Questions:

1. Name some commercially available products similar to this preparation.

 CIPRODEX® (ciprofloxacin 0.3% and dexamethasone 0.1%)

 Cortisporin ® (Hydrocortisone, polymyxin, neosporin)
 Triethanolamine (Cerumenex ®)
 Vosol Otic ® (acetic acid + propylene glycol)
 Auralgan ® (benzocaine + antipyrine)
 Ofloxacin (Floxin otic ®)
 Ciprofloxacin and hydrocortisone - Cipro HC Otic ®:
 carbamide peroxide (Debrox ®)

2. What are the methods used in preparing the solution?

1. Weigh a 100 cm3 beaker.

2. Measure 10 cm3 of Sodium Bicarbonate Ear Drops into the beaker.
3. Weigh the beaker and its contents.
4. Repeat steps 1-3 three more times.

3. What is eardrop?

Ear drops are liquid preparation or suspension or emulsion or solution of drug(s) in

water, diluted alcohol, glycerine or polyethylene glycol intended for instillation into the ear.

4. What is the mechanism of action of the preparation?

 Carbamide peroxide releases hydrogen peroxide which serves as a source of nascent

oxygen upon contact with catalase. Softens impacted cerumen due to its foaming action

 CERUMENEX Eardrops emulsify and disperse excess or impacted earwax. The

triethanolamine polypeptide oleate, a surfactant, in a hygroscopic vehicle lyses cerumen
to facilitate removal by subsequent water irrigation.

5. Why is distilled water used for compounding?

The theoretical pH of distilled water is 7.0. In practice, however, most distilled

water will have a pH that is slightly acidic (less than 7.0) due to the presence of carbon
dioxide (CO2) that is absorbed from the atmosphere. Dissolved carbon dioxide reacts
slowly with water to give the bicarbonate and hydronium ions.