Male Reproductive System: Nur Anisah

MALE REPRODUCTIVE SYSTEM
Nur Anisah

Department of Histology & Cell Biology
Faculty of Medicine Gadjah Mada University

1 nur anisah 24/2/09
Testis
-- Components:
Adventitia (lamina propria or tunica propria)
of seminiferous tubules
Cells: -- Leydig, Sertoli, spermatid,spermatocyte,
spermatogonium, spermatozoan
Mediastinum testis
Rete testis
Tubuli recti
Tunica albuginea
Tunica vaginalis (peritoneum)

Miscellaneous male tubules
Efferent duct
Epididymis-head and tail
Ductus deferens
Seminal vesicle
Ejaculatory duct
Spermatic cord
Stereocilia

Penis:
- Corpus cavernosum and
spongiosum
- Gland of Littre
- Tunica albuginea
- Urethra

Prostate:
- Corpora amylacea
- Prostate (young and old)
I. Testis and Passages

The tunica albuginea.
The visceral layer of the
tunica vaginalis testis.
The large blood vessel,
and inside of that the
Tunica Vasculosa.
Connective tissue septae
from the Tunica
Vasculosa separate the
seminiferous tubules
from one another.


Pararosanilinetoluidine
blue (PT) stain.
Medium magnification.
Testis :
- seminiferous
tubules
- groups of pale-
stained interstitial
(Leydig) cells
(arrowheads).
Fig. Epithelium of
seminiferous tubules
surrounded by myoid
cells.

- The spaces between
the tubules :
- connective tissue,
- blood and lymphatic
vessels, and
- interstitial cells.

PT stain.
Figure . Part of a seminiferous tubule with its surrounding tissues.
The seminiferous epithelium is formed by 2 cell populations: the
cells of the spermatogenic lineage and the supporting or Sertoli
cells.
Part of the wall of a
seminiferous tubule.
- Several cells of the
spermatogenic
lineage are present:
* a spermatogonium,
Primary
spermatocytes,
young and late
spermatids.

The approximate limits
of a Sertoli cell holding
several spermatids are
delineated.
H&E stain.
High magnification.
Sistem saluran
A. Tubulus seminifer convolutus lumen
terjadi sejak fetus berusia 7 bulan.
i. epithelium spermatogenicum : -2 jenis sel:
- gonocytus, sel kelamin, membentuk 3 lapis,
dari luar ke dalam/basal kearah lumen
Spermatogonium, dengan gambaran mitosis
Ada 2 jenis:
tipe A, Inti oval
Tipe B, inti berbentuk cakram
Spermatocytus primarius, inti dengan
gambaran meiosis
Spermatocytus secundarius, sel lebih kecil,
terdapat lebih ke arah lumen
Spermatidium, sel memanjang dengan inti
ovoid
Spermatozoon :
di dlm testis dng perantaran caput
terpancang pd epitheliocytus sustentans
(dulu dsbt sel Sertoli) inti berbentuk spt
piramid
pada epididymis terdapat di dlm lumen
Figure .
Diagram showing the clonal nature of the germ
cells.
Only the initial spermatogonia divide and produce
separate daughter cells.
Once committed to differentiation, the cells of all
subsequent divisions stay connected by
intercellular cytoplasmic bridges.
Only after they are separated from the residual
bodies can the spermatozoa be considered
isolated cells.
(Modified and reproduced, with permission, from
Bloom W, Fawcett DW: A Textbook of Histology, 10th
ed. Saunders, 1975.)
Fig. Interstitial cells and cells of the seminiferous
epithelium.
H&E stain. High magnification.
The Sertoli cells
form
the blood-testis
barrier.
Figure 2212. The Sertoli cells form the blood-testis
barrier. Neighbor Sertoli cells are attached by
occluding junctions that divide the seminiferous
tubules into 2 compartments and impede the passage
of substances between both compartments. The basal
compartment comprises the interstitial space and the
spaces occupied by the spermatogonia. The adluminal
compartment comprises the tubule lumen and the
intercellular spaces down to the level of the occluding
junctions (OJ). In this compartment are spermatocytes,
spermatids, and spermatozoa. Cytoplasmic residual
bodies from spermatids undergo phagocytosis by the
Sertoli cells and are digested by lysosomal enzymes.
The myoid cells surround the seminiferous epithelium.
Figure 2213. Hypophyseal
control of male reproduction.

Luteinizing hormone (LH) acts
on the Leydig cells, and follicle-
stimulating hormone (FSH) acts
on the seminiferous tubules.

A testicular hormone, inhibin,
inhibits FSH secretion in the
pituitary. ABP, androgen-binding
protein. (Modified and
reproduced, with permission,
from Bloom W, Fawcett DW: A
Textbook of Histology, 10th ed.
Saunders, 1975.)
Surrounding the
epithelium is a coat of
smooth muscle (that
thickens distally).
At the junction with the
ductus deferens (not
shown), this coat is
trilaminar.
In other words, as one
Human epididymis
- pseudostratified
columnar epithelium
consisting primarily of
tall principal cells
(getting shorter
distally) with
stereocilia (getting
shorter distally) and
basal cells.
In other words, as one moves from
head to tail, the epithelium gets
shorter, the stereocilia get shorter, and
the muscle gets thicker.
Figure 2215. The highly
coiled ductus epididymidis,
sectioned several times.

Its wall is made of a
pseudostratified columnar
epithelium surrounded by
connective tissue and smooth
muscle.

PSH stain. Medium
magnification. Inset: Higher
magnification of the epithelial
cells with their long microvilli
(stereocilia).
24/2/09 nur anisah 1
Ductus deferens, (human)
Note the longitudinal folds in the mucosa, which are lined by
pseudostratified columnar epithelium.
Find the smooth muscle layers and lamina propria.
What is the function of the extremely thick muscular coat?

Figure 2216. Section of
the ductus deferens
showing the mucosa
formed by pseudostratified
columnar epithelium with
stereocilia and a lamina
propria. The thick outer wall
is formed of smooth muscle
(brown) and collagen fibers
(blue). Trichrome stain. Low
magnification.
Figure 2217.
Seminal vesicle. A
section of this
tortuous tubular
gland with a much-
folded mucosa gives
the impression that
the gland consists of
many tubules. PSH
stain. Medium
magnification.
Figure 2218. Section of prostate showing the
distribution of its glands in 3 zones. The gland
ducts open into the urethra.
Figure 2219.
Section of the central
region of the prostate
showing the prostatic
urethra and
tubuloalveolar glands
surrounded by
connective tissue and
smooth muscle. PT
stain. Low
magnification.
Figure .Glands of the prostate surrounded by
connective tissue and smooth muscle. PT stain.
Figure. Transverse section of the penis.
1. Pars prostatica:
Tunica mucosa:
Epithelium transitionale,pseudostratificatum
bagian yang terbesar
Lamina propria jar. ikat fibroelastik
Tunicamuscularis:
Stratum longitudinale
Stratum circulare
2. Pars membranacea
3. Pars spongiosa/cavernosa
Urethra

Male Reproductive System: Nur Anisah

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MALE REPRODUCTIVE SYSTEM

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