ITotal No.

of Pages: 2 B-204-03-02

M.Sc. DEGREE EXAMINATIONS, MARCH/APRIL - 2022

THIRD SEMESTER
Branch: BIOCHEMISTRY
BCH-302: Paper 11: MOLECULAR BIOLOGY
(Revised Syllabus w.e.f 2017-18 for Campus Students and AfJiliated College Student1s)

Time 3 Hours Max. Marks: 80

SECTION - A

Answer any FOUR Questions, All Questions cary equal marks (4x5-20)
1. Semiconservativenmode of DNA replication
2. Mitochondrial DNA replication
3. Inhibitors of RNA Symthesis
4. Promoter and enhancer sequance
5. Central dogma in molecular biology
6. General features of genetic code

7. Ribosomal Switch

8. Post translational modifications

SECTION-B
Answer ALL questions. ALL questions carry equal marks. (4x15-60)
9. a) Give an account of proteins and enzymes involved in DNA replication in E-Coli.
(OR)
b) Write note on
i) Semi discontinuous mode of DNA replication

ii) Inhibitors of DNA Replication

i) Fedelity of DNA replication

B-204-03-02 (1) P.T.O.

 10. a) Discuss different stages of RNA synthesis in prokaryotes.

(OR)
b) Write note on
i) Molecular composition of RNA polymerase in prokaryotes
ii) Post translational modifications of eukaryotic m RNA Polymerase in Prokaryotes.
ii) Ribozyme activity of introns

11. a) Discuss the details of deciphering of genetic code.

(OR)
b) Write note on
i Wobble hypothesis
ii) Mitochondrial genetic code
ii) RNA editing
Discuss the role of different synthetases RNAs in protein synthesis and explain the
12. a)
importance of aminoacyl tRNA synthetases in translation process.

(OR)
b) Write note on

i) Elongation step of translation in prokaryotes

ii)
ii) Targetting the synthetic and membrane proteins.

B-204-03-02 (2)