ANTICOAGULATIION

ANTICOAGULENTS they are the drugs used in treatment

of coagulation of blood.

--coagulation process
1-Intrinsic pathway and extrinsic pathway both will leads
to formation of factor X

2- factor X upon activation will leads to formation of

prothrombine (factore 2)

3- prothrombine upon activation will form fibrinogen

(factore 1)

4- fibrinogen upon activation form fibrin(cloat formation

-Regulation of coagulation and cloating .

1-anti-thrombine 3 substances inhibite cloating factore
naturally .(factore x)

2-Vk produce cloating factore naturally in liver .

Anticoagulation grugs .
heparin warfarin
Injection oral
Can not crosse BBB Cross BBB
Fast acting or short Delay acting (8-12hrs)
Activate antithrombine 3 Inhibite Vk epoxidase
reductase enzyme
Used invivo and invitro Used invivo only
Protamine sulphate is Vk is antidote (10mg IV OR
antidote (1mg per 100u) IM ) or ALO2

LOW MOLECULARE WEIGHT HEPARINE

1-ENOXAPARINE
2- DALTEPARINE

Unfractionated LMWH
Less specific on factore x More specific on factore x
Low bioavaibility High B.A
Short T1/2 Long T1/2
High risk of bleeding Low risk of bleeding
Other drugs

-dabigatran ( specific in factore 2) orally

Idarucizumab as antidote .