.

.
.
 .

()
(
/. , )
( )


 99mTc-

in-vivo : )
-SnCl2 , )
)
30 min 99mTcO4-.
in-vitro : ) 10-15 ml
, )
-SnCl2 , )

) 99mTcO4- 5
min
.
99mTc-:
50 0C 20 min
.
99mTc- (-SnCl2 +
99mTcO -)
4

:
I. -Sn(II)
.
II. SnCl2

III. 99mTcO4-
,

 99mTc-

:
I. 99mTc-:
i.

(
),
ii.

iii.

II. 99mTc-

:
i. ()
 [51Cr]-
(Natrii Chromatis (51Cr) solutio sterilis)

51Cr: t1/2 =27.7 d, = 370 keV

20-30 mL (
)
a 51CrO4
37 0C 20 min.

( Cr6+ Cr3+)
T ,
.
:

: ,


I. 10, 20, 60 min

II. : C1V1=C2V2
C1=
V1= o
C2=

V2= o
. C1= 15x106cpm/ml,V1=1mL, C2=5x103cpm/ml
V2=3000mL




99mTc-HMPAO 111In-


5 hr.


111Cd (p, n) 111In
111In (t = 2.8 d) : , 173 keV, 245
1/2
keV




-
95%
,

:

 -67 (67Ga-citrate)

68Zn
(p, 2n) 67Ga
67GaCl + 67Ga-
3
(pH 5-8)
67Ga (t1/2= 72 h) : ,
93, 184, 300 keV
: ,



18F 18(p, n)18F 110 m + ( =511 keV) PET
123I 123e(p,n)123I 13.2 h (159 keV) SPECT
125I
(35.5 keV)
59.4 d /in vitro
124Xe(n,)125mXe125I Auger e-
131I - (606 keV),
130e(n,)131Te131I 8.02 d /
(364.5 keV)

a123/131I.
Na131I , Natrii iodidi (131I) capsulae ad usum
diagnosticum, Natrii iodidi (131I) capsulae ad
usum therapeuticium, Natrii iodidi (131I) solutio
> 99.9%


.
: -133, -135, a3
Per os :
3 hr pi.
90% , 50% 24 h
10-35 % 24 h pi
X: ,
, .

( )
- + , : , -, -
, .. :
O
* + ICl I- + *ICl Cl Cl
N N
O O O
O
S S
Na*I
NH NH2 + *ICl
H+ Electrophile
Cl N N
Chloramine-T Cl Cl

O
Iodogen

 125-

( )
125
-/.

.
: 125-SA
10, 20 , 30 min
.
.
=f(t)
~ 15% .
: C1V1=C2V2
C1=
V1= o
C2=
t=0
V2= o
 [131]--, [131]-IBG
(Iobenguane)
Iobenguani (131I) solutio iniectabilis ad usum diagnosticum:
>20 GBq/gr iobenguane
Iobenguani (131I) solutio iniectabilis ad usum therapeuticum:
>400 GBq/gr iobenguane

. : -,
.
: ,
.
33%
70-90 % 4 .
: :
.
 131-
(Natrii iodohippourati (131I) solutio iniectabilis)

: 97%, --
: 60-70%
.
(20%)
5%
: ,

NaOOC NaOOC

HN HN
O O
I 131 131I
Na I

100 0C

12 (57/58Co-)
57/58Co-, Cyanocobalamini (57Co) capsulae/
solutio, Cyanocobalamini (58Co) capsulae/ solutio,
57Co: t
1/2= 271 d, = 0.122 eV
58Co: t
1/2= 70.9 d, = 0.811 eV, ()=0.511 eV
H 12

.
pH 4-5, ( 6
5 0C).
Per os


12.

Schilling Test: 57Co-B12 58Co-B12

(
12 ).
24. ( 10-15%
12. ,
12)

201TlCl
201TlCl: t1/2 =73.1 h, =70 keV
:
Na+/K+ ATP,
+.
: ,
.
: 201Tl

,
.

.

-




:
,
,





/

-

 F-18

18F: 18(p,n)18F 20He(d,)18F

H218O K18F
18O2 18F2 ( 50%, F2 )
20He 18F2

18F2 + CH3CO2NH4 CH3CO218F + NH418F

: 18F2, CH3CO218F
: [222]/ 18F-

O O

N O K O N

O O
M
 [18F]-
FDG

[18F]-FDG

,
, ,
, , , ,



 [18F]-FDG



/
: ,
( )
:
I. : ,
II. ,
III.

:

(Fab)2, Fab:
,
(Fab)2 Fab
 99mTc
1. (V)
.

CEA-Scan: 99mTc-CEA (Fab, murine IgG1, IMMU-4),

.
: (
) (, ,
)


2. (2S2)
, -

Verluma: 99mTc-NR-LU-10 (Fab, murine IgG2b, )

:
 111In

,



, ,
,
.
 186/188Re-HEDP

186Re: (t1/290,6 h, -=1, 075eV, 137 eV) 185Re(n,) 186Re

188Re: (t 17 h, -=2,11eV, 155 eV) 188W/188Re
1/2

186/188Re-HEDP:
186/188ReO - + SnCl + HEDP 186/188Re-HEDP
4 2

(69% ): Ca10(PO4)6(OH)2

99mTc-TRODAT:

,


.
: Parkinson

E SPECT

99mTc-TRODAT.