urinary frequency. Two days prior to admission, consult was sought with a
private physician and was given Amoxicillin 53 mg/kg/day. Few hours PTA,
patient was noted to be dyspneic hence consultation was sought at emergency
room and subsequently admitted.

Past Medical History: No previous admission. No allergic reaction.

Family History: Denies of any heredofamilial diseases.
Personal/Social History: Patient was delivered at home assisted by a hilot by
NSVD with no complication. Breastfeeding was given until 11 months old and
solids were started at 6 months.
Immunization: Complete primary immunization
Growth and Development: At par with age

Physical Examination:
● CR: 140 / min, RR: 58 / min, T: 37 C
● BP: 140 / 100, Wt: 14 kg (75th percentile)
● HEENT: - with facial and periorbital edema with alar flaring, no
tonsillopharyngeal congestion, no lymphadenopathy
● SKIN: no rashes
● CHEST / LUNGS: no retractions, harsh breath sounds
● HEART: tachycardic, no murmur
● ADBOMEN: distended, positive fluid wave, liver and spleen not palpable
● EXREMITIES: with healed pyodermata scars on both lower extremities,
grade 2 pitting bipedal edema.
Case Discussion:

1. What is the possible diagnosis of the patient?

2. What are the significant features in the case? Why?
3. What complement is expected to be abnormal in this patient?
4. What is the pathophysiology of the disease causing the decreased level of complement?
5. How many weeks do you expect the complement level would return to be normal?

Guide Questions:

1. Briefly discuss the 3 pathways of the complement system.

2. What are the functions of the complement system?
3. Enumerate the other soluble mediators of the immune system.
 MLS 310 IMMUNOLOGY AND SEROLOGY
(Lecture)
GROUP ACTIVITY #2

CASE PRESENTATION

Please kindly print a copy of this page ONLY, ensuring there is ONE copy for each group.

GROUP Performance Excellent (5) Good (4) Fair (3) Needs

No. ___ Rubrics Improvement
MEMBERS (2)
Content It covers ALL It covers most of It covers some of It covers very
answers required the answers the answers few answers
for the given required for the required for the required for the
activity given activity given activity. given activity.
Demonstrated Shows complete Shows Response shows Response shows
Knowledge understanding of substantial some complete lack of
the case given. understanding of understanding of understanding of
the case given. the case given. the case given.
Explanation Complete Good solid Explanation is Misses key
answers to the response with unclear. points.
given questions clear
with a detailed explanation.
explanation.
Clarity Overall quality of Most part of the Some part of the The overall
the performance performance performance quality of the
is excellent displays clarity. displays clarity. performance is
not very good.
Team Absolute Most members Some members Most members
Participation participation is participated in did not did not
observed among the performance. participate in the participate in the
members of the performance. performance.
group.