Professional Documents
Culture Documents
By
Dr. M. Anthony David, MD,
Professor of Physiology
NERVOUS & ENDOCRINE CONTROL
SYSTEMS: A CONTRAST
NERVOUS ENDOCRINE
SYSTEM SYSTEM
Mechanism of Mechanism of
control: control:
Neurotransmitters Chemical
released in messengers
response to nervous delivered to target
stimuli. tissues.
Target Cells: Target Cells:
Muscles Virtually any or all
Glands of the cells of the
NERVOUS & ENDOCRINE CONTROL
SYSTEMS: A CONTRAST
RESULTANT RESULTANT
ACTION: ACTION:
Muscular Changes in
contraction Metabolic Activities.
Glandular secretion TIME TAKEN FOR
TIME TAKEN FOR ONSET OF ACTION:
ONSET OF ACTION: Seconds to hours or
Milliseconds. days.
DURATION OF THE DURATION OF THE
ACTION: ACTION:
Generally short. Generally long.
ENDOCRINE SYSTEM: WHAT?
1. HOMEOSTASIS.
3. COMBATING STRESS.
7. REPRODUCTION.
ENDOCRINES ARE USEFUL FOR…
1. HOMEOSTASIS
Endocrines help us
in maintaining the
homeostasis of:
Temperature:
Thermoregulation
or thermostasis.
Metabolism
Nutrition:
Glucostasis
Acid Base Balance
ENDOCRINES ARE USEFUL IN…
2. COMBATING STRESS
INFECTION
TRAUMA
SHOCK
ENDOCRINES ARE USEFUL FOR…
3. GROWTH & DEVELOPMENT
Increase in the
cell number:
Hyperplasia
Increase in cell
SIZE:
Hypertrophy.
ENDOCRINES ARE USEFUL FOR… 4.
REPRODUCTION
The Male and
female Gonads
secrete:
Sex Hormones
These sex
hormones cause
the development of
Primary sex organs
Secondary sexual
characteristics.
ENDOCRINE PHYSIOLOGY:
METHODS OF STUDY
DESCRIPTIVE: ANATOMICAL
CHEMICAL:
Proteins
Amino acids, Polypeptides, etc.
IMMUNOLOGICAL
EXPERIMENTAL
CLINICAL:
Hypo
Hyper
DESCRIPTIVE STUDIES
Anatomical:
There is a
structure,
looks like a
gland.
What does it
secrete?
Does it have a
function?
CHEMICAL STUDIES
Proteins
Polypeptides
Amino acids
Do they have any physiological
actions?
Experiment to find out.
Beginning with existing secreted
chemicals.
IMMUNOLOGICAL STUDIES
Testes
Ovaries
HORMONES PRODUCED IN THE
BODY
HYPOTHALAMUS:
CRH, TRH, GHRH, GHIH, GnRH, PIH.
ANTERIOR PITUITARY GLAND:
GH, ACTH, TSH, FSH, LH, Prolactin.
POSTERIOR PITUITARY GLAND:
ADH, & Oxytocin.
THYROID GLAND:
Thyroxin, T3, Calcitonin.
HORMONES PRODUCED IN THE
BODY
ADRENAL CORTEX:
Aldosterone, Cortisol, Sex steroids.
ADRENAL MEDULLA:
Epinephrine, Norepinephrine, Dopamine.
ENDOCRINE PANCREAS:
Glucagon, Insulin, Somatostatin, Pan
polypeptide.
HORMONES PRODUCED IN THE
BODY
TESTES:
Testosterone, Estrogen, Inhibin.
OVARY:
Estrogens, Progesterone, Relaxin.
PLACENTA:
Estrogens, Progesterone, HCG, HPL.
THYMUS:
Thymosin.
PINEAL GLAND:
Melatonin.
ENDOCRINE PHYSIOLOGY:
APPLIED PHYSIOLOGY
HYPERSECRETION:
Excessive Production of hormones due to:
Tumors in the gland.
Excess tropic influence.
Results in:
Clinical syndromes with signs/symptoms due to:
Increased blood levels of the hormone
Example: Hyperthyroidism: Thyroxin levels
Clinical features: Fine tremor, Anxiety, PR,
BMR
Acromegaly: Growth Hormone.
ENDOCRINE PHYSIOLOGY:
APPLIED PHYSIOLOGY
HYPOSECRETION:
Drop in the production of hormones due
to:
Excision of gland: Eg: Parathyroids.
Hypofunctioning of gland cellls: Eg: Diabetes
milletus.
Decreased tropic influence.
Results in:
Clinical features/ syndromes due to
blood levels of the hormone
HYPOTHALAMO
-HYPOPHYSIAL AXIS
By
Dr. M. Anthony David, MD
Professor of Physiology
WHAT IS Hypothalamo-
Hypophyseal AXIS?
The connection between the
Hypothalamus, a part of the Nervous
System and the Endocrine System.
The part of the Nervous System
involved is the Hypothalamus.
The part of the Endocrine System
involved is the Pituitary gland, also
called as Hypophysis Cerebri.
THE ENDOCRINE ORCHESTRA
HYPOTHALAMUS
THYROID
The Endocrine
ADRENAL
glands act as if
they are a part of
an orchestra.
The Conductor is
the Pituitary
Gland.
OVARY
The brains of the
Conductor, which
runs him, is the
Hypothalamus!
HYPOTHALAMO-HYPOPHYSIAL
CONNECTIONS
VASCULAR NEURAL
Between the Median Between the
Eminence of the Supraoptic &
Hypothalamus & the Paraventricular Nuclei
Anterior Pituitary. in the Hypothalamus
The Hypothalamo- & the Posterior
hypophysial portal Pituitary.
system. The Hypothalamo-
Vascular connection: hypophysial tract.
Carries Neural connection:
Hypophysiotropic Carries the secreted
hormones. hormones, ADH &
Oxytocin, from the
Hypothalamus to the
Post Pituitary.
H-H AXIS: Physiologic
Anatomy
HYPOTHALAMIC HORMONES
Synonym: Hypophysio-tropic
Hormones.
Secreted and released by the
Hypothalamic neuro-secretory cells,
to act on the Anterior Pituitary cells.
May be Stimulatory or Releasing
Hormones or Inhibitory in nature.
This hypothalamo - hypophysial
system is a Cascade Amplifier.
CASCADE AMPLIFICATION
HYPOTHALAMUS
Hypophysiotropic
Hormones in Nanograms
Eg: TRH
ADENOHYPOPHYSIS
Adenohypophysial tropic
Hormones in Micrograms
Eg: TSH
TARGET GLAND
Hormone
In Milligrams
Eg: Thyroxine
HYPOPHYSIOTROPIC
HORMONES
The neuro-secretory cells in the
Hypothalamus in turn are regulated
by numerous nerve pathways
projecting on to the Hypothalamus.
HYPOPHYSIOTROPIC
HORMONES
GONADOTROPIN RELEASING HORMONE
(GnRH)
GROWTH HORMONE RELEASING
HORMONE(GHRH)
GROWTH HORMONE INHIBITING HORMONE
( SOMATOSTATIN ) (GHIH)
THYROTROPIN RELEASING HORMONE
(TRH)
PROLACTIN INHIBITING HORMONE (PIH)
CORTICOTROPIN RELEASING HORMONE
HYPOTHALAMUS
GHIH
GnRH GHRH TRH PIH CRH
SS
ANTERIOR PITUITARY
RELEASING FACTORS INHIBITING FACTORS
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HYPOTHALAMO-HYPOPHYSIAL
NERVOUS TRACT
REVIEW: H- H AXIS
Two connections between the two
Control systems:
Vascular: Between the ME of
Hypothalamus & the Anterior Pituitary or
Adenohypophysis.
“The H-H Portal System”
Neural: Between the SO & PV Nuclei in
the Hypothalamus & the Posterior
Pituitary or the Neurohypophysis.
“The H-H Nervous Tract”