augmentini BD tabletebi

amoqsicilinis trihidrati - kaliumis klavulanati

xarisxobrivi da raodenobrivi Semadgenloba

augmentini 625 mg tabletebi: TiToeuli tableti Seicavs 500 mg amoqsicilins
(amoqsicilinis trihidratis saxiT) da 125 mg klavulanis mJavas (kaliumis klavulanatis
saxiT).
augmentini 1 g tabletebi: TiToeuli tableti Seicavs 875 mg amoqsicilins (amoqsicilinis
trihidratis saxiT) da 125 mg klavulanis mJavas (kaliumis klavulanatis saxiT).

farmacevtuli forma
augmentini 625 mg tabletebi: TeTri an moTeTro feris, ovaluri formis, apkiani garsiT
dafaruli tableti, gravirebiT «AC» da gamyofi xaziT erT mxares da meore mxare - sada.
augmentini 1 g tabletebi: TeTri an moTeTro feris, kafsulis formis, apkiani garsiT dafaruli
tableti, gravirebiT «AC» orive mxares da gamyofi xaziT cal mxares.

klinikuri maxasiaTeblebi
Cvenebebi
augmentini aris antibiotiki gamoxatuli farTo speqtris aqtivobiT ZiriTadad gavrcelebuli
baqteriuli paTogenebis winaaRmdeg da gamoiyeneba zogad praqtikaSi da hospitaluri
mkurnalobisaTvis. klavulanatis β-laqtamazuri mainhibirebeli moqmedeba afarToebs
amoqsicilinis speqtrs organizmebis ufro farTo speqtris winaaRmdeg, maT Soris moicavs
bevr β-laqtamuri antibiotikebis mimarT rezistentul mikroorganizms.
augmentini gamoyenebul unda iqnas antibiotikebis gamoyenebis adgilobrivi oficialuri
gaidlainebis da mgrZnobelobis monacemebis mixedviT.
augmentinis SigniT misaRebi forma orjer dReSi naCvenebia Semdegi baqteriuli
infeqciebis xanmokle mkurnalobisaTvis:
zeda respiratoruli gzebis infeqciebi (maT Soris yel-yur-cxviris), rogoricaa tonziliti,
sinusiti, Sua yuris anTeba.
qveda respiratoruli gzebis infeqciebi, rogoricaa qronikuli bronqitis gamwvaveba,
wilovani da bronqopnevmonia.
Sard-sasqeso gzebis infeqciebi, rogoricaa cistiti, ureTriti, pielonefriti.
kanisa da rbili qsovilebis infeqciebi: rogoricaa furunkuli, abscesi, celuliti, Wrilobis
infeqciebi.
Zvlisa da saxsrebis infeqciebi, rogoricaa osteomieliti.
dentaluri infeqciebi, rogoricaa dentoalveolaruli abscesi.
sxva infeqciebi: rogoricaa septikuri aborti, mSobiarobis Semdgomi sefsisi, intra-
abdominaluri sefsisi.
augmentinisadmi mgrZnobeloba icvleba geografiulad da drois mixedviT (damatebiTi
informaciisaTvis ix. farmakologiuri Tvisebebi, farmakodinamika). Tu xelmisawvdomia,
ganxilul unda iqnas adgilobrivi mgrZnobelobis monacemebi da saWiroebis SemTxvevaSi
gakeTdes mikrobiologiuri nimuSebis da mgrZnobelobis analizi.

dozireba da miRebis wesi

doza damokidebulia pacientis asaksa da Tirkmlis funqciaze da infeqciis simZimeze.
gastro-intestinuri autanlobis Sesamcireblad iniSneba Wamis dawyebisas. augmentinis
Sewova optimaluria, roca misi miReba xdeba kvebis dawyebasTan erTad.
Terapiis xangrZlivobam ar unda gadaaWarbos 14 dRes ganxilvis gareSe.
Terapia SeiZleba daiwyos parenteralurad da gagrZeldes SigniT misaRebi preparatiT.
tabletebi unda gadaiylapos mTlianad, daReWvis gareSe. saWiroebis SemTxvevaSi,
tabletebi SeiZleba gaiyos orad da gadaiylapos daReWvis gareSe.
augmentinis tabletebi ar aris rekomendebuli 12 wlis da naklebi asakis bavSvebisaTvis.

mozrdilebi da 12 wlis zemoT asakis bavSvebi

Cveulebriv rekomendebuli dRiuri dozaa:
msubuqi-saSualo simZimis augmentini 625 mg erTi tableti yovel 12 saaTSi
infeqciebi
mZime infeqciebi augmentini 1 g erTi tableti yovel 12 saaTSi
Tirkmlis dazianeba
ar aris saWiro dozis koreqcia pacientebSi, romelTa kreatininis klirensi (krkl) metia, vidre
30 ml/wT.
augmentini 1 g tableti gamoiyeneba mxolod im pacientebSi, romelTa kreatininis klirensi
(krkl) metia, vidre 30 ml/wT.

krkl 10-30 ml/wT augmentini 625 mg erTi tableti yovel 12 saaTSi

krkl < 10 ml/wT augmentini 625 mg erTi tableti yovel 24 saaTSi
hemodializi augmentini 625 mg erTi tableti yovel 24 saaTSi, plus erTi tableti
dializis dros, romelic unda gameordes dializis seansis bolos (radgan
amoqsicilinis da klavulanis mJavas plazmuri koncentraciebi
Semcirebulia)

RviZlis dazianeba
doza iniSneba sifrTxiliT; RviZlis funqciis monitoringi unda Catardes regularuli
intervalebiT.

ukuCvenebebi
augmentini ukunaCvenebia pacientebSi beta-laqtamuri hipermgrZnobelobiT anamnezSi,
mag. penicilinebis da cefalosporinebis mimarT.
augmentini ukunaCvenebia augmentinTan asocirebuli siyviTlis/RviZlis disfunqciis
anamnezis mqone pacientebSi.

gafrTxilebebi da sifrTxilis zomebi

augmentiniT Terapiis dawyebamde saWiroa anamnezis guldasmiT Sekreba
hipermgrZnobelobiTi reaqciebis Sesaxeb penicilinebis, cefalosporinebis an sxva
alergenebis mimarT.
mZime da zogjer sicocxlisaTvis saxifaTo hipermgrZnobelobiTi reaqciebi (maT Soris
anafilaqtoiduri da mZime kanismieri gverdiTi reaqciebi) aRiniSna pacientebSi peniciliniT
Terapiis dros. es reaqciebi ufro metad mosalodnelia ganviTardes penicilinis mimarT
hipermgrZnobelobis anamnezis mqone pirebSi (ix. ukuCvenebebi). Tu viTardeba alergiuli
reaqcia, augmentiniT Terapia unda Sewydes da daiwyos Sesabamisi alternatiuli Terapia.
mZime anafilaqsiuri reaqciebi moiTxovs dauyovnebliv mkurnalobas adrenaliniT. SeiZleba
aseve saWiro gaxdes Jangbadis miwodeba, intravenuri (i.v.) steroidebi da sasunTqi gzebis
funqciis SenarCuneba (maT Soris, intubacia).
augmentini ar unda dainiSnos, Tu eWvia infeqciur mononukleozze, radgan aRiniSna am
mdgomarobasTan dakavSirebuli wiTelas msgavsi gamonayaris ganviTareba amoqsicilinis
gamoyenebis Semdeg.
xangrZlivma gamoyenebam SeiZleba zogjer gamoiwvios aramgrZnobiare organizmebis
gamravleba.
fsevdomembranozuli koliti aRiniSna antibiotikebis miRebis dros da cvalebadobs simZimis
mixedviT sustidan sicocxlisaTvis saxifaTomde. amitom, mniSvnelovania ganxilul iqnas es
diagnozi im pacientebSi, romlebsac aReniSnebaT diarea antibiotikebiT mkurnalobis dros
an mis Semdeg. gaxangrZlivebuli an gamoxatuli diareis dros an Tu pacients aReniSneba
muclis kolika, mkurnaloba dauyovnebliv unda Sewydes da saWiroa pacientis Semdgomi
gamokvleva.
proTrombinis drois gaxangrZliveba (gazrdili INR) iSviaTad aRiniSna pacientebSi, romlebic
iRebdnen augmentins da oralur antikoagulantebs. antikoagulantebis erTdroulad
daniSvnisas saWiroa saTanado monitoringi. oraluri antikoagulantebis dozis koreqcia
SeiZleba saWiro iyos antikoagulaciis saWiro dozis SesanarCuneblad.
RviZlis funqciis testebis cvlilebebi aRiniSna zogierT pacientSi, romlebic iRebdnen
augmentins. am cvlilebebis klinikuri mniSvneloba ucnobia. augmentini sifrTxiliT unda
iyos gamoyenebuli RviZlis disfunqciis mqone pacientebSi.
qolestazuri siyviTle, romelic SeiZleba iyos mZime, magram ZiriTadad Seqcevadi,
aRiniSna iSviaTad. niSnebi da simptomebi SeiZleba ar gamovlindes mkurnalobis
Sewyvetidan 6 kviramde.
Tirkmlis dazianebis mqone pacientebSi augmentinis dozis koreqcia unda moxdes, rogorc
rekomendebulia paragrafSi “dozireba da miRebis wesi”.
Sardis raodenobis daqveiTebis dros Zalian iSviaTad aRiniSna kristaluria, upiratesad
parenteraluri Terapiis dros. amoqsicilinis maRali dozebis miRebisas rekomendebulia
siTxis adeqvaturi raodenobis miRebis da Sardis adeqvaturi raodenobis SenarCuneba,
raTa Semcirdes amoqsicilinis kristaluriis ganviTarebis albaToba (ix. dozis gadaWarbeba).

urTierTqmedebebi
ar aris rekomendebuli probenecidis erTdrouli gamoyeneba. probenecidi aqveiTebs
amoqsicilinis Tirkmelebis milakovan sekrecias. augmentinTan erTdroulma miRebam
SeiZleba gamoiwvios amoqsicilinis, magram ara klavulanis mJavas donis gazrda sisxlSi.
alopurinolis miRebam amoqsiciliniT Terapiis dros SeiZleba gazardos kanis alergiuli
reaqciebis riski. ar aris monacemebi augmentinis da alopurinolis erTdrouli gamoyenebis
Sesaxeb.
rogorc wesi, sxva antibiotikebis msgavsad, augmentinma SeiZleba gavlena iqonios
nawlavebis floraze, rac iwvevs estrogenis dabal reabsorbcias da kombinirebuli oraluri
kontraceptivebis daqveiTebul efeqturobas.
literaturaSi aRwerilia iSviaTi SemTxvevebi, roca izrdeba saerTaSoriso normalizebuli
Sefardebis maCvenebeli pacientebSi, romlebic iReben acenokumarols an varfarins da
amave dros itareben amoqsicilinis kurss. Tu aucilebelia erTdrouli daniSvna, augmentinis
damatebis an moxsnis dros saWiroa proTrombinis drois an saerTaSoriso normalizebuli
maCveneblis monitoringi.
pacientebSi, romlebic iReben mikofenolatis mofetils, mikofenolis mJavas aqtiuri
metabolitis koncentracia sisxlSi Semdegi dozis miRebamde (predozis koncentracia)
Semcirda daaxloebiT 50%-iT oraluri amoqsicilinis da klavulanis mJavas miRebis Semdeg.
predozis donis cvlileba SeiZleba zustad ar aCvenebdes mfa-s eqspoziciis saerTo
cvlilebas.

fexmZimoba da laqtacia
cxovelebze (Tagvebsa da virTagvebSi) reproduqciulma kvlevebma oraluri da
parenteraluri augmentinis miRebisas ar gamoavlina raime teratogenuli efeqti. erTjerad
kvlevaSi qalSi, naadrevi mSobiarobiT, sanayofe garsis naadrevi rupturiT (pPROM)
aRiniSna, rom augmentiniT profilaqtikuri mkurnaloba SeiZleba dakavSirebuli yofiliyo
nekrozuli enterokolitis gazrdil riskTan axalSobilSi. yvela sxva medikamentis msgavsad,
fexmZimobis dros, gansakuTrebiT pirvel trimestrSi, ar unda dainiSnos, garda im
SemTxvevisa Tu eqimi ar CaTvlis mas aucileblobad.
augmentini SeiZleba dainiSnos laqtaciis dros. mgrZnobelobis riskis garda, romelic
dakavSirebulia narCeni raodenobis gamoyofasTan dedis rZeSi, ar aRiniSneba saziano
gavlena Cvilze.
gavlena avtomobilis marTvis da sxva meqanizmebTan muSaobis unarze
gverdiTi efeqtebi avtomobilisa da sxva meqanizmebis marTvis unarze ar gamovlenila.

gverdiTi movlenebi
monacemebi farTo klinikuri kvlevebidan gamoyenebul iqna, raTa gansazRvruliyo gverdiTi
efeqtebis sixSire Zalian xSiridan iSviaTamde. sxva gverdiTi movlenebis sixSire (rogoricaa
<1/10.000 sixSiriT ganviTareba) ZiriTadad ganisazRvra postmarketinguli monacemebis
mixedviT da miuTiTebs ufro Setyobinebis sixSires, vidre WeSmarit sixSires.
qvemoT mocemuli SeTanxmeba gamoyenebulia sixSiris klasifikaciisaTvis:
Zalian xSiri ≥1/10
xSiri ≥1/100-dan <1/10-mde
araxSiri ≥1/1.000-dan <1/100-mde
iSviaTi ≥1/10.000-dan <1/1.000-mde
Zalian iSviaTi <1/10.000
infeqciebi da invaziebi
xSiri: kan-lorwovanis kandidozi
sisxlisa da limfuri sistemis mxriv darRvevebi
iSviaTi: Seqcevadi leikopenia (maT Soris neitropenia) da Trombocitopenia
Zalian iSviaTi: Seqcevadi agranulocitozi da hemolizuri anemia. sisxldenis drois da
proTrombinis drois gaxangrZliveba
imunuri sistemis mxriv darRvevebi
Zalian iSviaTi: angionevrozuli SeSupeba, anafilaqsia, Sratismieri daavadebis msgavsi
sindromi, hipermgrZnobelobiTi vaskuliti
nervuli sistemis mxriv darRvevebi
araxSiri: Tavbrusxveva, Tavis tkivili
Zalian iSviaTi: Seqcevadi hiperaqtiuroba, aseptikuri meningiti, krunCxvebi. krunCxvebi
SeiZleba ganviTardes pacientebSi, romlebsac aReniSnebaT daqveiTebuli Tirkmlis funqcia
an romlebic iReben maRal dozebs.
gastro-intestinuri darRvevebi
mozrdilebi:
Zalian xSiri: diarea
xSiri: gulisreva, Rebineba
bavSvebi:
xSiri: diarea, gulisreva, Rebineba
yvela populacia:
gulisreva xSirad dakavSirebulia maRal oralur dozebTan. Tu gastro-intestinuri reaqciebi
vlindeba, maTi Semcireba SesaZlebelia augmentinis miRebiT kvebis dasawyisSi.
araxSiri: dispefsia
Zalian iSviaTi: antibiotikTan asocirebuli koliti (maT Soris fsevdomembranozuli koliti da
hemoragiuli koliti – ix. gafrTxilebebi da sifrTxilis zomebi), Savi bususebiani ena.
hepato-biliaruli darRvevebi:
araxSiri: ast da/an alt donis zomieri momateba aRiniSna pacientebSi, romlebic
mkurnalobdnen beta-laqtamuri jgufis antibiotikebiT, Tumca am maCveneblebis
mniSvneloba ucnobia.
Zalian iSviaTi: hepatiti da qolestazuri siyviTle. es movlenebi aRiniSna sxva penicilinebis
da cefalosporinebis miRebis dros.
RviZlismieri movlenebi upiratesad aRiniSna mamakacebSi da xandazmul pacientebSi da
SeiZleba dakavSirebuli iyos gaxangrZlivebul mkurnalobasTan. es movlenebi Zalian
iSviaTad aRiniSna bavSvebSi. niSnebi da simptomebi Cveulebriv viTardeba mkurnalobis
dros an mkurnalobidan xanmokle periodis Semdeg, magram zogierT SemTxvevaSi
SeiZleba ar gamovlindes mkurnalobis Sewyvetidan ramdenime kviris ganmavlobaSi. es
simptomebi Cveulebriv Seqcevadi xasiaTisaa. RviZlismieri movlenebi SeiZleba iyos
mZime xasiaTis da ukiduresad iSviaT SemTxvevebSi aRiniSna sikvdili. TiTqmis yvela
SemTxvevaSi pacientebs aReniSnebodaT mZime Tanmxlebi daavadeba an iRebdnen
Tanmxleb medikamentebs, romlebsac aqvT potenciuri efeqti RviZlze.
kanisa da kanqveSa qsovilis mxriv darRvevebi
araxSiri: gamonayari kanze, qavili, WinWris cieba
iSviaTi: multiformuli eriTema
Zalian iSviaTi: stivens-jonsonis sindromi, toqsikuri epidermuli nekrolizi, bulozuri
eqsfoliaciuri dermatiti, mwvave generalizebuli egzanTematozuri pustulozi (AGEP) da
wamlismieri reaqcia eozinofiliiTa da sistemuri simptomebiT (DRESS).
Tu aRiniSneba hipermgrZnobelobiTi dermatitis reaqcia, mkurnaloba unda Sewydes.
Tirkmlisa da saSarde gzebis mxriv darRvevebi
Zalian iSviaTi: intersticiuli nefriti, kristaluria (ix. dozis gadaWarbeba).

dozis gadaWarbeba
SeiZleba ganviTardes gastro-intestinuri simptomebi da siTxisa da eleqtrolitebis balansis
darRveva.
gastro-intestinuri simptomebis mkurnaloba unda moxdes simptomurad wylisa da
eleqtrolitebis balansze yuradRebis miqceviT.
aRiniSna amoqsicilinis kristaluria, romelmac zogierT SemTxvevebSi gamoiwvia Tirkmlis
ukmarisoba (ix. gafrTxilebebi da sifrTxilis zomebi).
augmentinis gamoyofa SesaZlebelia hemodializis saSualebiT.

farmakologiuri Tvisebebi
farmakodinamika
bevri antibiotikis mimarT rezistentoba gamowveulia baqteriuli fermentebiT, romlebic
Slian antibiotiks, sanam is daiwyebs paTogenze zemoqmedebas. augmentinSi Semavali
klavulanati ewinaaRmdegeba am damcvelobiT meqanizms beta-laqtamazas fermentis
blokirebiT, rac organizmebs mgrZnobiares xdis amoqsicilinis swrafi baqteriociduli efeqtis
mimarT im koncentraciiT, romelic advilad miiRweva organizmSi. klavulanats TavisTavad
susti antibaqteriuli moqmedeba gaaCnia, Tumca amoqsicilinTan erTad, rogorc es
warmodgenilia augmentinSi, is warmoqmnis farTo speqtris antibiotiks, romelic farTod
gamoiyeneba hospitaluri mkurnalobisaTvis da zogad praqtikaSi.
qvemoT CamoTvlili organizmebi kategorizebulia augmentinis mimarT maTi in vitro
mgrZnobelobis mixedviT.

mikroorganizmebis in vitro mgrZnobeloba augmentinis mimarT

varskvlaviT (*) aRniSnulia augmentinis klinikuri efeqturoba klinikur kvlevebSi.
organizmebi, romlebic ar warmoqmnian beta-laqtamazas identificirebulebi arian niSniT (†). Tu organiz
mgrZnobiarea amoqsicilinis mimarT, is miCneulia augmentinis mimarT mgrZnobiared.
ZiriTadi mgrZnobiare saxeobebi
gram-dadebiTi aerobebi:
Bacillius anthracis
Enterococcus faecalis
Listeria monocytogenes
Nocardia asteroids
Streptococcus pyogenes*†
Streptococcus agalactiae*†
Streptococcus spp. (sxva beta-hemolizuri) *†
Staphylococcus aureus (meticilin mgrZnobiare)*
Staphylococcus saprophyticus (meticilin mgrZnobiare)
koagulaza uaryofiTi stafilokokebi (meticilin mgrZnobiare)
gram-uaryofiTi aerobebi:
Bordetella pertussis
Haemophilus influenzae*
Haemophilus parainfluenzae
Helicobacter pylori
Moraxella catarrhalis*
Neisseria gonorrhoeae
Pasteurella multocida
Vibrio cholerae
sxva:
Borrelia burgdorferi
Leptospira ictterohaemorrhagiae
Treponema pallidum
gram-dadebiTi anaerobebi:
Clostridium spp.
Peptococcus niger
Peptostreptococcus magnus
Peptostreptococcus micros
Peptostreptococcus spp.
gram-uaryofiTi anaerobebi:
Bacteroides fragilis
Bacteroides spp.
Capnocytophaga spp.
Eikenella corrodens
Fusobacterium nucleatum
Fusobacterium spp.
Porphyromonas spp.
Prevotella spp.
saxeobebi, romlebisTvisac SeZenili rezistentoba SeiZleba problemuri iyos
gram-uaryofiTi aerobebi:
Escherichia coli*
Klebsiella oxytoca
Klebsiella pneumoniae*
Klebsiella spp.
Proteus mirabilis
Proteus vulgaris
Proteus spp.
Salmonella spp.
Shigella spp.
gram-dadebiTi aerobebi:
Corynebacterium spp.
Enterococcus faecium
Streptococcus pneumoniae*†
Viridans group streptococcus
bunebrivad rezistentuli organizmebi
gram-uaryofiTi aerobebi:
Acinetobacter spp.
Citrobacter freundii
Enterobacter spp.
Hafnia alvei
Legionella pneumophila
Morganella morganii
Providencia spp.
 Pseudomonas spp.
Serratia spp.
Stenotrophomas maltophilia
Yersinia enterolitica
sxva:
Chlamydia pneumoniae
Chlamydia psittaci
Chlamydia spp.
Coxiella burnetti
Mycoplasma spp.

farmakokinetika
augmentinis ori komponentis farmakokinetika Zalian hgavs erTmaneTs. plazmaSi pikur
dones orive aRwevs daaxloebiT 1 saaTis Semdeg SigniT miRebisas. augmentinis Sewova
optimaluria Wamis dawyebisas.
augmentinis dozis gaormageba iwvevs plazmaSi misi donis daaxloebiT gaormagebas.
klavulanats da amoqsicilins plazmaSi dakavSirebis dabali done axasiaTebs;
daaxloebiT 70% Tavisufali rCeba plazmaSi.

usafrTxoebis preklinikuri monacemebi

ar aris damatebiTi informacia.

farmacevtuli maxasiaTeblebi
damxmare nivTierebebis CamonaTvali
augmentinis tabletebi Seicaven: natriumis saxameblis glikolati, magniumis stearati
(E572), koloiduri siliciumis dioqsidi, mikrokristaluri celuloza, titanis dioqsidi (E171),
hidroqsipropil meTilceluloza, polieTilenglikoli, dimeTikoni (silikonis zeTi).

SeuTavsebloba
ar aris cnobili.

Senaxvis vada
Senaxvis vada miTiTebulia SefuTvaze.

Senaxvis gansakuTrebuli sifrTxilis zomebi

dauSvebelia SefuTvaze miTiTebuli Senaxvis vadis gasvlis Semdeg gamoyeneba.
inaxeba originali SefuTviT mSral adgilas nestisagan dasacavad.
Senaxvis temperaturisaTvis ix. SefuTva.
augmentinis tabletebisaTvis, romelTa SefuTvaze miTiTebulia Senaxvis temperatura 25ºC-
mde, tabletebi gamoyenebul unda iqnas gaxsnidan 30 dRis ganmavlobaSi (ix. aseve,
gamoyenebis/moxmarebis instruqciebi).
augmentinis tabletebisaTvis, romelTa SefuTvaze miTiTebulia Senaxvis temperatura 30ºC-
mde, tabletebi gamoyenebul unda iqnas gaxsnidan 14 dRis ganmavlobaSi (ix. aseve,
gamoyenebis/moxmarebis instruqciebi).
augmentinis tabletebis SefuTva Seicavs desikantis saSetebs. maTi amoReba an Wama
dauSvebelia.

konteineris forma da Semcveloba

augmentinis tabletebi mowodebulia muyaos kolofSi, romelic Seicavs blisterul SefuTvas,
TiToeuli blisteri moTavsebulia daluqul paketSi desikantis saSetTan erTad.
gamoyenebis/moxmarebis instruqciebi
paketi blisteriT Seicavs desikantis saSets, romlis amoReba an Wama dauSvebelia.
nebismieri gaxsnili an gamouyenebeli tableti gadagdebul unda iqnas, rogorc es aRwerilia
qveTavSi “Senaxvis gansakuTrebuli sifrTxilis zomebi”.
nebismieri gamouyenebeli samkurnalo produqti an narCeni masala unda ganadgurdes
adgilobrivi moTxovnebis Sesabamisad.
yvela farmacevtuli forma xelmisawvdomi ar aris yvela qveyanaSi.

გაცემის წესი:
ფარმაცევტული პროდუქტის ჯგუფი - II , გაიცემა ფორმა №3 რეცეპტით

warmoebulia:
SmithKline Beecham Limited*
Clarendon Road
Worthing
West Sussex, BN14 8QH
United Kingdom

smiTklain biCem limiTed*

klarendon roud
vorsingi
vesT saseqsi, BN14 8QH
gaerTianebuli samefo

*gsk jgufis kompaniebis wevri

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