CH 09

Package Title: Pratt & Cornely Test Bank
Course Title: Pratt & Cornely

Chapter Number: 9
Question type: Multiple Choice
1) What is the membrane potential created by a sodium gradient where [Na+]out = 145 mM and
[Na+]in = 12mM at 37 C?
A) 67 mV
B) 7.9 mV
C) -7.9 mV
D) -29 mV
E) -67 mV
Answer: E
Difficulty: Hard
Section Reference: 9-1
Learning Objective: Analyze the thermodynamics of solute movement across membranes
2) What is the ratio [Na+]in/[Na+]out created by depolarization in a nerve cell if the final potential
is +50 mV at 37 C?
A) 6.4  106
B) 6.5
C) 1.5
D) 0.15
E) 1.6  10-7
Answer: B
Difficulty: Hard
3) Inside a nerve cell at rest, [Na+] is _____ and [K+] _____ relative to the concentrations seen
outside the cell.
A) high; high
B) high; low
C) low; high
D) low; low
E) low; equal
Answer: C
Difficulty: Medium
4) Nerve cells contain high levels of _____ which is a derivative of _____.
A) phosphatidylethanolamine; palmitic acid

B) cholesterol; isoprene
C) phosphatidylcholine, phosphatidic acid
D) sphingomyelin; sphingosine
E) ganglioside GM1; ceramide
Answer: D
Difficulty: Medium
5) After depolarization of a nerve cell, what event restores the resting potential?
A) K+ efflux
B) K+ influx
C) Na+ efflux
D) Na+ influx
E) Cl- efflux
Answer: A
Difficulty: Medium
6) For a cell with [Na+]out = 150 mM and [Na+]in = 15 mM at 37 C, what is the free energy for
movement of sodium ions from outside the cell to inside if the potential across the membrane is -
60 mV?
A) 11.7 kJ/mol
B) 0.145 kJ/mol
C) -0.145 kJ/mol
D) -11.7 kJ/mol
E) cannot be calculated from given information
Answer: D
Difficulty: Hard
7) The movement of glucose into a cell when blood sugar is high is accomplished by _____. The
movement of K+ against its concentration gradient is accomplished by _____.
A) simple diffusion; active transport

B) passive transport; passive transport
C) active transport; membrane potential
D) simple diffusion; passive transport
E) passive transport; active transport
Answer: E
Difficulty: Medium
8) All known porins are _____ proteins composed of _____.
A) monomeric; seven transmembrane -helices

B) dimeric; -barrels
C) dimeric; three transmembrane -helices
D) trimeric; -barrels
E) trimeric; four transmembrane -helices
Answer: D
Difficulty: Medium
Learning Objective: Describe the operation of passive transport systems such as ion channels and
transport proteins
9) Which of the following will cause the opening or closing of a gated ion channel?
A) pH change
B) phosphorylation
C) voltage change
D) ligand binding
E) all of the above
Answer: E
Difficulty: Easy
transport proteins
10) What type of transporter is responsible for moving water across membranes?
A) aquachannel
B) aquaporin
C) aquaphore
D) aquaporter
E) aquapermease
Answer: B
Difficulty: Easy
transport proteins
11) Which of the following statements regarding membrane transporters is true?
A) a porin is always open but only transports solutes in one direction

B) an ion channel selective for K+ will also allow Na+ through since both are small enough to fit
through the channel
C) amphotericin is able to assemble inside a membrane in such a manner to form a channel
through which K+ and Na+ flow, thus disrupting the ion gradient
D) K+ channels can work in both directions, allowing the neuronal action potential to move in
multiple directions
E) none of the above
Answer: C
Difficulty: Medium
transport proteins
12) Which amino acid in the aquaporin channel hydrogen bonds with water to prevent the
movement of protons?
A) Asn
B) Leu
C) Phe
D) Val
E) Ile
Answer: A
Difficulty: Easy
transport proteins
13) What is a transporter that moves two different molecules or ions in the same direction?
A) uniporter
B) diporter
C) symporter
D) antiporter
Answer: C
Difficulty: Easy
transport proteins
14) Which of the following is true regarding the glucose transporter?
A) in addition to glucose, it will transport any other monosaccharide with six carbons
B) binding of glucose causes a conformational change so that the transporter is never open on
both sides of the membrane
C) ATP hydrolysis prevents the transporter from working in reverse
D) it is able to transport glucose into a cell against a concentration gradient
Answer: B
Difficulty: Medium
transport proteins
15) The Na,K-ATPase is a(n) _____ that moves Na+ from _____ and K+ from _____.
A) antiporter; inside to out; outside to in

B) antiporter; outside to in; inside to out
C) symporter; inside to out; inside to out
D) symporter; outside to in; outside to in
Answer: A
Difficulty: Medium
Learning Objective: Describe the operation of active transport systems
16) Hydrolysis of ATP by the Na,K-ATPase moves _____ while hydrolysis of the phosphate
moves _____.
A) 3 Na+; 2 K+
B) 2 Na+; 3 K+
C) 3 K+; 2 Na+
D) 2 K+; 3 Na+
Answer: A
Difficulty: Medium
17) The P-glycoprotein is an example of a(n) _____ which has been linked to drug resistance in
the treatment of _____.
A) ABC transporter; bacterial infections

B) ABC transporter; cancer
C) Na,K-ATPase; viral infections
D) Na,K-ATPase; parasitic infections
Answer: B
Difficulty: Medium
18) Transport of glucose from the intestine into the intestinal cells is accomplished by a(n)
________. This is an example of ___________.
A) uniporter; passive transport

B) uniporter; primary active transport
C) symporter; primary active transport
D) symporter; secondary active transport
E) antiporter; secondary active transport
Answer: D
Difficulty: Hard
19) A sudden increase in the concentration of _____ causes the release of acetylcholine from the
axon of a nerve cell.
A) Na+
B) K+
C) Ca2+
D) Cl-
E) H+
Answer: C
Difficulty: Easy
Learning Objective: Outline the mechanics of membrane fusion
20) Which of the following would be the first to occur following opening of Ca2+ channels during
acetylcholine-mediated neurotransmission to a muscle cell?
A) binding of SNARE complex to synaptic vesicles and pre-synaptic membrane

B) binding of acetylcholine to muscle cell receptors
C) reuptake of acetylcholine by the nerve cell
D) hydrolysis of acetylcholine by acetylcholinesterase
E) release of acetylcholine by the nerve cell
Answer: A
Difficulty: Medium
21) Which type of ion channel is blocked by lidocaine, a local anesthetic?
A) K+
B) Na+
C) pre-synaptic Ca2+
D) post-synaptic Ca2+
Answer: B
Difficulty: Medium
22) Serotonin reuptake occurs by a(n) _____.
A) uniporter
B) antiporter using Na+
C) antiporter using Ca2+
D) symporter using Na+
E) symporter using Ca2+
Answer: D
Difficulty: Medium
23) Which of the following is true regarding SNARE complex formation?
A) prior to membrane association, SNARE proteins are in an unfolded state

B) two proteins of the SNARE complex come from the membrane and one from the synaptic
vesicle
C) formation of a four-helix complex is critical for membrane association of the vesicle
D) formation of the SNARE complex is thermodynamically favorable, as is membrane fusion
E) all of the above
Answer: E
Difficulty: Hard
24) Which of the following occurs during the fusion of a synaptic vesicle and cell membrane?
A) SNARE complexes dissociate to allow membrane fusion to occur

B) addition of triacylglycerols to the membrane allows the bilayer to bow inward
C) selective removal of acyl chains from membrane phospholipids allows the bilayer to bow
outward
D) the composition of the two membranes has no effect upon the rate of fusion
Answer: C
Difficulty: Hard

CH 09

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CH 09

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Package Title: Pratt & Cornely Test Bank

Course Title: Pratt & Cornely

Question type: Multiple Choice

4) Nerve cells contain high levels of _ which is a derivative of _.

A) phosphatidylethanolamine; palmitic acid

A) simple diffusion; active transport

8) All known porins are _ proteins composed of _.

A) monomeric; seven transmembrane -helices

11) Which of the following statements regarding membrane transporters is true?

A) a porin is always open but only transports solutes in one direction

14) Which of the following is true regarding the glucose transporter?

A) antiporter; inside to out; outside to in

A) ABC transporter; bacterial infections

A) uniporter; passive transport

A) binding of SNARE complex to synaptic vesicles and pre-synaptic membrane

21) Which type of ion channel is blocked by lidocaine, a local anesthetic?

22) Serotonin reuptake occurs by a(n) _____.

23) Which of the following is true regarding SNARE complex formation?

A) prior to membrane association, SNARE proteins are in an unfolded state

A) SNARE complexes dissociate to allow membrane fusion to occur

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