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  • ATROPIN

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    Atropin is an anticholinergic drug that acts as a competitive antagonist of acetylcholine on all three muscarinic receptor types. It is used as a mydriatic to dilate the pupils for up to 10 days and paralyze accommodation during eye exams. Atropin also suppresses sinus bradycardia, having effects on the sinus and AV nodes. Side effects include dilated pupils, accommodation disorders, increased intraocular pressure, photosensitivity, constipation, dry mouth and skin, tachycardia, somnolence, and hallucinations.

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    Atropin is an anticholinergic drug that acts as a competitive antagonist of acetylcholine on all three muscarinic receptor types. It is used as a mydriatic to dilate the pupils for up to 10 days and paralyze accommodation during eye exams. Atropin also suppresses sinus bradycardia, having effects on the sinus and AV nodes. Side effects include dilated pupils, accommodation disorders, increased intraocular pressure, photosensitivity, constipation, dry mouth and skin, tachycardia, somnolence, and hallucinations.

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    ATROPIN

    Uploaded by

    djuro
    Atropin is an anticholinergic drug that acts as a competitive antagonist of acetylcholine on all three muscarinic receptor types. It is used as a mydriatic to dilate the pupils for up to 10 days and paralyze accommodation during eye exams. Atropin also suppresses sinus bradycardia, having effects on the sinus and AV nodes. Side effects include dilated pupils, accommodation disorders, increased intraocular pressure, photosensitivity, constipation, dry mouth and skin, tachycardia, somnolence, and hallucinations.

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    ATROPIN

    (Atropa belladona, Hyosciamus niger, Datura stramonium)


    ®
    Atropin 0.5, 1%
    − parasimpatolitik = antiholinergik; kompetitivni antagonista Ach na M receptorima
    sva 3 tipa
    • dejstvo na oko
    − atropin i tropikamid (Unitropic ® 1%) se primenjuju kao midrijatici – širenje zenica;
    midrijaza izazvana na zdravom oku traje 7 – 10 dana
    − koriste se za paralizu akomodacije oka (proces u kom sočivo menja svoju dioptrijsku
    jačinu u cilju stvaranja oštre slike na makuli) → koriste se za određivanje dioptrije
    KI: glaukom (↑ intrakranijalni pritisak)
    • dejstvo na srce (M2 receptori)
    − suzbijanje sinusne bradikardije (posle AIM); dejstvo ispoljavaju preko sinusnog i AV
    čvora – imaju sva 4 + delovanja na miokard
    − s.c. / i.m. 0.5 – 1 mg
    • preoperativna medikacija
    • kolike (blokiraju M3 receptore → ↓ motilitet i otklanjaju spazam glatke muskulature)
    • inkontinencija (kontrahuju samo sfinkter mokraćne bešike)
    • antidot kod trovanja gljivama i organofosfatnim insekticidima
    NEŽELJENA DEJSTVA: midrijaza, poremećaj akomodacije, ↑ intraoku. p, fotoosetljivost
    opstipacija, nadutost trbuha i pareza creva
    retencija mokraće, anurija
    suve sluznice (usta, oka, bronha) → ↓ sekreciju žlezda
    suva koža
    tahikardija (refleksno ubrzanje srčanog rada zbog prevage Sy,
    odn. blokade uticaja n.vagusa)
    somnolencija, halucinacije, delirijum
    maligna hipertermija – najznačajniji znak trovanja atropinom
    Lokalno- kontaktni dermatitis

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