BONE REMODELLING

PRAKTIKUM
ANATOMI DAN FISIOLOGI MANUSIA

Mahadri Dhrik, S.Farm., M. Farm. Klin., Apt.

BONE CELLS

• Osteoblast  Build
• Ostecyte  Communicate
• Osteoclast  Chew
BONE PHYSIOLOGY

• Bone is made of collagen and mineral components.

• The collagen component gives bone its flexibility and
energy-absorbing capability.
• The mineral component gives bone its stiffness and
strength.

• The correct balance of these substances is needed

for bone to adequately accommodate to stress and
strain and resist fractures
• Imbalances can impair bone quality and lead to
reduced bone strength.
BONE PHYSIOLOGY

• Bone Resorbsi  Penghancuran tulang

• Osteoclast  Bone resorpsing Cell

• Bone Formasi  Pembentukan Tulang

• Osteoblast  Bone Forming Cell
Bone Remodelling cycle
Bone Remodelling cycle
Bone Remodelling cycle
 Bone Remodelling Description

• Bone is made of collagen and mineral components. The collagen

component gives bone its flexibility and energy-absorbing capability.9
The mineral component gives bone its stiffness and strength. The
correct balance of these substances is needed for bone to adequately
accommodate to stress and strain and resist fractures. Imbalances can
impair bone quality and lead to reduced bone strength.
Bone strength reflects the integration of bone quality and bone
mineral density (bone mass).
• Bone mass increases rapidly throughout childhood and adolescence. Ninety
percent of peak bone mass is
attained by age 18 to 20 years, with small gains until approximately
age 30 years. Peak bone mass is highly dependent on genetic factors
that account for approximately 60% to 80% of the variability.5,10,11
The remaining 20% to 40% is influenced by modifiable factors such
as nutritional intake (e.g., calcium, vitamin D, and protein), exercise,
adverse lifestyle practices (e.g., smoking), hormonal status, and
certain diseases and medications. Optimizing peak bone mass is
important for preventing osteoporosis. The higher the peak bone
mass, the more bone one can lose before being at an increased
fracture risk.
 Bone Remodelling Description

The skeleton is composed of mostly cortical bone (80%) with

some trabecular bone (20%), which varies by bone site. The forearm
is predominantly cortical bone (95%), the spine is predominantly
trabecular bone (66% to 75%), and the femoral neck of the hip and
wrist are mostly cortical bone (50% to 75%, respectively).12 Of note,
trabecular bone has a 5 to 10 times higher metabolic turnover rate
than cortical bone.